Acta dermato-venereologica最新文献_第8页

Chronic Pruritus in Predialysis Chronic Kidney Disease: Prevalence, Phenotype and Temporal Patterns in a Prospective Cohort. 透析前慢性肾脏疾病的慢性瘙痒：前瞻性队列的患病率、表型和时间模式。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-14 DOI: 10.2340/actadv.v106.adv-2026-0614

Severin Schricker, Thomas Mettang, Frank Strutz, Thorsten Rittweiler, Moritz Schanz, Leonie Kraft, Jörg Latus, Julian Müller-Kühnle

{"title":"Chronic Pruritus in Predialysis Chronic Kidney Disease: Prevalence, Phenotype and Temporal Patterns in a Prospective Cohort.","authors":"Severin Schricker, Thomas Mettang, Frank Strutz, Thorsten Rittweiler, Moritz Schanz, Leonie Kraft, Jörg Latus, Julian Müller-Kühnle","doi":"10.2340/actadv.v106.adv-2026-0614","DOIUrl":"10.2340/actadv.v106.adv-2026-0614","url":null,"abstract":"CKD-associated pruritus (CKD-aP) is a burden some symptom with incompletely understood pathophysiology and limited predialysis data. In this prospective observational study, 95 adult nondialysis CKD patients (stages G1-G5) were followed for up to 36 months (232 observations), 86 patients were analysed after exclusion of chronic dermatological conditions. Chronic pruritus (≥6 weeks) was assessed using a numerical rating scale (NRS) and anatomical mapping. Chronic pruritus occurred in 26 of 86 patients (30.2%), with numerically higher prevalence in advanced CKD (G3b-5 : 32.8% vs G1-3a: 22.7%), whereas intensity was numerically higher in early CKD (median 8 vs 5). The back, legs and head/ face were most frequently affected, consistent with the bilateral, nondermatomal pattern described in dialysis populations. Among patients with repeated assessments, 19.0% showed an episodic trajectory and 7.6% had persistent pruritus. Multivariable logistic regression and generalized estimating equations (GEE) were used to identify independent predictors of chronic pruritus. No laboratory parameter, including PTH, was independently associated with pruritus. Dyslipidaemia was the only clinical characteristic significantly associated with pruritus status (69.2% vs 43.3%, p=0.035). Given the modest sample size, smaller effect estimates may have been missed. CKD-aP affects approximately 1 in 3 predialysis patients, follows an episodic course, and is not explained by any single biochemical marker, supporting multifactorial pathophysiology.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Baricitinib in Treating Atopic Dermatitis in Difficult-to-treat Areas: A Retrospective Real-world Study. 巴西替尼治疗难治性部位特应性皮炎的有效性：一项回顾性现实世界研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-14 DOI: 10.2340/actadv.v106.adv-2026-0386

Giuseppe Lauletta, Maddalena Napolitano, Claudio Brescia, Francesca Di Vico, Melania Parisi, Cataldo Patruno

引用次数: 0

Resource Use and Cost Comparison of Mohs Micrographic Surgery vs Traditional Surgery for High-risk Facial Basal Cell Carcinoma. 莫氏显微手术与传统手术治疗高危面部基底细胞癌的资源利用及成本比较。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-09 DOI: 10.2340/actadv.v106.adv-2025-0263

Julia Fougelberg, Lovisa Klein, Emelie Pauli, Ann-Marie Wennberg Larkö, Hannah Ceder

{"title":"Resource Use and Cost Comparison of Mohs Micrographic Surgery vs Traditional Surgery for High-risk Facial Basal Cell Carcinoma.","authors":"Julia Fougelberg, Lovisa Klein, Emelie Pauli, Ann-Marie Wennberg Larkö, Hannah Ceder","doi":"10.2340/actadv.v106.adv-2025-0263","DOIUrl":"10.2340/actadv.v106.adv-2025-0263","url":null,"abstract":"High-risk facial basal cell carcinomas are preferably treated with Mohs micrographic surgery, but despite its documented benefits, it remains underused in Sweden. The aim of this study was to evaluate healthcare resource utilization and direct costs for patients with high-risk facial basal cell carcinomas treated with Mohs micrographic surgery compared with traditional surgical excision. In this retrospective registry study, all patients undergoing Mohs micrographic surgery or surgical excision at Sahlgrenska University Hospital between 2020 and 2024 were included, supplemented by regional healthcare data from the Vega registry, to assess long-term healthcare use up to 10 years after primary treatment. Mohs micrographic surgery was associated with higher initial costs than surgical excision but a slower accumulation of costs over time. Patients initially treated with surgical excision who later required Mohs micrographic surgery incurred the highest total costs, often after multiple prior procedures. These findings indicate that although Mohs micrographic surgery is costlier initially, early access prevents the substantial downstream costs associated with treatment failure. Primary Mohs micrographic surgery is a cost-efficient strategy for high-risk facial basal cell carcinomas and should be used more frequently in order to enable better utilization of resources and improved outcomes for the patient.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum: Does Teledermatology Enable Earlier Diagnosis of Cutaneous Squamous Cell Carcinoma Than Face-to-face Consultation? 勘误：远程皮肤科能比面对面咨询更早诊断皮肤鳞状细胞癌吗？

