Amelia Caretto, Gaetano Di Terlizzi, Erika Pedone, Renato Pennella, Francesco De Cobelli, Moreno Tresoldi, Marina Scavini, Emanuele Bosi, Andrea Laurenzi
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Respiratory function was evaluated as arterial partial pressure of oxygen (PaO<sub>2</sub>) to fraction of inspired oxygen (FiO<sub>2</sub>) ratio (PaO<sub>2</sub>:FiO<sub>2</sub>).</p><p><strong>Results: </strong>PaO<sub>2</sub>:FiO<sub>2</sub> ratio was positively correlated with time in tight range (TITR) 70-140 (r = 0.49, p < 0.001) and time in range (TIR) 70-180 (r = 0.32, p < 0.05), and negatively correlated with average glucose (r =- 0.31, p < 0.05), coefficient of glucose variation (CV) (r =- 0.47, p < 0.01) and time above range (TAR) > 140 (r =- 0.49, p < 0.001). No relations were observed with HbA1c. Multivariate regression analysis showed that normal respiratory function at time of CGM removal correlated positively with TITR 70-140 mg/dL (p < 0.01), negatively with CV and TAR > 140 mg/dL (both p < 0.05) and not with TIR 70-180 and average glucose.</p><p><strong>Conclusions: </strong>Lower glucose variability and optimal glucose control, expressed as CV and TITR, are CGM metrics predictive of a better prognosis in COVID-19 patients with pneumonia.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tight and stable glucose control is associated with better prognosis in patients hospitalized for Covid-19 and pneumonia.\",\"authors\":\"Amelia Caretto, Gaetano Di Terlizzi, Erika Pedone, Renato Pennella, Francesco De Cobelli, Moreno Tresoldi, Marina Scavini, Emanuele Bosi, Andrea Laurenzi\",\"doi\":\"10.1007/s00592-024-02409-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>To investigate possible associations of glucose patterns with outcomes of Corona Virus Disease 19 (COVID-19) using continuous glucose monitoring (CGM) in 43 patients hospitalized for COVID-19 mild-to-moderate pneumonia, regardless of diabetes.</p><p><strong>Methods: </strong>Prospective observational study conducted during two pandemic waves in 2020-2021. 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引用次数: 0
摘要
目的：通过对43例因COVID-19轻中度肺炎住院的患者进行连续血糖监测（CGM），探讨血糖模式与COVID-19结局的可能关联，无论是否患有糖尿病。方法：在2020-2021年两次大流行期间进行前瞻性观察研究。通过盲法CGM获得7天记录的葡萄糖传感器指标。以动脉血氧分压（PaO2）与吸入氧分压（FiO2）之比（PaO2:FiO2）评价呼吸功能。结果：PaO2:FiO2比值与紧密范围时间（TITR） 70-140 （r = 0.49, p =- 0.49, p 140 mg/dL）呈正相关（均为p）。结论：较低的血糖变异性和最佳血糖控制，以CV和TITR表示，是预测COVID-19合并肺炎患者预后较好的CGM指标。
Tight and stable glucose control is associated with better prognosis in patients hospitalized for Covid-19 and pneumonia.
Aims: To investigate possible associations of glucose patterns with outcomes of Corona Virus Disease 19 (COVID-19) using continuous glucose monitoring (CGM) in 43 patients hospitalized for COVID-19 mild-to-moderate pneumonia, regardless of diabetes.
Methods: Prospective observational study conducted during two pandemic waves in 2020-2021. Glucose sensor metrics of 7-day recording were obtained from blinded CGM. Respiratory function was evaluated as arterial partial pressure of oxygen (PaO2) to fraction of inspired oxygen (FiO2) ratio (PaO2:FiO2).
Results: PaO2:FiO2 ratio was positively correlated with time in tight range (TITR) 70-140 (r = 0.49, p < 0.001) and time in range (TIR) 70-180 (r = 0.32, p < 0.05), and negatively correlated with average glucose (r =- 0.31, p < 0.05), coefficient of glucose variation (CV) (r =- 0.47, p < 0.01) and time above range (TAR) > 140 (r =- 0.49, p < 0.001). No relations were observed with HbA1c. Multivariate regression analysis showed that normal respiratory function at time of CGM removal correlated positively with TITR 70-140 mg/dL (p < 0.01), negatively with CV and TAR > 140 mg/dL (both p < 0.05) and not with TIR 70-180 and average glucose.
Conclusions: Lower glucose variability and optimal glucose control, expressed as CV and TITR, are CGM metrics predictive of a better prognosis in COVID-19 patients with pneumonia.
期刊介绍：
Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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