Acta dermato-venereologica最新文献

{"title":"Truncal Acne Is Independently Associated with Stigmatization, Poorer Treatment Adherence and Greater Healthcare Utilization: A 20-country Survey.","authors":"Marco Rocha, Valérie Mangeaut, Jean-Daniel Daumont, Virginie Ribet, Charles Taieb, Bruno Halioua","doi":"10.2340/actadv.v106.adv-2026-0642","DOIUrl":"10.2340/actadv.v106.adv-2026-0642","url":null,"abstract":"<p><p>Truncal acne (TA) affects 40-50% of adults with acne vulgaris and remains understudied despite its psychosocial impact. We aimed to evaluate the association of TA with stigmatization, psychosocial burden, healthcare utilization and treatment adherence, compared with exclusively facial acne (FA). We hypothesized that TA would be independently associated with greater psychosocial burden and healthcare utilization than FA alone. In this cross-sectional international online survey of 1,879 adults with physician-diagnosed acne (FA n=1,075; TA n=804) across 20 countries, multivariable logistic regression adjusted for age, sex and country showed that TA was independently associated with stigmatization (aOR 1.41 [95%CI 1.16-1.71]), hospitalization (aOR 1.73 [1.25-2.38]) and poor treatment adherence (aOR 1.26 [1.03 1.53]). Stigmatization was equally prevalent in truncal-only (49.2%) and combined facial-and truncal (50.5%) patients (aOR 1.00), indicating that it is intrinsic to truncal involvement rather than a consequence of facial disease. Truncal-only patients had lower dermatologist access (63.8% vs 78.9%) yet markedly higher hospitalization and surgical consultation rates. TA is independently associated with psychosocial burden and higher healthcare resource utilization; systematic trunk examination during acne consultations is warranted.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colostomy May Improve Outcomes in Patients with Severe Anogenital and Gluteal Hidradenitis Suppurativa: Case Series.","authors":"Valdis Thorhallsdottir, Karin Berggård, Meirav Holmdahl, Martin Lindsten, Louis Banka Johnson, Artur Schmidtchen, Anja Pahlow Mose","doi":"10.2340/actadv.v106.adv-2026-0533","DOIUrl":"10.2340/actadv.v106.adv-2026-0533","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Risk Factors in Adults with Atopic Dermatitis: A Cross-sectional Study.","authors":"Raquel Sanabria-de la Torre, Andrés Oliver-Ramírez, Katrina Abuabara, Trinidad Montero-Vílchez, Salvador Arias-Santiago","doi":"10.2340/actadv.v106.adv-2026-0452","DOIUrl":"https://doi.org/10.2340/actadv.v106.adv-2026-0452","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a chronic inflammatory skin disease linked to systemic comorbidities, although its relationship with cardiovascular risk) remains controversial. The main objective of this study was to evaluate cardiovascular risk-related factors in AD and explore associations with disease severity. A cross-sectional study including adults with AD and healthy controls was conducted. Cardiovascular risk assessment included anthropometric, lifestyle, vascular and laboratory data, with global risk estimated using the PREVENT equations. The study included 100 adults (50 AD patients and 50 controls). Patients had moderate-to-severe disease (SCORAD 49.19±16.41). Compared with controls, AD patients showed higher BMI (27.25 vs 24.63 kg/m², p=0.01), lower Mediterranean diet adherence (p<0.001) and reduced physical activity (p=0.03). Mean arterial pressure (103.67 vs 93.55 mmHg, p=0.001), LDH (215.31 vs 183.88 IU/L; p=0.008) and CRP (7.90 vs 0.84 mg/L, p=0.05) were significantly higher in patients. Higher v-IGA scores were associated with increased fasting glucose and heart rate. Estimated 10 year cardiovascular risk was significantly higher in AD than in controls (p=0.04). Overall, AD patients exhibit an unfavourable cardiometabolic profile. Greater disease severity may be linked to vascular alterations, supporting the need for cardiovascular assessment in AD management.