Acta Informatica Medica最新文献

{"title":"Optical Coherence Tomography (OCT) Diagnostic of Retinitis Pigmentosa - Case Study.","authors":"Melita Adilovic,&nbsp;Emira Ignjatic,&nbsp;Arnes Cabric","doi":"10.5455/aim.2022.30.329-333","DOIUrl":"https://doi.org/10.5455/aim.2022.30.329-333","url":null,"abstract":"<p><strong>Background: </strong>Retinitis pigmentosa (RP) is a set of inherited rod-cone degenerative diseases that clinically presents with similar signs and symptoms. Mutations in one of more than 70 genes are involved. Patients will commonly present with bone-spicule pigment formation, waxy optic nerve pallor, and attenuated blood vessels in the posterior pole.Symptoms often begin with progressive night blindness, mid-peripheral visual field defects, and eventual tunnel vision. Central vision loss will ultimately occur following loss of rod function. Complete blindness is uncommon.</p><p><strong>Objective: </strong>The aim of this article is to present two cases of retinitis pigmentosa (mother and daughter) trough optalmologic exams in our clinic. The next aim it to show how to menage a low vision service and to treat cystoid macular oedema as a complication of retinitis pigmentosa.</p><p><strong>Methods: </strong>All medical reports are shown in this article. Every diagnostic tool as well as report is a part from our archived history of the patients and has been throughly analysed. We also reviewed available literature using the key words retinitis pigmentosa, cystoid macular oedema, gene therapy.</p><p><strong>Case presentation: </strong>A 38 year old female patient for a low vision consultation. The patient was legally blind secondary to retinitis pigmentosa, which was diagnosed in her late 20s. She reported gradually progressive hazy central vision and decreasing peripheral vision in both eyes as well as severe night blindness. Other than the diagnosis of retinitis pigmentosa in both eyes,the patient had no other remarkable ocular conditions. Findings at that visit included unaided distance visual acuities VOD: 0,04 VOS: 0,06. Pupils were round with brisk responses. Extraocular muscle motility was full in both eyes. Confrontation methode visual fields were noted as temporal loss in the right eye and superior and temporal loss in the left eye. The perimetry test could not be performed due to the lack of correspondece of the patient even after a couple repetitions of the perimetry. She had normal ocular adnexa and quiet lids, conjunctiva, and sclera in both eyes. Corneas in both eyes were noted as clear epithelium, clear stroma, and clear endothelium. Anterior chambers had normal depth, iris with no pathological findings in both eyes; lens incipient sclerotic. Intraocular pressures were noted as 22 mmHg in both eyes with Icare, 21mmHg and 19 mmHg with aplanation tonometry; pahimetry corretional factor was +1 on both eyes. The vitreous was clear in both eyes. Both optic nerves were measured as 0.4 cup-to-disc ratios with no disc edema, disc hemorrhages, notching, or thinning noted.Waxy disc pallor and attenuated blood vessels were observed in both eyes. The macula in both eyes had retinal pigment epithelium (RPE) changes with no edema or hemorrhages. Bone spicule changes were noted 360 in the periphery of both eyes with no holes or tears(Figu","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"329-333"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/66/AIM-30-329.PMC9665416.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the Development of a Mobile Application for Cardiac Patients.","authors":"Assiya Turgambayeva,&nbsp;Shynar Kulbayeva,&nbsp;Zhanat Sadibekova,&nbsp;Anar Tursynbekova,&nbsp;Gulzat Sarsenbayeva,&nbsp;Marina Zhanaliyeva,&nbsp;Tolkyn Zhakupova","doi":"10.5455/aim.2022.30.302-307","DOIUrl":"https://doi.org/10.5455/aim.2022.30.302-307","url":null,"abstract":"<p><strong>Background: </strong>An important global public health problem in many economically developed countries, in particular in Kazakhstan, is the leading cause of morbidity and mortality from cardiovascular disease (CVD), both in urban and rural areas.</p><p><strong>Objective: </strong>This study aims to develop the design of a mobile application for smartphones for cardiac patients, taking into account the specifics of outpatient care.