Predictive markers of early endothelial dysregulation in type-1 diabetes: a meta-analysis.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2024-11-11 DOI:10.1007/s00592-024-02401-2

Ranmali Ranasinghe, Michael Mathai, Mohammed Abdullah Alshawsh, Anthony Zulli, Ranmali Ranasinghe

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引用次数: 0

Abstract

Background: This study identifies a new set of salient risk factors that may trigger danger signals of vascular dysregulation in T1D. Vascular abnormalities and impairment of CVD is a major adverse effect of T1D, particularly affecting children, adolescents and young adults.

Methods: The patients of T1D were compared with the healthy control (HC) for the risk factors of vascular dysregulation in published studies from year 2013 to 2023. The PubMed, Web of Science and Google Scholar databases were searched from 1/1/2013 to 1/9/2023. The risk of bias was assessed with the Cochrane (ROBINS-I ) tool, relevant to clinical subjects. A random effects model was followed and analysed by RevMan 5.4 and GraphPad Prism software.

Results: 80 relevant case-control studies having 7492 T1D patients and 5293 HC were included. The age and sex-matched HC consisted of persons free of disease and not under any medication while clinical subjects of < 40 years were included. 28 risk factors were grouped into six primary outcome models, all of which favoured the T1D synonymous with a high risk of CVD.

Conclusion: Our findings have strong implications for improving the quality of life and health economics related to vascular disease in T1D. HbA1c% is the most effective biomarker, followed by FBG, LDL-c, AI%, sICAM-1, and FMD% which could be evaluated with a simple blood test or non-invasive techniques. These may serve dual purposes as biomarkers of rapid diagnosis that could offer prospective tailor-made therapeutics for T1D. (Protocol registered at https://www.crd.york.ac.uk/prospero/CRD42022384636 ).

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1 型糖尿病早期内皮失调的预测指标：一项荟萃分析。

背景：这项研究发现了一系列可能引发 T1D 血管失调危险信号的新的突出风险因素。血管异常和心血管疾病损害是 T1D 的主要不良反应，尤其影响儿童、青少年和年轻人：方法：将 2013 年至 2023 年发表的研究中 T1D 患者与健康对照（HC）的血管失调风险因素进行比较。从 2013 年 1 月 1 日至 2023 年 9 月 1 日，在 PubMed、Web of Science 和 Google Scholar 数据库中进行了检索。使用与临床科目相关的 Cochrane (ROBINS-I )工具评估了偏倚风险。采用随机效应模型，并使用 RevMan 5.4 和 GraphPad Prism 软件进行分析：结果：共纳入 80 项相关病例对照研究，包括 7492 名 T1D 患者和 5293 名 HC。与年龄和性别相匹配的 HC 包括无疾病且未接受任何药物治疗的人，而临床研究对象为 T1D 患者：我们的研究结果对改善 T1D 患者的生活质量和与血管疾病相关的健康经济学具有重要意义。HbA1c% 是最有效的生物标志物，其次是 FBG、LDL-c、AI%、sICAM-1 和 FMD%。这些指标具有双重作用，可作为快速诊断的生物标记物，为 T1D 提供量身定制的治疗方案。(协议注册于 https://www.crd.york.ac.uk/prospero/CRD42022384636 ）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.