Acta dermato-venereologica最新文献_第8页

Recurrent Vesiculonecrotic Lesions on the Lower Extremities in a Patient with Dermatomyositis: A Quiz. 皮肌炎患者下肢复发性囊性坏死病变：一个小测验。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-05 DOI: 10.2340/actadv.v105.42967

Zhen-Dong Wei, Yi-Ping Zhao, Chao Yu, Xin-Yue Ding, Ao-Xue Wang

引用次数: 0

Prevalence of Mycoplasma Penetrans in Urethral and Rectal Specimens from Men Attending an STI Clinic. 在性传播感染门诊就诊的男性尿道和直肠标本中穿透支原体的患病率。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-05 DOI: 10.2340/actadv.v105.43443

Mie Gesine Laake, Axel Skafte-Holm, Thomas Roland Pedersen, Jørgen Skov Jensen, Kirsten Salado-Rasmussen

{"title":"Prevalence of Mycoplasma Penetrans in Urethral and Rectal Specimens from Men Attending an STI Clinic.","authors":"Mie Gesine Laake, Axel Skafte-Holm, Thomas Roland Pedersen, Jørgen Skov Jensen, Kirsten Salado-Rasmussen","doi":"10.2340/actadv.v105.43443","DOIUrl":"https://doi.org/10.2340/actadv.v105.43443","url":null,"abstract":"Mycoplasma penetrans has gained attention in relation to non-gonococcal urethritis (NGU), a syndrome where a significant proportion of patients have no identified aetiological agent. In this study, we estimated the prevalence of urethral and rectal M. penetrans in a male population attending a sexually transmitted infection (STI) clinic in Copenhagen, Denmark. Specimens were assessed using M. penetrans-specific real-time polymerase chain reaction (PCR). Demographic characteristics and clinical symptoms were extracted from patient records. A total of 704 urethral specimens and 223 rectal specimens from 721 individual male patients were included. The prevalence of urethral and rectal M. penetrans was 0.3% and 2.7%, respectively. Overall, the prevalence among men who have sex with men (MSM) was 3.6%, significantly higher than in men who have sex with women (p < 0.001). Among MSM, a higher number of partners was associated with M. penetrans infection (p = 0.008). No association was found between the presence of M. penetrans and clinical symptom status, and its pathogenic potential remains unclear.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43443"},"PeriodicalIF":3.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts from the 36th Nordic Congress of Dermatology and Venereology. 第36届北欧皮肤病和性病学大会摘要。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-05 DOI: 10.2340/actadv.v105.43624

No Authors Listed

引用次数: 0

Development of Multiple Cherry Haemangiomas in a Patient with Androgenetic Alopecia after Topical Minoxidil Use. 局部使用米诺地尔后雄激素性脱发患者多发樱桃血管瘤的发展。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-29 DOI: 10.2340/actadv.v105.43447

Xiao-Shuang Yang, Ru Dai, Zhong-Fa Lyu

引用次数: 0

Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand-Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Keratinocyte Toxicity. 酮康唑对索拉非尼诱导的手足皮肤反应的可能临床影响及抗真菌药物对多激酶抑制剂诱导的角质细胞毒性的细胞保护机制。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-28 DOI: 10.2340/actadv.v105.40697

Rui Kato, Yayoi Kamata, Mitsutoshi Tominaga, Ryoma Kishi, Takahide Kaneko, Akira Tsujimura, Yasushi Suga, Kenji Takamori

{"title":"Possible Clinical Effects of Ketoconazole on Sorafenib-induced Hand-Foot Skin Reaction and Cytoprotection Mechanisms of Antifungal Agents against Multikinase Inhibitor-induced Keratinocyte Toxicity.","authors":"Rui Kato, Yayoi Kamata, Mitsutoshi Tominaga, Ryoma Kishi, Takahide Kaneko, Akira Tsujimura, Yasushi Suga, Kenji Takamori","doi":"10.2340/actadv.v105.40697","DOIUrl":"https://doi.org/10.2340/actadv.v105.40697","url":null,"abstract":"In recent years, molecular target drugs have become integral in treating malignant tumours. Multikinase inhibitors (MKIs) have been associated with serious skin disorders, including hand-foot skin reaction (HFSR), which impair patient quality of life, often disrupting activities of daily living necessitating dose reduction or discontinuation. As the pathogenic mechanisms of these skin disorders are unknown, no effective treatments have been established. Previously, by drug repurposing using an in vitro culture system, certain azole antifungal drugs (AFDs) were identified that prevented sorafenib-induced cell death of normal human epidermal keratinocytes. In this study, topical ketoconazole demonstrated clinical improvement in hyperkeratosis and pain associated with sorafenib-induced HFSR. Investigation of the mechanism using the in vitro culture system revealed sorafenib to be particularly cytotoxic among MKIs. Annexin V and TUNEL staining revealed apoptosis was mainly involved in this cytotoxicity. Antibody arrays and western blot showed increased levels of secretion of interleukin-1 receptor antagonist and macrophage migration inhibitory factor in culture supernatants. AFDs suppressed the secretion of these cytokines and reduced apoptosis in keratinocytes. This study reveals one aspect of the pathogenesis of sorafenib-induced HFSR and demonstrates that AFDs may be an effective treatment.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv40697"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients. 315例平顶苔藓伴额部纤维性脱发的全身治疗。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-28 DOI: 10.2340/actadv.v105.42465

