Acta Pharmaceutica最新文献_第3页

Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system. 替加环素、奥马达环素和依瓦环素的胃肠道风险概况：来自FDA不良事件报告系统的证据

IF 1.4 4区医学

Acta Pharmaceutica Pub Date : 2026-03-25 Print Date: 2026-03-01 DOI: 10.2478/acph-2026-0001

Zhu Wang, Guoping Gan, Haiping Yao

{"title":"Gastrointestinal risk profile of tigecycline, omadacycline and eravacycline: Evidence from the FDA adverse event reporting system.","authors":"Zhu Wang, Guoping Gan, Haiping Yao","doi":"10.2478/acph-2026-0001","DOIUrl":"10.2478/acph-2026-0001","url":null,"abstract":"This study assessed the gastrointestinal (GI) safety profiles of tigecycline, omadacycline, and eravacycline through a retrospective disproportionality analysis of reports submitted to the FDA Adverse Event Reporting System (FAERS) between the second quarter of 2005 and the first quarter of 2024. Among 3,261 adverse event reports associated with these agents, 809 (24.8 %) involved gastrointestinal disorders, with tigecycline accounting for the largest proportion (588 reports), followed by omadacycline (197) and eravacycline (24). Disproportionality analysis revealed that gastrointestinal disorders ranked among the top three system organ classes for all three drugs, with positive signals observed for tigecycline (ROR = 1.63), omadacycline (ROR = 3.04), and eravacycline (ROR = 1.79), the strongest association being with omadacycline. While most GI events were consistent with known safety information, several unexpected signals were identified, including gastrointestinal haemorrhage, melena, small-intestinal obstruction, tongue discolouration, and intestinal perforation for tigecycline, as well as lip swelling and tongue discolouration for omadacycline. The median onset times of GI events were 4, 0, and 2.5 days for tigecycline, omadacycline, and eravacycline, respectively, with nearly half of the events occurring within three days of treatment initiation. These findings reveal distinct GI safety patterns among newer tetracycline-derived antibiotics and underscore the importance of early and route-specific monitoring in clinical practice.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":" ","pages":"1-20"},"PeriodicalIF":1.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive analytical workflow for rapid structure elucidation and in silico toxicological qualification of an unidentified impurity in cefixime granules for oral suspension. 口服混悬剂头孢克肟颗粒中未知杂质的快速结构解析和硅毒性鉴定的预测分析工作流程。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-03-25 Print Date: 2026-03-01 DOI: 10.2478/acph-2026-0005

Ivana Mitrevska, Marina Chachorovska, Gjorgji Petrushevski

{"title":"Predictive analytical workflow for rapid structure elucidation and in silico toxicological qualification of an unidentified impurity in cefixime granules for oral suspension.","authors":"Ivana Mitrevska, Marina Chachorovska, Gjorgji Petrushevski","doi":"10.2478/acph-2026-0005","DOIUrl":"10.2478/acph-2026-0005","url":null,"abstract":"During in-use stability testing of cefixime granules for oral suspension, an impurity with a relative retention time of 0.19 was consistently detected and increased during storage. To ensure regulatory compliance and patient safety, the impurity was structurally identified and toxicologically qualified. A laboratory-scale formulation and commercial products were studied under refrigerated and ambient conditions. The impurity was isolated by automated fraction collection and characterised by liquid chromatography-mass spectrometry and tandem mass spectrometry. Kinetic evaluation showed pseudo-first-order formation, with faster accumulation at ambient temperature. The impurity was identified as a γ-lactone degradation product of cefixime, present as multiple stereoisomers stabilised under acidic conditions. In silico toxicological assessment using complementary platforms indicated no additional structural alerts, no mutagenic potential, and negligible acute toxicity. The impurity forms only after prolonged storage of reconstituted suspensions and is classified as an ICH M7 Class 5 impurity, requiring no further genotoxicity testing. The applied analytical-computational workflow provides an efficient approach for impurity qualification in β-lactam antibiotics.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"76 1","pages":"1-25"},"PeriodicalIF":1.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-Cdk inhibitor ZK304709 suppresses Cdc20 expression and potentiates the anticancer activity of apcin in HeLa cervical cancer cells. Pan-Cdk抑制剂ZK304709抑制HeLa宫颈癌细胞中Cdc20的表达，增强apcin的抗癌活性。

