Acta Diabetologica最新文献

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A nationwide registry-based cohort study of the association between childhood dental caries and gingivitis with type 2 diabetes in adulthood. 一项全国性的基于登记的队列研究,研究儿童龋齿和牙龈炎与成年期2型糖尿病的关系。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-13 DOI: 10.1007/s00592-024-02437-4
Nikoline Nygaard, Anne Kirstine Eriksen, Lars Ängquist, Daniel Belstrøm, Evelina Stankevic, Torben Hansen, Anja Olsen, Merete Markvart
{"title":"A nationwide registry-based cohort study of the association between childhood dental caries and gingivitis with type 2 diabetes in adulthood.","authors":"Nikoline Nygaard, Anne Kirstine Eriksen, Lars Ängquist, Daniel Belstrøm, Evelina Stankevic, Torben Hansen, Anja Olsen, Merete Markvart","doi":"10.1007/s00592-024-02437-4","DOIUrl":"https://doi.org/10.1007/s00592-024-02437-4","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests a bidirectional relationship between oral health status and type 2 diabetes (T2D) in adults. Studies on associations between childhood oral health and T2D in adulthood are lacking.</p><p><strong>Methods: </strong>This is a nationwide Danish registry-based cohort study of individuals born between 1963 and 1972, having at least one registration in the National Child Odontology Registry between 1972 and 1987 (n = 627,758). Follow-up lasted from 1995 to 2018. Main exposure variables were the highest achieved levels of dental caries and gingivitis between 1972 and 1987. The outcome was T2D diagnosis during follow-up. Data was analyzed using Cox-regression, stratified on sex, with age as the underlying timescale and highest achieved level of education between age 25-30 years as Cox-strata. Main analyses were conducted with and without age-restrictions (T2D diagnosis before/after age 40).</p><p><strong>Results: </strong>Compared to lowest-level references, high levels of gingivitis associated with increased hazard ratios (HRs) of T2D in both males (HR [95% confidence interval]: 1.59 [1.47; 1.72]) and females (1.87 [1.68; 2.08]), as did severe dental caries (males: (1.15 [1.04; 1.27], in females: 1.19 [1.06; 1.35]). Below age 40, gingivitis associated with increased HRs in males (1.84 ([1.58; 2.15]) and females (1.94 [1.63; 2.30]). Above age 40, both exposures displayed higher HRs in males (high gingivitis: 1.52 [1.39; 1.66] vs. severe caries: 1.23 [1.09; 1.38]) and females (1.83 [1.59; 2.10] vs. 1.37 [1.17; 1.59]).</p><p><strong>Conclusions: </strong>Data suggest an association between childhood dental caries and gingivitis with risk of receiving a T2D diagnosis in adulthood. However, results are affected by residual confounding warranting further studies.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated insulin delivery in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis. 1型糖尿病孕妇自动胰岛素输送:一项系统综述和荟萃分析
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-10 DOI: 10.1007/s00592-025-02446-x
Athina Stamati, Athanasios Christoforidis
{"title":"Automated insulin delivery in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis.","authors":"Athina Stamati, Athanasios Christoforidis","doi":"10.1007/s00592-025-02446-x","DOIUrl":"https://doi.org/10.1007/s00592-025-02446-x","url":null,"abstract":"<p><strong>Aims: </strong>To assess the efficacy and safety of automated insulin delivery (AID) systems compared to standard care in managing glycaemic control during pregnancy in women with Type 1 Diabetes Mellitus (T1DM).</p><p><strong>Methods: </strong>We searched MEDLINE, Cochrane Library, registries and conference abstracts up to June 2024 for randomized controlled trials (RCTs) and observational studies comparing AID to standard care in pregnant women with T1DM. We conducted random effects meta-analyses for % of 24-h time in range of 63-140 mg/dL (TIR), time in hyperglycaemia (> 140 mg/dl and > 180 mg/dL), hypoglycaemia (< 63 mg/dl and < 54 mg/dL), total insulin dose (units/kg/day), glycemic variability (%), changes in HbA1c (%), maternal and fetal outcomes.</p><p><strong>Results: </strong>Thirteen studies (450 participants) were included. AID significantly increased TIR (Mean difference, MD 7.01%, 95% CI 3.72-10.30) and reduced time in hyperglycaemia > 140 mg/dL and > 180 mg/dL (MD - 5.09%, 95% CI - 9.41 to - 0.78 and MD - 2.44%, 95% CI - 4.69 to - 0.20, respectively). Additionally, glycaemic variability was significantly reduced (MD - 1.66%, 95% CI - 2.73 to - 0.58). Other outcomes did not differ significantly.</p><p><strong>Conclusion: </strong>AID systems effectively improve glycaemic control during pregnancy in women with T1DM by increasing TIR and reducing hyperglycaemia without any observed adverse short-term effects on maternal and fetal outcomes.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk. 内脏脂肪组织与代谢健康状况和心血管疾病风险的年龄特异性和性别特异性关联
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-10 DOI: 10.1007/s00592-025-02447-w
Wenhao Zhang, Xiaoyu Su, SiHua Liu, Tong Yue, Zhixin Tu, Hongqiang Zhang, Chenghua Li, Haifeng Yao, Jumei Wang, Xueying Zheng, Sihui Luo, Yu Ding