Mathias Willaert, Tristan Van Dongen, Petra Dikrama, Tamar Nijsten, DirkJan Hijnen, Rick Waalboer-Spuij

{"title":"Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients.","authors":"Mathias Willaert, Tristan Van Dongen, Petra Dikrama, Tamar Nijsten, DirkJan Hijnen, Rick Waalboer-Spuij","doi":"10.2340/actadv.v105.42465","DOIUrl":"https://doi.org/10.2340/actadv.v105.42465","url":null,"abstract":"Lichen planopilaris and frontal fibrosing alopecia are common variants of primary lymphocytic cicatricial alopecia, leading to permanent hair loss. Despite widespread use of various systemic treatments, evidence-based guidelines for these conditions are lacking. This study investigates the effectiveness of systemic treatment options in patients with lichen planopilaris and frontal fibrosing alopecia through a retrospective cohort analysis. Medical records of patients treated at the Department of Dermatology between 2016 and 2022 at the Erasmus University Medical Center Rotterdam, the Netherlands were reviewed. Of 315 patients identified (161 lichen planopilaris and 154 frontal fibrosing alopecia), the majority were female (90.5%), with hydroxychloroquine being the most common systemic treatment, used by 65.2% of lichen planopilaris and 57.8% of frontal fibrosing alopecia patients. Methotrexate had the highest response rate for lichen planopilaris (79.2%), while retinoids showed the highest response for frontal fibrosing alopecia (73.9%). However, treatments with cyclosporine A and retinoids had higher discontinuation rates due to side effects. This study suggests methotrexate and cyclosporine A may be most effective for lichen planopilaris, and cyclosporine A and retinoids for frontal fibrosing alopecia, though side effects remain a concern. Limitations include the retrospective design and the absence of standardized outcomes. Prospective studies are recommended to validate these findings.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42465"},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Altered Vascular Endothelial Control of Facial Cutaneous Blood Flow in Rosacea. 酒渣鼻患者血管内皮对面部皮肤血流控制的改变。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-27 DOI: 10.2340/actadv.v105.42800

C Ilinca Ungureanu, Megan J Kube, Thad E Wilson, Kristen Metzler-Wilson

引用次数: 0

Contact Dermatitis Caused by Topical Minoxidil: Allergy or Just Irritation. 局部米诺地尔引起的接触性皮炎：过敏或只是刺激。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-27 DOI: 10.2340/actadv.v105.42401

Alexandra Junge, Susanne Radonjic-Hoesli, Simon Bossart, Dagmar Simon, Pierre De Viragh, Robert E Hunger, Kristine Heidemeyer, S Morteza Seyed Jafari

{"title":"Contact Dermatitis Caused by Topical Minoxidil: Allergy or Just Irritation.","authors":"Alexandra Junge, Susanne Radonjic-Hoesli, Simon Bossart, Dagmar Simon, Pierre De Viragh, Robert E Hunger, Kristine Heidemeyer, S Morteza Seyed Jafari","doi":"10.2340/actadv.v105.42401","DOIUrl":"10.2340/actadv.v105.42401","url":null,"abstract":"Topical minoxidil is the mainstay of treatment for androgenic alopecia and is also used off-label for other forms of hair loss. Despite its efficacy and favourable safety profile, the use of minoxidil is associated with various side effects, the most commonly reported of which is contact dermatitis. A clear distinction between allergic contact dermatitis and irritant contact dermatitis to minoxidil is critical for management of androgenic alopecia. This article presents a systematic review of the current literature, evaluating minoxidil-induced allergic contact dermatitis. Of the 251 records identified through the database search, a total of 21 studies were included in the review. Most patients presented with classic signs of contact dermatitis, including erythema, pruritus, and increased scaling of the scalp. Of the patients with positive patch tests, a total of 54 patients showed sensitization to minoxidil itself and 12 patients to vehicle components. Patients with suspected signs of contact dermatitis such as erythema, scaling, and pruritus after minoxidil application should undergo patch testing to confirm or exclude allergy. For the test, the differential reactivity of minoxidil in various vehicles should be considered. Patients who are sensitive to propylene glycol should be offered alternative minoxidil formulations.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42401"},"PeriodicalIF":3.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing Patients and Treatment Patterns in Moderate-to-severe Atopic Dermatitis in Finland: A Population-based Study Using National Health Data. 芬兰中重度特应性皮炎患者特征和治疗模式：一项使用国家健康数据的基于人群的研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-24 DOI: 10.2340/actadv.v105.41244

