Acta neurobiologiae experimentalis最新文献_第6页

The effect of a series of whole‑body cryotherapy treatments on the activity of antioxidant enzymes in healthy women and women with multiple sclerosis. 一系列全身冷冻治疗对健康女性和多发性硬化症女性抗氧化酶活性的影响。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2431

Bartłomiej Ptaszek, Szymon Podsiadło, Olga Czerwińska-Ledwig, Aneta Teległów, Wanda Pilch, Artur Wójcik, Ewa Sadowska-Krępa

引用次数: 0

Nesfatin‑1 exerts anticonvulsant effect by reducing oxidative stress in experimental epilepsy model. Nesfatin‑1通过降低实验性癫痫模型氧化应激发挥抗惊厥作用。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 Epub Date: 2023-09-07 DOI: 10.55782/ane-2023-2419

Seval Musuroglu Keloglan, Fatma Banu Aycik, Suleyman Emre Kocacan, Burak Yazgan, Mustafa Ayyildiz, Erdal Agar

{"title":"Nesfatin‑1 exerts anticonvulsant effect by reducing oxidative stress in experimental epilepsy model.","authors":"Seval Musuroglu Keloglan, Fatma Banu Aycik, Suleyman Emre Kocacan, Burak Yazgan, Mustafa Ayyildiz, Erdal Agar","doi":"10.55782/ane-2023-2419","DOIUrl":"10.55782/ane-2023-2419","url":null,"abstract":"Neuropeptides play an important role in the pathogenesis of epilepsy. In the present study, the effect of nesfatin‑1, a neuropeptide, was investigated on penicillin‑induced epilepsy model. Epileptiform activity was induced by an injection of penicillin into the somatomotor cortex at 56 albino Wistar rats. Nesfatin‑1 (i.c.v.) was administered at five different doses (12.5, 25, 50, 100, and 200 pmol) 30 min after a penicillin administration. Astressin 2B, a corticotropin‑releasing factor (CRF) receptor antagonist, was administered 10 minutes later the effective dose of nesfatin‑1 (50 pmol, i.c.v.). Superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and malondialdehyde (MDA) levels in cerebrum were analysed by ELISA method. Nesfatin‑1, at the doses of 25, 50 and 100 pmol, significantly reduced the frequency of epileptiform activity. However, none of the doses of nesfatin‑1 had any effect on the amplitude of epileptiform activity. Astressin 2B alone did not show any effect on epileptiform activity. In addition, astressin 2B had no effect on the anticonvulsant effect of nesfatin‑1. Nesfatin‑1 (at the doses of 25, 50, 100 pmol) did not alter SOD and GSH levels, but significantly increased the GPx and GR levels. Nesfatin‑1 (at a dose of 50 pmol) significantly decreased the MDA level in the cerebrum. Nesfatin‑1 shows anticonvulsant effect and astressin 2B did not affect the anticonvulsant effect of nesfatin‑1. We suggest that nesfatin‑1 has oxidative stress‑mediated anticonvulsant effect in the penicillin‑induced epileptic activity.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":" ","pages":"227-235"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10553881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR‑488‑3p alleviates neuropathic pain by regulating target gene ROCK1. miR‑488‑3p通过调节靶基因ROCK1减轻神经性疼痛。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2432

