Acta dermato-venereologica最新文献_第7页

Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis. 中央离心性瘢痕性脱发的系统性合并症：一项系统综述和荟萃分析。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-04 DOI: 10.2340/actadv.v106.adv-2026-0456

Juan Luis Sanz-Cabanillas, Francisco José Gómez-García, Benjamin Ungar, Elena Beatriz Sanz-Cabanillas, Jesús Gay-Mimbrera, Beatriz Isla-Tejera, Antonio José Vélez García-Nieto, Emma Guttman-Yassky, Juan Ruano

{"title":"Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis.","authors":"Juan Luis Sanz-Cabanillas, Francisco José Gómez-García, Benjamin Ungar, Elena Beatriz Sanz-Cabanillas, Jesús Gay-Mimbrera, Beatriz Isla-Tejera, Antonio José Vélez García-Nieto, Emma Guttman-Yassky, Juan Ruano","doi":"10.2340/actadv.v106.adv-2026-0456","DOIUrl":"10.2340/actadv.v106.adv-2026-0456","url":null,"abstract":"Central centrifugal cicatricial alopecia (CCCA) is the most common scarring alopecia among women of African descent and has been increasingly associated with systemic comorbidities, particularly cardiometabolic and fibroproliferative conditions. We conducted a PRISMA 2020 compliant systematic review and random-effects meta-analysis, prospectively registered in PROSPERO (CRD420250656067), to quantify pooled prevalence estimates and case-control associations for comorbidities in CCCA. MEDLINE and Embase were searched through 18 June 2025 for observational studies reporting comorbidities in CCCA. Twenty three studies, comprising 9,103 patients with CCCA, were eligible. Hypertension (51.9%, 95% CI 33.8-69.6), dyslipidemia (58.4%, 95% CI 29.0 82.8), obesity (37.1%, 95% CI 10.8-74.2) and uterine leiomyomas (28.0%, 95% CI 8.0-64.0) were frequently reported, with substantial heterogeneity across studies. In case-control analyses, CCCA was significantly associated with dyslipidaemia (OR 4.46, 95% CI 1.09-18.25), uterine leiomyomas (OR 2.25, 95% CI 1.10-4.58) and anxiety disorders (OR 3.27, 95% CI 1.22-8.79), whereas hypertension, obesity and thyroid disease were not consistently associated. Most included studies were retrospective and predominantly U.S.-based, contributing to methodological heterogeneity. These findings suggest that CCCA may be accompanied by a substantial burden of medically recorded systemic comorbidities and support holistic, individualized clinical assessment.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients with Psoriatic Arthritis Have Increased Dental Comorbidities: A Nationwide Population-based Cohort Study in Korea. 银屑病关节炎患者的牙齿合并症增加：韩国一项基于全国人群的队列研究

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-04 DOI: 10.2340/actadv.v106.adv-2025-0270

Seokjin Kong, Ko Eun Kim, Eun-Jung Kwak, Han-Na Kim, Anna Kim, Jiehyun Jeon, Chan Mi Park, Yoo Sang Baek

{"title":"Patients with Psoriatic Arthritis Have Increased Dental Comorbidities: A Nationwide Population-based Cohort Study in Korea.","authors":"Seokjin Kong, Ko Eun Kim, Eun-Jung Kwak, Han-Na Kim, Anna Kim, Jiehyun Jeon, Chan Mi Park, Yoo Sang Baek","doi":"10.2340/actadv.v106.adv-2025-0270","DOIUrl":"10.2340/actadv.v106.adv-2025-0270","url":null,"abstract":"Psoriatic arthritis is increasingly recognized as a systemic inflammatory disease with multiple comorbidities, yet the full spectrum of dental complications associated with psoriatic arthritis has not been clearly defined. This nationwide population based cohort study evaluated whether patients with psoriatic arthritis are at elevated risk of diverse dental diseases. Using a nationwide population-based health insurance database, we identified 40,920 newly diagnosed psoriatic arthritis cases and 204,468 age- and sex-matched controls. Dental outcomes included dental caries, pulp and periapical disease, periodontal disease, gingival changes and tooth loss. Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs). PsA patients exhibited significantly increased risks of dental caries (aHR 1.342), pulp and periapical disease (aHR 1.633) and periodontal disease (aHR 1.268). Subtype analyses revealed elevated risks for acute and chronic gingivitis, aggressive and chronic periodontitis, periodontosis and unspecified periodontal disease. These findings highlight the need for comprehensive oral health surveillance in patients with psoriatic arthritis.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination Therapy with Upadacitinib and Acitretin in Recalcitrant Darier Disease: A Case Report. 厄帕他替尼与阿维甲素联合治疗顽固性肾脏病1例报告。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-04 DOI: 10.2340/actadv.v106.adv-2026-0662

