Acta Diabetologica最新文献

{"title":"Advanced hybrid closed loop system (MiniMed 780G) achieving significant improvement of glucose control in a patient with maternally inherited diabetes and deafness: a case report","authors":"Michalis K. Picolos, Anastasia Papapostolou, Anastasia Christodoulou, George A. Tanteles, Anna Kyriakidou, Georgios Papaetis","doi":"10.1007/s00592-025-02524-0","DOIUrl":"10.1007/s00592-025-02524-0","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 9","pages":"1565 - 1568"},"PeriodicalIF":2.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00592-025-02524-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic ketoacidosis in a patient with type I diabetes treated with tirzepatide.","authors":"Ernest Roche, Julie Chapon, Laura Bogenmann, Cédric Luyton, Lucien Marchand","doi":"10.1007/s00592-025-02535-x","DOIUrl":"https://doi.org/10.1007/s00592-025-02535-x","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of GLP-1 receptor agonists with risk of intestinal obstruction in patients with type 2 diabetes mellitus: a retrospective cohort study.","authors":"Zhenxiang Gao, Tomasz Tabernacki, Ian Dorney, Pingjian Ding, David C Kaelber, Rong Xu","doi":"10.1007/s00592-025-02525-z","DOIUrl":"https://doi.org/10.1007/s00592-025-02525-z","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are approved for treating type 2 diabetes and weight loss. There have been concerns that GLP-1RAs may increase the risk of intestinal obstruction.</p><p><strong>Objective: </strong>Investigate the association between GLP-1RAs use and intestinal obstruction in a large cohort of patients with type 2 diabetes mellitus (T2DM) in the U.S.</p><p><strong>Design: </strong>A retrospective cohort study was conducted using longitudinal electronic health records sourced from TriNetX, a large-scale, population-based health database.</p><p><strong>Participants: </strong>The study included over 1.2 million T2DM patients who were prescribed anti-diabetic medications, including 181,795 prescribed GLP-1RAs between April 2013 and April 2019.</p><p><strong>Main measures: </strong>The incidence of intestinal obstruction was compared between GLP-1RAs and each of six other classes of non-GLP-1RA anti-diabetic medications. Hazard ratios (HRs) at 1, 3, and 5-year follow-up periods were calculated using Cox proportional hazards analysis. Separate analyses were performed in T2DM patients with and without obesity.</p><p><strong>Key results: </strong>The risk of intestinal obstruction did not differ between GLP-1RAs and other anti-diabetic medications except for a reduced risk compared with insulins. The results were consistent for 1, 3, and 5-year follow-up periods and in patients with and without obesity.</p><p><strong>Conclusions: </strong>Our findings do not support an increased risk of intestinal obstruction in T2DM patients prescribed GLP-1 RAs compared to other anti-diabetic medications.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NF-κB p65 mediated lnc-Traf3ip2 exacerbates renal fibrosis in diabetic kidney disease.","authors":"Keqian Wu, Peiling Li, He Zha, Tianhui Wu, Handeng Liu, Rui Peng, Dan Lv, Ziyue Lin, Xiaohui Liao, Yan Sun, Zheng Zhang","doi":"10.1007/s00592-025-02515-1","DOIUrl":"https://doi.org/10.1007/s00592-025-02515-1","url":null,"abstract":"<p><strong>Aims: </strong>Diabetic kidney disease (DKD) is the predominant type of end-stage renal disease. The fibrotic response in glomerular mesangial cells (MCs) acts as an initial injury during DKD progression, but the molecular mechanism remains to be explored. Here, this present study aimed to investigate the role of NF-κB p65 mediated long noncoding RNA (lncRNA) lnc-Traf3ip2 in renal fibrosis and DKD progression.</p><p><strong>Methods: </strong>The different expressions of lncRNAs in renal tissues of db/db DKD mice (n = 3) and db/dm controls (n = 3) were screened by scRNA-seq and RNA-seq. Plasma of DKD patients (n = 40) and renal tissues of DKD mice (n = 35) and their controls were further used to examine the expressions of lnc-Traf3ip2. Moreover, the relationship between the expression of lnc-Traf3ip2 and indexes of kidney function was also analyzed by Pearson correlation coefficient analysis. Furthermore, the biological functions of lnc-Traf3ip2 in mesangial cell fibrosis and renal injury were investigated by qRT-PCR, western blot and immunofluorescence in DKD in vivo and in vitro. Finally, the dual-luciferase reporter assay and ChIP were performed to investigate the regulatory mechanism of lnc-Traf3ip2 transcription.