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Safety of Dupilumab Therapy for Atopic Dermatitis during Pregnancy: A Systematic Review and Meta-analysis.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-12 DOI: 10.2340/actadv.v105.41307
Verónica Sánchez-García, Eva De-Miguel-Balsa, José-Manuel Ramos-Rincón, Isabel Belinchón-Romero
{"title":"Safety of Dupilumab Therapy for Atopic Dermatitis during Pregnancy: A Systematic Review and Meta-analysis.","authors":"Verónica Sánchez-García, Eva De-Miguel-Balsa, José-Manuel Ramos-Rincón, Isabel Belinchón-Romero","doi":"10.2340/actadv.v105.41307","DOIUrl":"10.2340/actadv.v105.41307","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is the most common skin condition among pregnant women. However, there is limited information on the safety of biologicals during pregnancy. A systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the effects of exposure to biologicals during pregnancy and/or preconception in women with AD, and to estimate the pooled prevalence of spontaneous abortions and congenital malformations in their newborns. MEDLINE, Embase, Scopus, and Web of Science to 31 May 2024 were searched to identify randomized controlled trials and non-randomized studies. To test the robustness of our findings, sensitivity analyses were performed. Fifteen observational studies involving 115 pregnant women with a mean age of 33.46 years (standard deviation [SD] 3.02 were included). All studies evaluated dupilumab. The mean duration of exposure to dupilumab during pregnancy was 27.52 weeks (SD 11.16). The weighted prevalence of spontaneous abortions was 18.9% (95% confidence interval 5.3 to 38.2). There were no reports of congenital malformations. The sensitivity analyses showed no significant differences in weighted prevalences. In conclusion, the current scientific evidence suggests that dupilumab is probably safe during pregnancy and preconception in women with AD, with no significant increase in the risk of miscarriage or congenital malformations compared to the general population. However, the results of this review are inconclusive due to the limited number of large, well-designed clinical studies.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41307"},"PeriodicalIF":3.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Terbinafine Resistant Trichophyton Indotineae in Sweden.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-10 DOI: 10.2340/actadv.v105.42089
Sahel Mohseni, Nissrine Abou-Chakra, Karl Oldberg, Erja Chryssanthou, Ewa Young
{"title":"Terbinafine Resistant Trichophyton Indotineae in Sweden.","authors":"Sahel Mohseni, Nissrine Abou-Chakra, Karl Oldberg, Erja Chryssanthou, Ewa Young","doi":"10.2340/actadv.v105.42089","DOIUrl":"10.2340/actadv.v105.42089","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42089"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pruritic Maculopapular Eruption of a 4-month-old Baby: A Quiz.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-10 DOI: 10.2340/actadv.v105.42512
Gustavo Almeida-Silva, Sónia Fernandes, Joana Antunes, Luís Soares-Almeida, Paulo Filipe
{"title":"Pruritic Maculopapular Eruption of a 4-month-old Baby: A Quiz.","authors":"Gustavo Almeida-Silva, Sónia Fernandes, Joana Antunes, Luís Soares-Almeida, Paulo Filipe","doi":"10.2340/actadv.v105.42512","DOIUrl":"10.2340/actadv.v105.42512","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42512"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatophyte Treatment Failure: A Rapid Global Response to an Emerging Global Health Issue.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-06 DOI: 10.2340/actadv.v105.42948
Sidra S Khan, Ditte M L Saunte
{"title":"Dermatophyte Treatment Failure: A Rapid Global Response to an Emerging Global Health Issue.","authors":"Sidra S Khan, Ditte M L Saunte","doi":"10.2340/actadv.v105.42948","DOIUrl":"10.2340/actadv.v105.42948","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42948"},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT).
