Acta Diabetologica最新文献

{"title":"Correction: microvascular disease and severe COVID-19 outcomes in UKBiobank participants with diabetes.","authors":"Claire Tochel, Justin Engelmann, Ylenia Giarratano, Baljean Dhillon, Roly Megaw, Miguel O Bernabeu","doi":"10.1007/s00592-025-02456-9","DOIUrl":"10.1007/s00592-025-02456-9","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous adipose tissue compensates for the perturbations in circulating one-carbon metabolism in women with gestational diabetes.","authors":"Xiaojing Wei, Shuangyu Wei, Miao Chen, Yutian Tan, Zhao Yang, Weijie Feng, Guiying Yang, Zhen Han, Xiao Luo","doi":"10.1007/s00592-025-02452-z","DOIUrl":"https://doi.org/10.1007/s00592-025-02452-z","url":null,"abstract":"<p><p>The prevalence of gestational diabetes mellitus (GDM) is rising and poses important health risks for the mother, developing fetus and offspring, even when maternal glycemic control is well managed. This study aimed to identify the differently expressed metabolites (DEMs) in maternal plasma between GDM pregnancies with good glycemic control and healthy pregnancies, along with the DEMs-related metabolism in adipose tissue. Pregnant women with scheduled caesarean sections were recruited. Venous blood samples were collected on the day prior to delivery for targeted metabolomics analysis focusing on the 200 polar metabolites in central carbon metabolism. Subcutaneous and omental white adipose tissue (sWAT and oWAT) were harvested at delivery. A total of 162 metabolites were quantified, revealing 2 up-regulated (D-glucose 6-phosphate (G6P), succinate) and 8 down-regulated DEMs, which exhibited a fold change of ≥ 1.5 or ≤ 0.67, respectively. Among the down-regulated DEMs, 5 metabolites-pyridoxine, glycine, S-methyl-L-cysteine, methionine, and S-carboxymethyl-L-cysteine-are related to one-carbon metabolism (OCM). In response to perturbation in circulating OCM, boosted methionine cycle, NAD + metabolism, and adipogenesis were observed in sWAT of GDM subjects, with no changes detected in oWAT. None of the 10 DEMs correlates with either blood glucose or insulin, but showed significant correlations with TG, TC, LDL-C and HDL-C. The present study indicates that sWAT compensates for the perturbations in circulating OCM associated with GDM and targeting to the OCM may be an effective strategy to control the long-term metabolic risk of GDM offsprings.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HYA ameliorated postprandial hyperglycemia in type 1 diabetes model rats with bolus insulin treatment.","authors":"Yuta Yamamoto, Katsuya Narumi, Naoko Yamagishi, Yasunori Yonejima, Ken Iseki, Masaki Kobayashi, Yoshimitsu Kanai","doi":"10.1007/s00592-025-02459-6","DOIUrl":"https://doi.org/10.1007/s00592-025-02459-6","url":null,"abstract":"<p><strong>Aims: </strong>The oral administration of linoleic acid immediately before glucose tolerance test (OGTT) ameliorated postprandial hyperglycemia via GPR120 pathway in normal and type 1 diabetes (T1DM) rats. Linoleic acid could promote inflammatory mediators, but 10-hydroxy-cis-12-octadecenoic acid (HYA) converted from linoleic acid by Lactobacillus plantarum has higher GPR120 agonistic activity without promoting inflammatory mediators. This study examined whether the oral-administration of HYA immediately before OGTT also ameliorated the postprandial hyperglycemia in normal rats and T1DM rats injected with bolus insulin.</p><p><strong>Methods: </strong>Normal and T1DM male Sprague-Dawley rats received HYA immediately before OGTT. Other T1DM rats were given HYA and Humulin R immediately before OGTT. We measured the concentration of glucose, insulin, glucagon-like peptide 1 (GLP-1) and cholecystokinin in blood before and after OGTT. We also measured the amount of glucose in the gastric tract after OGTT, and the amount of uptake of methyl-α-D-glucopyranoside in CACO-2 cells.