Acta physiologica et pharmacologica Bulgarica最新文献_第6页

Effect of transplantation of embryonic anterior hypothalamic tissue from spontaneously hypertensive rats to normotensive Wistar rats on circadian rhythms of systolic arterial pressure and heart rate. 自发性高血压大鼠胚胎下丘脑前叶组织移植至正常血压Wistar大鼠对收缩压和心率昼夜节律的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

A G Stoynev, P D Penev, O C Ikonomov, K G Usunoff

{"title":"Effect of transplantation of embryonic anterior hypothalamic tissue from spontaneously hypertensive rats to normotensive Wistar rats on circadian rhythms of systolic arterial pressure and heart rate.","authors":"A G Stoynev, P D Penev, O C Ikonomov, K G Usunoff","doi":"","DOIUrl":"","url":null,"abstract":"The anterior hypothalamus (AH) participates in the regulation of arterial pressure. The suprachiasmatic nuclei (SCN) of the AH are a major circadian oscillator necessary for the generation and/or the entrainment of circadian rhythms. Circadian rhythms of systolic arterial pressure (SAP) and heart rate (HR) were investigated in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats (NWI) with intact SCN, grafted with SHR embryonic AH tissue containing the SCN. Prominent circadian rhythms for SAP and HR in both NWI and SHR with acrophases during dark were found. The elevation of the MESOR (midline-estimated statistic of rhythm) of the SAP in normotensive rats grafted with AH embryonic tissue obtained from SHR was accompanied by disappearance of the circadian rhythm of SAP. This result suggests an interaction between the grafted tissue containing the SCN on the one hand, and the host SCN on the other hand. Our data ascribe a role for the SCN in the entrainment of the circadian rhythm of arterial pressure. The circadian rhythm of HR was not eliminated by the SCN graft in spite of the amplitude decrease and the phase delay observed. It seems that the entrainment of the circadian rhythm of HR is probably not crucially dependent on the SCN in rats. The circadian rhythms of SAP and HR in rats were differently affected by the grafts, thus suggesting a multioscillatory system for circadian regulation in rats.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20631670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological evidence for effects of the aging on the serotoninergic neurons in the rat brainstem nuclei. 衰老对大鼠脑干核5 -羟色胺能神经元影响的形态学证据。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

I S Lolova

引用次数: 0

Non-invasive electrocologram: non-invasive recording of the human colonic electrical activity. 非侵入性电图:人类结肠电活动的非侵入性记录。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

P Penchev, A Noeva, G Zlatarsky, H Kadiyan, V Kolev, R Toushev, E Atanassova

{"title":"Non-invasive electrocologram: non-invasive recording of the human colonic electrical activity.","authors":"P Penchev, A Noeva, G Zlatarsky, H Kadiyan, V Kolev, R Toushev, E Atanassova","doi":"","DOIUrl":"","url":null,"abstract":"The electrical activity of the descending colon of fifteen healthy volunteers was recorded non-invasively by cutaneous electrodes sticked on the abdominal wall along the descending colon projection--electrocologram (EColG). The electrical activity of the colon and stomach was recorded by an original electrogastrograph. The means, S.E.M. of the frequency of the colonic and gastric waves were calculated. Parallel studies of the EColG and the changes in the intracolonic pressure were performed on 10 patients with balloon inflated in the colon. Two kinds of EColG waves according to their frequency were identified: i) Type A waves with a frequency of 5.86 +/- 0.59 cpm and ii) Type B waves with a frequency of 2.35 +/- 0.25 cpm. There was a significant difference between the frequencies of the EColG waves and the frequency of the EGG waves -3.35 +/- 0.31 cpm. The type A waves were of low amplitude and corresponded to type A dog colonic waves i.e. they characterized the quiescent period of colonic motility. Type B waves were with a high amplitude, corresponded to type B dog colonic waves and characterised the activity periods of colonic motility. This was confirmed by the correspondence between type B waves and the changes in the intracolonic pressure. Thus the proposed non-invasive electrogastrographic method proved to be suitable for non-invasive registration of the electrical activity of the human colon.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20630950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasopressin- and oxytocin-immunoreactive nerve cells in the aging rat hypothalamus. 衰老大鼠下丘脑抗利尿激素和催产素免疫反应性神经细胞。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

I S Lolova, M S Davidoff, N A Yakimoff

引用次数: 0

Non-invasive electrocologram: correlation between the electrical activity of the dog colonic muscle wall recorded by cutaneous and implanted electrodes. 无创电图:皮电极和植入电极记录的狗结肠肌壁电活动的相关性。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

