Micro and Nano Systems Letters最新文献_第7页

Influence of multiple stenoses on thrombosis formation: an in vitro study 多种狭窄对血栓形成的影响：一项体外研究

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-11-19 DOI: 10.1186/s40486-022-00159-2

Helem B. Flores Marcial, Jiseob Choi, Donghwi Ham, Junghyun Kim, Pyeongho Jeong, Jinho Choi, Woo-Tae Park

{"title":"Influence of multiple stenoses on thrombosis formation: an in vitro study","authors":"Helem B. Flores Marcial, Jiseob Choi, Donghwi Ham, Junghyun Kim, Pyeongho Jeong, Jinho Choi, Woo-Tae Park","doi":"10.1186/s40486-022-00159-2","DOIUrl":"10.1186/s40486-022-00159-2","url":null,"abstract":"<div><p>Multiple lesions in the same vessel is one of the most common situations found in patients suffering from cardiovascular diseases, this complicates not only the assessment of the severity of each one but also their treatment. To date, the effect of multiple stenoses on different parameters has been simulated by numerical studies. Few others have implemented in vitro platforms for their investigation. However, visualization of thrombosis formation in this kind of lesion is still needed. This in vitro study monitors the formation of thrombus inside microchannels having one, two, and three stenoses. Whole blood was perfused through each channel at high shear rates (> 12,000 s<sup>−1</sup>), generating thrombosis. Flow changes across each lesion as well as the final percentage of aggregations were monitored. Thus, the location where total occlusion could be produced was found to be the first stenosis for all the cases. Less flow reaching the second and third stenoses was observed which demonstrates that aggregations were growing at the first one. This was verified by measuring the percentage of aggregations at the end of the test.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00159-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47422387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Highly stretchable strain sensors with improved sensitivity enabled by a hybrid of carbon nanotube and graphene 由碳纳米管和石墨烯混合而成的具有提高灵敏度的高拉伸应变传感器

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-11-12 DOI: 10.1186/s40486-022-00160-9

Leilei Wang, Jungwook Choi

{"title":"Highly stretchable strain sensors with improved sensitivity enabled by a hybrid of carbon nanotube and graphene","authors":"Leilei Wang, Jungwook Choi","doi":"10.1186/s40486-022-00160-9","DOIUrl":"10.1186/s40486-022-00160-9","url":null,"abstract":"<div><p>The development of high-performance strain sensors has attracted significant attention in the field of smart wearable devices. However, stretchable strain sensors usually suffer from a trade-off between sensitivity and sensing range. In this study, we investigate a highly sensitive and stretchable piezoresistive strain sensor composed of a hybrid film of 1D multi-walled carbon nanotube (MWCNT) and 2D graphene that forms a percolation network on Ecoflex substrate by spray coating. The mass of spray-coated MWCNT and graphene and their mass ratio are modulated to overcome the trade-off between strain sensitivity and sensing range. We experimentally found that a stable percolation network is formed by 0.18 mg of MWCNTs (coating area of 200 mm<sup>2</sup>), with a maximum gauge factor (GF) of 1,935.6 and stretchability of 814.2%. By incorporating the 0.36 mg of graphene into the MWCNT film (i.e., a mass ratio of 1:2 between MWCNT and graphene), the GF is further improved to 12,144.7 in a strain range of 650–700%. This high GF is caused by the easy separation of the graphene network under the applied strain due to its two-dimensional (2D) shape. High stretchability originates from the high aspect ratio of MWCNTs that bridges the randomly distributed graphenes, maintaining a conductive network even under sizeable tensile strain. Furthermore, a small difference in work function between MWCNT and graphene and their stable percolation network enables sensitive UV light detection even under a significant strain of 300% that cannot be achieved by sensors composed of MWCNT- or graphene-only. The hybrids of MWCNT and graphene provide an opportunity to achieve high-performance stretchable devices.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00160-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49601489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In-vivo recording of sensory signals from peripheral nerves using flexible 3D neural electrodes 利用柔性三维神经电极在体内记录周围神经的感觉信号

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-11-02 DOI: 10.1186/s40486-022-00158-3

Byungwook Park, Jae-Won Jang, Sohee Kim

{"title":"In-vivo recording of sensory signals from peripheral nerves using flexible 3D neural electrodes","authors":"Byungwook Park, Jae-Won Jang, Sohee Kim","doi":"10.1186/s40486-022-00158-3","DOIUrl":"10.1186/s40486-022-00158-3","url":null,"abstract":"<div><p>To overcome the limitations of muscle-based prostheses, studies on nerve-based prostheses for sensory feedback have recently been reported. To develop such prostheses, intrafascicular electrodes, a type of peripheral nerve interface, are essentially used to connect the nervous system and external systems. Through these electrodes, sensory feedback to induce sensations in patients is possible. To evoke natural sensations, precise recordings of nerve signals should precede sensory feedback, in order to identify patterns of sensory signals in the nerve and to mimic these patterns in stimulating the nerve. For this purpose, we previously developed a PDMS-based flexible penetrating microelectrode array (FPMA). In the current study, we verified the ability of the FPMA to record sensory nerve signals. The FPMA implanted in the rabbit sciatic nerve was able to record spontaneous neural signals, and the recorded signals were separated into action potential units. In addition, sensory nerve signals synchronized with ankle movement were successfully recorded, demonstrating that the FPMA is a useful peripheral neural interface capable of recording high-resolution sensory signals.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00158-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41725678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 3D-printed pneumatic dispenser with monitoring droplet ejection 具有液滴喷射监测功能的3D打印气动分配器

