{"title":"关于猪TSH受体。","authors":"N R Farid, G Fahraeus-van Ree","doi":"10.1530/acta.0.114s181","DOIUrl":null,"url":null,"abstract":"<p><p>Using a number of immunologic and biochemical approaches, we have identified a number of [125I]bTSH binding peptides with Mr approximately 45,000, 66,000-70,000, approximately 95,000; larger conjugates capable of binding the hormone have not been excluded. A conservative interpretation of the data suggest a basic receptor unit of Mr approximately 95,000 of which Mr 45,000 and 66,000-70,000 are proteolytic products of membrane-bound proteases. The association of two intact subunits by strong noncovalent forces may generate more than 3 TSH binding sites.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":"281 ","pages":"181-5"},"PeriodicalIF":0.0000,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s181","citationCount":"2","resultStr":"{\"title\":\"About the porcine TSH receptor.\",\"authors\":\"N R Farid, G Fahraeus-van Ree\",\"doi\":\"10.1530/acta.0.114s181\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Using a number of immunologic and biochemical approaches, we have identified a number of [125I]bTSH binding peptides with Mr approximately 45,000, 66,000-70,000, approximately 95,000; larger conjugates capable of binding the hormone have not been excluded. A conservative interpretation of the data suggest a basic receptor unit of Mr approximately 95,000 of which Mr 45,000 and 66,000-70,000 are proteolytic products of membrane-bound proteases. The association of two intact subunits by strong noncovalent forces may generate more than 3 TSH binding sites.</p>\",\"PeriodicalId\":6931,\"journal\":{\"name\":\"Acta endocrinologica. Supplementum\",\"volume\":\"281 \",\"pages\":\"181-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1530/acta.0.114s181\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta endocrinologica. Supplementum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1530/acta.0.114s181\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta endocrinologica. Supplementum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/acta.0.114s181","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Using a number of immunologic and biochemical approaches, we have identified a number of [125I]bTSH binding peptides with Mr approximately 45,000, 66,000-70,000, approximately 95,000; larger conjugates capable of binding the hormone have not been excluded. A conservative interpretation of the data suggest a basic receptor unit of Mr approximately 95,000 of which Mr 45,000 and 66,000-70,000 are proteolytic products of membrane-bound proteases. The association of two intact subunits by strong noncovalent forces may generate more than 3 TSH binding sites.
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