</p><p><strong>Methods: </strong>This methodological study includes identified educational and prevention content for CVD patients to develop an education and monitoring tool using a smartphone app. The application was developed according to the stages of analysis, design, development, implementation and evaluation, which is a systematic training model of design. The levels of satisfaction with the developed application for smartphones among 65 outpatients with CVD were assessed using a questionnaire during their visit to a medical organization.</p><p><strong>Results: </strong>The «My Heart» smartphone app was developed based on a review of the literature related to educating patients with CVD, consulting specialists, monitoring and searching for medical smartphone applications that are already available. The content of education and registration includes three main sections, containing basic questions on registration and monitoring of the condition, materials on education and prevention of CVD, such as a daily questionnaire and nutritional advice. After modification based on expert feedback, the application was finally developed and evaluated by patients who reported being satisfied with the usefulness of the application.</p><p><strong>Conclusions: </strong>This application is developed as a research tool to further conduct a study in CVD patients. Current evaluation was a pilot testing wherein this application showed promising results.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"302-307"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/2f/AIM-30-302.PMC9665427.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Time-Varying Biomarkers in Mortality Outcome in COVID-19: an Application of Extended Cox Regression Model.","authors":"Zahra Geraili,&nbsp;Karimollah Hajian-Tilaki,&nbsp;Masomeh Bayani,&nbsp;Seyed Reza Hosseini,&nbsp;Soraya Khafri,&nbsp;Soheil Ebrahimpour,&nbsp;Mostafa Javanian,&nbsp;Arefeh Babazadeh,&nbsp;Mehran Shokri","doi":"10.5455/aim.2022.30.295-301","DOIUrl":"https://doi.org/10.5455/aim.2022.30.295-301","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 pandemic has created many challenges for clinicians. The monitoring trend for laboratory biomarkers is helpful to provide additional information to determine the role of those in the severity status and death outcome.</p><p><strong>Objective: </strong>This article aimed to evaluate the time-varying biomarkers by LOWESS Plot, check the proportional hazard assumption, and use to extended Cox model if it is violated.</p><p><strong>Methods: </strong>In the retrospective study, we evaluated a total of 1641 samples of confirmed patients with COVID-19 from October until March 2021 and referred them to the central hospital of Ayatollah Rohani Hospital affiliated with Babol University of medical sciences, Iran. We measured four biomarkers AST, LDH, NLR, and lymphocyte in over the hospitalization to find out the influence of those on the rate of death of COVID-19 patients.</p><p><strong>Results: </strong>The standard Cox model suggested that all biomarkers were prognostic factors of death (AST: HR=2.89, P<0.001, Lymphocyte: HR=2.60, P=0.004, LDH: HR=2.60, P=0.006, NLR: HR=1.80, P<0.001). The additional evaluation showed that the PH assumption was not met for the NLR biomarker. NLR biomarkers had a significant time-varying effect, and its effect increase over time (HR(t)=exp (0.234+0.261×log(t)), p=0.001). While the main effect of NLR did not show any significant effect on death outcome (HR=1.26, P=0.097).</p><p><strong>Conclusion: </strong>The reversal of results between the Cox PH model and the extended Cox model provides insight into the value of considering time-varying covariates in the analysis, which can lead to misleading results otherwise.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/30/AIM-30-295.PMC9665419.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Occasion of 70th Anniversary of Life and 45 Years of Academic Work of Academician Izet Masic.","authors":"Slobodan M Jankovic,&nbsp;Doncho M Donev,&nbsp;Muharem Zildzic,&nbsp;Izet Hozo,&nbsp;Jacob Bergsland","doi":"10.5455/aim.2022.30.268-282","DOIUrl":"https://doi.org/10.5455/aim.2022.30.268-282","url":null,"abstract":"<p><p>In the hilly Balkans, a folk proverb has been circulating for a long time, \"It is most difficult to be a prophet in one's own village\", which reflects the age-old mistrust of the population towards new ideas. This is not surprising in the least, because since the written history of the peoples of the Balkans has existed, a continuous series of conquerors and local rulers who subjugated the common folks and imposed their world