[The role of the tryptophan-kynurenine pathway in neuropathic pain].

Q3 Medicine

生理学报 Pub Date : 2024-10-25

Zi-Han Wu, Hao-Jun You, Jing Lei

引用次数: 0

Abstract

The kynurenine pathway (KP) is the main metabolic pathway of tryptophan in the diet. Existing research has shown that KP plays a key role in the pathogenesis of various diseases. It has been demonstrated that kynurenine metabolic enzymes, such as indoleamine 2,3-dioxygenase (IDO) and kynurenine monooxygenase (KMO), are involved in various types of pain, particularly the occurrence and development of neuropathic pain. This article reviewed the role of KP, metabolites and enzymes, as well as the analgesic effects and mechanisms of KP in neuropathic pain, providing reference for the application of KP in the basic research and clinical treatment of neuropathic pain.

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[色氨酸-犬尿氨酸途径在神经性疼痛中的作用]。

犬尿氨酸途径（KP）是饮食中色氨酸的主要代谢途径。现有研究表明，KP 在各种疾病的发病机制中起着关键作用。研究表明，犬尿氨酸代谢酶，如吲哚胺 2,3-二氧化酶（IDO）和犬尿氨酸单加氧酶（KMO），参与了各种疼痛，尤其是神经病理性疼痛的发生和发展。本文综述了KP、代谢产物和酶的作用，以及KP在神经病理性疼痛中的镇痛作用和机制，为KP在神经病理性疼痛的基础研究和临床治疗中的应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.