Acta endocrinologica. Supplementum最新文献_第6页

SMS 201-995 and variceal haemorrhage. SMS 201-995和静脉曲张出血。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.115s037

J N Baxter, S A Jenkins, R Shields

引用次数: 10

Long-term treatment of acromegaly with Sandostatin (SMS 201-995). Normalization of most anomalous growth hormone responses. 山多司他汀长期治疗肢端肥大症(SMS 201-995)。大多数异常生长激素反应的正常化。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01

G F Pieters, P A van Liessum, A G Smals, J A van Gennep, T J Benraad, P W Kloppenborg

{"title":"Long-term treatment of acromegaly with Sandostatin (SMS 201-995). Normalization of most anomalous growth hormone responses.","authors":"G F Pieters, P A van Liessum, A G Smals, J A van Gennep, T J Benraad, P W Kloppenborg","doi":"","DOIUrl":"","url":null,"abstract":"Twelve patients with active acromegaly were treated with the long-acting somatostatin analogue SMS 201-995 (SMS), at a dose of 50 micrograms sc twice daily in the first 2 weeks of treatment and 100 micrograms sc thereafter. Four h after the first injection of SMS, GH levels became normal in 8 of the 12 patients. Basal glucose levels were significantly lower at the 28th day of treatment. This glucose lowering effect was stronger in the diabetic than in the nondiabetic patients. The postprandial rise of insulin levels was reversed by SMS, leading to a more pronounced postprandial rise of glucose, whereas the postprandial secretion of glucagon was also reversed by SMS. The rise of glucose levels during oral glucose loading was similar before and during SMS, despite a strong inhibitory effect of the drug on the insulin rise after glucose loading. Basal TSH levels were not influenced by SMS, the TRH-induced TSH response, however, was significantly blunted. Although the basal PRL levels were significantly reduced by SMS, the TRH-induced PRL rise was similar before and during administration of the analogue. Paradoxical GH responses to TRH disappeared in 7 out of 8 patients during SMS. Paradoxical GH responses to GnRH, however, persisted in 4 out of 4 patients. Paradoxical responses of GH after glucose loading disappeared in 2 out of 2 patients. The GH response after GHRH administration was strongly suppressed by SMS. During long-term treatment (up to 2 years), the GH level obtained within 5 h after the last injection of SMS remained normal in the patients whose GH levels normalized at the first day of treatment. There was a good response of the disease to this treatment, and no serious adverse reactions were observed. We conclude that SMS normalizes most anomalous growth hormone kinetics in acromegaly. The drug offers a new tool in the treatment of this disease.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"286 ","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14028417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin and insulin-like growth factor-I (IGF-I) regulate differentiation as well as growth in FRTL-5 cells. 胰岛素和胰岛素样生长因子- i (IGF-I)调节FRTL-5细胞的分化和生长。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s288

O Isozaki, P Santisteban, J Chan, E Grollman, L Kohn

引用次数: 12

Ciamexon-treatment in endocrine ophthalmopathy. 西亚美森治疗内分泌性眼病。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s342

C Utech, K G Wulle, P Pfannenstiel, W Adam

引用次数: 2

Graves' autoantibodies to extrathyroidal TSH receptor: their role in ophthalmopathy and pretibial myxedema. 甲状腺外TSH受体Graves自身抗体:在眼病和胫前黏液水肿中的作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s344

C M Rotella, F Alvarez, L D Kohn, R Toccafondi

引用次数: 16

Role of the adenylate cyclase-cAMP system on TSH-stimulated thyroid cell growth. 腺苷酸环化酶- camp系统在tsh刺激的甲状腺细胞生长中的作用。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s246

