[CDO1调控常见代谢性疾病的分子机制]。

Q3 Medicine

Acta physiologica Sinica Pub Date : 2024-08-25

Qi Liu, Wen-Qing Shen

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引用次数: 0

摘要

半胱氨酸二氧合酶 1 型（CDO1）属于半胱氨酸二氧合酶（CDO）家族。CDO1 是半胱氨酸分解和牛磺酸合成的关键酶。CDO1 在肝、脂肪组织、胰腺、肾、肺、脑和小肠中高度表达。CDO1 参与各种常见代谢性疾病的病理生理调控，如脂质代谢紊乱、胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病。本文总结了近年来CDO1调控常见代谢性疾病分子机制的研究进展，旨在为CDO1靶向治疗胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病提供新的理论和实践依据。

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本刊更多论文

[Molecular mechanism of CDO1 regulating common metabolic diseases].

Cysteine dioxygenase type 1 (CDO1) belongs to the cysteine dioxygenase (CDO) family. CDO1 is the key enzyme in cysteine catabolism and taurine synthesis. CDO1 is highly expressed in liver, adipose tissue, pancreas, kidney, lung, brain and small intestine. CDO1 is involved in the pathophysiological regulation of various common metabolic diseases, such as lipid metabolism disorders, insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases. This article summarizes the research progress on the molecular mechanisms of CDO1 regulation of common metabolic diseases in recent years, aiming to provide new theoretical and practical basis for CDO1-targeted therapy for insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases.

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来源期刊

Acta physiologica Sinica Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.