</p><p><strong>Results: </strong>Postprandial hyperglycemia was ameliorated by HYA in normal rats, and the postprandial blood glucose levels were slowly elevated by HYA in the T1DM model rats. HYA partially inhibited the uptake of methyl-α-D-glucopyranoside in CACO-2 cells. HYA slowed gastric motility and increased the plasma GLP-1 and cholecystokinin levels in normal rats. HYA also ameliorated the postprandial hyperglycemia in T1DM rats given bolus insulin.</p><p><strong>Conclusion: </strong>Oral administration of HYA immediately before OGTT ameliorated postprandial hyperglycemia through inhibition of glucose absorption and slowing of gastric motility in normal rats. Furthermore, this beneficial effect of HYA was also revealed in T1DM rats injected with bolus insulin.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of bedtime snacks on morning fasting blood glucose in gestational diabetes mellitus: a randomized controlled trial.","authors":"Tianli Zhu, Jingjing Liu, Tuyan Fan, Hui Gao, Shuangqin Yan, Xiaomin Jia, Fengyu Yang, Ziwei Ding, Le Wang, Lanfang Zhao, Peng Zhu, Fangbiao Tao, Beibei Zhu","doi":"10.1007/s00592-025-02445-y","DOIUrl":"https://doi.org/10.1007/s00592-025-02445-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;While guidelines recommend bedtime snacks for women with gestational diabetes mellitus (GDM), there is insufficient evidence championed those recommendation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate if bedtime snacking is effective in preventing high fasting blood glucose incidence among women with GDM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;An open-label, parallel-group, randomized controlled trial was conducted from December 2023 to July 2024 at Ma'anshan Maternal and Child Health Care Center, Anhui, China.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Interventions: &lt;/strong&gt;A total of 62 GDM cases at the nutrition clinics were enrolled, and were randomly and equally allocated to groups of bedtime snacks (25 g nuts, intervention group) and no bedtime snacks (control group). The intervention was lasted for 8 weeks, during which fasting blood glucose was measured 3 times per week, 1-hour postprandial glucose and 2-hour postprandial glucose 2 times per week with a home glucometer. In the late pregnancy (approximately at 34 weeks), the glycated haemoglobin, high-density lipoprotein, low-density lipoprotein, triglycerides, total cholesterol were measured in the laboratory and birth outcomes information (birth weight, gestational weeks at delivery, delivery mode) were collected.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The primary outcomes were the level of fasting blood glucose and the hyper-fasting blood glucose incidence during 8-week duration. The secondary outcomes were the level of the glycated haemoglobin, high-density lipoprotein, low-density lipoprotein, triglycerides and total cholesterol in the late pregnancy. Generalized estimating equations and analysis of covariates were conducted for the analysis of the primary outcomes. The multivariate linear regression was conducted for the analysis of the secondary outcomes. Post-hoc analysis was also conducted for the indicators of 1-hour postprandial glucose, 2-hour postprandial glucose and perinatal outcomes applying generalized estimating equations, analysis of covariates, the multivariate linear regression and logistics regression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After adjusting for maternal age, pre-pregnancy body mass index, mid-pregnancy glucose, mid-pregnancy blood lipids and diet in late pregnancy, neither the average fasting blood glucose (control group: 4.90 mmol l&lt;sup&gt;-1&lt;/sup&gt;, intervention group: 4.96 mmol l&lt;sup&gt;-1&lt;/sup&gt;) (β = 0.05, [95%CI-0.22 to 0.31], P = 0.720) nor hyper-fasting blood glucose incidence (control group: 0.19, intervention group:0.26) (β = 0.07, [95%CI-0.07 to 0.20], P = 0.335) were significant different between the two groups. And