IF 1.4 4区医学

Acta Pharmaceutica Pub Date : 2026-03-25 Print Date: 2026-03-01 DOI: 10.2478/acph-2026-0002

Xiangyang Le, Qingsong Chen, Shuyang Cao, Gaoyun Hu, Qianbin Li, Zhuo Chen

{"title":"Pan-Cdk inhibitor ZK304709 suppresses Cdc20 expression and potentiates the anticancer activity of apcin in HeLa cervical cancer cells.","authors":"Xiangyang Le, Qingsong Chen, Shuyang Cao, Gaoyun Hu, Qianbin Li, Zhuo Chen","doi":"10.2478/acph-2026-0002","DOIUrl":"10.2478/acph-2026-0002","url":null,"abstract":"Cell division cycle 20 homologue (Cdc20), a key regulator of the anaphase-promoting complex/cyclosome (APC/C), is frequently overexpressed in human cancers and represents a promising therapeutic target. However, monotherapy targeting Cdc20 has shown limited efficacy, partly due to compensatory activation of cyclin-dependent kinase 1 (Cdk1). In this study, we investigated the combinatorial potential of the pan-Cdk inhibitor ZK304709 with the Cdc20 inhibitor apcin in HeLa cervical cancer cells. Transcriptomic analysis revealed that both CDC20 and CDK1 are upregulated in cervical cancer tissues. Mechanistically, apcin treatment induced cyclin B1 accumulation and enhanced Cdk1 phosphorylation at Thr161, suggesting feedback activation. In contrast, ZK304709 reduced p-Cdk1(T161) levels and suppressed Cdc20 expression at both protein and mRNA levels. Functionally, the combination of apcin and ZK304709 synergistically inhibited cell proliferation and induced G2/M phase arrest in HeLa cells. These findings demonstrate that dual inhibition of Cdk1 and Cdc20 disrupts compensatory signalling pathways and enhances antitumour efficacy in HeLa cells, providing a rational strategy for combination therapy in cervical cancer.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145779710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative biodistribution analysis of umbilical cord mesenchymal stromal cells via different administration routes in rabbit models. 不同给药途径对兔脐带间充质间质细胞生物分布的比较分析。

IF 1.4 4区医学

Acta Pharmaceutica Pub Date : 2026-03-25 Print Date: 2026-03-01 DOI: 10.2478/acph-2026-0004

Liang Xiao, Chunlin Liu, Yuqian Wang, Fucheng Xiao, Jiahua Cai, Shoukang Qu, Xiaojuan Xu, Xiaoliang Wang, Yue Liu, Yutao Peng, Jia Liu

{"title":"Comparative biodistribution analysis of umbilical cord mesenchymal stromal cells via different administration routes in rabbit models.","authors":"Liang Xiao, Chunlin Liu, Yuqian Wang, Fucheng Xiao, Jiahua Cai, Shoukang Qu, Xiaojuan Xu, Xiaoliang Wang, Yue Liu, Yutao Peng, Jia Liu","doi":"10.2478/acph-2026-0004","DOIUrl":"10.2478/acph-2026-0004","url":null,"abstract":"Umbilical cord mesenchymal stem cells (UC-MSCs) have shown therapeutic potential in renal diseases due to their homing ability. This study compared the effects of three administration routes (intravenous, local renal injection, and interventional injection) on UC-MSC distribution in kidney tissue. Eighteen New Zealand rabbits were assigned to the three groups (n = 6 each), and DiI-labelled UC-MSCs were tracked using confocal microscopy to evaluate their distribution in the kidney, lung, and brain. Local renal injection led to high MSC concentrations at the injection site, but distribution to the contralateral kidney was minimal and comparable to that of intravenous injection. Intravenous delivery via the marginal ear vein was simple and convenient but resulted in limited renal homing (< 1 %) and no significant difference between kidneys. Interventional injection achieved the highest delivery efficiency (12.4 %) and a more uniform renal distribution. Notably, inflammatory cytokine levels (IL-6, TNF-α, IL-10) were significantly elevated in the local injection group (p < 0.05). These results indicated that the choice of administration route critically affects MSC targeting and therapeutic potential, and interventional injection may offer the most effective strategy for precise UC-MSC delivery in renal therapy.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":" ","pages":"1-17"},"PeriodicalIF":1.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of green analytical principles in the HPLC analysis of prednisolone derivatives: Method optimization and validation for nasal powder formulations. 绿色分析原理在强的松龙衍生物高效液相色谱分析中的应用：鼻用粉剂配方的方法优化与验证。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-01-13 Print Date: 2025-12-01 DOI: 10.2478/acph-2025-0032

