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[High-intensity interval training (HIIT) induces hepatic ketone body production possibly through altering expression of mTORC1, PPARα and FGF21 in mice]. [高强度间歇训练（HIIT）可能通过改变小鼠体内 mTORC1、PPARα 和 FGF21 的表达诱导肝酮体的产生】。］
Acta physiologica Sinica Pub Date : 2024-04-25
Jun Liu, Shu-Jie Lou
{"title":"[High-intensity interval training (HIIT) induces hepatic ketone body production possibly through altering expression of mTORC1, PPARα and FGF21 in mice].","authors":"Jun Liu, Shu-Jie Lou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study aims to investigate the production of ketone body in the liver of mice after 6 weeks of high-intensity interval training (HIIT) intervention and explore the possible mechanisms. Male C57BL/6J mice (7-week-old) were randomly divided into control and HIIT groups. The control group did not engage in exercise, while the HIIT group underwent a 6-week HIIT (10° slope treadmill exercise). Changes in weight and body composition were recorded, and blood ketone body levels were measured before, immediately after, and 1 h after each HIIT exercise. After 6-week HIIT, the levels of free fatty acids in the liver and serum were detected using reagent kits, and expression levels of regulatory factors and key enzymes of ketone body production in the mouse liver were detected by Western blot and qPCR. The results showed that, the blood ketone body levels in the HIIT group significantly increased immediately after a single HIIT and 1 h after HIIT, compared with that before HIIT. The body weight of the control group gradually increased within 6 weeks, while the HIIT group mice did not show significant weight gain. After 6-week HIIT, compared with the control group, the HIIT group showed decreased body fat ratio, increased lean body weight ratio, and increased free fatty acid levels in liver and serum. Liver carnitine palmitoyl transferase-I (CPT-I), peroxisome proliferator activated receptor α (PPARα), and fibroblast growth factor 21 (FGF21) protein expression levels were up-regulated, whereas mammalian target of rapamycin complex 1 (mTORC1) protein expression level was significantly down-regulated in the HIIT group, compared with those in the control group. These results suggest that HIIT induces hepatic ketone body production through altering mTORC1, PPARα and FGF21 expression in mice.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 2","pages":"224-232"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases. 关于鸢尾素对阿尔茨海默病患者认知功能障碍的调控机制以及鸢尾素在相关疾病中的干预作用的研究进展。
Acta physiologica Sinica Pub Date : 2024-04-25
Tian Lan, Zong-Cheng Guo, Hao-Ran Gu, Lu Qin, En-Peng He
{"title":"Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases.","authors":"Tian Lan, Zong-Cheng Guo, Hao-Ran Gu, Lu Qin, En-Peng He","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Irisin, a peptide produced during exercise, is believed to play a role in regulating energy levels within the body. Moreover, Irisin has the ability to traverse the blood-brain barrier and engage in various pathophysiological processes within the central nervous system. An increasing body of research identifies Irisin as a significant therapeutic target for neurodegenerative diseases, indicating a strong link between Irisin and the development of cognitive impairments. In this paper, we present a concise review of effects of different types of exercise on Irisin production, and the mechanisms underlying the Irisin's intervention in various diseases including metabolic diseases, kidney injury and depression. Following this, we delve into an in-depth exploration of its role in modulating cognitive dysfunction among patients with Alzheimer's disease (AD), focusing on recent advancements in three critical areas: neuroinflammation, mitochondrial dysfunction, and protein misfolding. Finally, we put forth 3 hypotheses: (1) exercise-induced fibronectin type III domain containing protein 5 (FNDC5) stimulation and subsequent Irisin cleavage may be associated with the stress response in energy metabolism; (2) Irisin, as a myokine, likely plays a role in mitochondrial repair mechanisms to ameliorate cognitive impairment in AD patients; (3) Irisin is a homeostatic factor that maintains energy homeostasis and is closely related to the dynamic stability of the body's internal environment.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 2","pages":"266-288"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma]. [参与肝癌糖酵解调控的非编码 RNA 的研究进展]。
