Acta pathologica et microbiologica Scandinavica. Section A, Pathology最新文献_第5页

Localisation of human alpha-foetoprotein synthesis in hepatoblastoma cells by immunofluorescence and immunoperoxidase methods. 用免疫荧光和免疫过氧化物酶方法定位肝母细胞瘤细胞中人甲胎蛋白合成。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1974.TB03839.X

B. No̸rgaard-Pedersen, E. Dabelsteen, C. Edeling

引用次数: 12

Skin grafts in nude mice. 2. Rat skin grafts in nude mice of three genetic backgrounds (BALB-c, C3H, C57-BL). The effects after preparation by thymus grafts. 裸鼠皮肤移植。2. 三种遗传背景(BALB-c, C3H, C57-BL)裸鼠皮肤移植。胸腺移植物制备后的效果。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1974.TB03830.X

J. Rygaard

引用次数: 10

Diabetic cardiopathy. Quantitative histological studies of the heart from young juvenile diabetics. 糖尿病心脏病。青少年糖尿病患者心脏的定量组织学研究。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1976.TB00136.X

T. Ledet

{"title":"Diabetic cardiopathy. Quantitative histological studies of the heart from young juvenile diabetics.","authors":"T. Ledet","doi":"10.1111/J.1699-0463.1976.TB00136.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00136.X","url":null,"abstract":"A quantitative morphological study, at light microscopical level, of hearts from young diabetics and nondiabetics was performed. The groups were comparable with respect to sex-ratio, age, heart weight and blood pressure. Findings in the hearts were as follows: In arterioles in which the luminal diameter ranged between 15-50 mu, a strongly PAS-positive stained vessel wall occurred at a higher frequency among diabetics than among non-diabetics (75 per cent respectively 33 per cent). The PAS-positive structures, however, occupied the same area of the vessel wall in the two groups. In arterioles from diabetics, the number of cells in tunica media was increased as compared with that in non-diabetics (2 p less than 0.01). The amount of perivascular connective tissue was also increased in the diabetics (2 p less than 0.01). There was no indication of an endothelial cell proliferation in the PAS-positive stained vessels from diabetics and non-diabetics. The wall of the capillaries was not thickened and it was not more PAS-positive in the hearts from diabetics than in those from non-diabetics. Moreover, the number of capillaries per square millimeter of heart muscle was the same in the two groups of hearts. In the present light microscopical study, the diabetic micro-angiography of the heart was demonstrable in the arterioles. The capillaropathy known to occur in other organs was not present in the heart muscle from patients with diabetes of long standing.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"33 1","pages":"421-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85508485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 116

Fluorodeoxyuridine-induced malformations in mice. Studies on the early stages of teratogenesis. 氟脱氧尿嘧啶致小鼠畸形。畸形早期阶段的研究。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1971.TB00514.X

F. Bro-Rasmussen, B. Jensen, O. Hansen, A. Ostergaard

{"title":"Fluorodeoxyuridine-induced malformations in mice. Studies on the early stages of teratogenesis.","authors":"F. Bro-Rasmussen, B. Jensen, O. Hansen, A. Ostergaard","doi":"10.1111/J.1699-0463.1971.TB00514.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1971.TB00514.X","url":null,"abstract":"At different stages of gestation, 104 mice were treated with fluorodeoxyuridine (FUDR). 34 pregnant mice served as controls. The experimental mice were examined at varying intervals after the FUDR injection. At term, the young exhibited the malformations of the limbs and skull so well-known after administration of FUDR. In addition, there was an increased number of resorptions. 24 hours after the injection on the 9th—12th day of gestation, vascular dilatations and fresh haemorrhages were found at the sites of predilection of malformations. Foetuses removed 2 or more days after the injections showed characteristic, saccular haematomas in the limbs and tail as well as flat, widespread haematomas in the skull. At increasing intervals after the injections, the haematomas decreased in number and were rarely present in foetuses at term. As the number of haematomas decreased, the number of malformations increased. Daily laparotomies, from the 12th to the 18th day, on 5 mice treated on the 11th day with FUDR revealed extremity haematomas which disappeared on the 13th—18th day. Electron microscopic pilot studies of 2 foetal limbs showed, 24 hours after the injection of FUDR, red blood cells in an extra-vascular situation. The control mice had 354 normal foetuses and 8 per cent spontaneous resorptions. This study, which was a screening experiment, showed that FUDR induces vascular injury with haemorrhages and formation of haematomas, resulting in congenital malformations. The vascular injuries are interpreted as the primary action of FUDR on the cellular level.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"28 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84503644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The endocrine pancreas in early alloxan diabetes. Including study of the alloxan inhibitory effect of feeding and some hexoses. 早期四氧嘧啶型糖尿病的胰腺内分泌。包括饲料和某些己糖对四氧嘧啶抑制作用的研究。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1977.TB00419.X

