Acta pathologica et microbiologica Scandinavica. Section A, Pathology最新文献

{"title":"Renal lesions in rats with long-term alloxan diabetes. A semiquantitative light microscopic study with particular reference to the glomeruli.","authors":"E. Hägg","doi":"10.1111/J.1699-0463.1974.TB03844.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB03844.X","url":null,"abstract":"A light microscopic quantitation and comparison of some selected glomerular structures (basement membrane and mesangial area) in nondiabetic and in untreated alloxan diabetic rats at various ages was performed. It applies to both groups of rats that a significant age-related increase of graded glomerular basement membrane thickness and of measured mesangial area developed. In time, however, this increase was significantly more pronounced in the diabetic than in the nondiabetic group. Tubular and interstitial changes were also observed, both in nondiabetic and in diabetic rats. The importance of using an adequate number of nondiabetic, age-matched controls in studies of the mentioned glomerular changes in diabetic rats is emphasized. A quantitation of the changes in “blind” studies is advisable.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"453 1","pages":"199-210"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82931561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental allergic thyroiditis in the guinea-pig. A light, fluorescence and electron microscopic study, with particular reference to the migration of lymphocytes through the vessel walls.","authors":"Rolf Kåresen","doi":"10.1111/J.1699-0463.1970.TB03515.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1970.TB03515.X","url":null,"abstract":"Thyroiditis was induced in guinea-pigs by the injection of (NH4)2S04 purified thyroglobulin in complete Freund's adjuvant, and the development of the disease was studied at intervals between 5 and 40 days after immunization. Inflammatory reactions, varying from small focal to severe, confluent infiltrations, were observed. In inflamed areas the follicular cells were hypertrophied. In perfusion-fixed thyroids focal accumulations of leucocytes adherent to the vessel wall of capillaries and venules could be seen. Studies with fluorescein isothiocyanate conjugated anti-γ-globulin serum revealed that the inflammatory cells contained γ-globulin. In general the intensity of the fluorescence was moderate, but especially in the more severe forms of thyroiditis scattered strongly labelled cells were seen in the interstitium. In the electron microscope the leucocytes adhering to the vessel wall turned out to be almost exclusively lymphocytes in different stages of transformation, from small lymphocytes to immunoblasts. The transformed lymphocytes traversed the vessel wall through the endothelial cell cytoplasm, and not through the intercellular junctions. Most of the inflammatory cells in the interstitium were lymphocytes exhibiting the same continuous picture of transformation as intravascularly. Further differentiated cells, from the plasmablast, through the proplasmacyte to the mature plasma cell were, however, also found. The thyroid follicles and their lumina were invaded by leucocytes, mainly transformed lymphocytes, but also a few granulocytes. Some of the lymphocytes bulged deeply into the cytoplasm of the follicular cell, often indenting its nucleus, but true emperipolesis was not observed. Penetration of the leucocytes into the follicular lumina appeared to take place through the intercellular spaces. The only changes noted in the follicular cells were the hypertrophy and their occasional deformation by the lymphocytes.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"4 1","pages":"625-48"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80630994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentrations of renin and renin substrate in plasma of rabbits during pregnancy and the post partum period.","authors":"J. Jørgensen","doi":"10.1111/J.1699-0463.1974.TB00401.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00401.X","url":null,"abstract":"The content of renin in rabbit uterus is known to increase many fold during pregnancy followed by a rapid fall to normal levels within a few days after delivery. In order to study this mechanism the blood concentrations of renin and its substrate were measured. Contrary to the concentration of renin in uterus, the plasma renin concentrations were not increased either during pregnancy or in the post partum period. The renin-substrate concentration was unchanged during the first part of pregnancy but was increased 2–3-fold in the days around delivery. This increase resulted in a corresponding increase in plasma renin activity. It was concluded that the rapid inactivation of uterine renin post partum was due to a local inactivation and not to a release of renin to the blood.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"20 1","pages":"742-6"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88942769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of supply and withdrawal of fluoride. Experimental studies on growing and adult rabbits. 6. The mineral content of microdissected fluorotic bone.","authors":"Rosenquist Jb","doi":"10.1111/J.1699-0463.1974.TB03585.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB03585.X","url":null,"abstract":"","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"7 1","pages":"618-622"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74826309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particles similar to mouse leukaemia virus in Ehrlich's ascites carcinoma and in reticulum cell noeplasms type B. An electron microscopic study in mice.","authors":"A. Myking, A. Abro","doi":"10.1111/J.1699-0463.1974.TB00388.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1974.TB00388.X","url":null,"abstract":"Particles with morphological features similar to mouse leukaemia virus have been detected in a transplant of Ehrlich's ascites carcinoma (EAC) and in two reticulum cell neoplasms (RCN) of histological type B. One RCN arose in a mouse subsequent to inoculation with vital EAC cells; the other, in a sham-treated mouse. The virus is considered a possible agent causing enhanced development of reticulum cell neoplasms.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"5 1","pages":"571-7"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89147385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic renal lipofuscinosis. Two cases.","authors":"T. Lund, S. Olsen","doi":"10.1111/J.1699-0463.1970.TB02520.