Teratopharmacological and behavioral effects of coffee in mice.

J S Ajarem, M Ahmad
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Abstract

The possible relationship between coffee exposure during pregnancy and the teratopharmacological effects on the developing neonates was evaluated in albino mice. The body weight of pups of treated dams was significantly affected after birth and as the pups grew, their weight gains were lower compared to controls. This effect was time- and dose-dependent and the perinatal treatment was more effective (F(6) = 5.06, p < 0.02) than the prepartum treatment (F(6) = 3.12, p < 0.05). Body hair appearance and eye opening were delayed in all treated groups and again, the perinatal treatment was more effective and dose-dependent. Almost all indices for "locomotor behavior" were affected by all doses of coffee but only in the perinatally treated groups and the effects were neither time- nor dose-dependent. In the "tube restraint test", the latency to the first bite was decreased and the number of bites was increased in the offspring, while in female offspring the effect was opposite. The body weight of female offspring remained low even in young adult animals (F(6) = 9.89, p < 0.005). The brain weight in males was unaffected but in females it was decreased but only at the dose of 2 mg/kg. The liver and kidney weights of both sexes decreased at the lower doses. The protein content of these organs was also significantly affected by coffee treatment. These results suggest that coffee intake during pregnancy should be limited since it produces significant and long-lasting teratopharmacological and behavioral alterations in the offspring.

咖啡对小鼠致畸药理学和行为学的影响。
在白化病小鼠中评估了妊娠期间咖啡暴露与发育中的新生儿致畸药理学效应之间的可能关系。经过处理的幼崽出生后体重受到显著影响,随着幼崽的成长,它们的体重增加比对照组要低。该效应具有时间和剂量依赖性,围产期治疗比孕前治疗更有效(F(6) = 5.06, p < 0.02)。所有治疗组的体毛出现和睁眼时间均延迟,围产期治疗更有效,剂量依赖性更强。几乎所有的“运动行为”指标都受到所有剂量咖啡的影响,但仅在围产期治疗组中,这种影响既不依赖于时间也不依赖于剂量。在“管约束试验”中,子代的第一次咬的潜伏期减少,咬的次数增加,而雌性子代则相反。雌性后代的体重即使在幼龄成年动物中也很低(F(6) = 9.89, p < 0.005)。雄性的脑重量没有受到影响,但雌性的脑重量只有在剂量为2毫克/公斤时才会减少。在较低剂量下,两性的肝脏和肾脏重量均有所下降。这些器官的蛋白质含量也受到咖啡处理的显著影响。这些结果表明,怀孕期间的咖啡摄入量应该受到限制,因为它会对后代产生显著而持久的致畸药理学和行为改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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