Qiang Fu, Yuanqing Deng, Bo Zhou, Juan Lei, Ke Peng, Can Feng

{"title":"miR‑488‑3p alleviates neuropathic pain by regulating target gene ROCK1.","authors":"Qiang Fu, Yuanqing Deng, Bo Zhou, Juan Lei, Ke Peng, Can Feng","doi":"10.55782/ane-2023-2432","DOIUrl":"10.55782/ane-2023-2432","url":null,"abstract":"The function of microRNA (miRNA) in neuropathic pain (NP) has received widespread attention. The current research sought to address the contribution of miR‑488‑3p in NP and its downstream mechanisms. The NP rat model was constructed by chronic constriction injury (CCI) surgery in rats. Regulation of miR‑488‑3p or Rho‑associated coiled‑coil‑containing protein kinase 1 (ROCK1) in rats by intrathecal injection of lentivirus or plasmid. Real‑time quantitative reverse transcription polymerase chain reaction (RT‑qPCR) to examine the levels of miR‑488‑3p and ROCK1 in the dorsal root ganglion (DRG). Enzyme‑linked immunosorbent assay (ELISA) to monitor the secretion of pro‑inflammatory and anti‑inflammatory factors. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) for the evaluation of mechanosensitive and thermal nociceptive hypersensitivity of NP behaviors. Validation of molecular mechanism between miR‑488‑3p and ROCK1 using RNA immunoprecipitation assay and dual‑luciferase reporter (DLR) assay. miR‑488‑3p was vigorously less expressed in the DRGs of CCI rats, while ROCK1 was upregulated. Elevated miR‑488‑3p alleviated the decrease of PWL and PWT in CCI rats, inhibited the secretion of pro‑inflammatory factors, and enhanced anti‑inflammatory factors levels. Mechanistically, ROCK1 was the target of miR‑488‑3p. Raised ROCK1 partially attenuated the mitigating effect of miR‑488‑3p on NP behavior and the suppression of inflammatory responses in rats. Current research demonstrated that miR‑488‑3p may be a novel therapeutic target for NP.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"271-279"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling. 山奈酚治疗通过作用于reelin信号，改善STZ诱导的神经退行性变的记忆障碍。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2427

Melike Uysal, Mert Celikten, Merve Beker, Nurhayat Polat, Onder Huseyinbas, Sule Terzioglu-Usak, Birsen Elibol

{"title":"Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling.","authors":"Melike Uysal, Mert Celikten, Merve Beker, Nurhayat Polat, Onder Huseyinbas, Sule Terzioglu-Usak, Birsen Elibol","doi":"10.55782/ane-2023-2427","DOIUrl":"10.55782/ane-2023-2427","url":null,"abstract":"Many treatment initiatives, like herbal products and their active ingredients, aim to alleviate neurodegeneration to increase cognitive functions. Kaempferol may be a candidate molecule for treating neurodegeneration because of its antioxidant effects. In the present study, we examined the molecular changes associated with kaempferol's memory‑enhancing effects on streptozotocin (STZ)‑induced neurodegeneration. After intracerebroventricular STZ injection in Long‑Evans male rats, intraperitoneal kaempferol was administered for 12 days. The Morris water maze (MWM) was used to measure learning and memory performance in the rats, and proteins related to memory formation were investigated in the hippocampi with western blotting. Kaempferol improved learning performance and memory decline in STZ‑treated rats. At the molecular level, STZ‑induced neurodegeneration resulted in a decrease in the expression of GAD67, reelin, and phosphorylated‑NMDAR. However, kaempferol treatment ameliorated these changes by enhancing their levels similar to the controls. While neither STZ injection nor kaempferol treatment produced any significant change in phosphorylated‑CAMKII levels, they increased the expression of klotho and prealbumin. These results show that kaempferol has positive effects on memory loss, affecting synaptic plasticity by ameliorating both the levels and activity of memory‑relevant molecules through reelin signaling. In summary, this study provides a guide to future studies by examining in detail the healing effect of kaempferol as a candidate molecule in the treatment of neurodegeneration, such as that observed in Alzheimer's disease.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"236-245"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway. 富氢盐水通过AMPK/mTOR信号介导的自噬途径促进脑缺血小鼠的神经元恢复。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2437