Acta physiologica Sinica Pub Date : 2024-04-25
Xiao-Feng Hu, Qing Zhang, Mei-Lv Liang, Qing-Niao Zhou, Rui-Qiang Zhao, Zu-Kang Gong, Wen-Zhen Lin
{"title":"[Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma].","authors":"Xiao-Feng Hu, Qing Zhang, Mei-Lv Liang, Qing-Niao Zhou, Rui-Qiang Zhao, Zu-Kang Gong, Wen-Zhen Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis. Glucose metabolism is one of the main ways for cells to produce energy. Glycolysis, as the basic reaction of glucose metabolism, plays an important role in cell metabolism. Therefore, the regulation of glycolysis is of great significance to the proliferation and evolution of tumors. More and more non-coding RNAs (ncRNA) have been proved to play an important role in the regulation of tumor glycolysis. This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 2","pages":"319-328"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in the study of the actin nucleation factor Spire]. [肌动蛋白成核因子 Spire 的研究进展]。
Acta physiologica Sinica Pub Date : 2024-04-25
Tao Pang, Li-Xia Zhang, An-Na Bai, Wen Yang, Li-Xia Hao
{"title":"[Advances in the study of the actin nucleation factor Spire].","authors":"Tao Pang, Li-Xia Zhang, An-Na Bai, Wen Yang, Li-Xia Hao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There are three main classes of actin nucleation factors: Arp2/3 complexes, Spire and Formin. Spire assembles microfilaments by nucleating stable longitudinal tetramers and binding actin to the growing end of the microfilament. As early as 1999, Wellington et al. identified Spire as an actin nucleating agent, however, over the years, most studies have focused on Arp2/3 and Formin proteins; there has been relatively less research on Spire as a member of the actin nucleating factors. Recent studies have shown that Spire is involved in the vesicular transport through the synthesis of actin and plays an important role in neural development. In this paper, we reviewed the structure, expression and function of Spire, and its association with disease in order to identify meaningful potential directions for studies on Spire.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 2","pages":"341-345"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Deficiency of cathepsin K improves ischemic angiogenesis in high-fat diet fed mice]. [缺乏 cathepsin K 可改善高脂饮食喂养小鼠的缺血性血管生成]。
Acta physiologica Sinica Pub Date : 2024-02-25
Xin-Yi Wang, Xu Wang, Zhen-Jie He, Shi-Piao Chen, Wei-Jian Li, Ren-Shan Cui, Hai-Ying Jiang
{"title":"[Deficiency of cathepsin K improves ischemic angiogenesis in high-fat diet fed mice].","authors":"Xin-Yi Wang, Xu Wang, Zhen-Jie He, Shi-Piao Chen, Wei-Jian Li, Ren-Shan Cui, Hai-Ying Jiang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study aims to investigate the effect of cathepsin K (CatK) on ischemic angiogenesis in high-fat diet fed mice. The mice were subjected to unilateral hindlimb ischemic surgery, and the ischemic blood flow was measured with a laser Doppler blood flow imager. Immunohistochemical staining was used to observe the quantity of new capillaries in the ischemic lower extremity, and Western blot was used to detect the expression of insulin receptor substrate-1 (IRS-1), p-Akt, Akt and vascular endothelial growth factor (VEGF). Firstly, the effect of high-fat diet on ischemic angiogenesis was observed in wild-type mice, which were randomly divided into control group and high-fat diet group and were fed with normal diet or 60% high-fat diet respectively for 16 weeks. The results showed the body weight and the plasma CatK concentration of the high-fat diet group was significantly increased compared with the control group (P < 0.05), and the blood flow recovery of the high-fat diet group was significantly lower than control group (P < 0.05). Then, wild-type and CatK knock out (CatK<sup>-/-</sup>) mice were both fed with high-fat diet to further observe the effect and mechanism of CatK on ischemic angiogenesis under high-fat diet. The results showed that the blood flow recovery in the CatK<sup>-/-</sup> group was significantly greater than the wild-type group, and the number of CD31 positive cells was significantly increased (P < 0.05). At the same time, the protein expression levels of IRS-1, p-Akt and VEGF in the ischemic skeletal muscle were significantly increased in the CatK<sup>-/-</sup> group compared with the wild-type group (P < 0.05). These results suggest that the deficiency of CatK improves ischemic angiogenesis in high-fat diet fed mice through IRS-1-Akt-VEGF signaling pathway.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of trace amine-associated receptor 1 signaling pathways]. [痕量胺相关受体 1 信号通路的研究进展]。
