Acta Medica Philippina最新文献

{"title":"A Case Study on a Novel Teaching Method on Integumentary and Musculoskeletal Anatomy for First Year Medical Students in a National University in the Philippines (University of the Philippines College of Medicine) as a Potential Alternative to Traditional Cadaveric Dissection.","authors":"Christopher S Constantino, Rowena F Genuino, Jose V Tecson, Rafael C Bundoc, Donnel Alexis T Rubio","doi":"10.47895/amp.vi0.10252","DOIUrl":"10.47895/amp.vi0.10252","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic resulted in the lack of traditional cadaveric dissection among first year medical students in Anatomy courses in the University of the Philippines College of Medicine. The Learning Enhancement in Anatomy Program (LEAP) was implemented as a bridging program to enhance knowledge and understanding of gross anatomy and histology. As part of this program, a novel multi-strategy teaching method was conducted for the Integumentary and Musculoskeletal Anatomy Module.</p><p><strong>Objective: </strong>This case study described a novel multi-strategy teaching method on Integumentary and Musculoskeletal anatomy for first year medical students which was done after the COVID-19 pandemic wherein there was a shortage of cadavers. By describing this multi-strategy teaching method, this case study aims to present a potential alternative teaching method in a situation where there is an unexpected shortage of human cadavers.</p><p><strong>Methods: </strong>A retrospective review of documents related to this teaching method among first year medical students at the University of the Philippines College of Medicine was conducted from November 15, 2023, to January 15, 2024. The novel teaching method for the Integumentary and Musculoskeletal station was taught using five different methods: proctor demonstration, a prosected lower extremity with a self-directed manual, dissection education videos viewed on a large screen, skeletons for osteology, and individual light microscopes with a self-directed laboratory histology manual. We described the data and analyzed according to strengths and limitations, and formulated recommendations to improve the module.</p><p><strong>Results: </strong>The Integumentary and Musculoskeletal Module of the LEAP provided an interactive, hands-on experience in anatomy education. The five-pronged method facilitated a multifaceted approach to learning through cadaveric prosections, self-directed manuals, dissection videos, osteology exercises, and microscopic study. There was active engagement, overall positive student feedback, and increased post-test scores. However, certain limitations, such as the lack of direct cadaveric dissection, potential underutilization of histology components, and reliance on faculty guidance, highlight areas for improvement.</p><p><strong>Conclusion: </strong>The Integumentary and Musculoskeletal Module of the LEAP has demonstrated significant strengths in enhancing anatomical education through a multimodal approach that fosters active learning, improves knowledge retention, and provides a structured curriculum adaptable to various resource constraints. Student feedback and test performance support the effectiveness of the module, particularly in gross anatomy. Addressing challenges in future iterations will be crucial in refining the program and expanding its applicability to different educational contexts. By building on its strengths and mitigating its weakne","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 6","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mental Health Care Setting as a Clinical Exposure Site for Interprofessional Education: a Qualitative Study.","authors":"Evangeline Bascara Dela Fuente","doi":"10.47895/amp.vi0.9523","DOIUrl":"10.47895/amp.vi0.9523","url":null,"abstract":"<p><strong>Background: </strong>Interprofessional collaboration is required as a learning outcome for medical school graduates. Clinical exposure to collaborative practice is one of the recommended strategies in the implementation of interprofessional education. Professionals in mental health units customarily engage in collaborative practice and can provide learning opportunities for medical students. Local data on interprofessional collaboration among practitioners in a mental health care setting in the pandemic is limited and merits study.</p><p><strong>Objectives: </strong>The goal of this study was to determine and then describe factors that influence collaborative practice among health professionals in an inpatient mental health care unit in the pandemic. It aimed to generate recommendations from practitioners on strategies to optimize opportunities for medical students to learn interprofessional collaboration.</p><p><strong>Methods: </strong>This is a qualitative study which made use of key informant interviews (KIIs) and focused group discussions (FGDs) with members of a multiprofessional mental health team in the mental health unit of a tertiary medical center. Data was analyzed using thematic analysis.