Jing Wang, Xiang-Jian Zhang, Yuan-Yuan Du, Guang Shi, Cong-Cong Zhang, Rong Chen

{"title":"Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway.","authors":"Jing Wang, Xiang-Jian Zhang, Yuan-Yuan Du, Guang Shi, Cong-Cong Zhang, Rong Chen","doi":"10.55782/ane-2023-2437","DOIUrl":"10.55782/ane-2023-2437","url":null,"abstract":"This study explored the protective effect and mechanism of hydrogen‑rich saline (HRS) on the neurological function of mice with cerebral ischemia. Effects of HRS on neurological function in mice with cerebral ischemia were evaluated by neurological function scores. Infarct volume and histological damage were evaluated by 2,3,5‑triphenyl tetrazolium chloride staining (TTC staining). Golgi‑Cox staining was conducted to measure the morphological changes of neuronal dendrites and dendritic spines. The expression of neuronal markers was detected by immunofluorescence. Western blot was used to detect protein expression. The infarct volume of mice in the HRS‑H group decreased significantly compared to that of the distal middle cerebral artery occlusion (dMCAO) group. Mice in the HRS‑H group had a lower neurological deficit score than that in the dMCAO group. Compared to the dMCAO group, the activity of superoxide dismutase (SOD) and the level of glutathione (GSH) significantly increased in the HRS‑H group. Compared with the dMCAO group, the number of apoptotic cells in the HRS‑H group decreased. Administration of HRS was shown to be able to decrease cavitation of the brain cortex after ischemia. The spine density in the HRS‑H group increased compared to that of the dMCAO group. In the in vitro experiment, compared with the oxygen‑glucose deprivation (OGD) group, the active oxygen content in the 75% HRM group decreased, and the mitochondrial membrane potential and adenosine triphosphate (ATP) content increased. Compared with the OGD group, the ratio of P‑AMPK and the levels of LC3II/LC3I in the hydrogen‑rich medium (HRM) group was upregulated, and P‑mTOR levels and P62 levels in the HRM group were down‑regulated. HRS can enhance neuroplasticity after ischemia and promote neurological recovery in mice with cerebral ischemia, which may involve the autophagy pathway mediated by the AMPK/mTOR signaling pathway.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"317-330"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of vitamin D on mood alteration in women's life: Focus on depression. 维生素D对女性生活中情绪变化的影响：关注抑郁症。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2436

Isidoros Mentis

{"title":"The effects of vitamin D on mood alteration in women's life: Focus on depression.","authors":"Isidoros Mentis","doi":"10.55782/ane-2023-2436","DOIUrl":"10.55782/ane-2023-2436","url":null,"abstract":"Vitamin D (VD) is a vital liposoluble neurosteroid micronutrient, particularly crucial for women's health. International literature strongly correlates sufficient VD levels with comprehensive mental well‑being in women. This link is intricately related to neurobiological pathways and hormonal fluctuations, where low VD levels are notably associated with depression. This study comprehensively explores the neurobiological mechanisms that link VD and altered mood in women. Considering the increased susceptibility to hormonal shifts in women, our research investigates the intricate interplay between VD's neurobiology and mood regulation. Through the focused analysis of specific studies, we untangle the complex web of connections between VD and mood changes in women. Our approach takes into account the dynamic nature of hormonal changes, deepening our understanding of these mechanisms. Our study underscores VD's significant role as a neurosteroid micronutrient, especially in women's health. By examining the intricate relationships between VD's neurobiology and hormones, we propose strategies to improve mood regulation and psychological well‑being in women. In addition, we recommend targeted measures to achieve optimal VD levels, helping to manage challenges arising from hormonal fluctuations. The present review highlights the multifaceted contribution of VD to women's health, particularly in mood regulation. Through the analysis of the interplay of neurobiology, hormones and VD, our study provides avenues for enhancing women's mental and emotional well‑being through customized interventions.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"307-316"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential approach to stroke aphasia and primary progressive aphasia using transcranial magnetic stimulation: A systematic review. 经颅磁刺激治疗脑卒中失语症和原发性进行性失语症的鉴别方法：一项系统综述。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2433