Acta physiologica Sinica Pub Date : 2024-02-25
Meng Sun, Chen-Chen Zhang, Ji-Tao Li, Tian-Mei Si, Yun-Ai Su
{"title":"[Research progress of trace amine-associated receptor 1 signaling pathways].","authors":"Meng Sun, Chen-Chen Zhang, Ji-Tao Li, Tian-Mei Si, Yun-Ai Su","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Trace amine-associated receptor 1 (TAAR1) is a classical type of G-protein-coupled receptor, which is widely distributed in the brain of mammals, especially in the limbic system and the region rich in monoaminergic neurons, and it is a highly conserved TAAR subtype in all species. TAAR1 can specifically respond to endogenous trace amines in the central nervous system and peripheral tissues, and plays an important role in the pathophysiological mechanisms involving the dysregulation of monoamine system and glutamate system leading to mental disorders. In addition, TAAR1 modulator can act on inwardly rectifying potassium channels and regulate synaptic transmission and neuronal activity. According to the latest research findings, TAAR1 exerts a series of functions by regulating signal pathways and substrate phosphorylation, which is related to emotion, cognition, fear and addiction. Therefore, we conducted a detailed review of relevant studies on the TAAR1 signaling pathways, aiming at revealing the great potential of TAAR1 as a new target for drug treatment of neuropsychiatric disorders.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 1","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Recording and identification of depolarization-activated current in intercalated cells]. [记录和识别闰层细胞中的去极化激活电流]。
Acta physiologica Sinica Pub Date : 2024-02-25
Wen-Sen Shi, Zheng Ding, Qi Sun, Xin-Peng Duan, Cheng-Biao Zhang
{"title":"[Recording and identification of depolarization-activated current in intercalated cells].","authors":"Wen-Sen Shi, Zheng Ding, Qi Sun, Xin-Peng Duan, Cheng-Biao Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The depolarization-activated current of intercalated cells in the distal nephron was detected for the first time, and the type of ion channel mediating the current was identified based on electrophysiological and pharmacological properties. The whole-cell current of distal nephron in kidney of C57BL/6J mice was recorded by Axon MultiClamp 700B patch-clamp system, and the effects of several K<sup>+</sup> channel inhibitors on the depolarization-activated current in intercalated cells were observed. In addition, the immunofluorescence technique was used to investigate the localization of the channel in intercalated cells. The results showed that when K<sup>+</sup> concentration of the bath solution was equal to intracellular fluid (140 mmol/L K<sup>+</sup>), the depolarization-activated current could be recorded in intercalated cells, but this current was not observed in the principal cells. The depolarization-activated current detected in the intercalated cells could be blocked by Kv4.1 inhibitors. The immunofluorescence experiment showed that the fluorescence of Kv4.1 protein was only present in intercalated cells and not observed in principal cells. Kv4.1 protein immunofluorescence was observed in the luminal and basolateral membrane of intercalated cells, but the fluorescence intensity of luminal membrane was higher than that of basolateral membrane. We conclude that the depolarization-activated current detected in intercalated cells is mediated by Kv4.1 and this channel is mainly expressed in the luminal membrane of intercalated cells.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research advances of prostaglandin E2 receptor 1 (EP1)]. [前列腺素 E2 受体 1（EP1）的研究进展]。
