Acta dermato-venereologica最新文献_第6页

Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudi-nal Study. 带状疱疹无细胞DNA水平：横断面纵向研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.42137

Chaya Bracha Gordon, Yaron Zenaty, Ayelet Ollech, Gidon Test, Amos Douvdevani, Amir Horev

{"title":"Cell-free DNA Levels in Herpes Zoster: A Cross-sectional Longitudi-nal Study.","authors":"Chaya Bracha Gordon, Yaron Zenaty, Ayelet Ollech, Gidon Test, Amos Douvdevani, Amir Horev","doi":"10.2340/actadv.v105.42137","DOIUrl":"10.2340/actadv.v105.42137","url":null,"abstract":"This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls. The findings demonstrated elevated cell-free DNA levels in patients with herpes zoster, which remained elevated for 3 months or longer following treat-ment. These results suggest the presence of a subacute inflammatory state after herpes zoster infection. Furthermore, patients who developed post-herpetic neuralgia did not show elevated cell-free DNA levels, while those who did not develop post-herpetic neuralgia exhibited increased levels. This indicates that post-herpetic neuralgia is likely a localized response to prior nerve damage rather than a systemic inflammatory process with acute tissue damage.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42137"},"PeriodicalIF":3.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing ChatGPT-4's Capabilities in Generating Dermatology Board Examination Content: An Explorational Study. 评估ChatGPT-4在生成皮肤病委员会考试内容方面的能力：一项探索性研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.41208

Jonathan Shapiro, Anna Lyakhovitsky, Tamar Freud, Felix Pavlotsky, Ziyad Khamaysi, Yulia Valdman-Grinshpoun, Roni Dodiuk-Gad, Ilan Goldberg, Arieh Ingber, Baruch Kaplan, Emily Avitan-Hersh

引用次数: 0

Novel ABCA12 Missense Variant in a Patient with Congenital Ichthyosis and Palmoplantar Keratoderma. 先天性鱼鳞病和掌跖角化病患者的新型ABCA12错义变异。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.42502

Pauline Bernard, Nuria Pell, Juliette Mazereeuw-Hautier, Nathalie Jonca

引用次数: 0

Prognostic Factors Predicting Remission Following Rituximab Therapy for Pemphigus Vulgaris. 预测寻常型天疱疮利妥昔单抗治疗后缓解的预后因素。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.27140

Tal Raviv, Keren Pevzner, Aviv Barzilai, Felix Pavlotsky, Sharon Baum

{"title":"Prognostic Factors Predicting Remission Following Rituximab Therapy for Pemphigus Vulgaris.","authors":"Tal Raviv, Keren Pevzner, Aviv Barzilai, Felix Pavlotsky, Sharon Baum","doi":"10.2340/actadv.v105.27140","DOIUrl":"10.2340/actadv.v105.27140","url":null,"abstract":"Pemphigus vulgaris is a chronic autoimmune blistering disease with significant morbidity. Rituximab, approved as its first-line treatment, effectively induces remission. However, few studies have analysed the prognostic factors for improved rituximab outcomes. Therefore, this study aimed to identify such factors in a cohort of pemphigus vulgaris patients. A total of 142 pemphigus vulgaris patients treated with rituximab at Sheba Medical Center, with data encompassing demographics, comorbidities, disease characteristics, and treatment outcomes, were retrospectively examined. Results showed that 61.9% of patients previously treated with mycophenolate mofetil achieved partial remission, whereas only 34.7% achieved complete remission. Patients with diabetes mellitus exhibited a significantly shorter median time to relapse compared with those without. Patients with a disease duration ≤ 16 months before rituximab therapy exhibited a shorter median time to relapse. Moreover, previous dapsone treatment extended time to relapse. Notably, sex, age at symptom onset and rituximab therapy, ethnicity, comorbidities, skin involvement, weight, rituximab dosing protocol, and other variables were not statistically significant between the complete remission and partial remission groups. These findings highlight the influence of specific patient characteristics and treatment histories on response to rituximab and time to relapse in pemphigus vulgaris patients. Understanding these factors can aid clinicians in predicting treatment outcomes and selecting the appropriate patient population for rituximab therapy.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv27140"},"PeriodicalIF":3.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi. 人工智能辅助全身皮肤镜评估妊娠期间黑素细胞痣的变化：一项2799例痣的前瞻性比较研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.41025

Jelissa K Peter, Fabrice Helfenstein, Sara E Cerminara, Julia-Tatjana Maul, Mara L Zehnder, Dagmar Jamiolkowski, Elisabeth Roider, Beda Mühleisen, Irene Hösli, Alexander A Navarini, Lara V Maul