Verónica Pérez-Martínez, Candela Zorzo, Marta Méndez

{"title":"Differential approach to stroke aphasia and primary progressive aphasia using transcranial magnetic stimulation: A systematic review.","authors":"Verónica Pérez-Martínez, Candela Zorzo, Marta Méndez","doi":"10.55782/ane-2023-2433","DOIUrl":"10.55782/ane-2023-2433","url":null,"abstract":"Language disorders can occur as a consequence of stroke or neurodegenerative disorders, among other causes. Post‑stroke aphasia (PSA) and primary progressive aphasia (PPA) are syndromes that, despite having common features, differ in the brain mechanisms that cause their symptoms. These differences in the underlying functional neuroanatomical changes may influence the way they are addressed by different non‑invasive brain stimulation techniques and, in particular, by repetitive transcranial magnetic stimulation (rTMS). The aim of this systematic review is to evaluate the efficacy of rTMS in the treatment of PSA and PPA, as well as the differences in the approach to these disorders using rTMS. To this end, a total of 36 articles were found in the Web of Science, Scopus, and PubMed. The results obtained suggest that whereas in PSA, the selection of the stimulation paradigm is based on bi‑hemispheric functional reorganisation models with a tendency towards the application of inhibitory rTMS in the contralateral right hemisphere, in PPA, the application of excitatory rTMS in functionally compromised areas seems to show promising changes. It is concluded that rTMS is a potential treatment in the therapy of both disorders, although differences in the underlying brain mechanisms differentiate the rTMS approach in each case.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"280-298"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effect of 1,25‑dihydroxyvitamin D3 against hyperoxia‑induced brain injury in premature rats. 1,25-二羟基维生素D3对早产大鼠高氧诱导的脑损伤的神经保护作用。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2435

Rong Chen, Fahua Yao, Xiaodan Deng, Xiaofeng Yuan, Nian Wei, Dongfan Xiao, Benli Yu

{"title":"Neuroprotective effect of 1,25‑dihydroxyvitamin D3 against hyperoxia‑induced brain injury in premature rats.","authors":"Rong Chen, Fahua Yao, Xiaodan Deng, Xiaofeng Yuan, Nian Wei, Dongfan Xiao, Benli Yu","doi":"10.55782/ane-2023-2435","DOIUrl":"10.55782/ane-2023-2435","url":null,"abstract":"Studies have shown that vitamin D plays a crucial role in brain development, brain metabolism and neuroprotection. There is little evidence for the neuroprotective effect of 1, 25‑dihydroxyvitamin D3 (1,25‑(OH)2D3) on various brain injury models. The aim of this study was to investigate the neuroprotection effect of 1,25‑(OH)2D3 against hyperoxia‑induced brain injury in premature rats. Sprague‑Dawley rats were exposed to 95% oxygen or room air for 24 h and treated with 1,25‑(OH)2D3 or normal saline for 14 consecutive days. The histopathological changes of optic chiasma tissue were observed by hematoxylin‑eosin staining. Immunohistochemistry, qRT‑PCR, and western blot were performed to detect the expression of integrin‑β1 and yes‑associated protein (YAP) in the organization of the optic chiasm. Histopathological sections of optic chiasma showed visible optic nerve swelling, expanded nerve fiber space, uneven staining, obvious oligodendrocyte proliferation and disordered cell arrangement accompanied by inflammatory cell infiltration and exudation after 7 days and 14 days of hyperoxia exposure. The hyperoxia group treated with 1,25‑(OH)2D3 were showed improvement of brain injury with reduced inflammatory exudation, uniform nerve fiber staining and less obvious oligodendrocyte proliferation. Immunohistochemical staining, qRT‑PCR and western blot indicated that 1,25‑(OH)2D3 treatment upregulated the expression of integrin‑β1 and YAP in the hyperoxia group on day 7. However, the expression of YAP was significantly increased compared with control group and treatment with 1,25‑(OH)2D3 reduced the expression of YAP in the hyperoxic group on day 14. 1,25‑(OH)2D3 may regulate the expression of integrin‑β1 and YAP to alleviate hyperoxia‑induced brain injury in premature rats.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"299-306"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of bee venom on behavior and the role of leptin in rats. 蜂毒对大鼠行为的影响及瘦素的作用。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-09-29 DOI: 10.55782/ane-2023-2430