Man Yu, Xin Peng, Fanlin Meng

引用次数: 0

Commentary on "Reported Penicillin Allergy Affects the Length of Hospital Stay in Patients with Erysipelas". 对“报道青霉素过敏影响丹毒患者住院时间”的评论。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-04 DOI: 10.2340/actadv.v106.adv-2026-0848

Tingsong Lai, Changqiang Li

引用次数: 0

Clinical Characterization and Outcomes of Dupilumab for Pemphigoid Gestationis: A Case Series of Five Patients and Literature Review. 杜匹单抗治疗类天疱疮妊娠的临床特征和结局：5例患者的病例系列和文献综述。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-28 DOI: 10.2340/actadv.v106.adv-2026-0669

Joost M Meijer, Elise J Leeman, Dominika Grabik, Lisette M Prens, Klasiena Bouwman, Jelmer R Prins, Sanne J Gordijn, Mirthe H Schoots, Maria C Bolling, Gilles F H Diercks, Jeroen Bremer, Barbara Horváth

{"title":"Clinical Characterization and Outcomes of Dupilumab for Pemphigoid Gestationis: A Case Series of Five Patients and Literature Review.","authors":"Joost M Meijer, Elise J Leeman, Dominika Grabik, Lisette M Prens, Klasiena Bouwman, Jelmer R Prins, Sanne J Gordijn, Mirthe H Schoots, Maria C Bolling, Gilles F H Diercks, Jeroen Bremer, Barbara Horváth","doi":"10.2340/actadv.v106.adv-2026-0669","DOIUrl":"10.2340/actadv.v106.adv-2026-0669","url":null,"abstract":"Treatment of pemphigoid gestationis (PG) mainly consists of systemic and potent topical corticosteroids. This retrospective case series describes patients with severe PG treated with dupilumab, including serological follow-up, and reviews all published cases. PG was confirmed by direct immunofluorescence (linear C3 and/or IgG deposition along the basement membrane zone) and serology (IgG epidermal staining on salt-split skin or anti-BP180 NC16A IgG ELISA). Pruritus, quality of life and anti-BP180 NC16A IgG and anti-BP180 NC16A IgE were monitored longitudinally. In 5 pregnant women, dupilumab was initiated with a 600 mg loading dose followed by 300 mg biweekly. Baseline pruritus was severe (NRS 8-10), with high DLQI scores (18-30). Blistering ceased within 1 week in 2 patients and within 4 weeks in 1. Two patients required weekly dosing for disease control. Systemic corticosteroids were discontinued in 3 patients and tapered to ≤10 mg/day in 2 before delivery. In one case, anti-BP180 IgG paralleled clinical improvement. Anti-BP180 IgE remained negative. All patients delivered healthy infants. In 10 reported cases, pruritus improved rapidly and systemic corticosteroids were tapered. These findings suggest dupilumab may be a promising corticosteroid-sparing option for PG, with rapid clinical response and a favourable safety profile, despite off-label use in pregnancy.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13408254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148597466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungal Skin Infections in Cutaneous T-cell Lymphoma Patients under Mogamulizumab Treatment. Mogamulizumab治疗下皮肤t细胞淋巴瘤患者的真菌皮肤感染

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-28 DOI: 10.2340/actadv.v106.adv-2026-0693

Susanne Melchers, Marlis Gerigk, Maren Hedke, Christel Weiß, Jan P Nicolay

引用次数: 0

Persistent SARS-CoV-2 Spike Protein in Vasculitic Skin Lesions after Infection or mRNA Vaccination: A Retrospective Case control Immunofluorescence Study. 感染或mRNA疫苗接种后血管性皮肤病变中持续的SARS-CoV-2刺突蛋白：回顾性病例对照免疫荧光研究

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-28 DOI: 10.2340/actadv.v106.adv-2025-0308

Andrea Gawaz, Anneli Yilmaz, Birgit Fehrenbacher, Simon Riel, Jule Riebelmann, Elena Hagelauer, Michael Schindler, Matthias Hahn, Sebastian Volc, Martin Schaller, Stephan Forchhammer