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-09 DOI: 10.2340/actadv.v106.46508

Marta Cebolla Verdugo

引用次数: 0

Actinic Folliculitis (Formerly Acne Aestivalis and Mallora Acne): A Report of 18 Patients and Review of the Literature. 光化性毛囊炎（原痤疮和马洛拉痤疮）：18例报告及文献复习。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-09 DOI: 10.2340/actadv.v106.adv-2026-0423

Mario Maniscalco, Laura Maniscalco, Italo Francesco Aromolo, Gianluca Nazzaro, Stefano Veraldi

引用次数: 0

The Role of RCM and LC-OCT in Genodermatoses Associated with Skin Cancer: A Narrative Review. RCM和LC-OCT在与皮肤癌相关的遗传性皮肤病中的作用：一个叙述性的回顾。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-09 DOI: 10.2340/actadv.v106.adv-2026-0385

Francesco Piscazzi, Cristina Carrera, Josep Riera-Monroig, Susana Puig, Josep Malvehy, Javiera Anker, Marco Ardigò

{"title":"The Role of RCM and LC-OCT in Genodermatoses Associated with Skin Cancer: A Narrative Review.","authors":"Francesco Piscazzi, Cristina Carrera, Josep Riera-Monroig, Susana Puig, Josep Malvehy, Javiera Anker, Marco Ardigò","doi":"10.2340/actadv.v106.adv-2026-0385","DOIUrl":"10.2340/actadv.v106.adv-2026-0385","url":null,"abstract":"Patients with genodermatoses, such as nevoid basal cell carcinoma syndrome, recessive dystrophic epidermolysis bullosa, familial atypical multiple mole and melanoma syndrome, xeroderma pigmentosum and ichthyosis with confetti, face a high risk of skin malignancies. While dermoscopy significantly improves diagnostic accuracy compared to clinical examination, its specificity remains limited when evaluating ambiguous lesions in these complex patients. This narrative review examines the role of reflectance confocal microscopy and line-field confocal optical coherence tomography in high-risk populations. By enabling the in vivo visualization of histologic-like features at cellular resolution, these noninvasive imaging technologies overcome the limitations of dermoscopy. The analysis of illustrative cases demonstrates that integrating these tools enhances both sensitivity and specificity, allowing for a precise differentiation between true malignancies and benign mimics. While reflectance confocal microscopy remains the standard for melanocytic criteria, line-field confocal optical coherence tomography complements it by overcoming depth limitations. Consequently, the use of combined noninvasive imaging supports a more conservative management strategy, potentially reducing the number of unnecessary excisions while ensuring the timely detection of skin cancer in patients with rare genetic syndromes.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of Basal Cell Carcinoma across Different Treatment Modalities: A Nationwide Study with 8 Years of Follow-up and Modelled Prediction. 不同治疗方式的基底细胞癌复发：一项8年随访和模型预测的全国性研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-09 DOI: 10.2340/actadv.v106.adv-2025-0064

Johan Sieborg, Emily Wenande, Alexander Egeberg, Henrik Sølvsten, Ulrikke Lei, Emilie Westerlin Kjeldsen, Merete Haedersdal

