糖尿病心脏病。青少年糖尿病患者心脏的定量组织学研究。

T. Ledet
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引用次数: 116

摘要

在光镜下对青年糖尿病患者和非糖尿病患者的心脏进行了定量形态学研究。两组在性别比例、年龄、心脏重量和血压方面具有可比性。心脏的结果如下:在管腔直径在15-50 μ之间的小动脉中,糖尿病患者比非糖尿病患者出现强烈pas阳性染色的频率更高(分别为75%和33%)。然而,pas阳性结构在两组中占据了相同的血管壁面积。与非糖尿病患者相比,糖尿病患者小动脉中膜细胞数量明显增加(p < 0.01)。糖尿病患者血管周围结缔组织数量也明显增加(p < 0.01)。在糖尿病患者和非糖尿病患者的pas阳性染色血管中没有内皮细胞增殖的迹象。糖尿病患者的心脏毛细血管壁没有增厚,pas阳性水平也没有高于非糖尿病患者。此外,两组心脏中每平方毫米心肌的毛细血管数量是相同的。在目前的光镜研究中,糖尿病心脏微血管造影显示在小动脉中。已知发生在其他器官的毛细血管病变在长期糖尿病患者的心肌中并不存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diabetic cardiopathy. Quantitative histological studies of the heart from young juvenile diabetics.
A quantitative morphological study, at light microscopical level, of hearts from young diabetics and nondiabetics was performed. The groups were comparable with respect to sex-ratio, age, heart weight and blood pressure. Findings in the hearts were as follows: In arterioles in which the luminal diameter ranged between 15-50 mu, a strongly PAS-positive stained vessel wall occurred at a higher frequency among diabetics than among non-diabetics (75 per cent respectively 33 per cent). The PAS-positive structures, however, occupied the same area of the vessel wall in the two groups. In arterioles from diabetics, the number of cells in tunica media was increased as compared with that in non-diabetics (2 p less than 0.01). The amount of perivascular connective tissue was also increased in the diabetics (2 p less than 0.01). There was no indication of an endothelial cell proliferation in the PAS-positive stained vessels from diabetics and non-diabetics. The wall of the capillaries was not thickened and it was not more PAS-positive in the hearts from diabetics than in those from non-diabetics. Moreover, the number of capillaries per square millimeter of heart muscle was the same in the two groups of hearts. In the present light microscopical study, the diabetic micro-angiography of the heart was demonstrable in the arterioles. The capillaropathy known to occur in other organs was not present in the heart muscle from patients with diabetes of long standing.
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