L. Boquist

{"title":"The endocrine pancreas in early alloxan diabetes. Including study of the alloxan inhibitory effect of feeding and some hexoses.","authors":"L. Boquist","doi":"10.1111/J.1699-0463.1977.TB00419.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00419.X","url":null,"abstract":"Starved animals were sensitive to alloxan, whereas a more or less inhibitory effect towards alloxan was observed in fed animals, and in starved animals pretreated with glucose, mannose or fructose, but not in those pretreated with galactose. The islets of starved controls possessed larger B-cell mitochondria than those of fed ones. The earliest B-cell changes in the alloxan-treated animals were localized to the mitochondria which showed swelling, and disruption of inner and occasionally outer membranes. Later, many mitochondria were disintegrated, and the endoplasmic reticulum and Golgi complex disorganized. The secretory granules were preserved, although sometimes with atypical configuration, in degenerating but non-necrotic B-cells, suggesting that insulin stored in granules is not released until the cells are necrotic. Finally, frank necrosis was seen in some B-cells, whereas others were unaffected. The Ca2+-precipitation studied by pyroantimonate technique and x-ray analysis differed in the B-cells of the alloxan-treated animals from that in the controls; the former animals exhibited no or only sparse precipitation in mitochondria and secretory granules, but a rich precipitation in the cytoplasmic ground substance, whereas the precipitation in the controls mainly was localized to mitochondria and secretory granules. The primary site of alloxan action in the B-cells is believed to be localized to the mitochondria.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"28 1","pages":"219-29"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83268742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Cell-associated immunoglobulin in human non-Hodgkin lymphomas. A comparative study of surface immunoglobulin on cells in suspension and cytoplasmic immunoglobulin by immunohistochemistry. 细胞相关免疫球蛋白在人类非霍奇金淋巴瘤中的作用。免疫组织化学方法对悬浮细胞表面免疫球蛋白与细胞质免疫球蛋白的比较研究。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1981.TB00194.X