we found low-density lipoprotein level were higher in the intervention group (3.21 mmol l&lt;sup&gt;-1&lt;/sup&gt;) compared to the control group (2.52 mmol l&lt;sup&gt;-1&lt;/sup&gt;) (β = 0.70, [95%CI0.07 to 1.34], P = 0.031). Additionally, post-hoc analysis showed that the incidence of elevated 1-hour postprandial glucose was significantly higher in th","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia in independent oldest-old individuals treated for diabetes, with or without metformin: a case-control study.","authors":"Maísa Braga Aguiar, Solomon Kim, Adriana Bruscato Bortoluzzo, Ana Beatriz Di Tommaso, Maysa Seabra Cendoroglo, Gisele W B Colleoni","doi":"10.1007/s00592-025-02448-9","DOIUrl":"https://doi.org/10.1007/s00592-025-02448-9","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a common condition in the elderly, especially in diabetics (DM). Metformin (MTF), known to reduce glucose levels, can also be a therapeutic intervention in age-related diseases, although it may contribute to muscle loss.</p><p><strong>Objectives: </strong>To compare the prevalence of sarcopenia among elderly people treated for DM, with or without MTF, and non-diabetic patients (NDM) and evaluate whether there is an association between the use of MTF and the development of sarcopenia.</p><p><strong>Methods: </strong>194 independent elderly people over 80 years old were analyzed. Sarcopenia was defined by handgrip (HG), calf circumference (CC), and gait speed (GS). Non-parametric statistical analysis and Kaplan-Meier survival curves were used.</p><p><strong>Results: </strong>The prevalence of DM was 24.7%, of which 56.25% used MTF. The median fasting blood glucose in the NDM and DM groups was 95 and 104 mg/dL. The median glycated hemoglobin in the NDM and DM groups was 5.7% and 6.4%. There was no statistical difference between the DM and NDM groups when comparing clinical characteristics, functionality, weight, physical tests, and mortality. The prevalence of sarcopenia was similar between NDM and DM (16.55% and 14.63%), with few cases of severe sarcopenia in both groups, without statistical differences. We did not find differences in the same variables when we analyzed NDM and DM using or not MTF. Survival curves showed no significant differences between patients with and without sarcopenia/severe sarcopenia.</p><p><strong>Conclusions: </strong>Long-lived people with well-controlled DM did not show significant differences concerning those without DM for the outcome of sarcopenia or death.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to change guidelines? Suboptimal glycemic control measures by CGM associated with cystic fibrosis exacerbations despite adequate HbA1c","authors":"I. Aguilera García,&nbsp;B. Barquiel Alcalá,&nbsp;P. Vázquez Pérez,&nbsp;M. C. Prados Sánchez,&nbsp;N. González Pérez de Villar","doi":"10.1007/s00592-025-02457-8","DOIUrl":"10.1007/s00592-025-02457-8","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 3","pages":"429 - 431"},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Autologous cell therapy for ischemic diabetic foot: a meta-analysis of randomized controlled trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome.","authors":"Alessia Scatena, Matteo Apicella, Michele Mantuano, Benedetta Ragghianti, Antonio Silverii, Cesare Miranda, Luca Monge, Luigi Uccioli, Germano Scevola, Eugenio Stabile, Mauro Gargiulo, Cristiana Vermigli, Matteo Monami","doi":"10.1007/s00592-025-02455-w","DOIUrl":"https://doi.org/10.1007/s00592-025-02455-w","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical nutrition therapy in physiological pregnancy and in pregnancy complicated by obesity and/or diabetes: SID-AMD recommendations.","authors":"Annunziata Lapolla, Maria Grazia Dalfrà, Giuseppe Marelli, Mario Parrillo, Laura Sciacca, Maria Angela Sculli, Elena Succurro, Elisabetta Torlone, Ester