view can be traced. Nevertheless, from time to time, people with great strength appear who not only break the shackles imposed by the powerful, but through their actions find a way to the souls of their compatriots and gain their unreserved trust. One of such spontaneous creators is professor Izet Mašić, who achieved a miracle of medical publishing in his Sarajevo and Bosnia and Herzegovina and traced the path of medical science. There may be thousands of medical journals in the world, more or less reputable, and researchers from the Balkans can publish their work in them, but only domestic medical journals can initiate and direct domestic medical research, and educate young researchers in the right way. Professor Mašić made it possible for authors from Bosnia and Herzegovina and other Balkan countries to present their results to the world and receive an incentive from impartial experts to continue their work and progress more and more by editing and publishing three domestic journals at once, which are visible in the most important world bases,. The progress in research then translated into improving medical practice and health care of the population. The following details from Professor Mašić's biography tell us how this miracle happened. This year, academician Izet Mašić, Editor-in-Chief of a few biomedical journals, including Acta Informatica Medica journal, celebrates his 70th birthday and also 45 years of his academic and scientific work.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"268-282"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/d1/AIM-30-268.PMC9665420.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35347276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Surveillance Model of Tuberculosis Transmission Control Based on Geographic Information System in the Primary Health Care.","authors":"Bahtera Bindavid Purba,&nbsp;Albiner Siagian,&nbsp;Juanita,&nbsp;Evawany Aritonang,&nbsp;Dahlia Purba","doi":"10.5455/aim.2022.30.287-294","DOIUrl":"https://doi.org/10.5455/aim.2022.30.287-294","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis can cause a substantial challenge against public health, especially in the developing countries which have low level of socio-economic condition that does not support the control over tuberculosis transmission and infection.</p><p><strong>Objective: </strong>To find a new surveillance model of tuberculosis transmission control based on geographic information system data in improving the tuberculosis transmission control and treatment outcome.</p><p><strong>Methods: </strong>Effectiveness test of the self-monitoring of calendar documentation on the tuberculosis transmission control and outcome treatment with quasi-experimental post-test only with control group design. The analytical unit consisted of 96 tuberculosis cases as the self-monitoring group of calendar documentation (intervention) and 87 tuberculosis cases as the control group sourced of two different primary health care.</p><p><strong>Results: </strong>The self-monitoring intervention of calendar documentation increased the average treatment effect on medicines intake control 0.11 (95% CI: 0.01-0.21), environment control 0.32 (95% CI: 0.19-46), droplets nuclei control 0.49 (95% CI: 0.36-0.61), cured 0.22 (95% CI: 0.09-0.36), completed 0.18 (95% CI: 0.09-0.26), drop out 0.09 (95% CI: 0.01-0.16), and failure of treatment 0.18 (95% CI: 0.09-0.26) of the control group (baseline).</p><p><strong>Conclusion: </strong>The final result of this research found a new surveillance model of tuberculosis transmission control in google earth mapping aplication based on Geographic Information system.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"287-294"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/b3/AIM-30-287.PMC9665415.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35347278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PD-L1 Expression Among Triple-Negative Breast Cancer Patients in Universitas Sumatera Utara Teaching Hospital, Indonesia.","authors":"Dedy Hermansyah,&nbsp;Dede Kurniawan,&nbsp;Daniel KristianPrawira Lesmana,&nbsp;Yolanda Rahayu Simamora,&nbsp;Desiree Anggia Paramita,&nbsp;Edwin Saleh Siregar","doi":"10.5455/aim.2022.30.308-311","DOIUrl":"https://doi.org/10.5455/aim.2022.30.308-311","url":null,"abstract":"<p><strong>Background: </strong>The emerging role of precision medicine among in oncologic science is a potentially explorable area to solve long-standing implication of triple-negative breast cancer (TNBC)'s management, especially by identifying programmed cell death ligand-1 (PD-L1) in its population.