Anita Remitz, Essi J Peltonen, Laura Korhonen, Pekka Nortamo, Ilona Iso-Mustajärvi, Tuire Prami, Lasse Oinonen, Beatrice Gittens, Lill-Brith Von Arx, Vibeke Porsdal

{"title":"Characterizing Patients and Treatment Patterns in Moderate-to-severe Atopic Dermatitis in Finland: A Population-based Study Using National Health Data.","authors":"Anita Remitz, Essi J Peltonen, Laura Korhonen, Pekka Nortamo, Ilona Iso-Mustajärvi, Tuire Prami, Lasse Oinonen, Beatrice Gittens, Lill-Brith Von Arx, Vibeke Porsdal","doi":"10.2340/actadv.v105.41244","DOIUrl":"10.2340/actadv.v105.41244","url":null,"abstract":"This observational study evaluated demographics, disease characteristics, and treatment patterns in children, adolescents, and adults with moderate-to-severe atopic dermatitis (AD) and compared comorbidities (adults only) and healthcare resource use with those of matched reference subjects without moderate-to-severe AD in Finland between 2016 and 2020. A total of 68,216 patients with moderate-to-severe AD and a reference population of 338,325 people without moderate-to-severe AD were identified and included in the study. Among children aged 0-11 years in the moderate-to-severe AD cohort, most were diagnosed with AD and were identified to have moderate-to-severe AD before they reached 4 years of age (92.4% and 79.3%, respectively). Atopic disorders and psychiatric, gastrointestinal, and other diseases were more common in adults with moderate-to-severe AD than in the reference population. Regardless of age, patients with moderate-to-severe AD had a higher number of primary and secondary healthcare visits annually compared with the reference population. Across all 3 age groups, topical corticosteroids and emollients were the 2 categories of AD medications most frequently used throughout the study period. In adults, the use of methotrexate and dupilumab increased over the course of the study. Moderate-to-severe AD affects people of all ages in Finland.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41244"},"PeriodicalIF":3.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acne-induced Post-inflammatory Hyperpigmentation: From Grading to Treatment. 痤疮引起的炎症后色素沉着：从分级到治疗。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-22 DOI: 10.2340/actadv.v105.42925

Nicole Auffret, Marie-Thérèse Leccia, Fabienne Ballanger, Jean Paul Claudel, Serge Dahan, Brigitte Dréno

{"title":"Acne-induced Post-inflammatory Hyperpigmentation: From Grading to Treatment.","authors":"Nicole Auffret, Marie-Thérèse Leccia, Fabienne Ballanger, Jean Paul Claudel, Serge Dahan, Brigitte Dréno","doi":"10.2340/actadv.v105.42925","DOIUrl":"https://doi.org/10.2340/actadv.v105.42925","url":null,"abstract":"Acne-induced post-inflammatory hyperpigmentation (AI-PIH) can occur without any visible clinical evidence of significant inflammation, even in patients with mild to moderate acne. Currently, visual assessment is the main criterion for evaluating the severity of PIH, including that of AI-PIH in daily clinical practice. Treatment indications are lacking. This work provides an easy-to-use AI-PIH severity grading tool for daily clinical practice as well as indications on how to prevent and treat AI-PIH using currently available treatment options. Five experts in acne provided a short overview concerning the epidemiology and physiopathology of AI-PIH, developed an AI-PIH severity grading tool, and proposed preventive measures as well as an AI-PIH treatment algorithm. Only a small number of epidemiological data on AI-PIH are available, confirming that the condition is mainly observed in patients with Phototypes IV to VI. The physiopathology of AI-PIH is still not completely understood. Innate immunity, Cutibacterium acnes, and external factors such as UV radiation, visible light, and air pollution play a role in its development. An easy-to-use AI-PIH severity grading tool (Acne PIgmentation Grading) allows quick assessment of acne severity during the consultation, and, in addition to proposed preventive measures, a treatment algorithm is proposed according to AI-PH severity. Patient education remains key. Providing an AI-PIH severity assessment tool as well as preventive and treatment recommendations may help to manage AI-PIH more efficiently.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42925"},"PeriodicalIF":3.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0