Acta physiologica Sinica Pub Date : 2024-02-25
Shu-Tao Chen, Shuang Ji, Mei-Na Guo, Li-Hong Chen
{"title":"[Research advances of prostaglandin E<sub>2</sub> receptor 1 (EP1)].","authors":"Shu-Tao Chen, Shuang Ji, Mei-Na Guo, Li-Hong Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prostaglandin E<sub>2</sub> (PGE2) is an important lipid molecule derived from arachidonic acid, which regulates a variety of physiological and pathological activities. Based on the inhibition of inflammatory PGE<sub>2</sub> production, non-steroidal anti-inflammatory drugs (NSAIDs) are considered as the most commonly used drugs to treat inflammatory diseases and to relieve fever and pain symptoms. PGE<sub>2</sub> mediates its functions via four different G protein-coupled receptors, named EP1-EP4. Though the limited distribution and low PGE<sub>2</sub> affinity of EP1, it plays important roles in the maintenance of many physiological functions and homeostasis. Moreover, EP1 is widely involved in the inflammatory response, pain perception and multisystem pathological function regulation. In this review, we will briefly summarize the recent advances on the physiological and pathophysiological function of EP1 and its targeted drugs development.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 1","pages":"105-118"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Abnormalities in signal transduction of Purkinje cells in spinocerebellar ataxias: a review]. [脊髓小脑共济失调症中普金杰细胞信号传导异常：综述]。
Acta physiologica Sinica Pub Date : 2024-02-25
Qiong Wu, Qing-Yun Huang, Guo-He Tan
{"title":"[Abnormalities in signal transduction of Purkinje cells in spinocerebellar ataxias: a review].","authors":"Qiong Wu, Qing-Yun Huang, Guo-He Tan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spinocerebellar ataxias (SCAs) are a group of autosomal dominant neurodegenerative diseases that have been currently identified with numerous subtypes exhibiting genetic heterogeneity and clinical variability. Purkinje neuronal degeneration and cerebellar atrophy are common pathological features among most SCA subtypes. The physiological functions of Purkinje cells are regulated by multiple factors, and their dysfunction in signal transduction may lead to abnormal cerebellar motor control. This review summarizes the abnormalities in voltage-gated ionic channels, intracellular calcium signaling, and glutamate signaling transduction of Purkinje cells in SCAs, aiming to provide a theoretical basis for further understanding the common pathogenesis of SCAs and developing specific treatments.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 1","pages":"77-88"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulatory mechanisms of mitochondrial dynamics and its emerging role in renal pathophysiology]. [线粒体动力学的调控机制及其在肾脏病理生理学中的新作用]。
Acta physiologica Sinica Pub Date : 2024-02-25
Zi-Xuan Tan, Wu-Zheng Zhu
{"title":"[Regulatory mechanisms of mitochondrial dynamics and its emerging role in renal pathophysiology].","authors":"Zi-Xuan Tan, Wu-Zheng Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mitochondria are dynamically changing organelles that maintain stable mitochondrial morphology, number, and function through constant fusion and division, a process known as mitochondrial dynamics, which is an important mechanism for mitochondrial quality control. Excessive fusion and division of mitochondria can lead to a homeostatic imbalance in mitochondrial dynamics, causing mitochondrial dysfunction, leading to cellular damage, and even death. The physiological functions of the kidney are mainly powered by mitochondria, and homeostatic imbalance in mitochondrial dynamics affects mitochondrial function and is closely related to renal diseases such as acute kidney injury and diabetic nephropathy. This article reviews the regulation of mitochondrial kinetics, how imbalances in mitochondrial kinetic homeostasis affect mitochondrial injury, and the impact of mitochondrial injury on renal pathophysiology, in order to improve understanding and knowledge of the role of mitochondria in renal disease.</p>","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"76 1","pages":"148-160"},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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