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Acta endocrinologica. Supplementum最新文献

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Thyrostatic drugs act through modulation of thyroid cell activity to induce remissions in Graves' disease. 甲状腺抑制药物通过调节甲状腺细胞活性来诱导Graves病的缓解。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s305
R Volpé, A Karlsson, R Jansson, P A Dahlberg
{"title":"Thyrostatic drugs act through modulation of thyroid cell activity to induce remissions in Graves' disease.","authors":"R Volpé, A Karlsson, R Jansson, P A Dahlberg","doi":"10.1530/acta.0.114s305","DOIUrl":"https://doi.org/10.1530/acta.0.114s305","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"305-11"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13588904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Clinical evaluation of SMS 201-995. Long-term treatment in gut neuroendocrine tumours, efficacy of oral administration, and possible use in non-tumoural inappropriate TSH hypersecretion. SMS 201-995的临床评价。肠神经内分泌肿瘤的长期治疗，口服给药的疗效，以及非肿瘤性不适当TSH高分泌的可能应用。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01
G Williams, J V Anderson, S J Williams, S R Bloom
{"title":"Clinical evaluation of SMS 201-995. Long-term treatment in gut neuroendocrine tumours, efficacy of oral administration, and possible use in non-tumoural inappropriate TSH hypersecretion.","authors":"G Williams,&nbsp;J V Anderson,&nbsp;S J Williams,&nbsp;S R Bloom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Long-acting somatostatin analogues such as SMS 201-995 (Sandoz) are being evaluated in a wide range of clinical indications, including gut neuroendocrine tumours and acrogemaly. Long-term continuous SMS 201-995 treatment has achieved useful symptomatic improvement in diarrhoea in 4 patients with metastatic VIPomas who had relapsed following previous treatment. Clinical improvement has outlasted suppression of VIP secretion (suggesting an additional direct antisecretory action of SMS 201-995) and has occurred despite expansion of hepatic metastases. In 6 patients with tumours secreting gastrin and/or glucagon, secretion of these peptides was acutely inhibited by SMS 201-995. However, endocrine and clinical responses to chronic treatment have been less consistent. SMS 201-995 is active orally at doses of 4-8 mg and when given thrice-daily to 6 patients with active acromegaly, suppressed mean 24-h growth hormone levels by 51-88%. Despite significantly reduced plasma insulin concentrations, glucose tolerance did not deteriorate. SMS 201-995 was also effective in suppressing thyroid-stimulating hormone (TSH) and thyroid hormone secretion in a patient with mild thyrotoxicosis due to non-tumoural inappropriate TSH hypersecretion. In all cases SMS 201-995 treatment has been well tolerated and has few side-effects.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"286 ","pages":"26-36"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14027666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium/proton exchange in FRTL-5 thyroid cells: role in the maintenance of intracellular pH and TSH-stimulated cell growth. 甲状腺FRTL-5细胞中的钠/质子交换:在维持细胞内pH和tsh刺激的细胞生长中的作用
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s293
C Marcocci, A Pinchera, E F Grollman
{"title":"Sodium/proton exchange in FRTL-5 thyroid cells: role in the maintenance of intracellular pH and TSH-stimulated cell growth.","authors":"C Marcocci,&nbsp;A Pinchera,&nbsp;E F Grollman","doi":"10.1530/acta.0.114s293","DOIUrl":"https://doi.org/10.1530/acta.0.114s293","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"293-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14172292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Thyrotropin (TSH) stimulates cell growth and DNA synthesis in monolayer cultures of human thyrocytes independent of the adenylate-cyclase system. 促甲状腺激素(TSH)刺激细胞生长和DNA合成的单层培养的人甲状腺细胞独立于腺苷酸环化酶系统。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s273
P E Goretzki, R Koob, C Koller, H D Röher
