[Progress on the effects of cancer-related fibroblast induced by Helicobacter pylori infection on gastric epithelial-mesenchymal transition].

Q3 Medicine

生理学报 Pub Date : 2024-08-25

Yi-Lin Li, Li-Fei Zheng

引用次数: 0

Abstract

Helicobacter pylori (Hp) is a Gram-negative bacterium that colonizes in the gastric mucosa. Hp induces the production of cancer-associated fibroblasts (CAF) in the stomach. The virulence factors of Hp and CAF trigger epithelial-mesenchymal transition (EMT), leading to local inflammation, damage to the gastric mucosa, and the occurrence of chronic gastritis. Here, we summarize the molecular mechanisms of CAF mediated gastric EMT after Hp infection, providing new insights into potential molecular targets and strategies for the future treatment of Hp infection associated gastric cancer.

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[幽门螺杆菌感染诱导的癌症相关成纤维细胞对胃上皮-间质转化影响的研究进展]。

幽门螺杆菌（Hp）是一种定植于胃黏膜的革兰氏阴性细菌。Hp 在胃中诱导产生癌相关成纤维细胞（CAF）。Hp 和 CAF 的毒力因子触发上皮-间质转化（EMT），导致局部炎症、胃黏膜损伤和慢性胃炎的发生。在此，我们总结了Hp感染后CAF介导胃EMT的分子机制，为未来治疗Hp感染相关胃癌的潜在分子靶点和策略提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.