</p><p><strong>Results: </strong>The onset of the COVID-19 pandemic had drastically disrupted health care services and opportunities for interprofessional collaboration. Participants described their roles and identified six factors essential to reenergizing collaborative practice: resources and opportunities for meaningful interaction, quality of relationship and communication among team members, management goals and strategies relevant to the mental health needs and the context of patients and their families, guidelines for collaboration, interprofessional education appropriate to participant levels, and monitoring for quality assurance and improvement. Practical guidelines for promoting the identified factors were outlined. Recommendations to optimize opportunities for interprofessional education were also given.</p><p><strong>Conclusion: </strong>Six factors were identified and described in the study. These can provide practitioners and students with a frame of reference for participating in and learning from collaborative practice in a mental health care unit as they work with other professionals on a shared concern. Addressing practical issues in real life settings will enhance their capacity to meaningfully collaborate with other professionals in managing patients, institutions, projects, and similar situations.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 6","pages":"110-119"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating Praxis into Community Engagement-Self Monitoring: A Case Study on Applied Social Innovation in Rural Philippines.","authors":"Arturo M Ongkeko, Pauline Marie P Tiangco, Jana Deborah Mier-Alpaño, Jose Rene Bagani Cruz, Alfredo M Coro, Joey G Escauso, Wilfredo P Awitan, Beatrice M Halpaap, Uche V Amazigo, Meredith Del Pilar-Labarda","doi":"10.47895/amp.vi0.9847","DOIUrl":"10.47895/amp.vi0.9847","url":null,"abstract":"<p><strong>Background: </strong>Social Innovation in Health Initiative Philippines introduced the community engagement self-monitoring strategy in two community-managed social innovations in 2021. Phase 1 demonstrated the strategy's viability by identifying community \"local monitors,\" selecting indicators, monitoring, and conducting feedback sessions. In 2022, a second phase was implemented to improve the process by integrating capacity-building activities and praxis sessions, and gathering insights on the strategy's sustainability.</p><p><strong>Objective: </strong>In this paper, we sought to describe the stages of the CE-SM strategy applied within a Philippine local health system in geographically isolated and disadvantaged contexts. Specifically, we: 1) Identified the key competencies of the local CE-SM monitors; 2) facilitated capacity building to strengthen their skills and abilities; 3) explored sustainability mechanisms; and 4) identified integration points of the CE-SM in strengthening local health systems.</p><p><strong>Methods: </strong>Two communities in a rural municipality implementing a social innovation called the \"Seal of Health Governance'' were chosen for the expanded community engagement self-monitoring (CE-SM) pilot. Profiling of local monitors and self-assessment of competencies were facilitated. Capacity-building activities were conducted for community engagement, data processing, and data analysis, complemented by praxis sessions guided by people-centered principles.</p><p><strong>Results: </strong>Local monitors from both communities showed determination in performing their responsibilities but differed in their levels of participation. Their appreciation of their role increased as it broadened from merely collecting data to understanding and using it to advocate for their community's needs. The minimum resources for communities to implement the strategy include financial mechanisms to ensure the availability of resources. Local monitors have improved their ability to analyze their communities' realities, particularly regarding health leadership and governance.</p><p><strong>Conclusions: </strong>Community engagement self-monitoring is a feasible and sustainable strategy for monitoring and evaluating health interventions if adequate support is provided and complemented by capacity-building and praxis sessions. It promotes listening to the community and empowering them to participate in decision-making, which are vital in fostering ownership and sustainability of social innovations in health.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"36-51"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Infant and Young Child Feeding (IYCF) Practices in Mindanao: Lessons from Select Municipalities in Maguindanao.","authors":"Chona F Patalen","doi":"10.47895/amp.v59i5.13391","DOIUrl":"10.47895/amp.v59i5.13391","url":null,"abstract":"","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Truly Matters in Community Partnerships.","authors":"Gene Alzona Nisperos","doi":"10.47895/amp.v59i5.13392","DOIUrl":"10.47895/amp.v59i5.13392","url":null,"abstract":"","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Vanishing Mandible: Diagnosis and Treatment Considerations for Gorham-Stout Disease of the Mandible.","authors":"Harroun Valdimir T Wong, Johanna Patricia A Cañal","doi":"10.47895/amp.vi0.7516","DOIUrl":"10.47895/amp.vi0.7516","url":null,"abstract":"<p><p>Gorham-Stout disease is a rare osteolytic disorder with an unclear pathophysiology. It presents as lesions characterized by the loss of the bony matrix and the proliferation of malformed vasculature. At present, there are no gold-standard diagnostic evaluation protocols and it is diagnosed through a mixture of clinical, histopathologic, and radiographic findings. We report a case of a 19-year-old female with Gorham-Stout disease presenting with an 8-year