Micro and Nano Systems Letters最新文献

{"title":"Influence of citrate buffer and flash heating in enhancing the sensitivity of ratiometric genosensing of Hepatitis C virus using plasmonic gold nanoparticles","authors":"Hrishikesh Shashi Prakash,&nbsp;Pranay Amruth Maroju,&nbsp;Naga Sai Sriteja Boppudi,&nbsp;Aniket Balapure,&nbsp;Ramakrishnan Ganesan,&nbsp;Jayati Ray Dutta","doi":"10.1186/s40486-021-00134-3","DOIUrl":"10.1186/s40486-021-00134-3","url":null,"abstract":"<div><p>Gold nanoparticles (Au NPs) based technology has been shown to possess enormous potential in the viral nucleic acid diagnosis. Despite significant advancement in this domain, the existing literature reveals the diversity in the conditions employed for hybridization and tagging of thiolated nucleic acid probes over the Au NPs. Here we employ the probe sequence derived from the Hepatitis C virus to identify the optimal hybridization and thiol-Au NP tagging conditions. In a typical polymerase chain reaction, the probes are initially subjected to flash heating at elevated temperatures to obtain efficient annealing. Motivated by this, in the current study, the hybridization between the target and the antisense oligonucleotide (ASO) has been studied at 65 °C with and without employing flash heating at temperatures from 75 to 95 °C. Besides, the efficiency of the thiolated ASO’s tagging over the Au NPs with and without citrate buffer has been explored. The study has revealed the beneficial role of flash heating at 95 °C for efficient hybridization and the presence of citrate buffer for rapid and effective thiol tagging over the Au NPs. The combinatorial effect of these conditions has been found to be advantageous in enhancing the sensitivity of ratiometric genosensing using Au NPs.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-021-00134-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138520604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous preparation of bicelles using hydrodynamic focusing method for bicelle to vesicle transition","authors":"SungHak Choi,&nbsp;BongSu Kang,&nbsp;Toshinori Shimanouchi,&nbsp;Keesung Kim,&nbsp;HoSup Jung","doi":"10.1186/s40486-021-00133-4","DOIUrl":"10.1186/s40486-021-00133-4","url":null,"abstract":"<div><p>Bicelle is one of the most stable phospholipid assemblies, which has tremendous applications in the research areas for drug delivery or structural studies of membrane proteins owing to its bio-membrane mimicking characteristics and high thermal stability. However, the conventional preparation method for bicelle demands complicated manufacturing processes and a long time so that the continuous synthesis method of bicelle using microfluidic chip has been playing an important role to expand its feasibility. We verified the general availability of hydrodynamic focusing method with microfluidic chip for bicelle synthesis using various kinds of lipids which have a phase transition temperature ranged from − 2 to 41 °C. Bicelle can be formed only when the inside temperature of microfluidic chip was over the phase transition temperature. Moreover, the concentration condition for bicelle formation varied depending on the lipids. Furthermore, the transition process characteristics from bicelle to vesicle were analyzed by effective q-value, mixing time and dilution condition. We verified that the size of transition vesicles was controlled according to the effective q-value, mixing time, and temperature.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-021-00133-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138520619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper micromesh-based lightweight transparent conductor with short response time for wearable heaters","authors":"Han-Jung Kim,&nbsp;Yoonkap Kim","doi":"10.1186/s40486-021-00132-5","DOIUrl":"10.1186/s40486-021-00132-5","url":null,"abstract":"<div><p>Thickness-controlled transparent conducting films (TCFs) were fabricated by transfer printing a 100 nm thick Cu micromesh structure onto poly(vinyl alcohol) (PVA) substrates of different thicknesses (~ 50, ~ 80, and ~ 120 μm) to develop a lightweight transparent wearable heater with short response time. The Cu mesh-based TCF fabricated on a ~ 50 µm thick PVA substrate exhibited excellent optical and electrical properties with a light transmittance of 86.7% at 550 nm, sheet resistance of ~ 10.8 Ω/sq, and figure-of-merit of approximately 236, which are comparable to commercial indium tin oxide film-based transparent conductors. The remarkable flexibility of the Cu mesh-based TCF was demonstrated through cyclic mechanical bending tests. In addition, the Cu mesh-based TCF with ~ 50 μm thick PVA substrate demonstrated a fast Joule heating performance with a thermal response time of ~ 18.0 s and a ramping rate of ~ 3.0 ℃/s under a driving voltage of 2.5 V. Lastly, the reliable response and recovery characteristics of the Cu mesh/PVA film-based transparent heater were confirmed through the cyclic power test. We believe that the results of this study is useful in the development of flexible transparent heaters, including lightweight deicing/defogging films, wearable sensors/actuators, and medical thermotherapy pads.