Increased incidence of anemia in individuals with impaired fasting glucose: a cohort study.

IF 2.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-05-27 DOI:10.1007/s00592-025-02517-z

Jianmei Zhang, Xiaocheng Huang, Xiaofeng Guo, Luying Dong, Yachao Yang, Lijie Ding

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Abstract

Aims: Anemia is common in diabetes patients, but its prevalence in pre-diabetes remains under-researched. Therefore, we aimed to investigate the incidence of anemia and potential risk factors in individuals with impaired fasting glucose using health examination data.

Methods: A cohort of 7075 participants, all aged over 18 years and free of anemia at baseline, were included in this study to monitor the incidence of anemia through annual routine health check-ups. Cox regression models were used to estimate the age- and sex-adjusted hazard ratios of each risk factor.

Results: The incidence of anemia among patients with impaired fasting glucose was 7.04 (95%CI: 6.08-8.00) per 1000 person-years overall, with a gender-specific incidence of 4.24 (95%CI: 3.37-5.10) and 15.21 (95%CI: 12.45-18.02) per 1000 person-years in men and women. COX regression analysis identified that female, lower levels of TC, LDL-C, ALT, AST, ALB, and alcohol drinking were associated with higher risk of anemia in individuals with impaired fasting glucose.

Conclusions: In individuals with impaired fasting glucose, anemia incidence differed by gender and age, being higher in women than men and surpassing that of the general Chinese population. Furthermore, lower levels of TC, LDL-C, ALT, AST, ALB, and alcohol drinking were associated with higher risk of anemia in individuals with impaired fasting glucose.

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空腹血糖受损个体贫血发生率增高：一项队列研究

目的：贫血在糖尿病患者中很常见，但其在糖尿病前期的患病率仍未得到充分研究。因此，我们旨在利用健康检查数据调查空腹血糖受损个体的贫血发生率和潜在危险因素。方法：选取7075名年龄在18岁以上、基线时无贫血的受试者，通过年度常规健康检查监测其贫血发生率。采用Cox回归模型估计各危险因素经年龄和性别调整后的危险比。结果：空腹血糖受损患者的贫血发生率为7.04 (95%CI: 6.08-8.00) / 1000人年，男性和女性的特定性别发生率分别为4.24 （95%CI: 3.37-5.10）和15.21 (95%CI: 12.45-18.02) / 1000人年。COX回归分析发现，女性、较低水平的TC、LDL-C、ALT、AST、ALB和饮酒与空腹血糖受损个体的贫血风险较高相关。结论：在空腹血糖受损的个体中，贫血发生率因性别和年龄而异，女性高于男性，超过中国一般人群。此外，较低水平的TC、LDL-C、ALT、AST、ALB和饮酒与空腹血糖受损个体的贫血风险较高相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.