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-06 DOI: 10.2340/actadv.v105.42296
Ramtin Lichtenberger, Lara Valeska Maul, Ion Birkenmaier, Iker Oyanguren, Melike Ak, Kristine Heidemeyer, Christoph Schlapbach, Nikhil Yawalkar, Alexander Egeberg, Simon Francis Thomsen, Jacob P Thyssen, Christina Sorbe, Wolf-Henning Boehncke, Curdin Conrad, Antonio Cozzio, Georgios Kokolakis, Raphael Micheroli, Jashin J Wu, Thomas Kündig, Alexander Navarini, Julia-Tatjana Maul
{"title":"Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT).","authors":"Ramtin Lichtenberger, Lara Valeska Maul, Ion Birkenmaier, Iker Oyanguren, Melike Ak, Kristine Heidemeyer, Christoph Schlapbach, Nikhil Yawalkar, Alexander Egeberg, Simon Francis Thomsen, Jacob P Thyssen, Christina Sorbe, Wolf-Henning Boehncke, Curdin Conrad, Antonio Cozzio, Georgios Kokolakis, Raphael Micheroli, Jashin J Wu, Thomas Kündig, Alexander Navarini, Julia-Tatjana Maul","doi":"10.2340/actadv.v105.42296","DOIUrl":"10.2340/actadv.v105.42296","url":null,"abstract":"<p><p>Real-world data on gender differences in quality of life among psoriasis patients before and during treatment are scarce. This study analysed data of 748 adults with moderate-to-severe psoriasis enrolled in the Swiss Dermatology Network of Targeted Therapy registry between 2011 and 2023. Quality of life was assessed using the Dermatological Life Quality Index at baseline and at 3, 6, 12, 18, and 24 months. At baseline, women reported significantly lower quality of life than men, with higher Dermatological Life Quality Index scores in the IL-17 inhibitor group (15.0 vs 11.0, p = 0.027), IL-12/23 inhibitor group (7.5 vs 7.0, p = 0.049), and non-biologic therapy group (13.0 vs 9.0, p < 0.001). Although quality of life improved across all subgroups during the follow-up period, women treated with IL-12/23 inhibitors continued to report worse quality of life compared with men after 2 years (p < 0.05), while no significant differences were observed with other therapies. These findings emphasize that women with psoriasis experience lower quality of life at treatment initiation and throughout non-biologic and biologic therapies, underlining the importance of addressing gender-specific differences in the management of psoriasis.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42296"},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plaques and Ulcers of Both Lower Limbs: A Quiz.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-06 DOI: 10.2340/actadv.v105.42510
Qianling Zhang, Sha Lu, Xiqing Li, Liangchun Wang, Jianchi Ma
{"title":"Plaques and Ulcers of Both Lower Limbs: A Quiz.","authors":"Qianling Zhang, Sha Lu, Xiqing Li, Liangchun Wang, Jianchi Ma","doi":"10.2340/actadv.v105.42510","DOIUrl":"10.2340/actadv.v105.42510","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42510"},"PeriodicalIF":3.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Red Skin Nodule on the Dorsum of the Left Hand: A Quiz.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-05 DOI: 10.2340/actadv.v105.42133
Yoshihito Mima, Tsutomu Ohtsuka
{"title":"Persistent Red Skin Nodule on the Dorsum of the Left Hand: A Quiz.","authors":"Yoshihito Mima, Tsutomu Ohtsuka","doi":"10.2340/actadv.v105.42133","DOIUrl":"10.2340/actadv.v105.42133","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42133"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Acquired Idiopathic Generalized Anhidrosis with Anti-mucin 7 Seropositivity.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-05 DOI: 10.2340/actadv.v105.42883
Marie Kitamura, Kazuki M Matsuda, Hirohito Kotani, Ayumi Yoshizaki, Shinichi Sato
{"title":"A Case of Acquired Idiopathic Generalized Anhidrosis with Anti-mucin 7 Seropositivity.","authors":"Marie Kitamura, Kazuki M Matsuda, Hirohito Kotani, Ayumi Yoshizaki, Shinichi Sato","doi":"10.2340/actadv.v105.42883","DOIUrl":"10.2340/actadv.v105.42883","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42883"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Single-centre Retrospective Study.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-05 DOI: 10.2340/actadv.v105.42879
Yoshiki Okada, Masahiro Kamata, Kotaro Hayashi, Kazumitsu Sugiura, Yayoi Tada
{"title":"Effectiveness and Safety of Spesolimab in Patients with Generalized Pustular Psoriasis: A Single-centre Retrospective Study.","authors":"Yoshiki Okada, Masahiro Kamata, Kotaro Hayashi, Kazumitsu Sugiura, Yayoi Tada","doi":"10.2340/actadv.v105.42879","DOIUrl":"10.2340/actadv.v105.42879","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42879"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crusted Scabies in a Patient being Treated with Spesolimab for Generalized Pustular Psoriasis.
IF 3.5 4区 医学
Acta dermato-venereologica Pub Date : 2025-02-05 DOI: 10.2340/actadv.v105.42177
Hanna Schratter, Thomas Graier, Franz Legat, Rainer Hofmann-Wellenhof, Peter Wolf
{"title":"Crusted Scabies in a Patient being Treated with Spesolimab for Generalized Pustular Psoriasis.","authors":"Hanna Schratter, Thomas Graier, Franz Legat, Rainer Hofmann-Wellenhof, Peter Wolf","doi":"10.2340/actadv.v105.42177","DOIUrl":"10.2340/actadv.v105.42177","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42177"},"PeriodicalIF":3.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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