progressive soft tissue mass in the mandible. Extensive osteolysis of the mandible with clustering of the mandibular dentition is noted on computed tomography (CT) imaging. Her case was discussed in a multidisciplinary conference and her treatment was radiotherapy followed by surgery ± reconstruction. We used a CT-based three-dimensional planning technique to give 40 Gy over 20 treatment sessions to the involved areas. Post treatment, a repeat CT was done at six weeks to reassess for disease progression or stabilization, followed by surgical excision. As of 31 October 2021, no evidence of recurrence is noted 48 months after treatment. Arriving at a definitive diagnosis with Gorham-Stout disease is challenging and a multidisciplinary team approach can help determine the treatment choice with best outcomes.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"75-81"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Toxicity and Hypoglycemic Effect in Alloxan-induced Diabetic Mice of <i>Manihot esculenta</i> Crantz (Fam. Euphorbiaceae) Aqueous Crude Leaf Extract and its Fractions.","authors":"Carmina Mae S Bautista, Bryan M Amante, Edwin C Ruamero","doi":"10.47895/amp.vi0.7624","DOIUrl":"10.47895/amp.vi0.7624","url":null,"abstract":"<p><strong>Objective: </strong><i>Manihot esculenta</i> (Crantz) leaves have been used for the management of diabetes based on cited ethnopharmacological studies. However, scientific evidence to support its efficacy is lacking. The aim of the study was to assess the cytotoxicity of the aqueous leaf extract and fractions of <i>Manihot esculenta</i> and its potential hypoglycemic effect on male Swiss albino mice.</p><p><strong>Methods: </strong>The cytotoxicity assay was necessary to screen which extract and fractions will be used for the <i>in vivo</i> hypoglycemic study.Phytochemical screening identified the composition of the aqueous crude extract and its fractions. The phytochemical results showed the presence of alkaloids, anthraquinone glycosides, carbohydrates, phenolic glycosides, saponins, and flavonoids.Cytotoxicity was screened using CytoTox 96^® (Promega), a NonRadioactive Cytotoxicity Assay on liver cancer (HepG2) and normal kidney (HK-2) cell lines. Five samples were tagged as highly cytotoxic and were flagged for further assays. These samples were DCM fraction (100 ppm), n-Hexane fraction (1 and 10 ppm), Ethyl acetate fraction (1 ppm), and Aqueous fraction (100 ppm).</p><p><strong>Results: </strong>The hypoglycemic activity was examined in alloxan-induced diabetic mice using <i>in vivo</i> hypoglycemic study. The aqueous crude extract at dose levels of 200 mg/kg and 300 mg/kg body weight showed significant reduction in blood glucose levels compared to the diabetic control but not exceeding the results in the metformin treatment group. A <i>p-value</i> of 0.05 set a priori was used to consider whether the intervention had a statistically significant difference compared to the diabetic control.</p><p><strong>Conclusion: </strong>The effectiveness of aqueous crude extract in reduction of blood glucose in mice may be attributed to the synergistic effects of phytochemicals present, especially the alkaloids which were retained in the extract but were undetectable in the fractionated samples. The results of this study also support the findings of existing ethnopharmacological studies on <i>M. esculenta</i> leaf extract as a hypoglycemic agent.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"65-74"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motivating and Hindering Factors Affecting Muslim Mothers' Infant and Young Child Feeding (IYCF) Practices in Select Municipalities of Maguindanao, BARMM, Philippines.","authors":"Paul Alteo A Bagabaldo, Maria Theresa M Talavera, Divine Grace C Domingo, Angelina R Bustos, Leila S Africa, Angelina Dr Felix, Anna Teresa O Orillo, Nancy A Tandang, Warren T K Lee, Maria Cecilia F Pastores","doi":"10.47895/amp.vi0.9487","DOIUrl":"10.47895/amp.vi0.9487","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the motivating and hindering factors affecting the Infant and Young Child Feeding (IYCF) practices of Muslim mothers in select municipalities of Maguindanao.</p><p><strong>Methods: </strong>A pretested questionnaire was administered through face-to-face interviews conducted among 320 randomly selected Muslim mothers with a child aged 6-23 months.</p><p><strong>Results: </strong>Results revealed that prelacteal feeding was practiced by 16.6% of the Muslim mothers, giving mostly plain water. Solid/semi-solid foods were introduced at a mean age of 6.1 ± 1.4 months, with home-cooked lugao (porridge) (55.0%) and commercial baby food (31.3%) as the top foods introduced. The majority of Muslim mothers (82.5%) fed processed foods as complementary food to their children, including instant noodles (85.2%) and canned goods (51.5%). These processed foods were mostly obtained from sari-sari stores, with TV as the top source of information. More than 80% of the Muslim mothers cited food availability, economic reasons, and convenience in food preparation as the top three motivating factors in the practice of complementary feeding (CF). In addition, almost all the Muslim mothers (~97%) mentioned seeing their children grow healthy as the top reason for improving their food preparation practices, followed by positive feedback from their families. Meanwhile, household duties, low milk output, and a new pregnancy make it difficult to continue breastfeeding, while high complementary food costs, a limited budget, and a lack of food make it difficult to provide complementary food. The preparation of food for infants and young children is hindered by an increased workload and a lack of understanding.