{"title":"Recurrence of Basal Cell Carcinoma across Different Treatment Modalities: A Nationwide Study with 8 Years of Follow-up and Modelled Prediction.","authors":"Johan Sieborg, Emily Wenande, Alexander Egeberg, Henrik Sølvsten, Ulrikke Lei, Emilie Westerlin Kjeldsen, Merete Haedersdal","doi":"10.2340/actadv.v106.adv-2025-0064","DOIUrl":"10.2340/actadv.v106.adv-2025-0064","url":null,"abstract":"Despite the rising incidence of basal cell carcinoma (BCC), few studies have compared treatment outcomes or predicted recurrences using nationwide real-world datasets. Hence, the objective was to investigate and compare recurrence rates of nodular BCC (nBCC) and superficial BCC (sBCC) following treatment with standard excision (SE), curettage, cryotherapy, photodynamic therapy and imiquimod. Additionally, we identified predictors of BCC 2 year recurrence using machine-learning. The study examined BCCs treated in state-funded, office-based dermatology practices registered in the Danish Skin Cancer Registry from 2014 to 2024. A total of 131,119 tumours were included, comprising 100,221 nBCCs and 30,898 sBCCs. For nBCC, the lowest rate of recurrence was observed for SE, with an 8-year cumulative recurrence rate (CRR) of 16.5% (95% confidence interval: 14.4-19.0%) and hazard ratio of 0.80 (0.76-0.84) compared with curettage. For sBCC, both SE and curettage had similarly low 8 year CRRs of 16.3% (12.7-20.8%) and 16.3% (15.2 17.5%), respectively, with no significant difference in hazard. The machine-learning model identified key predictors of BCC recurrence, including facial location, larger tumour size, having a high number of hospital-registered diagnoses and short distance to dermatological clinics. These findings highlight the impact of treatment selection and patient-specific factors in guiding dermatologists towards optimal BCC management.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of IL-17A Inhibitors in Psoriasis Complicated by Multiple Infections - Successful Treatment and Insights from a Case of Psoriasis with HIV and Neurosyphilis. IL-17A抑制剂在银屑病合并多重感染中的应用——1例银屑病伴HIV和神经梅毒的成功治疗及启示

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-06 DOI: 10.2340/actadv.v106.adv-2026-0392

Ting-Ting Mao, Fang-Fang Yu, Ping Ma, Man-Li Qi

引用次数: 0

A Systematic Literature Review on Methotrexate Hepatotoxicity in Psoriasis Management: Preconceived Notion or Real Threat? 甲氨蝶呤在银屑病治疗中的肝毒性：先入为主还是真正的威胁？

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-06 DOI: 10.2340/actadv.v106.adv-2025-0021

Wolf-Henning Boehncke, Maria-Magdalena Constantin, José-Manuel Carrascosa-Carrillo, Pariyawan Rakvit, Alice-Anaïs Varlet, Solenn Le Clanche, Linda A W Verhagen, Manuelle Viguier

{"title":"A Systematic Literature Review on Methotrexate Hepatotoxicity in Psoriasis Management: Preconceived Notion or Real Threat?","authors":"Wolf-Henning Boehncke, Maria-Magdalena Constantin, José-Manuel Carrascosa-Carrillo, Pariyawan Rakvit, Alice-Anaïs Varlet, Solenn Le Clanche, Linda A W Verhagen, Manuelle Viguier","doi":"10.2340/actadv.v106.adv-2025-0021","DOIUrl":"10.2340/actadv.v106.adv-2025-0021","url":null,"abstract":"Methotrexate (MTX) is a widely used, cost-effective systemic treatment for moderate-to-severe psoriasis, but concerns about hepatotoxicity often limit its long-term use. Hepatic adverse effects range from transient enzyme elevations to fibrosis and cirrhosis. Despite established guidelines, monitoring practices remain inconsistent, and the mechanisms underlying MTX-induced hepatotoxicity in psoriasis patients are not fully elucidated. This systematic literature review evaluates the association between MTX and hepatotoxicity, identifies key risk factors, assesses monitoring strategies and addresses misconceptions about its hepatic safety. A comprehensive search of MEDLINE/PubMed, EMBASE, Cochrane Library and grey literature (2003-2024) included English and French studies on human subjects, encompassing guidelines, reviews and observational/interventional studies. MTX-related hepatotoxicity is multifactorial, with risk factors including obesity, diabetes, hyperlipidaemia, excessive alcohol consumption and pre-existing liver disease. Psoriasis itself may also contribute to liver dysfunction. There is no consensus on optimal monitoring frequency for liver function tests or the role of noninvasive tools like transient elastography. While folic acid supplementation may mitigate risk, dosing remains inconsistent.Though MTX carries a potential hepatotoxic risk, this is patient-specific rather than inherent to the drug. Standardized monitoring protocols and risk stratification are essential to optimize safety, prevent unnecessary treatment discontinuation and improve long-term psoriasis management.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythematous Nodules and Plaques on the Neck: A Quiz. 颈部红斑结节和斑块：一个小测验。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-06 DOI: 10.2340/actadv.v106.adv-2026-0498

Yingying Xiang, Yue Mou, Jian Li, Hong Ren, Xiao Tan, Renqiong Chen

引用次数: 0