{"title":"AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi.","authors":"Jelissa K Peter, Fabrice Helfenstein, Sara E Cerminara, Julia-Tatjana Maul, Mara L Zehnder, Dagmar Jamiolkowski, Elisabeth Roider, Beda Mühleisen, Irene Hösli, Alexander A Navarini, Lara V Maul","doi":"10.2340/actadv.v105.41025","DOIUrl":"10.2340/actadv.v105.41025","url":null,"abstract":"Pregnancy-associated changes in melanocytic nevi (MN), apart from size increase on the trunk, remain a topic of debate. We conducted the first prospective study to investigate dermoscopic changes in MN comparing pregnant with non-pregnant women on all body parts using a market-approved convolutional neural network (CNN). We included 25 pregnant and 25 non-pregnant women from Basel, Switzerland, who underwent standard skin cancer screenings and whose MN > 2 mm were digitally recorded and analysed by a CNN. Pregnant women were examined three times: in the first and third trimester and 8-12 weeks postpartum; non-pregnant women twice in an interval of 17-21 weeks. We analysed 2,799 MN. In pregnant women, diameter[p < 0.001], area[p < 0.001], number of colours [p = 0.009], shape asymmetry[p = 0.005] and border sharpness[p = 0.006] (inversely proportional value) increased while ellipseness [p < 0.001] decreased from first trimester to postpartum. Changes occurred mainly during the third trimester to postpartum. Compared to non-pregnant women (only first to third trimester) MN on the upper extremities of pregnant women increased in area[p = 0.011] and diameter[p = 0.025] and decreased in ellipseness[p = 0.037]. MN on the lower extremities increased in area[p = 0.044] and MN on the back increased in colour asymmetry[p = 0.022].","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41025"},"PeriodicalIF":3.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Comorbidity Cycle Between Psoriasis and Addiction Based on ICD Coding in the Stockholm Psoriasis Cohort. 基于ICD编码的斯德哥尔摩银屑病队列中银屑病和成瘾的共病周期评估

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.41221

Hannah Wecker, Axel Svedbom, Fabio Sánchez Orrego, Stefanie Ziehfreund, Mona Ståhle, Alexander Zink

{"title":"Assessing the Comorbidity Cycle Between Psoriasis and Addiction Based on ICD Coding in the Stockholm Psoriasis Cohort.","authors":"Hannah Wecker, Axel Svedbom, Fabio Sánchez Orrego, Stefanie Ziehfreund, Mona Ståhle, Alexander Zink","doi":"10.2340/actadv.v105.41221","DOIUrl":"10.2340/actadv.v105.41221","url":null,"abstract":"The comorbidity cycle between psoriasis and addictions remains unclear. The study aimed to investigate the cumulative incidence of addictions in psoriasis patients and controls in the Stockholm Psoriasis Cohort (SPC). The SPC is an observational cohort study that enrolled psoriasis patients between 2001 and 2005 and matched controls using the Swedish Total Population Register. Data were complemented by medical records from 1987-2013, focusing on 11 addiction diagnoses and the date of their assignment. Overall, 4,545 individuals (56.4% female; median age: 40) were included: 722 psoriasis patients and 3,823 controls. Patients showed 1.4 times (95% confidence interval: 0.98-1.98) higher odds of addiction diagnosis than controls. Alcohol dependency was the most common addiction diagnosis (78.2%), which was more frequent in patients than in controls (94.3% vs 73.6%, p = 0.009). Furthermore, patients showed 4.3 times (1.85-11.56) higher odds of receiving an addiction diagnosis after their initial psoriasis diagnosis than before. Results showed a tendency towards a higher risk of addiction in psoriasis patients, suggesting potential psoriasis-triggered addictive behaviour. Nevertheless, both substance abuse triggering psoriasis and chronic psoriasis inflammation triggering addictions have to be considered. In both cases, addictive behaviour needs to be addressed in psoriasis healthcare as a driver for poor disease outcome and comorbidities.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41221"},"PeriodicalIF":3.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Cutaneous Immune-related Adverse Events with Overall Survival and Progression-free Survival in Oncology Patients Receiving Immune Checkpoint Inhibitors: A Prospective Study of 189 Patients in a Spanish Tertiary Care Hospital. 接受免疫检查点抑制剂的肿瘤患者皮肤免疫相关不良事件与总生存期和无进展生存期的关联：一项西班牙三级医院189例患者的前瞻性研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-01-03 DOI: 10.2340/actadv.v105.42023

Gloria Juan-Carpena, Natividad Martínez Banaclocha, Juan Carlos Palazón Cabanes, Maria Niveiro-de Jaime, Isabel Betlloch Mas, Mar Blanes-Martínez