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-021-00132-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138520620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple ratiometric nanothermometry using semiconductor BiFeO3 nanowires and quantitative validation of thermal sensitivity","authors":"K. Prashanthi, K. K. Krishna Mohan, Ž. Antić, K. Ahadi, M. Dramićanin","doi":"10.36227/techrxiv.16780459","DOIUrl":"https://doi.org/10.36227/techrxiv.16780459","url":null,"abstract":"Here, we report a very sensitive, non-contact, ratio-metric, and robust luminescence-based temperature sensing using a combination of conventional photoluminescence (PL) and negative thermal quenching (NTQ) mechanisms of semiconductor BiFeO 3 (BFO) nanowires. Using this approach, we have demonstrated the absolute thermal sensitivity of ~ 10 mK −1 over the 300–438 K temperature range and the relative sensitivity of 0.75% K −1 at 300 K. Further, we have validated thermal sensitivity of BFO nanowires quantitatively using linear regression and analytical hierarchy process (AHP) and found close match with the experimental results. These results indicated that BFO nanowires are excellent candidates for developing high‐performance luminescence-based temperature sensors. Graphical abstract","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":"1-12"},"PeriodicalIF":3.6,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45143150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity","authors":"Nancy Jain,&nbsp;Priyanshu Jain,&nbsp;Devyani Rajput,&nbsp;Umesh Kumar Patil","doi":"10.1186/s40486-021-00131-6","DOIUrl":"https://doi.org/10.1186/s40486-021-00131-6","url":null,"abstract":"<p>Nanotechnology holds an emerging domain of medical science as it can be utilized virtually in all areas. Phyto-constituents are valuable and encouraging candidates for synthesizing green silver nanoparticles (AgNPs) which possess great potentials toward chronic diseases. This review gives an overview of the Green approach of AgNPs synthesis and its characterization. The present review further explores the potentials of Phyto-based AgNPs toward anticancer and antiviral activity including its probable mechanism of action. Green synthesized AgNPs prepared by numerous medicinal plants extract are critically reviewed for cancer and viral infection. Thus, this article mainly highlights green synthesized Phyto-based AgNPs with their potential applications for cancer and viral infection including mechanism of action and therapeutic future prospective in a single window. </p>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40486-021-00131-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4479604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High speed silicon wet anisotropic etching for applications in bulk micromachining: a review","authors":"Prem Pal,&nbsp;Veerla Swarnalatha,&nbsp;Avvaru Venkata Narasimha Rao,&nbsp;Ashok Kumar Pandey,&nbsp;Hiroshi Tanaka,&nbsp;Kazuo Sato","doi":"10.1186/s40486-021-00129-0","DOIUrl":"https://doi.org/10.1186/s40486-021-00129-0","url":null,"abstract":"<p>Wet anisotropic etching is extensively employed in silicon bulk micromachining to fabricate microstructures for various applications in the field of microelectromechanical systems (MEMS). In addition, it is most widely used for surface texturing to minimize the reflectance of light to improve the efficiency of crystalline silicon solar cells. In wet bulk micromachining, the etch rate is a major factor that affects the throughput. Slower etch rate increases the fabrication time and therefore is of great concern in MEMS industry where wet anisotropic etching is employed to perform the silicon bulk micromachining, especially to fabricate deep cavities and freestanding microstructures by removal of underneath material through undercutting process. Several methods have been proposed to increase the etch rate of silicon in wet anisotropic etchants either by physical means (e.g. agitation, microwave irradiation) or chemically by incorporation of additives. The ultrasonic agitation during etching and microwave irradiation on the etchants increase the etch rate. However, ultrasonic method may rupture the fragile structures and microwave irradiation causes irradiation damage to the structures. Another method is to increase the etching temperature towards the boiling point of the etchant. The etching characteristics of pure potassium hydroxide solution (KOH) is studied near the boiling point of KOH, while surfactant added tetramethylammonium hydroxide (TMAH) is investigated at higher temperature to increase the etch rate. Both these studies have shown a potential way of increasing the etch rate by elevating the temperature of the etchants to its boiling point, which is a function of concentration of etch solution. The effect of various kinds of additives on the etch rate of silicon is investigated in TMAH and KOH. In this paper, the additives which improve the etch rate have been discussed. Recently the effect of hydroxylamine (NH₂OH) on the etching characteristics of TMAH and KOH is investigated in detail. The concentration of NH₂OH in TMAH/KOH is varied to optimize the etchant composition to obtain improved etching characteristics especially the etch rate and undercutting which are important parameters for increasing throughput. In this article, different methods explored to improve the etch rate of silicon have been discussed so that the researchers/scientists/engineers can get the details of these methods in a single reference.