Daniela Amidžić Klarić, Jelena Kovačić, Ilija Klarić, Petra Bajt, Lana Pribolšan, Erika Križanić, Laura Nižić Nodilo, Ana Mornar

{"title":"Application of green analytical principles in the HPLC analysis of prednisolone derivatives: Method optimization and validation for nasal powder formulations.","authors":"Daniela Amidžić Klarić, Jelena Kovačić, Ilija Klarić, Petra Bajt, Lana Pribolšan, Erika Križanić, Laura Nižić Nodilo, Ana Mornar","doi":"10.2478/acph-2025-0032","DOIUrl":"10.2478/acph-2025-0032","url":null,"abstract":"Glucocorticoids are a group of drugs increasingly used in modern medical practice due to their pronounced anti--inflammatory and immunosuppressive properties. In this study, prednisolone disodium phosphate and prednisolone acetate were analysed, with the aim of developing and validating an HPLC method in accordance with ICH Q2(R2) guidelines and quantifying their content in the active pharmaceutical ingredient powder and a model in--house sample. By applying the HPLC-DAD method with gradient elution, effective separation of the analytes was achieved. The method met all validation parameter requirements. The obtained results showed that the content of both analytes in the tested samples (bulk API powders and in-house prepared model formulation) was within the prescribed limits according to current pharmacopoeial standards. The proposed HPLC-DAD method was assessed for its applicability and environmental profile utilizing a range of green and blue metric tools. This comprehensive evaluation confirms that the method adheres to green analytical principles, making it suitable for sustainable pharmaceutical analysis.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 4","pages":"577-595"},"PeriodicalIF":1.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double-blind randomised controlled trial of an emollient cream with and without 1 % supercritical CO₂ extract of Calendula officinalis in contact dermatitis. 含和不含1%金盏花超临界CO2提取物的润肤膏治疗接触性皮炎的双盲随机对照试验。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-01-13 Print Date: 2025-12-01 DOI: 10.2478/acph-2025-0035

Mia Šušak Crnčević, Toni Durdov, Doris Rušić, Lara Ramić, Ana Ćosić, Josipa Bukić, Stela Jokić, Krunoslav Aladić

{"title":"Double-blind randomised controlled trial of an emollient cream with and without 1 % supercritical CO2 extract of Calendula officinalis in contact dermatitis.","authors":"Mia Šušak Crnčević, Toni Durdov, Doris Rušić, Lara Ramić, Ana Ćosić, Josipa Bukić, Stela Jokić, Krunoslav Aladić","doi":"10.2478/acph-2025-0035","DOIUrl":"10.2478/acph-2025-0035","url":null,"abstract":"This double-blind randomised controlled trial aimed to evaluate the efficacy of an emollient cream with and without 1 % supercritical CO2 extract of Calendula officinalis in contact dermatitis. Twenty healthy volunteers without pre-existing dermatological conditions participated in this single-centre study. Each participant's forearm was divided into three test sites: control (no treatment), placebo (base emollient), and intervention (calendula cream). The study employed random allocation of test sites using Microsoft Excel software. Both investigators and participants were blinded to the treatment assignments. The main outcomes were changes in skin hydration and transepidermal water loss (TEWL), measured with non-invasive probes (Corneometer CM 825, Tewameter TM 300), and erythema measured by Mexameter MX 18. Following irritant exposure, all sites showed increased TEWL and reduced hydration, confirming skin barrier impairment. The intervention site demonstrated significantly greater hydration compared with both the control (p = 0.017) and placebo sites (p = 0.035) on day 4, with this improvement persisting on day 8 (p = 0.043). TEWL values at the intervention site were significantly lower than control on day 3 (p = 0.022), indicating faster barrier recovery. No significant differences in erythema were observed between groups, and no adverse events occurred. Results of this study indicate that the addition of 1 % Calendula officinalis extract to an emollient cream enhanced skin hydration and accelerated recovery after irritant exposure, suggesting potential benefit in managing contact dermatitis with non-pharmacological skincare formulations.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 4","pages":"699-708"},"PeriodicalIF":1.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motility, biofilm, and endotoxin in Ralstonia pickettii isolates obtained from purified and ultrapure pharmaceutical water systems. 从纯化和超纯制药水系统中分离的皮氏Ralstonia的运动性，生物膜和内毒素。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-01-13 Print Date: 2025-12-01 DOI: 10.2478/acph-2025-0030

