甲状腺受体抗体(TRAb)在Graves病中的甲状腺外合成及生物学作用。

R Paschke, H G Heinze, J Teuber, R Schmeidl, K H Usadel
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引用次数: 4

摘要

在格雷夫斯病患者行甲状腺切除术后放射碘治疗甲状腺受体抗体可以检测放射配体试验。131i - scitiscan未见甲状腺组织。甲状腺球蛋白反复阴性。该患者血清的生物活性可在裸鼠生物实验中得到证实。131i -用格雷夫斯病患者甲状腺组织移植的胸腺发育不良裸鼠注射甲状腺患者血清,可刺激人甲状腺球蛋白的掺入和分泌。这些结果证明了甲状腺外生成和体内TRAb的生物活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease.

In a patient with Graves' disease who underwent thyroidectomy with subsequent radioiodine therapy thyroid receptor antibody could be detected by radioligand assay. No thyroid tissue could be detected by 131I-scintiscanning. Thyroglobulin was repeatedly negative. Biologic activity of this patients serum could be demonstrated in the nude mice bio assay. 131I-incorporation and secretion of human thyroglobulin could be stimulated by injecting thymusdysplastic nude mice with transplants of thyroid tissue from a patient with Graves' disease with the athyroid patients serum. These results demonstrate evidence for extrathyroidal production and biological activity of TRAb in vivo.

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