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosomatic Burden and Childhood Trauma in Chronic Pruritus without Primary Dermatosis or Systemic Disease: A Case-control Study.","authors":"Zeynep Nur Demırok, Erdoğdu Akça, Zeynep Şahın Teke, Sena Ece Ilgın, Tuğba Satılmış, Ömer Yanartaş, Aslı Kaptanoğlu","doi":"10.2340/actadv.v106.adv-2026-0658","DOIUrl":"https://doi.org/10.2340/actadv.v106.adv-2026-0658","url":null,"abstract":"<p><p>Chronic pruritus without a primary dermatosis or systemic disease is a clinically challenging condition in which psychological factors may be relevant and substantial psychosomatic burden may be present. This case-control study examined childhood trauma, psychological symptoms and psychosomatic characteristics in this patient population. A total of 75 patients and 75 healthy controls aged 18-65 years were included. Childhood trauma, dissociation, depressive and anxiety symptoms, somatic symptom burden, alexithymia, health anxiety, somatosensory amplification and itch burden were assessed using validated self-report instruments. Group differences were analysed using multivariate analysis of covariance and follow-up ANCOVAs adjusted for age, sex and education. Patients showed higher somatic symptom burden, alexithymia, health anxiety, somatosensory amplification, anxiety and depressive symptoms than controls, whereas dissociative symptoms did not differ. Among childhood trauma dimensions, emotional abuse and physical abuse were higher in patients, while other trauma domains were not significantly different. Itch severity was correlated with depressive symptoms, anxiety symptoms and somatic symptom burden; in exploratory regression analyses, depressive symptoms emerged as the only independent predictor of itch severity. These findings suggest that patients with chronic pruritus without a primary dermatosis or systemic disease may have a broad psychosomatic burden extending beyond affective symptoms alone.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Correlation between Dermatology Life Quality Index and Psoriasis Area and Severity Index in Patients with Psoriasis: A Cross-sectional Global Healthcare Study on Psoriasis.","authors":"Julia-Tatjana Maul","doi":"10.2340/actadv.v106.46727","DOIUrl":"https://doi.org/10.2340/actadv.v106.46727","url":null,"abstract":"<p><p>Corrigendum to article: https://doi.org/10.2340/actadv.v104.20329.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":"adv46727"},"PeriodicalIF":3.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world Effectiveness and Safety of Lebrikizumab in Atopic Dermatitis: A TREATgermany Analysis.","authors":"Barbara Kind, Christina Pham, Luise Heinrich, Tatjana Honstein, Annice Heratizadeh, Inken Harder, Dora Stölzl, Petra Staubach-Renz, Thomas Schaefer, Susanne Abraham, Matthias Augustin, Jutta Ramaker-Brunke, Andreas Pinter, Kathrin Meinhardt, Sven Quist, Sabine Anders, Beate Schwarz, Michael Schulz-Kiesow, Sabine Steinke, Nicole Adler, Christiane Handrick, Knut Schaekel, Michael Sticherling, Anne Bong, Felix D Jacobs, Bernd Großmann, Maren Stahl, Carl-Philipp Buerkle, Hannah L Gorriahn-Maiterth, Tilo Biedermann, Jochen Schmitt, Stephan Weidinger, Thomas Werfel","doi":"10.2340/actadv.v106.adv-2026-0542","DOIUrl":"10.2340/actadv.v106.adv-2026-0542","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is driven by type 2 inflammation, with interleukin-13 (IL-13) as one of the central operators. Lebrikizumab is a monoclonal antibody that inhibits IL-13 signalling. Adult patients with moderate-to-severe AD who received lebrikizumab in the TREATgermany registry until 12/2024 were selected, and patient characteristics as well as effectiveness and safety outcomes after 1, 3 and 6 months were evaluated. A total of 108 patients were initiated on lebrikizumab, with 80 having follow-up data available for this analysis (\"registry cohort\"). Forty-one patients were switched to lebrikizumab without a \"washout period\" from another advanced systemic therapy (\"switchers\"). The mean Eczema Area and Severity Index (EASI) decreased from 14.8 at baseline to 5.6 and 3.0 at month 3 and month 6 and was comparable between switchers and nonswitchers. Clinically meaningful improvements were also seen across all patient reported outcomes (PROs) equally in both groups, e.g. a decrease of the mean peak pruritus numeric rating scale (PP-NRS) from 6.6 to 3.8 and 3.4 and the Dermatology Life Quality Index (DLQI) from 11.9 to 4.9 and 4.8. Overall, adverse events (AEs) were reported for 26.6% of patients within the first 3. The most frequently reported AE was conjunctivitis or other ocular complications, reported in 13 patients (20.3%). 32 patients (40%) had an initial EASI≥16 and were comparable to patients in lebrikizumab phase 3 studies. In this \"trial-like\" cohort, EASI-75 and EASI-90 response rates were 60% and 26.7% at month 3 and 70% and 50% at month 6. Lebrikizumab shows effectiveness in routine care well comparable to observations made in randomized controlled trials.