Acta dermato-venereologica最新文献_第7页

A Thick-walled Pink Bulla with a Firm Nodule Underneath: A Quiz. 一个厚壁的粉红色球，下面有一个坚固的结节：一个小测验。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-16 DOI: 10.2340/actadv.v105.43674

Moe Kanaya, Yasuhiro Mitsui, Chinatsu Shobatake, Satoka Tatebayashi, Takashi Nakanishi

引用次数: 0

Bidirectional Relationship Between Atopic Dermatitis and Psychiatric Comorbidities in Individuals of European Ancestry: A Mendelian Randomization Study. 欧洲血统个体特应性皮炎与精神合并症的双向关系：一项孟德尔随机化研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-15 DOI: 10.2340/actadv.v105.43133

Zhe Wu, Chenglong Wu, Xuanyi Chen, Qiufang Qian, Zhirong Yao

{"title":"Bidirectional Relationship Between Atopic Dermatitis and Psychiatric Comorbidities in Individuals of European Ancestry: A Mendelian Randomization Study.","authors":"Zhe Wu, Chenglong Wu, Xuanyi Chen, Qiufang Qian, Zhirong Yao","doi":"10.2340/actadv.v105.43133","DOIUrl":"10.2340/actadv.v105.43133","url":null,"abstract":"Atopic dermatitis is a chronic inflammatory skin disorder that significantly impacts quality of life and is often associated with psychiatric comorbidities. How-ever, the causal relationship between atopic dermatitis and psychiatric disorders remains unclear. This study employed bidirectional 2-sample Mendelian randomization to investigate the potential causal relationships between atopic dermatitis and 8 psychiatric conditions: depression, anxiety, autism spectrum disorder, attention deficit hyperactivity disorder, suicidality, bipolar disorder, obsessive-compulsive disorder, and schizophrenia. Genetic instruments were derived from large-scale genome-wide association studies of European ancestry. Forward Mendelian randomization analysis indicated that atopic dermatitis causally increases the risk of anxiety (inverse variance weighting p = 0.016; odds ratio = 1.110, 95% confidence interval: 1.019-1.208). Reverse Mendelian randomization analysis revealed a significant causal effect of bipolar disorder on increasing the risk of atopic dermatitis (inverse variance weighting p = 0.005; odds ratio = 1.062, 95% confidence interval: 1.018-1.107). No significant causal relationships were found for other psychiatric conditions. Sensitivity analyses confirmed the robustness of these findings, with no evidence of horizontal pleiotropy. These results highlight the need for integrated dermatological and psychiatric care, emphasizing early mental health screening for atopic dermatitis patients and dermatological evaluation for individuals with bipolar disorder. Future research should explore underlying biological mechanisms and validate findings across diverse populations.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43133"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rates of Infections, Malignancies, Cardiovascular Outcomes, and Death in Individuals with Hospital-treated Alopecia Areata: A Registry-based Cohort Study in Denmark. 医院治疗的斑秃患者的感染率、恶性肿瘤、心血管结局和死亡率：丹麦一项基于登记的队列研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-15 DOI: 10.2340/actadv.v105.42646

Sissel Brandt Toft Sørensen, Prethibha George, Oladayo Jagun, Robert Wolk, Lynne Napatalung, Samuel H Zwillich, Lars Iversen, Vera Ehrenstein

{"title":"Rates of Infections, Malignancies, Cardiovascular Outcomes, and Death in Individuals with Hospital-treated Alopecia Areata: A Registry-based Cohort Study in Denmark.","authors":"Sissel Brandt Toft Sørensen, Prethibha George, Oladayo Jagun, Robert Wolk, Lynne Napatalung, Samuel H Zwillich, Lars Iversen, Vera Ehrenstein","doi":"10.2340/actadv.v105.42646","DOIUrl":"10.2340/actadv.v105.42646","url":null,"abstract":"The emergence of new systemic treatments for alopecia areata underscores the importance of estimating rates of potential treatment safety events among individuals with alopecia areata. In this population-based cohort study, data linked across Danish population-based registries were used to examine the rates of the following safety events of interest before approval of Janus kinase inhibitor treatments by the European Medicines Agency: serious infections, herpes zoster infections, malignancies, arterial and venous cardiovascular events, and all-cause death in an alopecia areata cohort, defined as individuals ≥ 12 years old with hospital-treated alopecia areata, including its sub-types alopecia totalis and alopecia universalis. Incidence rates of the safety events of interest were computed and their associations with alopecia areata were estimated as standardized incidence ratios computed with regard to the age- and sex-matched general Danish population. The alopecia areata cohort included 2,778 individuals (472 with alopecia totalis/alopecia universalis) with a first-recorded diagnosis of alopecia areata in 1995-2016, followed through to the end of 2016, during a hospital admission or treatment at an outpatient clinic. Hospital-treated alopecia areata was associated with serious infections (standardized incidence ratio [95% confidence interval], 1.89 [1.72-2.06]), herpes zoster infections (1.83 [1.63-2.05]), lymphoma (3.44 [1.88-5.77]), arterial and venous cardiovascular outcomes (1.41 [1.12-1.75]), and death (1.16 [1.00-1.34]).","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42646"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory Effect of 505 nm Green Light Emitting Diode on Melanin Synthesis in Cellular Experiments and a Human Intervention Study. 505 nm绿色发光二极管抑制黑色素合成的细胞实验及人为干预研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-15 DOI: 10.2340/actadv.v105.43441