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1970.TB02520.X","url":null,"abstract":"Two cases of dark-brown or black discoloration of the human kidney are described and the condition compared with two previously reported cases. The abnormal colour is due to a deposition of brown pigment in the epithelium of the proximal tubules. The staining properties and histochemistry of the pigment granules seem to allow identification of the pigment as a lipofuscin. In one case the patient is still alive and the condition does not seeto have had any harmful effect on kidney function. This abnormality seems to be extremely rare. It is perhaps analogous to the disease, “Black Kidney” in cattle.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"106 1","pages":"414-20"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoid tumours. Frequency in a defined population during a 12-year period.","authors":"","doi":"10.1111/J.1699-0463.1976.TB00122.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00122.X","url":null,"abstract":"The frequency of carcinoids was studied in a 12-year-period (1958-1969) in Malmo, a town with a population of 220,000 at the beginning of the period and 250,000 at the end of it. Of all persons who had died in Malmo, 46 per cent were necropsied in the first year of the study and 70 per cent in the last (altogether 62.6 per cent). The series was examined in a uniform way at one department of pathology. Carcinoid tumours were found in 1.22 per cent (199 patients) of patients comprised in the entire necropsy series (16,294 autopsies). Bronchial carcinoid accounted for 0.1 percent, the remaining lesions were found in the digestive tract. About 90 per cent of the carcinoids were found incidentally at necropsy. During the same period, 44 carcinoids were diagnosed in surgical specimens examined in Malmo. The average annual frequency of carcinoid in the entire series was about 8.4 per 100,000 inhabitants, which is about 7 times as high as that recorded in the National Cancer Register applying to the whole of Sweden. The value of such country-wide reports is discussed. The carcinoid syndrome is extremely rare and was observed only once during the entire 12-year-period. The localization, frequency of metastases and sex-distribution of carcinoids are described and discussed in detail.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"107 1","pages":"322-330"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85589813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiolymphoid hyperplasia with eosinophilia of the skin. Light microscopic and ultrastructural study of 4 cases.","authors":"L. Kindblom, A. Fassina","doi":"10.1111/J.1699-0463.1981.TB00221.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1981.TB00221.X","url":null,"abstract":"A clinical, light and electron microscopic study of four patients with angiolymphoid hyperplasia with eosinophilia of the skin is presented. Light-microscopically, the lesions were characterized by the small size and superficial location, the proliferation of mostly delicate vessels with prominent endothelial hyperplasia and cellular areas without distinct vessel structures, but with infiltrates of eosinophilic leukocytes, lymphocytes and plasma cells. Ultrastructurally, a marked proliferation of both endothelial cells and pericytes could be demonstrated and the solid cellular areas were shown to be composed of solid vascular buds. A multi-layered basal lamina was enclosing pericytes and external surfaces of endothelial cells. The differential diagnosis is discussed and it is emphasized that this lesion may be misinterpreted as angiosarcoma.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"75 1","pages":"271-83"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87039780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-VARIATIONS IN NEIGHBOURING EPITHELIUM IN PATIENTS WITH BLADDER CARCINOMA","authors":"S. Fosså","doi":"10.1111/J.1699-0463.1977.TB00451.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1977.TB00451.X","url":null,"abstract":": Histologically atypical urothelium taken from bladder mucosa neighbouring transitional cell carcinoma showed similar, though less marked, DNA-changes as observed in the corresponding tumours. A definite increase in the number of non-diploid DNA-values was found in 6 (of 12 urothelial specimens. The clinical significance of urothelial DNA-changes is discussed.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"65 1","pages":"603-610"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82842496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical fibroxanthoma of the skin. A clinico-pathological study of 57 cases.","authors":"I. Dahl","doi":"10.1111/J.1699-0463.1976.TB00088.X","DOIUrl":"https://doi.org/10.1111/J.1699-0463.1976.TB00088.X","url":null,"abstract":"A retrospective study of 57 patients with atypical fibroxanthoma of the skin is presented. The light microscopy is described and the differential diagnosis is discussed. Most of the atypical fibroxanthomas (32 out of 57 cases) were originally diagnosed as soft tissue sarcomas, e.g. fibrosarcoma, dermatofibrosarcoma, neurofibrosarcoma, myosarcoma and unspecified sarcoma. The tumour occurred chiefly in middle-aged and elderly patients; three patients were 15 years old or younger. The median age was 73 years in patients in whom the tumour occurred in the head and neck, and 34 years in patients in whom the tumour developed on the extremities and trunk. The sex ratio (male to female) was almost equal. Follow-up information about 43 patients was available. The follow-up period ranged from 1 year to 25 years with a median of 9 years. Eight patients died from intercurrent disease; all the other 35 patients are alive and well. The clinical course was benign in all but one patient in whom a recurrence developed and metastases to the regional lymph nodes appeared 7 years after the initial excision. The tumour in this case did not differ histologically from the other atypical fibroxanthomas with respect to cellularity, cellular and nuclear atypia or mitotic activity. It is suggested that the recurrence per se might be of prognostic importance.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"37 1","pages":"183-197"},"PeriodicalIF":0.0,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86160470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}