C Marcocci, G F Fenzi, E F Grollman

{"title":"Role of the adenylate cyclase-cAMP system on TSH-stimulated thyroid cell growth.","authors":"C Marcocci, G F Fenzi, E F Grollman","doi":"10.1530/acta.0.114s246","DOIUrl":"https://doi.org/10.1530/acta.0.114s246","url":null,"abstract":"TSH is a trophic factor for cultured rat thyroid cells (FRTL-5). In the present study we have investigated the mechanism by which TSH promotes cell growth and evaluated the possible role of the adenylate cyclase (AC)-cAMP system in this process. The mitogenic activity of several agents was evaluated by measuring their effect on cell number or 3H-thymidine incorporation into DNA. Forskolin and cholera toxin, two potent and specific activators of the AC, induced a dose dependent increase of 3H-thymidine incorporation. The maximal stimulation, observed at concentrations of 10 microM and 10 ng/ml, respectively, was beta 80% of that obtained with optimal concentrations of TSH. A similar effect was obtained with a Graves' IgG preparation (0.2 mg/ml) able to stimulate the thyroid AC or with 3-isobutyl-1-methyl-xanthine (IBMX, 0.5 mM), a phosphodiesterase inhibitor. 8-bromo cAMP (0.5 mM), a cAMP analog, also stimulated 3H-thymidine incorporation, and its potency was approximately 60% of that of TSH. Similar results were obtained when the mitogenic activity of these compounds was evaluated by cell number. Norepinephrine (NE, 10 microM), although devoid of AC stimulatory activity in these cells, also stimulated 3H-thymidine incorporation, but its potency was only 20-30% of that of TSH. Indomethacin (100 microM), an inhibitor of phospholipid and arachidonic acid metabolism, was able to inhibit the stimulatory effect of NE (84%), and to a lesser extent of TSH (63%) and cholera toxin, had minor effect on forskolin (24%), IBMX (16%) and Graves' IgG (8%), and no effect on 8-bromo cAMP.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"246-51"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14172290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Effects of high and low doses of methimazole in patients with Graves' thyrotoxicosis. 高、低剂量甲巯咪唑对Graves甲状腺毒症患者的影响。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s312

G Benker, D Reinwein, H Creutzig, H Hirche, W D Alexander, D McCruden, G Galvan, G Kahály, J Beyer, J H Lazarus

引用次数: 10

Clinical use of somatostatin analogues (Sandostatin, SMS 20l-995). Proceedings of a symposium. Amsterdam, November 14, 1986. 生长抑素类似物(Sandostatin, SMS 201 -995)的临床应用。研讨会记录。1986年11月14日，阿姆斯特丹。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01

引用次数: 0

A guide to the clinical use of the somatostatin analogue SMS 201-995 (Sandostatin). 生长抑素类似物SMS 201-995 (Sandostatin)的临床使用指南。

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.115s054

S W Lamberts

引用次数: 35

The thyroid microenvironment in autoimmune thyroid disease: effects of TSH and lymphokines on thyroid lymphocytes and thyroid cells. 自身免疫性甲状腺疾病的甲状腺微环境:TSH和淋巴因子对甲状腺淋巴细胞和甲状腺细胞的影响

Acta endocrinologica. Supplementum Pub Date : 1987-01-01 DOI: 10.1530/acta.0.114s125

S M McLachlan, C A Pegg, M C Atherton, S L Middleton, A Dickinson, F Clark, B R Smith

{"title":"The thyroid microenvironment in autoimmune thyroid disease: effects of TSH and lymphokines on thyroid lymphocytes and thyroid cells.","authors":"S M McLachlan, C A Pegg, M C Atherton, S L Middleton, A Dickinson, F Clark, B R Smith","doi":"10.1530/acta.0.114s125","DOIUrl":"https://doi.org/10.1530/acta.0.114s125","url":null,"abstract":"Thyroid lymphocytes synthesize thyroid autoantibodies in close proximity to thyroid cells and consequently soluble mediators such as TSH and interleukins (IL) 1 and 2 may have unforeseen effects on lymphocytes and thyrocytes, respectively. Investigations of thyroid autoantibody synthesis by thyroid lymphocytes in vitro showed that TSH did not affect microsomal (Mic) antibody production, but thyroglobulin (Tg) antibody synthesis was decreased, probably as a result of complexing between Tg antibody and Tg secreted by small numbers of thyrocytes in the cell suspension. IL-1 and IL-2 partially mimicked the inhibitory effects on spontaneous autoantibody synthesis induced by Pokeweed mitogen (PWM) in cultures of thyroid lymphocytes. This inhibition may require a number of soluble mediators released by T cells in response to the mitogen; however, depletion studies indicated that the cell type responsible for PWM inhibition is unlikely to be a suppressor T cell and may be an NK cell. IL-1 and IL-2 had little effect on the viability of thyrocyte monolayers in an 18 h assay, but antibody dependent cells cytotoxicity (ADCC) using blood lymphocytes and thyroid autoantibody positive sera was demonstrated; further, the cytotoxicity appeared to be due to Mic antibodies. It is possible that IL-1 and/or IL-2 (as well as other cytokines) may affect thyroid cells after longer periods of exposure, either by altering them functionally or by direct damage. However, assuming that NK cells are present in sufficient numbers in the gland, ADCC could play a major role in the development of hypothyroidism in Hashimoto's disease.","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"125-32"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13