Yoshihito Mima, Takehiro Yamada, Jun Omatsu, Takashi Yamashita, Shota Suzuki, Takayuki Takechi, Mayumi Ichikawa, Kentaro Yamazaki, Shinichi Sato, Ayumi Yoshizaki

{"title":"Inhibitory Effect of 505 nm Green Light Emitting Diode on Melanin Synthesis in Cellular Experiments and a Human Intervention Study.","authors":"Yoshihito Mima, Takehiro Yamada, Jun Omatsu, Takashi Yamashita, Shota Suzuki, Takayuki Takechi, Mayumi Ichikawa, Kentaro Yamazaki, Shinichi Sato, Ayumi Yoshizaki","doi":"10.2340/actadv.v105.43441","DOIUrl":"10.2340/actadv.v105.43441","url":null,"abstract":"Light-emitting diodes (LEDs) are currently gaining attention in aesthetic medicine for their applications in the treatment of pigmentation and wrinkles. While several wavelengths of LEDs have been reported to inhibit melanin production by targeting melanin synthesis-related enzymes, melanosomes, and paracrine factors stimulating melanogenesis from keratinocytes, the effects of green LED (GLED) remain largely unexplored. This study aimed to investigate the effects of GLED on cell viability, melanin production, and melanin-related gene expression using B16 melanoma cells and 3-dimensional (3D) skin models. Furthermore, its efficacy in improving skin pigmentation was evaluated through a human intervention study with GLED-equipped facial masks. The melanin synthesis inhibitory effects of 505 nm GLED were evaluated using B16 mouse melanoma cells, a 3D skin model containing melanocytes, and a human intervention study with 505 nm GLED-equipped masks. 505 nm GLED irradiation reduced melanin production in melanogenesis-induced B16 mouse melanoma cells by suppressing the gene expression levels of microphthalmia-associated transcription factor and tyrosinase. Furthermore, GLED irradiation also reduced melanin content in 3D skin models without affecting cell viability. Finally, a human intervention study demonstrated that GLED irradiation on human facial skin effectively decrease pigmentation. These findings suggest 505 nm GLED is a potential depigmentation strategy.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43441"},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subtotal Scrotectomy and Scrotoplasty: An Effective Treatment for Idiopathic Scrotal Calcinosis. 阴囊次全切除术和阴囊成形术：特发性阴囊钙化症的有效治疗方法。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-13 DOI: 10.2340/actadv.v105.43100

Ricardo Moreno-Borque, Carmen Carranza-Romero, Ana Sirgado-Martínez, Elena Lozano-Martínez, Eduardo López-Bran

引用次数: 0

Dementia Risk in Psoriasis Patients Treated with Biologics: A Propensity Score-matched Population-based Cohort Study. 使用生物制剂治疗的银屑病患者痴呆风险：一项倾向评分匹配的基于人群的队列研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-13 DOI: 10.2340/actadv.v105.43243

Jen A Barak Levitt, Michael Ziv

引用次数: 0

Identifying Mild-to-Moderate Atopic Dermatitis Using a Generic Machine Learning Approach: A Danish National Health Register Study. 使用通用机器学习方法识别轻度至中度特应性皮炎：丹麦国家健康登记研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-13 DOI: 10.2340/actadv.v105.42250

Mie Sylow Liljendahl, Kristina Ibler, Christian Vestergaard, Lone Skov, Pavika Jain, Jan Håkon Rudolfsen, Ann Hærskjold, Mathias Torpet