</p><p><strong>Conclusion: </strong>The results revealed suboptimal practices in prelacteal feeding and the reliance on processed foods among Muslim mothers, with economic factors, availability, and convenience as motivating factors in complementary feeding practices. Challenges such as household duties, low milk output, and financial constraints hinder breastfeeding and nutritious food provision for infants and young children. The study reinforced the necessity for holistic strategies in IYCF promotion among Muslim mothers.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship of Education, Knowledge, Perception, Family Support, and Socio-Culture to Early Marriage for Some Women in Banjar Regency, South Kalimantan Province, Indonesia.","authors":"Firdha Yuserina, Winardi Budiwinata, Fauzie Rahman, Siti Rahmi, Husnul Fatimah, Zuhrufa Wanna Yolanda, Agus Muhammad Ridwan, Dewi Saptarina","doi":"10.47895/amp.vi0.6568","DOIUrl":"https://doi.org/10.47895/amp.vi0.6568","url":null,"abstract":"<p><strong>Background: </strong>Early marriage is a formal or informal marriage performed under the age of 19 years. In Indonesia, cases of early marriage have always been a strategic issue that needs to be addressed because it will have a long-term impact on the health of mothers and children.</p><p><strong>Objective: </strong>The study aimed to analyze the relationship of education, knowledge, perception, family support, and socio-culture to early marriage behavior in women in Banjar Regency.</p><p><strong>Methods: </strong>This is a cross-sectional study using Fisher exact test with a 95% confidence level. The education variable was measured based on the respondent's highest educational level. The knowledge variable was measured using a multiple-choice questionnaire. The variable of perception used a list of statements with a Likert scale. Family support and socio-cultural variables use questionnaires with two choices (Yes/No).</p><p><strong>Results: </strong>The results of the analysis of 31 respondents using Fisher's exact test showed education (p-value = 1.000), knowledge (p-value = 0.097), perception (not identified), family support (p-value = 0.237), and socioculture (p-value=0.296).</p><p><strong>Conclusion: </strong>There is no relationship between education, knowledge, perception, family support, and socioculture on early marriage behavior in Banjar Regency. This is because there are many factors that influence early marriage behavior that cannot be investigated in this study, such as attitude, economics, peer support, community leaders, and others.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"30-35"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal-type Epithelioid Sarcoma of the Vulva: A Case Report.","authors":"Pauline Mae R Dy, Erick Martin H Yturralde, Jericho Thaddeus P Luna","doi":"10.47895/amp.vi0.10057","DOIUrl":"10.47895/amp.vi0.10057","url":null,"abstract":"<p><p>Epithelioid sarcoma is an uncommon mesenchymal malignancy which represents less than 1% of all sarcomas. Rarer still are reports of this tumor initially presenting in the vulva. We report a case of vulvar proximal-type epithelioid sarcoma. A 52-year-old had a 5-month history of slowly growing papule on the right labia majora. Excision of the mass revealed a tumor composed of large polygonal cells with abundant eosinophilic cytoplasm. An immunohistochemistry panel revealed cytokeratin AE1/AE3 positivity only. She underwent radical vulvectomy with bilateral groin node dissection. The specimen revealed a cream tan, firm, fairly defined mass at the right vulva. Microscopic examination showed a sheet-like growth pattern of large pleomorphic epithelioid cells with large vesicular nuclei and prominent nucleoli. The tumor showed loss of INI1 nuclear expression and absence of CD34 staining. EMA was positive. The case was signed out as proximal-type epithelioid sarcoma of the right vulva. Two months post-operatively, the patient was given concurrent chemotherapy with 5 cycles of cisplatin 40 mg/m² and 6600 centigray vulvar intensity-modulated radiotherapy. She had no evidence of disease for five months until repeat workup showed tumor recurrence in the perineum. She was subsequently given 6 cycles of gemcitabine 900 mg/m² and gemcitabine 900 mg/m² with docetaxel 100 mg/m². Two months after, repeat workup showed persistent progressive disease in the vulva. She was subsequently given 4 cycles of doxorubicin 60 mg/m² and is for repeat workup. The immunohistomorphologic features of this tumor, in addition to its unusual location, present a diagnostic challenge. Clues to the diagnosis include an initial presentation as a soft tissue mass and microscopic features showing the presence of epithelioid to spindle cytomorphology with an infiltrative growth pattern. Immunohistochemistry studies revealing the loss of INI1 nuclear expression and expression of epithelial markers would ultimately establish the diagnosis of this rare clinical entity.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 5","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}