Vitacolonna","doi":"10.1007/s00592-024-02442-7","DOIUrl":"https://doi.org/10.1007/s00592-024-02442-7","url":null,"abstract":"<p><p>Proper nutrition is essential during pregnancy to ensure an adequate supply of nutrients to the foetus and adequate maternal weight gain. In pregnancy complicated by diabetes (both gestational and pre-gestational), diet in terms of both the intake and quality of carbohydrates is an essential factor in glycaemic control. Maternal BMI at conception defines the correct weight increase during gestation in order to reduce maternal-foetal complications related to hypo- or hyper-nutrition. The recommendations presented here, which are based on national and international guidelines and the most recently published data on nutrition in physiological pregnancy and pregnancy complicated by hyperglycaemia and/or obesity, are designed to help healthcare professionals prescribe suitable eating patterns to safeguard the health of the mother and the foetus.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untreated women with first trimester fasting glycaemia 92-125 mg/dL and risk of gestational diabetes mellitus in the 24-28th week OGTT: prevalence and predictors.","authors":"Catarina Cidade-Rodrigues, Bruna Silva, Vânia Benido Silva, Catarina Chaves, Maria Luís Mazeda, Alexandra Araújo, Cláudia Machado, Catarina A Pereira, Vânia Gomes, Odete Figueiredo, Anabela Melo, Anabela Ferreira, Mariana Martinho, Ana Morgado, Ana Saavedra, Maria Céu Almeida, Margarida Almeida, Filipe M Cunha","doi":"10.1007/s00592-025-02450-1","DOIUrl":"https://doi.org/10.1007/s00592-025-02450-1","url":null,"abstract":"<p><strong>Introduction: </strong>Women with first trimester fasting glycaemia (FTFG) 92-125 mg/dL may present with normal 24-28th week OGTT (2T-OGTT). Predictors of persistent hyperglycaemia were scarcely investigated. We studied the prevalence and predictors of gestational diabetes mellitus (GDM) in the 2T-OGTT in women with untreated elevated FTFG.</p><p><strong>Methods: </strong>Retrospective study of women from the national GDM registry with FTFG between 92 and 125 mg/dL that had passed unnoticed and untreated until the 2T-OGTT.</p><p><strong>Primary endpoint: </strong>GDM in the 2T-OGTT. Women with and without GDM were compared. A multivariate logistic regression analysis was used to study GDM predictors. Included variables: FTFG, newborn sex, and known GDM risk factors.</p><p><strong>Results: </strong>We studied 407 women. 82% (82.1%) of women had a positive 2T-OGTT. Women with abnormal 2T-OGTT were older, had higher BMI, and more often carried female newborns. There were no differences concerning other known GDM risk factors, FTFG, and obstetric or neonatal complications. Age, BMI and newborn sex were associated with higher risk of GDM independently of other GDM risk factors or FTFG. Per 1 year of age and 1 kg/m2 of BMI, the OR (95%CI) for this association were 1.10 (1.05-1.16) and 1.07 (1.02-1.12), respectively. Alternatively, women older than 35 years or with a BMI ≥ 30Kg/m2 had an OR of 2.53 (1.30-4.90) and 2.20 (1.22-3.98), respectively. Women with male newborns had approximately half the risk of abnormal 2T-OGTT [OR 0.51 (0.30-0.87)].</p><p><strong>Conclusions: </strong>Nearly 18% of women with FTFG between 92 and 125 mg/dL had a normal 2T-OGTT. Older age, higher BMI, and female newborns were associated with increased risk of abnormal 2T-OGTT.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A web-based application for diabetes subtyping: The DDZ Diabetes-Cluster-Tool","authors":"Tim Mori,&nbsp;Katsiaryna Prystupa,&nbsp;Klaus Straßburger,&nbsp;Marc Bonn,&nbsp;Oana Patricia Zaharia,&nbsp;Olaf Spörkel,&nbsp;Oliver Kuß,&nbsp;Michael Roden,&nbsp;Robert Wagner","doi":"10.1007/s00592-024-02436-5","DOIUrl":"10.1007/s00592-024-02436-5","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 2","pages":"281 - 283"},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00592-024-02436-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}