</p><p><strong>Results: </strong>In our study, the results of scRNA-seq, RNA-seq and qRT-PCR revealed that lnc-Traf3ip2, which was highly expressed in mesangial cells and upregulated in renal tissues of DKD mice and the plasma of DKD patients. Data also showed lnc-Traf3ip2 was positively correlated with UACR in DKD. Moreover, overexpression of lnc-Traf3ip2 could promote fibrosis of MCs in vitro, whereas silencing lnc-Traf3ip2 alleviated MCs fibrosis under high glucose condition. Additionally, lnc-Traf3ip2 knockdown alleviated renal fibrosis in DKD mice. Mechanistically, transcription factor NF-κB subunit p65 could promote the expression of lnc-Traf3ip2 via directly binding to the promoter of lnc-Traf3ip2.</p><p><strong>Conclusions: </strong>Taken together, our data suggest the role of lnc-Traf3ip2 in fibrogenic factor in DKD induced by transcription factor NF-κB p65 and identified it as an therapeutic target for DKD.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis between hemoglobin and type 2 diabetic nephropathy: a two-center retrospective study","authors":"Xiaoling Liu,&nbsp;Ze Zhang,&nbsp;Lu Lin,&nbsp;Jinghui Li,&nbsp;Bende Liu,&nbsp;Xiangjin Xu,&nbsp;Huaqian Chen,&nbsp;Junwei Zhou,&nbsp;Pin Chen","doi":"10.1007/s00592-025-02529-9","DOIUrl":"10.1007/s00592-025-02529-9","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the relationship between hemoglobin (Hb) levels and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).</p><h3>Methods</h3><p>We recruited patients with T2DM from two centers, collected their clinical data, and analyzed the relationship between Hb levels and DN using binary logistic regression analysis and restricted cubic spline squares (RCS) plots.</p><h3>Results</h3><p>A total of 1956 patients with T2DM were enrolled, including 784 (40.1%) with DN. After adjusting for several confounding factors, the proportion of patients with DN in Q1 of Hb was significantly higher than that in the other group. The RCS curve revealed that Hb levels were inversely proportional to DN. Subgroup analysis demonstrated that age, gender, history of hypertension, history of nonalcoholic fatty liver disease and history of diabetic retinopathy exhibited no significant correlation with Hb levels and DN.</p><h3>Conclusions</h3><p>Low Hb level is closely associated with DN occurrence, and can be used as a predictive biomarker for DN.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 7","pages":"1149 - 1156"},"PeriodicalIF":2.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of major amputation in patients with diabetic foot ulcers treated by peripheral blood mononuclear cells.","authors":"Marco Meloni, Ermanno Bellizzi, Luigi Uccioli, Laura Giurato, Valeria Ruotolo, Martina Salvi, Federico Rolando Bonanni, Aikaterini Andreadi, Alfonso Bellia, Davide Lauro","doi":"10.1007/s00592-025-02522-2","DOIUrl":"https://doi.org/10.1007/s00592-025-02522-2","url":null,"abstract":"<p><strong>Aim: </strong>Peripheral blood mononuclear cells (PB-MNCs) therapy is an adjuvant treatment for patients with ischaemic diabetic foot ulcers (DFUs) and no-option critical limb ischemia (NO-CLI). This study aimed to evaluate factors influencing the effectiveness of PB-MNC therapy.</p><p><strong>Method: </strong>This prospective, not controlled study included a cohort of patients with DFUs and NO-CLI treated by PB-MNCs. NO-CLI was defined as the revascularization failure with desert foot (absence of any artery below-the-ankle) or partial desert foot (absence of a wound-related artery with TcPO₂ < 30 mmHg) at the final post-procedural angiogram. After one year of follow-up, the rate of major amputation was evaluated such as clinical, wound, and vascular features of amputees in comparison to not amputees. In addition, the factors influencing the risk of major amputation were analyzed.</p><p><strong>Results/discussion: </strong>Sixty-four patients were included. The mean age was 73.8 ± 5.8 years, 75% were male, and all of them had type 2 diabetes. At one year of follow-up, major amputation was documented in 12.5% of patients. Amputees had a higher rate of desert foot (vs. partial desert foot) (100% vs. 25%, p < 0.0001), higher post-procedural pain (5.7 ± 1.9 vs. 2.2 ± 1.3, p < 0.0001), lower TcPO₂ after PB-MNCs therapy (30 ± 8 vs. 43 ± 8 mmHg, p = 0.0001), and more cases of heel ulcers (75% vs. 21.4%, p = 0.002). Independent predictors of major amputation resulted the presence of desert foot, persistence of post-procedural pain, heel involvement with multiple ulcers, and inability to stand or walk without assistance.