</p><p><strong>Objective: </strong>To describe the PD-L1's expression among TNBC populations in our Indonesia-based centers.</p><p><strong>Methods: </strong>This descriptive study was conducted in the teaching hospitals of Universitas Sumatera Utara ranging from April 2019 to July 2020. Our investigation encompassed female individuals with histopathologically confirmed TNBC and complete medical record data, especially the status of PD-L1 expression to be reported in this study. We use Daco 22C3 antibodies to confirm the latter protein immunohistochemical positivity after thorough specimen preparation and staining.</p><p><strong>Results: </strong>This study included 60 females with TNBC of which 40 participants were issued in the final report. Our populations were dominated by middle-aged individuals (41-50 years old; 45%), and remarkable presentation of LVSI, angioinvasion, or lymph-node metastatic status. In PD-L1 expression status, our study reported that 45.0% patients were confirmed with confirmed PD-L1 positivity.</p><p><strong>Conclusion: </strong>PD-L1 expression among TNBC patients is concordant with the global report hence anti-PD-1-based treatment trial in Asia or even Indonesia region should be considered.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"308-311"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/69/AIM-30-308.PMC9665422.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Most Influential Scientists in the Development of Medical Informatics (34): Steven Huesing (1944- 2009).","authors":"Izet Masic","doi":"10.5455/aim.2022.30.334-335","DOIUrl":"https://doi.org/10.5455/aim.2022.30.334-335","url":null,"abstract":"<jats:p />","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"334-335"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/29/AIM-30-334.PMC9665414.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of PANSS Scores and P100 Latency in Patients with Schizophrenia and Migrene Hedache Using Visual Evoked Potentials (VEPS) According to Gender and Age.","authors":"Gorana Sulejmanpasic,&nbsp;Amra Memic-Serdarevic,&nbsp;Selma Sabanagic-Hajric,&nbsp;Nermina Bajramagic","doi":"10.5455/aim.2022.30.318-323","DOIUrl":"https://doi.org/10.5455/aim.2022.30.318-323","url":null,"abstract":"<p><strong>Background: </strong>The VEPs provide an objective measure of brain function, analyzing integrity of visual processing. With patients affected with schizophrenia, the changes with the implementation of VEP are evident, such as symmetrical deceleration of the impulse and the continuance of latency, which points to a degenerative illness, suggesting the presence of optical neuritis or hemianopsia conjoined with mentioned intracranial illness.</p><p><strong>Objective: </strong>The aim of the study was to determine the correlation of positive and negative symptoms (PANSS scores) and P100 latency between patients with schizophrenia and patients with migraine headache according to gender and age. Visual evoked potentials (VEPs) were applied.</p><p><strong>Methods: </strong>The sample included 80 subjects: a) S group- 40 patients with schizophrenia (21 males; 19 females); b) H group-40 healthy subjects with migraine headache (10 males; 30 females). The study was conducted at the Department of Psychiatry and Neurology University Clinical Center Sarajevo.</p><p><strong>Results: </strong>Our research revealed positive correlation of the P100 latency and the PANSS score of negative symptoms, which means that the subjects of the observed group with a higher latency of the P100 wave of the entire visual field in both eyes have higher PANSS scores of negative symptoms. The correlation is significantly higher in female subjects (37% shared variance) than in male subjects (12% shared variance). All male subjects have a PANSS negative symptoms score of 17 or higher, while all female subjects have a PANSS negative symptoms score of less than 17 positive correlations were registered in P100 latency in left view field of both eyes and in P100 amplitude in the region of right eye (p=0.01) in comparation with left eye region (p=0.05) in patients with schizophrenia.</p><p><strong>Conclusion: </strong>Results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing. Our study is useful to initiate new questions and recommendations for further studies, specifically on changes in the occipital lobe in the schizophrenic patient's brain.