A Noeva, P Gurkov, P Penchev, E Atanassova

{"title":"Non-invasive electrocologram: correlation between the electrical activity of the dog colonic muscle wall recorded by cutaneous and implanted electrodes.","authors":"A Noeva, P Gurkov, P Penchev, E Atanassova","doi":"","DOIUrl":"","url":null,"abstract":"Chronic experiments were performed on dogs with silver, bipolar, ball-shaped electrodes implanted on the colonic and of the gastric muscle wall. Cutaneous electrodes were placed on the abdominal wall, along the projection of descending colon and also of the stomach, at the beginning of each experiment. Slow waves were led off in the electrocolomyogram (EColMG), corresponding to low-amplitude waves in the non-invasive electrocologram (EColG) with a frequency of 6.39 +/- 0.58 cpm (type A). When bursts of spike potentials appeared with the slow waves in the EColMG, increase of the amplitude of the EColG waves and decrease of the frequency (1.90 +/- 0.20 cpm) was observed. There was a significant difference between the colonic wave frequency and the frequency of the gastric waves (3.96 +/- 0.28 cpm). A good correlation was found between the number and frequency of the spike potentials in a group in the EColMG and the wave amplitude in the EColG. A sequence of low-frequency, high-amplitude waves (type B) characterized an activity period, while a sequence of low-amplitude, high-frequency waves (type A) corresponded to a quiescent period of the colonic motility. Thus the functional state of the colonic muscle wall could be judged by the differences in the frequency and amplitude of the EColG waves.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20631671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teratopharmacological and behavioral effects of coffee in mice. 咖啡对小鼠致畸药理学和行为学的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

J S Ajarem, M Ahmad

{"title":"Teratopharmacological and behavioral effects of coffee in mice.","authors":"J S Ajarem, M Ahmad","doi":"","DOIUrl":"","url":null,"abstract":"The possible relationship between coffee exposure during pregnancy and the teratopharmacological effects on the developing neonates was evaluated in albino mice. The body weight of pups of treated dams was significantly affected after birth and as the pups grew, their weight gains were lower compared to controls. This effect was time- and dose-dependent and the perinatal treatment was more effective (F(6) = 5.06, p < 0.02) than the prepartum treatment (F(6) = 3.12, p < 0.05). Body hair appearance and eye opening were delayed in all treated groups and again, the perinatal treatment was more effective and dose-dependent. Almost all indices for \"locomotor behavior\" were affected by all doses of coffee but only in the perinatally treated groups and the effects were neither time- nor dose-dependent. In the \"tube restraint test\", the latency to the first bite was decreased and the number of bites was increased in the offspring, while in female offspring the effect was opposite. The body weight of female offspring remained low even in young adult animals (F(6) = 9.89, p < 0.005). The brain weight in males was unaffected but in females it was decreased but only at the dose of 2 mg/kg. The liver and kidney weights of both sexes decreased at the lower doses. The protein content of these organs was also significantly affected by coffee treatment. These results suggest that coffee intake during pregnancy should be limited since it produces significant and long-lasting teratopharmacological and behavioral alterations in the offspring.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20391042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of response development in time: an isolated organ study. 反应发展的及时分析:一项离体器官研究。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

M S Jankovic, B D Beleslin, D Kouvelas, G A Paradelis

引用次数: 0

Lack of effect of suprachiasmatic infusion of a vasopressin antagonist on the circadian rhythm of wheel-running activity in rats. 视交叉上输注抗利尿激素拮抗剂对大鼠轮跑活动昼夜节律的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

A G Stoynev, K Nagai

引用次数: 0

Effects of carbontetrachloride and chenodeoxycholic acid on hepatic monooxygenase system, lipid peroxidation and some immunologic parameters in rats. 四氯化碳和鹅去氧胆酸对大鼠肝脏单加氧酶系统、脂质过氧化及一些免疫参数的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1996-01-01

I N Alexeyeva, V A Berezovsky, T M Bryzgina, S I Pavlovich, L I Alexyuk, N V Makogon, Gotsulyak YaN, T V Martinova

引用次数: 0

Effect of verapamil and diltiazem on the rCBF and the rCBF autoregulation in cortex and thalamus of cats. 维拉帕米和地尔硫卓对猫皮质和丘脑rCBF及自动调节的影响。

Acta physiologica et pharmacologica Bulgarica Pub Date : 1995-01-01

E Gatchev, V Vlahov

{"title":"Effect of verapamil and diltiazem on the rCBF and the rCBF autoregulation in cortex and thalamus of cats.","authors":"E Gatchev, V Vlahov","doi":"","DOIUrl":"","url":null,"abstract":"The effects of Verapamil and Diltiazem, administered at a dose of 0.3 mg/kg i.v., on the autoregulation of the regional cerebral blood flow (rCBF) in the cortex and the thalamus were studied on 28 cats. The animals were anesthetized with ether and alfa-chloralose. The rCBF was registered by the hydrogen clearance method with locally generated hydrogen. The mean arterial blood pressure (MABP) elevation was performed by an i.v. infusion of angiotensin (0.2 microgram/min). The mean initial values of the cortical rCBF were 71.15 ml/100g/min and of the thalamic rCBF -46.85 ml/100 g/min. The mean limits of the cortical rCBF autoregulation were: 137.5 mm Hg for the absolute limit (La) and 31.25 mm Hg for the relative limit (Lr). The mean limits of the thalamic rCBF autoregulation were: 157.75 mm Hg for the (La) and 46.5 mm Hg for the (Lr). Verapamil increased the cortical rCBF by 40% and the thalamic rCBF by 24%. The absolute limits of rCBF autoregulation were decreased by 22% in the cortex, and by 15% in the thalamus. The relative limits were decreased by 31% in the cortex and by 35% in the thalamus. Diltiazem increased the cortical rCBF by 42% and the thalamic rCBF by 6%. The absolute limits of rCBF autoregulation were decreased by 21% in the cortex and the thalamus. The relative limits were decreased by 52% in the cortex, and by 38% in the thalamus.","PeriodicalId":7035,"journal":{"name":"Acta physiologica et pharmacologica Bulgarica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19835442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0