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-10-31 DOI: 10.1186/s40486-022-00157-4

Dong Kwan Kang, Jeong Woo Park, Sangmin Lee

引用次数: 0

Methods to analyze extracellular vesicles at single particle level 方法在单颗粒水平上分析细胞外囊泡

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-10-28 DOI: 10.1186/s40486-022-00156-5

Yongmin Kwon, Jaesung Park

引用次数: 5

SnO2/rGO nanocomposite for the detection of biomarkers of lung cancer SnO2/rGO纳米复合材料用于肺癌生物标志物的检测

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-09-16 DOI: 10.1186/s40486-022-00154-7

Arunkumar Shanmugasundaram, Dong-Weon Lee

{"title":"SnO2/rGO nanocomposite for the detection of biomarkers of lung cancer","authors":"Arunkumar Shanmugasundaram, Dong-Weon Lee","doi":"10.1186/s40486-022-00154-7","DOIUrl":"10.1186/s40486-022-00154-7","url":null,"abstract":"<div><p>Metal oxide-based sensors have been widely used to detection biomarkers in exhaled breath for identification of various diseases such as asthma, diabetes, halitosis, and lung cancer. Herein, we proposed one step hydrothermal method for the preparation of SnO<sub>2</sub> nanospheres and reduced graphene oxide incorporated SnO<sub>2</sub> nanospheres for the detection of two important biomarkers such as decane and heptane from the exhaled breath of lung cancer patients. The as prepared materials are investigated in detail through various analytical techniques and the findings are consistent with each other. The sensing response of the proposed sensors were systematically investigated to enhance their sensing performance as a function of operating temperatures and gas concentration, and different analyte gases. The sensors showed maximum sensing response toward heptane and decane compared to other interfering gases such as hydrogen, carbon monoxide, acetone, ethanol, and methanol at 125 °C. The proposed sensors exhibit excellent detection range as low as 1 ppm with appreciably fast response and recovery time. Lung cancer patients may be easily screened using the proposed sensor, by detecting decane and heptane in their exhaled breath.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00154-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48501412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Optimization of deep reactive ion etching for microscale silicon hole arrays with high aspect ratio 高纵横比微尺度硅孔阵列的深度反应离子刻蚀优化

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-09-09 DOI: 10.1186/s40486-022-00155-6

Taeyeong Kim, Jungchul Lee

{"title":"Optimization of deep reactive ion etching for microscale silicon hole arrays with high aspect ratio","authors":"Taeyeong Kim, Jungchul Lee","doi":"10.1186/s40486-022-00155-6","DOIUrl":"10.1186/s40486-022-00155-6","url":null,"abstract":"<div><p>During deep reactive ion etching (DRIE), microscale etch masks with small opening such as trenches or holes suffer from limited aspect ratio because diffusion of reactive ions and free radicals become progressively difficult as the number of DRIE cycle increases. For this reason, high aspect ratio structures of microscale trenches or holes are not readily available with standard DRIE recipes and microscale holes are more problematic than trenches due to omnidirectional confinement. In this letter, we propose an optimization for fabrication of high aspect ratio microscale hole arrays with an improved cross-sectional etch profile. Bias voltage and inductively coupled plasma power are considered as optimization parameters to promote the bottom etching of the high aspect ratio hole array. In addition, flow rates of octafluorocyclobutane (C<span>(_{4})</span>F<span>(_{8})</span>) and sulfur hexafluoride (SF<span>(_{6})</span>) for passivation and depassivation steps, respectively, are considered as optimization parameters to reduce the etch undercut. As a result of optimization, the aspect ratio of 20 is achieved for 1.3 μm-diameter hole array and etch area reduction at the bottom relative to the top is improved to 21%.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00155-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65886617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Microarray detection method for pathogen genes by on-chip signal amplification using terminal deoxynucleotidyl transferase 利用末端脱氧核苷酸转移酶在片上扩增信号的微阵列检测病原体基因的方法

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-08-22 DOI: 10.1186/s40486-022-00153-8