{"title":"Identifying Mild-to-Moderate Atopic Dermatitis Using a Generic Machine Learning Approach: A Danish National Health Register Study.","authors":"Mie Sylow Liljendahl, Kristina Ibler, Christian Vestergaard, Lone Skov, Pavika Jain, Jan Håkon Rudolfsen, Ann Hærskjold, Mathias Torpet","doi":"10.2340/actadv.v105.42250","DOIUrl":"10.2340/actadv.v105.42250","url":null,"abstract":"Atopic dermatitis is a chronic skin disease, causing itching and recurrent eczematous lesions. In Danish national register data, adults with atopic dermatitis can only be identified if they have a hospital-diagnosed atopic dermatitis. The purpose of this study was to develop a machine learning model to identify all patients with atopic dermatitis by proxy, using data for contacts with primary care, prescription medication, and hospital contacts not related to skin diseases. Individuals redeeming a prescription for dermatological preparations were extracted as potential patients with atopic dermatitis. Individuals with a registered hospital diagnosis of atopic dermatitis were classified as \"Known AD\", \"Other skin disease\" (registrations of other dermatological diagnosis codes indicating other skin disease), or \"Uncertain AD status\"' (no hospital diagnosis registered). Patients categorized as \"Known AD\" and \"Other skin disease\" were used to develop the model. All uses of healthcare services 2 years prior to hospital diagnosis were used as potential predictors. The data were split into training and validation sets (70/30). From 1996 to 2022, 385,135 individuals had uncertain atopic dermatitis status. The most important predictors were corticosteroid prescriptions for dermatological use, consultations with dermatologist, and age. Of the 385,135 individuals, the model predicted that 230,522 individuals likely have atopic dermatitis.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42250"},"PeriodicalIF":3.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Variation of the Burden of Atopic Dermatitis in Finnish Primary Care: A Database Study on Effects of Weather and Air Quality. 芬兰初级保健中特应性皮炎负担的季节变化：天气和空气质量影响的数据库研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-12 DOI: 10.2340/actadv.v105.43041

Emilia Räisänen, Anita Remitz, Alexander Salava

{"title":"Seasonal Variation of the Burden of Atopic Dermatitis in Finnish Primary Care: A Database Study on Effects of Weather and Air Quality.","authors":"Emilia Räisänen, Anita Remitz, Alexander Salava","doi":"10.2340/actadv.v105.43041","DOIUrl":"10.2340/actadv.v105.43041","url":null,"abstract":"The burden of atopic dermatitis has been increasing in Finland during recent decades and seems to vary seasonally. The aim was to investigate the effect of season and weather factors on patient numbers of primary care. Data bank information of the Finnish Institute for Health and Welfare was analysed for frequency of atopic dermatitis patients in the primary care of Helsinki during 2018-2023. In addition, the seasonal burden was compared with weather data from the Finnish Meteorological Institute. Patient numbers varied significantly during the year (p = 0.028). There was a recurrent seasonal variation with most atopic dermatitis diagnoses in January, February, March, and November and the least in July and August. A significant inverse association was observed between atopic dermatitis patients and outside temperature (p = 0.004) and UV Index (p = 0.008). Low air quality was associated with a higher burden in primary care (p = 0.013). There was no significant association regarding rain (p = 0.103) or relative air humidity (p = 0.392). The burden of atopic dermatitis in primary care shows a significant seasonal variation. There are specific weather parameters that follow similar patterns and likely comprise important extrinsic pathogenetic factors. It is reasonable to address the changing burden of atopic dermatitis with seasonally directed medical measures, education, and resources.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43041"},"PeriodicalIF":3.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Extragenital Lichen Sclerosus with Narrow-band UVB Phototherapy. 窄带UVB光疗成功治疗外阴硬化地衣。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-12 DOI: 10.2340/actadv.v105.43470

Lanyu Sun, Diogo De Sousa, Pedro De Vasconcelos, Sónia Fernandes, Paulo Filipe

引用次数: 0

Olanzapine-induced Drug Reaction with Eosinophilia and Systemic Symptoms: Case Report and Review of the Literature. 奥氮平诱导的药物反应伴嗜酸性粒细胞增多及全身症状：病例报告及文献复习。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-05-12 DOI: 10.2340/actadv.v105.42576

Katrin Ickrath, Hermann Kneitz, Astrid Schmieder, Matthias Goebeler, Johanna Stoevesandt

引用次数: 0