Ivanka Batarilo, Branka Bedenić, Mia Slade-Vitković, Gordana Maravić-Vlahoviček

{"title":"Motility, biofilm, and endotoxin in Ralstonia pickettii isolates obtained from purified and ultrapure pharmaceutical water systems.","authors":"Ivanka Batarilo, Branka Bedenić, Mia Slade-Vitković, Gordana Maravić-Vlahoviček","doi":"10.2478/acph-2025-0030","DOIUrl":"10.2478/acph-2025-0030","url":null,"abstract":"This study aimed to examine the motility, biofilm production, endotoxin release, and antibiotic resistance of 81 Ralstonia pickettii isolates collected from different pharmaceutical water systems in Croatia. Swimming and twitching motility were detected in all isolates, while swarming was not observed. Biofilm production was detected in approximately 40 % of the isolates under the tested conditions. Notably, extracellular polymeric substance (EPS) production was a common trait among all isolates. Endotoxin production was detected with the Limulus Amoebocyte Lysate test. Antibiotic susceptibility testing revealed consistent resistance to colistin, as well as significant resistance rates to β-lactam antibiotics, ertapenem, amoxicillin/clavulanic acid, ticarcillin and ampicillin. High susceptibility to first-generation cephalosporins, cephalexin, cefoxitin and chloramphenicol was observed. All isolates were susceptible to tigecycline and tetracycline. The isolates were grouped into three genetically closely related clusters, yet notable phenotypic diversity in biofilm production and antibiotic susceptibility persisted within these groups. The study highlights R. pickettii's adaptability in pharmaceutical water systems, marked by its motility, biofilm-forming capabilities, and multidrug resistance. These results emphasise the importance of rigorous monitoring of water systems to reduce transmission risks and prevent the emergence of resistant strains in clinical environments.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 4","pages":"597-612"},"PeriodicalIF":1.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant activity of methyl caffeate: Evidence of proton-coupled electron transfer reaction mechanism. 咖啡酸甲酯的抗氧化活性：质子耦合电子转移反应机理的证据。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-01-13 Print Date: 2025-12-01 DOI: 10.2478/acph-2025-0031

Ana Karković Marković, Viktor Pilepić, Cvijeta Jakobušić Brala, Agneza Rukavina, Andrea Štehec

{"title":"Antioxidant activity of methyl caffeate: Evidence of proton-coupled electron transfer reaction mechanism.","authors":"Ana Karković Marković, Viktor Pilepić, Cvijeta Jakobušić Brala, Agneza Rukavina, Andrea Štehec","doi":"10.2478/acph-2025-0031","DOIUrl":"10.2478/acph-2025-0031","url":null,"abstract":"Methyl caffeate (MC), a naturally occurring methyl ester of caffeic acid (CA), exhibits potent antioxidant activity and a broad spectrum of biological effects. This study investigates the antioxidant mechanism of MC through its reaction with the stable radical DPPH•, employing both experimental and computational approaches. Kinetic measurements were conducted in a predo minantly nonpolar medium (1,4-dioxane with phosphate buffer), revealing concerted proton and electron transfer. This experimental evidence was supported by values of kinetic isotope effects (KIEs) and thermodynamic activation parameters. Analysis of the intrinsic bond orbitals (IBOs) along the calculated intrinsic reaction coordinate (IRC) trajectories supported the proposed proton- coupled electron transfer (PCET) reaction mechanism. Additionally, the Fe(II) complexation ability of MC was evaluated spectrophotometrically, demonstrating stable complex formation at pH 7.0, suggesting potential for mitigating hydroxyl radical generation in physiological conditions. These findings offer new insights into the antioxidant behaviour of MC and its potential applications in pharmaceutical and nutraceutical formulations.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 4","pages":"613-628"},"PeriodicalIF":1.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide chirality and opioid receptor modulation: Hepatoprotective effect of d-Met-enkephalin in acetaminophen-induced liver injury. 肽手性和阿片受体调节：d-甲基脑啡肽在对乙酰氨基酚诱导的肝损伤中的保护作用。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-01-13 Print Date: 2025-12-01 DOI: 10.2478/acph-2025-0036