</p><p><strong>Conclusion: </strong>PB-MNCs therapy resulted less effective in patients with complete desert foot, persistence of paint after therapy, heel involvement in persons with multiple ulcers, and impaired walking.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased incidence of anemia in individuals with impaired fasting glucose: a cohort study.","authors":"Jianmei Zhang, Xiaocheng Huang, Xiaofeng Guo, Luying Dong, Yachao Yang, Lijie Ding","doi":"10.1007/s00592-025-02517-z","DOIUrl":"https://doi.org/10.1007/s00592-025-02517-z","url":null,"abstract":"<p><strong>Aims: </strong>Anemia is common in diabetes patients, but its prevalence in pre-diabetes remains under-researched. Therefore, we aimed to investigate the incidence of anemia and potential risk factors in individuals with impaired fasting glucose using health examination data.</p><p><strong>Methods: </strong>A cohort of 7075 participants, all aged over 18 years and free of anemia at baseline, were included in this study to monitor the incidence of anemia through annual routine health check-ups. Cox regression models were used to estimate the age- and sex-adjusted hazard ratios of each risk factor.</p><p><strong>Results: </strong>The incidence of anemia among patients with impaired fasting glucose was 7.04 (95%CI: 6.08-8.00) per 1000 person-years overall, with a gender-specific incidence of 4.24 (95%CI: 3.37-5.10) and 15.21 (95%CI: 12.45-18.02) per 1000 person-years in men and women. COX regression analysis identified that female, lower levels of TC, LDL-C, ALT, AST, ALB, and alcohol drinking were associated with higher risk of anemia in individuals with impaired fasting glucose.</p><p><strong>Conclusions: </strong>In individuals with impaired fasting glucose, anemia incidence differed by gender and age, being higher in women than men and surpassing that of the general Chinese population. Furthermore, lower levels of TC, LDL-C, ALT, AST, ALB, and alcohol drinking were associated with higher risk of anemia in individuals with impaired fasting glucose.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with sleep duration in a Chinese middle-aged and elderly diabetic population: a cross-sectional study.","authors":"Min Fan, Xia Zhao, Sheng-Li Wang, Xin-Qiong Zhang","doi":"10.1007/s00592-025-02512-4","DOIUrl":"https://doi.org/10.1007/s00592-025-02512-4","url":null,"abstract":"<p><strong>Background: </strong>The adverse effects of excessively short or long sleep duration on diabetes have been confirmed in previous studies. However, there is a lack of research on the factors associated with sleep duration in diabetic patients, and this study aims to identify the factors associated with sleep duration in diabetes mellitus.</p><p><strong>Methods: </strong>This study collected data from 2116 middle-aged and elderly individuals with diabetes mellitus who were surveyed by the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Sleep duration was assessed based on patient self-reports, defined as the total amount of sleep patients obtained on average at night over the past month (average nightly sleep duration), it was categorized into short sleep duration (< 6 h), adequate sleep duration (6-9 h) and long sleep duration (> 9 h). Stepwise multivariable multinomial logistic regression was used to explore the associated factors related to short sleep duration (< 6 h) and long sleep duration (> 9 h), using adequate sleep duration as the reference.</p><p><strong>Results: </strong>The mean self-reported sleep duration in the study sample was (6.34 ± 1.86) hours, with 66.6% reporting adequate sleep duration, 29.6% short sleep duration, and 3.8% long sleep duration. Short sleep duration was positively associated with older age, having low level of education, no health insurance, poor sleep quality, short napping time, and poor self-reported health status. The probability of short sleep duration was lower among good sleep quality (OR = 0.14; 95%CI = 0.11-0.18), good self-reported health status (OR = 0.62; 95%CI = 0.44-0.88). Long sleep duration was positively associated with being male, never smoked, good sleep quality, and traditional Chinese medicine treatment. Long sleep duration was negatively associated with the cognitive function score (OR = 0.94; 95%CI = 0.90-0.99), and having one comorbidity (OR = 0.42; 95%CI = 0.20-0.87).