{"title":"Persistent SARS-CoV-2 Spike Protein in Vasculitic Skin Lesions after Infection or mRNA Vaccination: A Retrospective Case control Immunofluorescence Study.","authors":"Andrea Gawaz, Anneli Yilmaz, Birgit Fehrenbacher, Simon Riel, Jule Riebelmann, Elena Hagelauer, Michael Schindler, Matthias Hahn, Sebastian Volc, Martin Schaller, Stephan Forchhammer","doi":"10.2340/actadv.v106.adv-2025-0308","DOIUrl":"10.2340/actadv.v106.adv-2025-0308","url":null,"abstract":"Vasculitic skin lesions have been reported in association with both SARS-CoV-2 infection and vaccination. Whether viral proteins persist in lesional vessels beyond the acute phase remains unclear. The aim of this study was to investigate the presence of SARS-CoV-2 spike protein in persistent or delayed-onset cutaneous vasculitis temporally associated with COVID-19 infection or vaccination. This retrospective case-control study includes 9 patients with persistent or delayed-onset vasculitic skin lesions following COVID-19 infection (n=4) or mRNA vaccination (n=5). Skin biopsies were analysed using immunofluorescence for SARS-CoV-2 spike protein. Prepandemic leukocytoclastic vasculitis (n=3) and healthy postinfection/postvaccination skin (n=3) served as controls. Spike protein was detected in vascular endothelial cells of all 9 patients with COVID-19- or vaccine-associated vasculitis. Staining was absent in all prepandemic vasculitis and healthy control samples. Histopathology showed typical features of leukocytoclastic vasculitis without evidence of viral cytopathic changes. We found that SARS-CoV-2 spike protein can persist in endothelial cells of vasculitic skin lesions weeks to months after COVID-19 infection or mRNA vaccination. These findings suggest that retained viral proteins may contribute to prolonged or delayed-onset vasculitic skin manifestations. Further studies are needed to clarify the mechanisms underlying spike persistence and its clinical significance.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13408253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148597492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Clinicians' Knowledge of Terbinafine-resistant Extensive Dermatophytosis in France. 法国临床医生对特比萘芬耐药广泛皮肤真菌病知识的评估。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-21 DOI: 10.2340/actadv.v106.adv-2026-0565

Alicia Moreno Sabater, Pablo Ruiz, Marc Reverte, Sophie Tan, Jeanne Bigot, Geneviève Cremer, Pascal Del Giudice, Claude Bachmeyer, Jean-Pierre Gangneux, Olivier Chosidow

引用次数: 0

Psychological Distress, Symptom Burden and Quality of Life in Patients with Mycosis Fungoides and Sézary Syndrome. 蕈样真菌病和ssamzary综合征患者的心理困扰、症状负担和生活质量。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-15 DOI: 10.2340/actadv.v106.adv-2026-0463

Rudy Bittar, Karolina Wojewoda, Martin Gillstedt, Catharina Lewerin, Mikael Alsterholm, Amra Osmancevic

{"title":"Psychological Distress, Symptom Burden and Quality of Life in Patients with Mycosis Fungoides and Sézary Syndrome.","authors":"Rudy Bittar, Karolina Wojewoda, Martin Gillstedt, Catharina Lewerin, Mikael Alsterholm, Amra Osmancevic","doi":"10.2340/actadv.v106.adv-2026-0463","DOIUrl":"10.2340/actadv.v106.adv-2026-0463","url":null,"abstract":"Mycosis fungoides (MF) and Sézary syndrome (SS) are rare cutaneous lymphomas with limited data on psychological burden. This observational, cross sectional questionnaire study assessed symptom burden, psychological distress and quality of life (QoL) in patients with MF and SS in Western Sweden and compared outcomes with psoriasis. Sixty patients were included, 80% with early-stage disease. Most reported minimal depression, anxiety and QoL impairment. Moderate-to-severe depression occurred in 36% of advanced disease cases and 16% of early disease cases and moderate-to-severe QoL impairment in 33% and 17%, respectively. Pruritus correlated strongly with impaired QoL (ρ=0.67, p<0.001). Fatigue correlated with depression (Montgomery-Åsberg Depression Rating Scale Self-report (MADRS-S): ρ=0.60, Hospital Anxiety and Depression Scale-Depression subscale: ρ=0.63), anxiety (ρ=0.49) and QoL impairment (ρ=0.53), all p<0.001. Compared with psoriasis, patients reported lower pain and QoL impairment. Overall, psychological burden was limited but increased with advanced disease and fatigue severity.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13370663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Postzygotic TRPM4 Variant in a Patient with Inflammatory Linear Verrucous Epidermal Nevus. 炎性线状疣状表皮痣患者的合子后TRPM4变异。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-07-14 DOI: 10.2340/actadv.v106.adv-2026-0503

Teng Yan, Zeqiao Zhang, Sisi Zhao, Chao Yang, Huijun Wang, Zhimiao Lin

引用次数: 0