Tai-Yong Kim, Min-Cheol Lim, Jeong-A Lim, Sung-Wook Choi, Min-Ah Woo

{"title":"Microarray detection method for pathogen genes by on-chip signal amplification using terminal deoxynucleotidyl transferase","authors":"Tai-Yong Kim, Min-Cheol Lim, Jeong-A Lim, Sung-Wook Choi, Min-Ah Woo","doi":"10.1186/s40486-022-00153-8","DOIUrl":"10.1186/s40486-022-00153-8","url":null,"abstract":"<div><p>A microarray detection method based on on-chip signal amplification using terminal deoxynucleotidyl transferase (TdT) was developed to visualize pathogenic genes. Cyclic olefin copolymer (COC) substrate for microarrays was treated with oxygen plasma to induce hydrophilic surface properties. The capture probe DNA was immobilized on the COC surface by UV irradiation. The 3ʹ end of the capture probe DNA immobilized on the COC surface was modified with a phosphate group to provide resistance against the TdT reaction. Therefore, the TdT reaction was triggered only when the capture probe DNA acquired the target gene, and biotin-11-deoxyuridine triphosphate (b-dUTP) was continuously added to the 3ʹ end of the target gene. Thereafter, streptavidin-conjugated gold nanoparticles (s-AuNPs) tagged the poly uridine tails by the biotin–streptavidin interaction. The visual signal was amplified by silver enhancement in the presence of the s-AuNPs. The usefulness of this detection method was confirmed by analyzing four pathogens and allowing their visual identification.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00153-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134878376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Enhanced etching characteristics of Si{100} in NaOH-based two-component solution Si{100}在naoh基双组分溶液中的增强蚀刻特性

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-08-01 DOI: 10.1186/s40486-022-00152-9

V. Swarnalatha, S. Purohit, P. Pal, R. K. Sharma

{"title":"Enhanced etching characteristics of Si{100} in NaOH-based two-component solution","authors":"V. Swarnalatha, S. Purohit, P. Pal, R. K. Sharma","doi":"10.1186/s40486-022-00152-9","DOIUrl":"10.1186/s40486-022-00152-9","url":null,"abstract":"<div><p>Silicon wet bulk micromachining is the most widely used technique for the fabrication of diverse microstructures such as cantilevers, cavities, etc. in laboratory as well as in industry for micro-electromechanical system (MEMS) application. Although, increasing the throughput remains inevitable, and can be done by increasing the etching rate. Furthermore, freestanding structure release time can be reduced by the improved undercutting rate at convex corners. In this work, we have investigated the etching characteristics of a non-conventional etchant in the form of hydroxylamine (NH<sub>2</sub>OH) added sodium hydroxide (NaOH) solution. This research is focused on Si{100} wafer as this orientation is largely used in the fabrication of planer devices (e.g., complementary metal-oxide semiconductors) and microelectromechanical systems (e.g., inertial sensors). We have performed a systematic and parametric analysis without and with 12% NH<sub>2</sub>OH in 10 M NaOH for improved etching characteristics such as etch rate, undercutting at convex corners, and etched surface morphology. 3D scanning laser microscope is used to measure average surface roughness (<i>R</i><sub><i>a</i></sub>), etch depth (d), and undercutting length (<i>l</i>). Morphology of the etched Si{100} surface is examined using optical and scanning electron microscopes. The addition of NH<sub>2</sub>OH in NaOH solution remarkably exhibited a two-fold increment in the etching rate of a Si{100} surface. Furthermore, the addition of NH<sub>2</sub>OH significantly improves the etched surface morphology and undercutting at convex corners. Undercutting at convex corners is highly prudent for the quick release of microstructures from the substrate. In addition, we have studied the effect of etchant age on etching characteristics. Results presented in this article are of large significance for engineering applications in both academic and industrial laboratories.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00152-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65886563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Carbon nanotube-graphene hybrids for soft electronics, sensors, and actuators 碳纳米管-石墨烯混合材料的软电子，传感器和执行器

IF 3.6

Micro and Nano Systems Letters Pub Date : 2022-07-19 DOI: 10.1186/s40486-022-00151-w

Soonjae Pyo, Youngkee Eun, Jaesam Sim, Kwanoh Kim, Jungwook Choi

{"title":"Carbon nanotube-graphene hybrids for soft electronics, sensors, and actuators","authors":"Soonjae Pyo, Youngkee Eun, Jaesam Sim, Kwanoh Kim, Jungwook Choi","doi":"10.1186/s40486-022-00151-w","DOIUrl":"10.1186/s40486-022-00151-w","url":null,"abstract":"<div><p>Soft devices that are mechanically flexible and stretchable are considered as the building blocks for various applications ranging from wearable devices to robotics. Among the many candidate materials for constructing soft devices, carbon nanomaterials such as carbon nanotubes (CNTs) and graphene have been actively investigated owing to their outstanding characteristics, including their intrinsic flexibility, tunable conductivity, and potential for large-area processing. In particular, hybrids of CNTs and graphene can improve the performance of soft devices and provide them with novel capabilities. In this review, the advances in CNT-graphene hybrid-based soft electrodes, transistors, pressure and strain sensors, and actuators are discussed, highlighting the performance improvements of these devices originating from the synergistic effects of the hybrids of CNT and graphene. The integration of multidimensional heterogeneous carbon nanomaterials is expected to be a promising approach for accelerating the development of high-performance soft devices. Finally, current challenges and future opportunities are summarized, from the processing of hybrid materials to the system-level integration of multiple components.</p></div>","PeriodicalId":704,"journal":{"name":"Micro and Nano Systems Letters","volume":"10 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://mnsl-journal.springeropen.com/counter/pdf/10.1186/s40486-022-00151-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65886512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5