T. Landaas, Tore Godal, PER F. Marton, Stein Kvaløy, Ruth Langholm, Tore Lindmo, OLE G. Jørgensen, Herman Høst

{"title":"Cell-associated immunoglobulin in human non-Hodgkin lymphomas. A comparative study of surface immunoglobulin on cells in suspension and cytoplasmic immunoglobulin by immunohistochemistry.","authors":"T. Landaas, Tore Godal, PER F. Marton, Stein Kvaløy, Ruth Langholm, Tore Lindmo, OLE G. Jørgensen, Herman Høst","doi":"10.1111/J.1699-0463.1981.TB00194.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00194.X","url":null,"abstract":"Eighty-three non-Hodgkin lymphomas classified according to the Kiel classification have been studied with regard to surface immunoglobulin (sIg) on cells in suspension and cytoplasmic immunoglobulin (cIg) by the peroxidase anti-peroxidase method (PAP) on formaline-fixed tissue sections. Fifty-six out of 66 examined (i.e. 85%) revealed a monoclonal staining pattern for sIg, whereas 37/70 (53%) gave a monoclonal staining pattern for cIg by PAP. The methods combined gave a monoclonal staining pattern in 73/83, i.e. in 88%, of the biopsies tested. The discrepancies between the two methods were largest in centroblastic/centrocytic and lymphocytic lymphomas. With regard to the light chain staining patterns, complete agreement between the two methods was obtained in the 20 cases that allowed such analysis to be made. This suggests that the specificity of PAP, as carried out in this study with reagents purified by immunoabsorbent techniques, is satisfactory. On a basis of heavy chain isotypes centroblastic/centrocytic, lymphoplasmacytoid, and immunoblastic lymphomas could be divided into distinct immunological subgroups. In four biopsies the sIg heavy chains were mu + delta, whereas mu + gamma chains were detected by PAP. This finding may be relevant to the mu leads to gamma switch known to occur during normal B-cell differentiation. Immunoglobulin inclusions were found in 8 cases--3 belonging to the immunoblastic group, and 5 to the lymphoplasmacytoid group.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"1 1","pages":"91-101"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89739852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Amyloid tumour of the lung. Report of a case and a short review of the literature. 肺淀粉样瘤。报告一个病例和简短的文献回顾。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1977.TB03907.X

J. Mäkinen, J. Nickels, P. Halttunen

引用次数: 3

Nitrofurantoin-induced alterations in pulmonary tissue. A report on five patients with acute or subacute reactions. 呋喃妥因引起的肺组织改变。急性或亚急性反应5例报告。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1977.TB00463.X

E. Taskinen, P. Tukiainen, A. Sovijärvi

引用次数: 18

Myxofibrosarcoma. A study of 30 cases. Myxofibrosarcoma。对30个案例的研究。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1977.TB00410.X

L. Angervall, L. Kindblom, C. Merck

{"title":"Myxofibrosarcoma. A study of 30 cases.","authors":"L. Angervall, L. Kindblom, C. Merck","doi":"10.1111/J.1699-0463.1977.TB00410.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00410.X","url":null,"abstract":": A series of 30 myxofibrosarcomas is described. These malignant soft tissue tumours are characterized by a mucoid and nodular appearance, a coarse plexiform capillary pattern, and they are mostly seen subcutaneously (26 out of 30) in the extremities (24 out of 30) and trunk (4 out of 30) elderly people. Histochemical studies, comprising staining with Alcian blue and toluidine blue at different pH's with and without preceding digestion with testicular hyaluronidase and with the Scott technique, indicated the presence of hyaluronic acid but not sulphated glycosaminoglycans as chondroitinsulphates. Myxofibrosarcoma is believed to belong to the general category of fibroblastic and histiocytic malignant soft tissue tumours. The median diameter of the tumours was 7 cm. They were divided into 4 grades according to cellularity, cell atypia and mitotic activity. The grade III and IV tumours showed pronounced atypia, often with the bi- and multinucleated giant tumour cells and occasionally with giant cells of Touton's type, suggesting a relationship to malignant fibroxanthoma. All of the patients were treated surgically and one received also pre- and post-operative irradiation. None of the 2 grade I myxofibrosarcomas recurred, while 2 out of 7 grade II tumours, 6 out of 10 grade III tumours, and 7 out of 11 grade IV tumours recurred once and up to 9 times. Metastasis appeared in 7 out of 30 patients; grade I tumours were not seen in any of these cases. By the time of follow-up after intervals ranging from 1 month up to 27 years, 14 patients had died; 6 of these had died post-operatively or of intercurrent disease. The differential diagnosis between myxofibrosarcoma and other myxoid soft tissue tumours is discussed.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"33 1","pages":"127-140"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74540660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 210

Primary polycythaemia. 2. Types of chromosome aberrations in 21 clones found in bone marrow samples from 50 patients. 主要polycythaemia。2. 在50名患者的骨髓样本中发现了21个克隆的染色体畸变类型。

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI: 10.1111/J.1699-0463.1971.TB01853.X

J. Visfeldt

引用次数: 7