Acta endocrinologica. Supplementum最新文献_第7页

The TSH receptor: structure and interaction with autoantibodies in thyroid disease. 甲状腺疾病中TSH受体的结构及其与自身抗体的相互作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s157

J Furmaniak, Y Nakajima, F A Hashim, F M Creagh, E Davies Jones, R D Howells, S M McLachlan, B Rees Smith

引用次数: 9

About the porcine TSH receptor. 关于猪TSH受体。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s181

N R Farid, G Fahraeus-van Ree

引用次数: 2

Role of non-TSH factors in thyroid cell growth. 非tsh因子在甲状腺细胞生长中的作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s231

M C Eggo, L K Bachrach, G N Burrow

{"title":"Role of non-TSH factors in thyroid cell growth.","authors":"M C Eggo, L K Bachrach, G N Burrow","doi":"10.1530/acta.0.114s231","DOIUrl":"https://doi.org/10.1530/acta.0.114s231","url":null,"abstract":"The effects of insulin, the tumour promotor tetradecanoyl phorbol acetate (TPA), TSH and combinations of these factors on growth and DNA synthesis have been examined in the FRTL-5 cell strain and in sheep thyroid cells. In addition the regulation of the production by sheep thyroid cells of the insulin-like growth factors (IGF) by TSH and their possible autocrine roles have been investigated. We found that insulin and the IGF's stimulated DNA synthesis in both rat FRTL-5 cells and sheep cells. TPA also stimulated growth in both cell types, and its effects were additive to those of insulin. In the FRTL-5 cells, TPA was a less potent stimulator of growth than TSH, but the effects of TPA and TSH were not additive which may imply growth stimulation through a common pathway. In sheep cells TSH was not mitogenic and did not appear to activate protein kinase C, the receptor for TPA. Sheep cells, unlike FRTL-5 cells, were found to produce IGF-I and IGF-II, and their syntheses were regulated by TSH. Sheep cells were also found to produce IGF-binding proteins which may modulate the biologic effects of the IGF's. Sheep thyroid IGF binding proteins were found to copurify with urokinase-like plasminogen activator on immunoaffinity chromatography. The production of this serine protease has also been shown to be regulated by TSH.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"231-7"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Aberrant expression of class II HLA antigens by the target cell: cause or consequence of the autoimmune aggression? 靶细胞异常表达II类HLA抗原:自身免疫攻击的原因还是结果?

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s035

E L Khoury

{"title":"Aberrant expression of class II HLA antigens by the target cell: cause or consequence of the autoimmune aggression?","authors":"E L Khoury","doi":"10.1530/acta.0.114s035","DOIUrl":"https://doi.org/10.1530/acta.0.114s035","url":null,"abstract":"Since the aberrant HLA-DR expression on thyroid follicular cells (TFC) has been found in glands already having an ongoing immune response, the possibility exists that this ectopic expression is not the primary event leading to the infiltration by autoreactive lymphocytes, but rather a consequence of that infiltration. We have explored that possibility in studies on the behaviour of TFC from normal and autoimmune glands with respect to their expression of HLA-DR antigens when they are cultured with or without autologous mononuclear cells from the intrathyroidal infiltrates or peripheral blood. Our findings suggest that 1) the ectopic expression of class II HLA antigens by TFC in autoimmune conditions is not the result of a primary or intrinsic defect of those cells but a consequence of their response to an environmental stimulus operating in situ; 2) this stimulus appears to be the lymphoid infiltration itself; 3) there are no significant differences in the responses given by TFC from autoimmune and normal glands. In alopecia areata, another presumably autoimmune condition characterized by the presence of lymphoid infiltration precedes that ectopic HLA-DR expression in vivo. In addition, we have found that human adrenocortical cells in the zona reticularis of adult glands normally express HLA-DR antigenic determinants. Therefore, the co-existence of both HLA-DR and potentially autoantigenic cell-surface constituents does not seem to be a sufficient stimulus to trigger an organ-specific autoimmune response.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The mechanism of TSH induced increase in binding of EGF to porcine thyroid cell monolayers; the role of thyroid hormones. TSH诱导EGF与猪甲状腺细胞单层结合增加的机制甲状腺激素的作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s260

S Atkinson, P Kendall-Taylor

引用次数: 3

Is remission of Graves' disease regulated by anti-idiotypic antibodies? 抗独特型抗体调节格雷夫斯病的缓解吗?

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s099

R Paschke, J Teuber, U Schwedes, K H Usadel

引用次数: 5

Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease. 甲状腺受体抗体(TRAb)在Graves病中的甲状腺外合成及生物学作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s352

R Paschke, H G Heinze, J Teuber, R Schmeidl, K H Usadel

引用次数: 4

Thyrocytes can synthesize HLA class II molecules. 甲状腺细胞可以合成HLA II类分子。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s082

M Londei, B Grubeck-Loebenstein, M Kissonerghis, P Austin, J Trowsdale, C Greenall, M Feldmann

引用次数: 2

The management of hyperthyroidism due to Graves' disease in Europe in 1986. Results of an international survey. 1986年欧洲Graves病致甲状腺机能亢进的治疗。一项国际调查的结果。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01

D Glinoer, D Hesch, R Lagasse, P Laurberg

引用次数: 0

Characterization of monoclonal antibodies directed against the TSH receptor, as revealed with the cytochemical bioassay. 单克隆抗体直接针对TSH受体的特性，与细胞化学生物测定显示。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s173

N J Marshall, L D Kohn, P A Ealey

引用次数: 1