{"title":"Thyrotropin (TSH) stimulates cell growth and DNA synthesis in monolayer cultures of human thyrocytes independent of the adenylate-cyclase system.","authors":"P E Goretzki,&nbsp;R Koob,&nbsp;C Koller,&nbsp;H D Röher","doi":"10.1530/acta.0.114s273","DOIUrl":"https://doi.org/10.1530/acta.0.114s273","url":null,"abstract":"<p><p>Monolayer cultures of human thyrocytes from normal thyroids (n = 13), thyroid adenomas (n = 8), differentiated (n = 7), poorly and undifferentiated (n = 5) thyroid cancers as well as thyroid cancer metastases (n = 2) were established to assess the significance of TSH and cAMP on cell growth and DNA synthesis. Cell growth was stimulated by 0.1 IU bTSH/ml and inhibited by 1.0 IU bTSH/ml (P less than 0.01), while dibutyryl-cAMP (dbcAMP) failed to show any effect on cell growth at the concentrations (10-5; 10-3 mol/l), tested. Neither did the adenylate-cyclase inhibitor dideoxy-adenosine (ddA) (2 X 10-5 mol/l) stimulate thyrocyte growth. DNA synthesis, however, measured indirectly by [3H]thymidine incorporation, was stimulated not only by TSH 2-12-fold, but also by ddA 1.3-7-fold (P less than 0.01), and was not affected by dbcAMP. TSH had no effect on [3H]thymidine incorporation in fibroblasts and c-cells from c-cell carcinomas. The stimulatory effect of TSH on thyrocyte growth and DNA synthesis was unpredictable in thyrocytes from cancerous tissues (n = 14) with no obvious correlation to tumour differentiation or stage. Thus, we showed that TSH is a promotor for cell growth and DNA synthesis in monolayer cultures of human thyrocytes from normal and adenomatous human thyroid tissues with no obvious correlation to the AC system. This TSH effect is unpredictable, however, in thyrocytes from human thyroid cancer.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"273-80"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Evidence of autoimmune pathogenesis in autonomous thyroid adenoma. 自体免疫性甲状腺腺瘤发病机制的证据。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s355
C Sellschopp, M Derwahl, H Schaube, H Hamelmann
{"title":"Evidence of autoimmune pathogenesis in autonomous thyroid adenoma.","authors":"C Sellschopp,&nbsp;M Derwahl,&nbsp;H Schaube,&nbsp;H Hamelmann","doi":"10.1530/acta.0.114s355","DOIUrl":"https://doi.org/10.1530/acta.0.114s355","url":null,"abstract":"<p><p>Using an immunohistochemical attempt to immunostain thyroid related autoantibodies, 30 specimens of autonomous adenomas of the thyroid were investigated. Twelve out of 23 inflammatory infiltrates surrounding the 'hot' nodules contained plasma cells, which gave a positive staining reaction for thyroid related autoantibodies. Seven adenomas showed no significant lymphoplasmacellular infiltration. It is concluded that this phenomenon might be due to an autoimmune pathogenesis in a part of patients with autonomous adenomas, indicating that there is no sharp line between autoimmune and non autoimmune thyroid disorder.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"355-7"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Stimulation of thyroid cell growth by thyrotropin and epidermal growth factor in isolated porcine thyroid follicles. 促甲状腺素和表皮生长因子对猪离体甲状腺滤泡甲状腺细胞生长的刺激作用。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01
H Stracke, R Bär, F Müller, H Schatz
{"title":"Stimulation of thyroid cell growth by thyrotropin and epidermal growth factor in isolated porcine thyroid follicles.","authors":"H Stracke,&nbsp;R Bär,&nbsp;F Müller,&nbsp;H Schatz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"270-2"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14620413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases. 人体内分泌组织移植到裸鼠:一种适合研究自身免疫性甲状腺疾病病理机制的体内模型
Acta endocrinologica. Supplementum Pub Date : 1987-01-01
K H Usadel, J Teuber, R Paschke, M Junker, U Schwedes
{"title":"Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases.","authors":"K H Usadel,&nbsp;J Teuber,&nbsp;R Paschke,&nbsp;M Junker,&nbsp;U Schwedes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After transplantation of human tissue to nu/nu mice the human lymphocytes disappear. In this context, interestingly, the DR-expression is not detectable anymore after transplantation of the tissues from patients with autoimmune thyrotoxicosis and cancer. Neopterin release was only demonstrable when T-lymphocytes from patients with autoimmune thyrotoxicosis or PHA-stimulated lymphocytes were added, independently of the presence of DR-expression in the used culture tissues. These results seem to exclude a functional role of DR-expression as a trigger mechanism of autoimmunity. It is supposed that DR-priming on epithelial cells is mediated by kinine production of activated T-lymphocytes or macrophages.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14620414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of thyroid infiltrating lymphocytes in Hashimoto's thyroiditis: detection of B and T cells specific for thyroid antigens. 桥本甲状腺炎甲状腺浸润淋巴细胞的特征:甲状腺抗原特异性B细胞和T细胞的检测。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s111