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine-learning-based Phenomapping of Patients with Keratinocyte Carcinoma: Data-driven Subgrouping by Disease Burden, Comorbidities and Socioeconomic Status.","authors":"Johan Sieborg, Emily Wenande, Mia-Louise Nielsen, Mads Nielsen, David Thein, Merete Haedersdal","doi":"10.2340/actadv.v106.10.2340/adv-2026-0843","DOIUrl":"10.2340/actadv.v106.10.2340/adv-2026-0843","url":null,"abstract":"<p><p>Keratinocyte carcinoma (KC) places a considerable and growing burden on healthcare systems. Given the KC population's heterogeneity, tailored clinical pathways are needed to accommodate diverse management needs. This study applied machine learning (ML)-based phenomapping to identify distinct real-world subgroups within a national KC population using demographic and medical history variables. The study included KC patients treated in publicly-funded, office-based dermatology practices and registered in the Danish Skin Cancer Registry (2014-2022). In 106,490 KC patients, 7 ML-derived clusters were identified. One cluster (22.2%; n=23,590) consisted primarily of young, well educated high-income medically noncomplex females presenting with low-risk basal cell carcinomas (BCCs). Four clusters (55.2%; n=58,736) comprised patients with a greater dermatological disease burden, characterized by facial BCCs, multiple BCCs, a greater proportion of squamous cell carcinomas (SCCs), a history of skin cancer or previous actinic keratosis-related treatment. The remaining 2 clusters (22.7%; n=24,164) comprised highly comorbid patients with a greater proportion of SCCs, a high number of KCs on the head and neck and high immunosuppressive drug exposure. ML-derived phenomapping of a national KC population identified distinct, clinically relevant KC subgroups, providing a basis for tailored clinical pathways with differentiated resource needs.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enalapril, Atenolol, Alendronate and DRESS Syndrome - A Case Report.","authors":"S Bertil Olsson, Mats Ehinger","doi":"10.2340/actadv.v106.adv-2026-0767","DOIUrl":"10.2340/actadv.v106.adv-2026-0767","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Clinical Presentation of a Birthmark: A Quiz.","authors":"Avery H Seward, Jacqueline E Leyrer, Sarah H Carlock","doi":"10.2340/actadv.v106.adv-2026-0714","DOIUrl":"10.2340/actadv.v106.adv-2026-0714","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunosuppression Outweighs Clinical AEIOU Heuristics in Predicting Disease Progression of Merkel Cell Carcinoma: A Retrospective Cohort Study.","authors":"Laetitia S Chiarella, Entela Kupina, Maximilian Kückelhaus, Tobias Hirsch, Hans-Joachim Schulze, Jan-Dirk Raguse, Sascha Wellenbrock","doi":"10.2340/actadv.v106.adv-2026-0443","DOIUrl":"10.2340/actadv.v106.adv-2026-0443","url":null,"abstract":"<p><p>Merkel cell carcinoma (MCC)is a rare but aggressive cutaneous malignancy with increasing incidence and poor prognosis. Host immune status is a key determinant of MCCmerkel cell carcinoma development and outcome. While the AEIOU criteria are widely used to facilitate clinical recognition, their value for prognostic assessment remains unclear. To evaluate the association between individual AEIOU presentation features and disease progression in patients with merkel cell carcinoma, with particular emphasis on immunosuppression. We performed a retrospective single-centre cohort study including 400 patients diagnosed with merkel cell carcinoma. Disease progression, defined as local recurrence, nodal involvement or distant metastasis, served as the primary endpoint. AEIOU criteria were assessed at diagnosis and analysed using logistic regression. Complete follow-up data were available for 241 patients, of whom 81 (33.6%) experienced disease progression. Patients with progression were significantly older and more frequently male. Among the AEIOU components, immunosuppression was the only criterion significantly associated with disease progression, conferring an increased risk compared with immunocompetent patients (p<0.001). Other AEIOU features showed no consistent prognostic association. Complete follow-up data were available for 241 patients, of whom 81 (33.6%) experienced disease progression. Patients with progression were significantly older and more frequently male. Among the AEIOU components, immunosuppression was the only criterion significantly associated with disease progression, conferring an increased risk compared with immunocompetent patients (p<0.001). Other AEIOU features showed no consistent prognostic association.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13464361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}