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"318-323"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/43/AIM-30-318.PMC9665418.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Aging Activity of Andaliman (Zanthoxylum Acanthopodium DC) Fruit Ethanol Extract on Brain Weight and p16INK4a Expression of Hippocampus in Aging Model Rats.","authors":"Dwi Rita Anggraini,&nbsp;Syafruddin Ilyas,&nbsp;Poppy Anjelisa Zaitun Hasibuan,&nbsp;Yetty Machrina,&nbsp;Ambrosius Purba,&nbsp;Delfitri Munir,&nbsp;Imam Budi Putra,&nbsp;Betty","doi":"10.5455/aim.2022.30.283-286","DOIUrl":"https://doi.org/10.5455/aim.2022.30.283-286","url":null,"abstract":"<p><strong>Background: </strong>Physiological aging and due to oxidative stress in long term will have an impact on cellular response disorders, can caused aging of hippocampus and senility. Brain weight is known to decrease with age and p16INK4a as aging biomarkers have been investigated. Andaliman is one of typical herbal plants from North Sumatra has been widely used as an antioxidant, anti-inflammatory and anti-aging.</p><p><strong>Objective: </strong>This study was evaluated effect of andaliman (Zanthoxylum acanthopodium DC) fruit ethanol extract (AEE) on brain weight and p16INK4a expression in aging model rats.</p><p><strong>Methods: </strong>This study was carried out experimentally of 24 male wistar rats. The treatment group consisted of 4 groups; KN= negatif control (normal), KP= positif control (aging model rat), P1 and P2= aging model rat + AEE at dose 150 and 300mg/kgbw, respectively. The aging model rats were D-galactose-induced at dose of 150mg/kgbw for 8 weeks. Brain weigth were recorded by digital scales. p16INK4a expression using immunohistochemical methods. The data analysis with Anova test.</p><p><strong>Results: </strong>This study showed differences brain weight between groups (p=0.523). Brain weight in P1 (1.34±0,06) and P2 (1.30±0.09) tendency increased than KP (1.29±0.62). The p16INK4a expression between groups significant difference (p=0.041), continued with post hoc Least Significant Difference (LSD) showed p16INK4a expression in KN significant decreased than KP (p=0.027). Likewise, p16INK4a expression in P2 was significant decreased than KP (p=0.010).</p><p><strong>Conclusion: </strong>Andaliman ethanol extract at a dose 300mg/kgbw for 8 weeks was improved aging process caused D-galactose induced.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"283-286"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/63/AIM-30-283.PMC9665423.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35255651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kawasaki Disease Shock Syndrome Presented with Giant Coronary Artery Dilatation - Presentation of Two Cases and a Literature Review.","authors":"Ramush Bejiqi,&nbsp;Nafije Pajaziti,&nbsp;Shqipe Agushi","doi":"10.5455/aim.2022.30.253-256","DOIUrl":"https://doi.org/10.5455/aim.2022.30.253-256","url":null,"abstract":"<p><strong>Background: </strong>Kawasaki disease is an acute, self-limited vasculitis of childhood characterized by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy. Coronary artery aneurysms or ectasia develop in approximately 15 to 25% of untreated children with the disease and may lead to myocardial infarction, sudden death, or ischemic heart disease. Despite an overlap of clinical features with toxic shock syndrome, children with Kawasaki disease generally do not develop shock.</p><p><strong>Objective: </strong>Here we present two adolescent boys who had KDSS and discuss their differentiating features from MIS-C.</p><p><strong>Case reports: </strong>Two adolescent children presented with a toxic shock-like illness, and were subsequently diagnosed with Kawasaki disease shock syndrome when coronary artery abnormalities were found on transthoracic echocardiography.</p><p><strong>Conclusion: </strong>Pediatricians and paediatric cardiologists alike should be aware of this potentially severe form of manifestation of the Kawasaki disease which needs to be differentiated from the multisystem inflammatory syndrome in children.</p>","PeriodicalId":7074,"journal":{"name":"Acta Informatica Medica","volume":" ","pages":"253-256"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/39/AIM-30-253.PMC9559664.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40670949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}