G F Del Prete, S Mariotti, A Tiri, M Ricci, A Pinchera, S Romagnani
{"title":"Characterization of thyroid infiltrating lymphocytes in Hashimoto's thyroiditis: detection of B and T cells specific for thyroid antigens.","authors":"G F Del Prete,&nbsp;S Mariotti,&nbsp;A Tiri,&nbsp;M Ricci,&nbsp;A Pinchera,&nbsp;S Romagnani","doi":"10.1530/acta.0.114s111","DOIUrl":"https://doi.org/10.1530/acta.0.114s111","url":null,"abstract":"","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14621200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Expression of the c-myc proto-oncogene in growth stimulated porcine thyroid follicle cells. c-myc原癌基因在促生长猪甲状腺滤泡细胞中的表达。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s238
N E Heldin, F A Karlsson, B Westermark
{"title":"Expression of the c-myc proto-oncogene in growth stimulated porcine thyroid follicle cells.","authors":"N E Heldin,&nbsp;F A Karlsson,&nbsp;B Westermark","doi":"10.1530/acta.0.114s238","DOIUrl":"https://doi.org/10.1530/acta.0.114s238","url":null,"abstract":"<p><p>In the present investigation the expression of c-myc in porcine thyroid follicle cells following the incubation with TSH or EGF was studied. EGF did not only have a mitotic effect on thyroid follicles but also increased c-myc mRNA. The increase in c-myc RNA is an early event in EGF stimulated thyroid cells. TSH had no effect on c-myc RNA levels of porcine thyroid cells. EGF-binding and sensitization to the mitotic activity of EGF, however, is increased by TSH. While TSH stimulates cAMP production and functional activity but not growth or c-myc expression of porcine thyroid cells, EGF produces cell division accompanied with c-myc expression.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"238-41"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14621202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence that thyroid growth promoting activity of immunoglobulin preparations is due to contamination with EGF. 有证据表明，免疫球蛋白制剂促进甲状腺生长的活性是由于EGF的污染。
Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s256
R Gärtner, C Tsavella, G Bechtner, W Greil
{"title":"Evidence that thyroid growth promoting activity of immunoglobulin preparations is due to contamination with EGF.","authors":"R Gärtner,&nbsp;C Tsavella,&nbsp;G Bechtner,&nbsp;W Greil","doi":"10.1530/acta.0.114s256","DOIUrl":"https://doi.org/10.1530/acta.0.114s256","url":null,"abstract":"<p><p>Immunoglobulin (IG) preparations may be contaminated with growth factors. Therefore, we investigated whether the growth promoting activity in IG preparations (thyroid growth stimulating immunoglobulins = TGI) from patients with sporadic goitre may be caused by contaminating EGF (epidermal growth factor). EGF in sera as well as in indifferently prepared IG of patients with recurrent goitre (n = 23), Graves' disease (n = 19) and normals (n = 17) was determined by EGF receptor assay. Comparatively, the ability for stimulating thyroid cell growth was determined in these IG preparations (2 mg/ml). EGF in ammoniumsulphate (AS) precipitates was about 2-fold higher than serum EGF. The growth promoting activity of indifferent IG preparations correlated with the EGF content. After additional purification on protein A-sepharose, neither EGF, nor a growth promoting activity was found in these IG preparations. We therefore conclude, that the growth promoting activity of crude IG preparations may be due to a contamination with EGF.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"256-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14621203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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