Petra Turčić, Roko Martinić, Nikola Štambuk, Tin Weitner, Mirna Momčilović, Alenka Boban-Blagaić, Marina Kos, Ranko Stojković

{"title":"Peptide chirality and opioid receptor modulation: Hepatoprotective effect of d-Met-enkephalin in acetaminophen-induced liver injury.","authors":"Petra Turčić, Roko Martinić, Nikola Štambuk, Tin Weitner, Mirna Momčilović, Alenka Boban-Blagaić, Marina Kos, Ranko Stojković","doi":"10.2478/acph-2025-0036","DOIUrl":"10.2478/acph-2025-0036","url":null,"abstract":"l-Met-enkephalin is a neuropeptide known to exert protective effects in various experimental models of autoimmune and inflammatory diseases. These effects are mediated through opioid receptors and can be abolished by the opioid receptor antagonist naltrexone. Investigation of peptide enantiomerism and the incorporation of d-amino acids are crucial for designing novel peptides with altered structural and biological properties compared with their native l-forms. Since no data are currently available on the properties or biological activity of the d-Met-enkephalin enantiomer, we evaluated its hepatoprotective potential in a mouse model of acetaminophen-induced hepatotoxicity. Male CBA mice were treated with d-Met-enkephalin, and hepatoprotection was assessed by measuring plasma alanine aminotransferase (ALT) and aspartate amino-transferase (AST) activities, along with histological liver necrosis scores. The peptide's secondary structure and antisense peptide binding were analysed using circular dichroism and fluorescence spectroscopy, respectively. d-Met-enkephalin demonstrated dose-dependent hepatoprotective effects within the range of 0.5-20 mg kg-1, with maximal protection observed at 5 mg kg-1, a dose comparable to that of the l-enantiomer (7.5 mg kg-1). This preservation of biological activity may be attributed to the presence of the achiral amino acid glycine at positions 2 and 3, which maintains the functional conformation of the d-enantiomer. The role of opioid receptor involvement was further examined through direct receptor blockade using naltrexone and indirect inhibition with the antisense peptide IPPKY.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 4","pages":"659-672"},"PeriodicalIF":1.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating preeclampsia risk factors and angiogenic profiles in low-screening area. 低筛查地区子痫前期危险因素及血管生成情况的调查。

IF 1.8 4区医学

Acta Pharmaceutica Pub Date : 2026-01-13 Print Date: 2025-12-01 DOI: 10.2478/acph-2025-0040

Adriana Bokulić, Dražan Butorac, Ivka Djaković, Marijo Čukelj, Marija Grdić Rajković

{"title":"Investigating preeclampsia risk factors and angiogenic profiles in low-screening area.","authors":"Adriana Bokulić, Dražan Butorac, Ivka Djaković, Marijo Čukelj, Marija Grdić Rajković","doi":"10.2478/acph-2025-0040","DOIUrl":"10.2478/acph-2025-0040","url":null,"abstract":"Preeclampsia (PE) is a complex pregnancy disorder that may cause adverse outcomes for mother and baby. Combining risk factors with clinical, laboratory, and ultrasonographic data can help identify women at risk. This study investigated the relationship between maternal risk factors, soluble fms-like tyro-sine kinase 1 (sFlt-1), placental growth factor (PlGF), their ratio, and pregnancy outcomes, involving 68 women with PE risk factors and 21 controls. There were no significant differences in the frequency of adverse outcomes (PE, foetal death, and infants with abnormal birth weight), sFlt-1, PlGF, the sFlt-1/PlGF ratio, or birth weight centiles between the PE-risk and control groups. The most frequently recorded high-risk factor was gestational diabetes mellitus, whereas moderate risk was a pre-pregnancy body mass index of over 30 kg m-2. The most prominent difference was observed in the subgroups with gestational hypertension and first-time pregnant women as risk factors, with significantly higher sFlt-1/PlGF ratios compared to the control group. Combining multiple risk factors increased the sFlt-1/PlGF ratio compared to both the control group and the group with only one risk factor. The study documented PE risk factors and outcomes at a Croatian hospital where angiogenic markers are not routinely used in screening. Findings highlighted the importance of integrating PE screening into standard practice.","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 4","pages":"687-697"},"PeriodicalIF":1.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0