Anna Bergström, Hans Hägglund, Anders Berglund, Gunnar Nilsson, Mats Lambe
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引用次数: 0
Abstract
There is some evidence that mastocytosis patients are at increased risk of skin cancer. This study aimed to assess the risk of malignant melanoma (MM), melanoma in situ (Mis), and basal cell carcinoma (BCC). A dataset was generated by individual-level record linkages between Swedish population registers including the National Patient Register (NPR), the Swedish Cancer Register (SCR), and the Population Register (PR). Adult patients with a mastocytosis diagnosis between 2001 and 2018 were identified in the SCR and NPR. For each case, 5 mastocytosis-free comparators matched on age, sex, and county of residence were randomly chosen from the PR. Records of skin cancer were identified in the SCR and NPR. In total, the study encompassed 2,040 mastocytosis patients of whom 63 had a record of MM/Mis and 168 a record of BCC. Compared with comparators, the risk of MM/Mis was more than twofold higher (OR 2.39, 95% CI 1.8-3.2). Risk estimates for BCC were also elevated (OR 1.77, 95% CI 1.49-2.14). When assessing the timing of skin cancers, a substantial portion were diagnosed near index date. Taken together, in the present study these findings of increased risk of MM/Mis and BCC in mastocytosis patients may reflect an influence of detection bias.
有证据表明,肥大细胞增多症患者患皮肤癌的风险增加。本研究旨在评估恶性黑色素瘤(MM)、原位黑色素瘤(Mis)和基底细胞癌(BCC)的风险。通过瑞典人口登记(包括国家患者登记(NPR)、瑞典癌症登记(SCR)和人口登记(PR)之间的个人水平记录联系生成数据集。在SCR和NPR中发现了2001年至2018年间诊断为肥大细胞增多症的成年患者。对于每个病例,从PR中随机选择5名符合年龄、性别和居住县的无肥大细胞增生比较者。在SCR和NPR中确定皮肤癌记录。该研究共纳入2040例肥大细胞增多症患者,其中63例有MM/Mis记录,168例有BCC记录。与比较组相比,MM/Mis的风险高出两倍多(OR 2.39, 95% CI 1.8-3.2)。BCC的风险估计值也升高(OR 1.77, 95% CI 1.49-2.14)。当评估皮肤癌发生的时间时,相当一部分是在指数日期附近被诊断出来的。综上所述,在本研究中,肥大细胞增多症患者MM/Mis和BCC风险增加的发现可能反映了检测偏差的影响。
期刊介绍:
Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.