</p><p><strong>Conclusion: </strong>Sleep duration was influenced by a combination of factors among middle-aged and elderly patients with diabetes in China. The study suggested that we should focus on key populations, such as older adults, individuals without health insurance, those with poor sleep quality, low cognitive function and poor self-reported health status, to promote healthy sleep.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BFGF alleviates diabetic endothelial dysfunction by downregulating Endoplasmic reticulum stress.","authors":"Fei Hu, Jie Li, Xin Zhang, Yueyue Fu, Yufei Mao, Songlin Tong, Hongming Xu","doi":"10.1007/s00592-025-02504-4","DOIUrl":"10.1007/s00592-025-02504-4","url":null,"abstract":"<p><p>Diabetes is a chronic metabolic disorder characterized by hyperglycemia, resulting from absolute or relative insufficiency in insulin secretion and disorder in insulin utilization. Diabetes has emerged as a global public health issue, with its incidence rate escalating year on year. Its vascular complications pose a severe challenge in clinical practice and constitute one of the principal causes of death among diabetes patients. Basic fibroblast growth factor, a member of the fibroblast growth factor family, exhibits a robust protective effect on numerous diseases. Consequently, it has become a research focus in the treatment of vascular complications related to diabetes. Nevertheless, the specific mechanism underlying basic fibroblast growth factor's vascular protective effect remains unclear. This study aims to explore whether basic fibroblast growth factor can alleviate endothelial dysfunction in diabetes by inhibiting endoplasmic reticulum stress. The research outcomes demonstrated that basic fibroblast growth factor significantly decreased the production of endoplasmic reticulum stress in db/db mice and endothelial cells incubated with high glucose and palmitic acid, augmented nitric oxide production, and reduced endothelial cell apoptosis. Treatment with the endoplasmic reticulum stress inducer Tunicamycin nullified the basic fibroblast growth factor mediated reduction in endoplasmic reticulum stress generation and endothelial protective effects. In conclusion, these discoveries imply that the endothelial protective effect of basic fibroblast growth factor in diabetes can be partially ascribed to its inhibition of endoplasmic reticulum stress.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 14-year prospective cohort study of type 2 diabetes development in Dutch healthy adults of South Asian origin: risk factors and the association with metabolic syndrome and HOMA-IR.","authors":"Sebastian B Beckmann, Priyanti Bhawan, Tobias Bruning, T Martijn Kuijper, Sjaam Jainandunsing","doi":"10.1007/s00592-025-02513-3","DOIUrl":"https://doi.org/10.1007/s00592-025-02513-3","url":null,"abstract":"<p><strong>Objective: </strong>Type 2 Diabetes (T2D) imposes a disproportionate burden on the South Asian population. Their phenotype is characterized by heightened insulin resistance, even in individuals without overt T2D. Commonly used screening tools underestimate the T2D incidence in this population. The Metabolic syndrome (MetS) and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) are indicators of insulin resistance; however, their predictive value for the development of T2D remains unexplored.</p><p><strong>Methods: </strong>Among 698 initially enrolled healthy South Asian adults aged 30 to 65 in a Rotterdam-based cardiovascular disease prevention study, 270 participants were included after a 14-year follow-up. At baseline, an extensive history, physical examination, and metabolic screening were taken. A follow-up assessment of incident T2D was conducted. Multivariable logistic regression models calculated odds ratios (ORs) for MetS, its components, and HOMA-IR and adjusted for confounders.</p><p><strong>Results: </strong>33 (12.2%) of participants developed T2D. The presence of MetS at baseline showed an adjusted OR of 2.6, (95% confidence interval (CI) 1.2-5.7, p = 0.02) for incident T2D. Fasting plasma glucose was the most strongly associated component of MetS (OR 3.0, CI 1.1-8.6, p = 0.04) HOMA-IR was also associated and showed an OR of 1.2 per point increase (CI 1.0-1.4, p=0.05).</p><p><strong>Conclusions: </strong>MetS and FPG were the most important predictors of T2D development in this South Asian cohort. These results underscore the value of diverse variables in T2D detection and give insight into which screening tools for T2D prediction should be used in this high-risk population.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}