</p>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5155008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-step electropolymerization of methylene blue films on highly flexible carbon fiber electrode as supercapacitors","authors":"Leandro Marques Samyn,&nbsp;Rajendran Suresh Babu,&nbsp;Mani Devendiran,&nbsp;Ana Lucia Ferreira de Barros","doi":"10.1186/s40486-021-00130-7","DOIUrl":"https://doi.org/10.1186/s40486-021-00130-7","url":null,"abstract":"<p>Energy crisis and environmental pollution have been one of the major global issues. In this regard, the search for new energy storage materials is cheap, flexible and high-performance supercapacitors electrode which has become intensive. Also, reducing the amount of organic dyes polluting in water is a great significance. Herein, one-step electropolymerization of methylene blue on carbon fiber and the resulting films were applied to the supercapacitor. The high performance is associated to the outstanding conductivity, electrochemical stability and superior mechanical flexibility of carbon fiber. A new flexible electrode for supercapacitors was successfully fabricated by demonstrating with a good electrochemical performance and a promising alternative to reduce the water pollution.</p>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40486-021-00130-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4853791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on thickness-dependence characteristics of bismuth ferrite (BFO) for ultraviolet (UV) photodetector application","authors":"Shahnaz Kossar,&nbsp;R. Amiruddin,&nbsp;Asif Rasool","doi":"10.1186/s40486-020-00128-7","DOIUrl":"https://doi.org/10.1186/s40486-020-00128-7","url":null,"abstract":"<p>The present research work reports on the fabrication of ultraviolet (UV) photodetectors using bismuth ferrite (BiFeO_3, BFO) thin films with varying thickness. Using the spray pyrolysis technique, BFO thin films were deposited on the glass substrate at 673?K. The deposited BFO thin films were characterized by Raman and FTIR spectroscopic analysis. The morphological analysis reveals uniform grain distribution for the prepared BFO samples. The optical analysis reveals that transmittance value decreases upon an increase in the thickness of BFO thin films and the calculated optical band gap value lies between 2.0 to 2.3?eV. The varying thickness of the BFO active layer was stacked between ITO and Al electrodes and the current–voltage (I–V) characteristics of the fabricated ITO/BFO/Al devices were studied under dark and UV illumination (λ?=?365?nm). It was observed that BFO with an optimum thickness (365?nm) exhibits higher photoresponsivity of 110?mA/W with an external quantum efficiency (EQE) of 37.30%. The impact of different thickness of the BFO active layer, the role of adsorption and desorption of oxygen (O₂) molecules upon the surface of BFO layers towards UV photoresponse characteristics were investigated.</p>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2021-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40486-020-00128-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4501805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-soft multiaxial force sensor based on liquid metal for electronic skin","authors":"Kyuyoung Kim,&nbsp;Junseong Ahn,&nbsp;Yongrok Jeong,&nbsp;Jungrak Choi,&nbsp;Osman Gul,&nbsp;Inkyu Park","doi":"10.1186/s40486-020-00126-9","DOIUrl":"https://doi.org/10.1186/s40486-020-00126-9","url":null,"abstract":"<p>Electronic skin (E-skin) capable of detecting various physical stimuli is required for monitoring external environments accurately. Here, we report an all-soft multiaxial force sensor based on liquid metal microchannel array for electronic skin applications. The proposed sensor is composed of stretchable elastomer and Galinstan, a eutectic gallium-indium alloy, providing a high mechanical flexibility and electro-mechanical durability. Liquid metal microchannel arrays are fabricated in multilayer and positioned along a dome structure to detect multi-directional forces, supported by numerical simulation results. By adjusting the height of the dome, we could control the response of the multiaxial sensor with respect to the deflection. As a demonstration of multiaxial force sensing, we were able to monitor the direction of multidirectional forces using a finger by the response of liquid metal microchannel arrays. This research could be applied to various fields including soft robotics, wearable devices, and smart prosthetics for artificial intelligent skin applications.</p>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"9 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2021-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40486-020-00126-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4163145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hollow polydimethylsiloxane (PDMS) foam with a 3D interconnected network for highly sensitive capacitive pressure sensors","authors":"Dong Hwan Kim,&nbsp;Young Jung,&nbsp;Kyungkuk Jung,&nbsp;Dong Hwa Kwak,&nbsp;Dong Min Park,&nbsp;Myung Gyu Shin,&nbsp;Hyeong Jun Tak,&nbsp;Jong Soo Ko","doi":"10.1186/s40486-020-00127-8","DOIUrl":"https://doi.org/10.1186/s40486-020-00127-8","url":null,"abstract":"<p>We propose a highly sensitive capacitive pressure sensor made of hollow polydimethylsiloxane (PDMS) foam with a three-dimensional network structure. The stiffness of the foam is adjusted by the viscosity of the PDMS solution. The fabricated PDMS-30 (PDMS 30 wt%) foam shows extremely high porosity (&gt;?86%) approximately 19 times that of bare PDMS (PDMS 100 wt%) foam. Capacitive pressure sensors fabricated using the foam possess high sensitivity, good compressibility (up to 80% strain), and consistent output characteristics in a 2000-cycle test.</p>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"8 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40486-020-00127-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4568222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}