Localisation of human alpha-foetoprotein synthesis in hepatoblastoma cells by immunofluorescence and immunoperoxidase methods.

Abstract

By means of indirect immunofluorescence (IF) and indirect immunoperoxidase (IP) technique the presence of α-foetoprotein (AFP) has been demonstrated in foetal liver tissue as well as in liver tissue from two cases of hepatoblastoma. In both cases of hepatoblastoma the serum AFP were determined by rocket immunoelectrophoresis. Removal of the tumours caused a rapid fall in the concentration of serum AFP.