{"title":"Association of Cutaneous Immune-related Adverse Events with Overall Survival and Progression-free Survival in Oncology Patients Receiving Immune Checkpoint Inhibitors: A Prospective Study of 189 Patients in a Spanish Tertiary Care Hospital.","authors":"Gloria Juan-Carpena, Natividad Martínez Banaclocha, Juan Carlos Palazón Cabanes, Maria Niveiro-de Jaime, Isabel Betlloch Mas, Mar Blanes-Martínez","doi":"10.2340/actadv.v105.42023","DOIUrl":"10.2340/actadv.v105.42023","url":null,"abstract":"Cutaneous immune-related adverse events (cirAEs) may be associated with tumoral response and survival in patients using immune checkpoint inhibitors, but this relationship remains unclear because previous reports on the topic have various limitations. The purpose of this study was to examine the association of cirAEs with overall survival and progression-free survival in patients starting immune checkpoint inhibitors. A prospective observational study was conducted in a Spanish tertiary care hospital, including participants between March 2020 and May 2022. The statistical analysis involved the Kaplan-Meier method, log-rank test, and multivariable Cox proportional hazards regression models. At total of 189 patients were included, of whom 82 (43.4%) presented cirAEs. Most participants (56.6%) were diagnosed with non-small cell lung cancer (NSCLC). Mortality and progression rates were lower in patients with vs without cirAEs (p < 0.0001). Cox models showed that cirAEs were a protective factor for overall survival (adjusted HR 0.50; p < 0.0001) and progression-free survival (adjusted HR 0.54; p = 0.001) independently of cancer type, tumour stage or immune checkpoint inhibitor category. There were similar results for extracutaneous irAEs. A limitation was the single-centre design. CirAE occurrence is positively associated with longer survival and less cancer progression among immune checkpoint inhibitor recipients independently of other factors.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42023"},"PeriodicalIF":3.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An International Examination of Skin Concerns Impacting Self-Confidence Among 5,138 Males. 一项对5138名男性皮肤问题影响自信的国际调查。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-13 DOI: 10.2340/actadv.v104.42016

Frederic Flament, Aurelie Maudet, Caroline Delaunay, David Amar, Muriel Bayer-Vanmoen, Audrey Imbert Legrain, Charles Taieb, Charbel Skayem, Laurence Lebarbanchon

引用次数: 0

Impact of Skin Type and Sensitivity on Dermatological Concerns and Self-confidence: Insights from an International Study of 14,317 Women. 皮肤类型和敏感性对皮肤病学关注和自信的影响：来自14,317名女性的国际研究的见解。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-13 DOI: 10.2340/actadv.v104.42424

Frederic Flament, Aurelie Maudet, Caroline Delauney, David Amar, Muriel Bayer-Vanmoen, Audrey Imbert Legrain, Charles Taieb, Charbel Skayem, Laurence Lebarbanchon

引用次数: 0

Effect of Therapeutic Patient Education in Adults with Atopic Dermatitis: Analysis of Efficacy and Treatment Needs. 治疗性患者教育对成人特应性皮炎的疗效及治疗需求分析。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-12 DOI: 10.2340/actadv.v104.41184

Marine Fargeas, Mathieu Fauvernier, Marie Tauber, Julien Seneschal, Virginie Verdu, Magali Bourrel Bouttaz, Florence Hacard, Anne-Sophie Darrigade, Audrey Nosbaum

{"title":"Effect of Therapeutic Patient Education in Adults with Atopic Dermatitis: Analysis of Efficacy and Treatment Needs.","authors":"Marine Fargeas, Mathieu Fauvernier, Marie Tauber, Julien Seneschal, Virginie Verdu, Magali Bourrel Bouttaz, Florence Hacard, Anne-Sophie Darrigade, Audrey Nosbaum","doi":"10.2340/actadv.v104.41184","DOIUrl":"10.2340/actadv.v104.41184","url":null,"abstract":"In the era of biological treatments and small molecules, this study assessed therapeutic patient education (TPE) in managing adult atopic dermatitis (AD), focusing on disease severity, quality of life, and the use of systemic treatments. This multicentre study included 260 adult AD patients, with 184 undergoing a full TPE programme and 76 control patients. Evaluations included disease severity, quality of life (DLQI), and systemic treatment use. The primary goal was to measure AD improvement, with secondary goals assessing DLQI score changes and systemic treatment use. AD severity improved in 64.7% of TPE patients vs 45.7% of controls (p = 0.008). The mean DLQI score dropped by 5.7 points in the TPE group vs 2.4 points in controls (p = 0.006). Additionally, 69.8% of TPE patients had a DLQI score ≤ 4/30 compared with 50% of controls (p = 0.025). Regarding therapeutics, 83.6% of patients naive to systemic treatment at inclusion were maintained exclusively under topical treatment vs 21.7% in the control group. The likelihood of needing systemic treatment was 66% in controls vs 6% in the TPE group. TPE enhances AD severity and quality of life, ensures better disease control, and reduces systemic treatment use, highlighting its importance in managing adult AD.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41184"},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0