Bahar Dalkiran, Burcu Acikgoz, Ilkay Aksu, Amac Kiray, Muge Kiray

{"title":"The effects of bee venom on behavior and the role of leptin in rats.","authors":"Bahar Dalkiran, Burcu Acikgoz, Ilkay Aksu, Amac Kiray, Muge Kiray","doi":"10.55782/ane-2023-2430","DOIUrl":"10.55782/ane-2023-2430","url":null,"abstract":"The aim of this study is to evaluate the dose‑dependent effect of bee venom (BV) on behavioral functions in rats and the physiological role of leptin in the prefrontal cortex, hippocampus, and amygdala tissues. Adult Sprague‑Dawley male rats were used in the experiments. The rats were divided into three groups of control, 0.1 mg/kg BV, and 0.5 mg/kg BV. The rats were injected with BV subcutaneously for 15 consecutive days. The open field test (OFT), the elevated plus maze test (EPM), and the forced swimming test (FST) were performed as behavioral assessments. Animals were sacrificed, and brain regions were removed. Leptin levels were measured in various brain regions by ELISA. In the OFT, the total distance and speed for the 0.1 mg/kg BV group increased compared to controls and the 0.5 mg/kg BV group. In the EPM, the 0.1 mg/kg BV group remained in the open arm for a significantly longer period of time compared to the other groups. In the FST, the 0.5 mg/kg BV group was more mobile than the other groups. Leptin levels in the prefrontal cortex were significantly higher in the 0.1 mg/kg BV group compared to the control and 0.5 mg/kg groups. There were no significant differences between groups in hippocampus and amygdala leptin levels. The results of the study show that BV has a positive effect on behavioral parameters. BV may have a positive effect on anxiety‑ and depression‑like behaviors by increasing leptin levels in the prefrontal cortex.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 3","pages":"255-261"},"PeriodicalIF":1.4,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The paraventricular nucleus of the hypothalamus - the concertmaster of autonomic control. Focus on blood pressure regulation. 下丘脑室旁核——自主神经控制的大师。关注血压调节。

IF 1.4 4区医学

Acta neurobiologiae experimentalis Pub Date : 2023-01-01 DOI: 10.55782/ane-2023-004

Emilia Grzęda, Kamil Ziarniak, Joanna H Sliwowska

{"title":"The paraventricular nucleus of the hypothalamus - the concertmaster of autonomic control. Focus on blood pressure regulation.","authors":"Emilia Grzęda, Kamil Ziarniak, Joanna H Sliwowska","doi":"10.55782/ane-2023-004","DOIUrl":"https://doi.org/10.55782/ane-2023-004","url":null,"abstract":"The autonomic nervous system regulates internal organs and peripheral circulation, which enables the maintenance of homeostasis in vertebrate species. One of the brain regions involved in autonomic and endocrine homeostasis regulation is the paraventricular nucleus of the hypothalamus (PVN). The PVN is a unique site at which multiple input signals can be assessed and integrated. The regulation of the autonomic system by the PVN and, especially, the sympathetic flow, depends upon the integration of inhibitory and excitatory neurotransmitter action. The excitatory neurotransmitters such as glutamate and angiotensin II, and inhibitory neurotransmitters such as γ‑aminobutyric acid and nitric oxide, play a key role in the physiological function of the PVN. Moreover, arginine-vasopressin (AVP) and oxytocin (OXT) are important in the regulation of sympathetic system activity. The PVN is also crucial for maintaining cardiovascular regulation, with its integrity being pivotal for blood pressure regulation. Studies have shown that pre‑autonomic sympathetic PVN neurons increase blood pressure and the dysfunction of these neurons is directly related to elevated sympathetic nervous system activity under hypertension. Etiology of hypertension in patients is not fully known. Thus, understanding the role of PVN in the generation of hypertension may help to treat this cardiovascular disease. This review focuses on the PVN's inhibitory and excitatory neurotransmitter interactions that regulate sympathetic system activity in physiological conditions and hypertension.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"83 1","pages":"34-44"},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9384494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3