{"title":"Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk.","authors":"Wenhao Zhang, Xiaoyu Su, SiHua Liu, Tong Yue, Zhixin Tu, Hongqiang Zhang, Chenghua Li, Haifeng Yao, Jumei Wang, Xueying Zheng, Sihui Luo, Yu Ding","doi":"10.1007/s00592-025-02447-w","DOIUrl":"https://doi.org/10.1007/s00592-025-02447-w","url":null,"abstract":"<p><strong>Background: </strong>Visceral adipose tissue (VAT) is known to play a role in the development of metabolic and cardiovascular disease (CVD). However, the age- and sex-specific associations between VAT and these diseases remain unclear.</p><p><strong>Methods: </strong>In this cross-sectional study, 1,150 participants (39.5% women; mean age 61.5 years) underwent VAT measurement using dual abdominal bioelectrical impedance analysis (BIA). The four age groups that the participants were divided into were 18-44, 45-59, 60-74, and ≥ 75 years. The relationships between VAT and cardiometabolic outcomes were analyzed by age and sex using multivariable logistic regression.</p><p><strong>Results: </strong>Significant associations between VAT and metabolic health status were observed in middle-aged (45-59 years; OR = 1.41, 95% CI: 1.04-1.92) and elderly adults (60-74 years; OR = 1.45, 95% CI: 1.10-1.92). VAT demonstrated age-dependent relationships with cardiovascular risk factors, with the strongest associations found in the 60-74 years group for hypertension (OR: 1.55, 95% CI: 1.22-1.98) and low high-density lipoprotein cholesterol (OR: 1.66, 95% CI: 1.33-2.08). Notably, the VAT-CVD association was most pronounced in elderly women (60-74 years; OR: 1.86, 95% CI: 1.14-3.11), while no significant associations were observed in men across all age groups.</p><p><strong>Conclusions: </strong>The impact of VAT on metabolic and cardiovascular disease risk varies by age and sex, with particularly strong associations observed in elderly women. This highlights the need for tailored prevention and treatment strategies.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS). 衰弱指数与新发糖尿病的关系:来自中国健康与退休纵向研究(CHARLS)
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-06 DOI: 10.1007/s00592-024-02441-8
Lisha Zhang, Chao Chu, Yan Zhang, Man Wang
{"title":"Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS).","authors":"Lisha Zhang, Chao Chu, Yan Zhang, Man Wang","doi":"10.1007/s00592-024-02441-8","DOIUrl":"https://doi.org/10.1007/s00592-024-02441-8","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association of frailty status and its changes with new-onset diabetes.</p><p><strong>Methods: </strong>A total of 4638 participants from the China Health and Retirement Longitudinal Study (CHARLS) were included. Frailty status was assessed by the frailty index (FI) and categorized as robust, pre-frail, and frail. Changes in frailty were assessed based on frailty status at wave1 and wave3 of CHARLS. New-onset diabetes was identified by self-reported physician-diagnosed or diagnosed by glucose or glycosylated haemoglobin during follow-up period. Logistic regression was used to examine the association of frailty and outcomes.</p><p><strong>Results: </strong>51.6%, 38.1% and 10.3% of the individuals were respectively classified as robust, pre-frail, and frail at baseline. The risk of new-onset diabetes was significantly higher in the pre-frailty [odds ratio (OR) (95% confidence interval (CI)): 1.326 (1.101-1.597), p = 0.003)] and frailty [OR(95% CI): 1.721 (1.304-2.271), p < 0.001)] than the robust. A total of 3145 participants were included in the changes of frailty status analyses. Compared with the stable robust individuals, individuals who developed from robust to frailty status [OR (95%CI): 3.752 (1.647-8.547), p = 0.002] had an elevated risk of new-onset diabetes. In addition, participants who ever had a robust status in the two surveys had a significantly lower risk of new-onset diabetes compared to those who never had a robust status [OR (95%CI) 0.666 (0.483-0.920), p = 0.014)].</p><p><strong>Conclusion: </strong>Frailty status is significantly associated with the risk of new-onset diabetes. The progression from robust to frailty or pre-frailty increased the risk of new-onset diabetes.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel antimicrobial strategies for diabetic foot infections: addressing challenges and resistance 糖尿病足感染的新型抗菌策略:解决挑战和耐药性。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-06 DOI: 10.1007/s00592-024-02438-3
Fahaad Alenazi, Mohd Shahid Khan
{"title":"Novel antimicrobial strategies for diabetic foot infections: addressing challenges and resistance","authors":"Fahaad Alenazi,&nbsp;Mohd Shahid Khan","doi":"10.1007/s00592-024-02438-3","DOIUrl":"10.1007/s00592-024-02438-3","url":null,"abstract":"<div><h3>Aims</h3><p>This review examines the challenges posed by Diabetic Foot Infections (DFIs), focusing on the impact of neuropathy, peripheral arterial disease, immunopathy, and the polymicrobial nature of these infections. The aim is to explore the factors contributing to antimicrobial resistance and assess the potential of novel antimicrobial treatments and drug delivery systems in improving patient outcomes.</p><h3>Method</h3><p>A comprehensive analysis of existing literature on DFIs was conducted, highlighting the multifactorial pathogenesis and polymicrobial composition of these infections. The review delves into the rise of antimicrobial resistance due to the overuse of antimicrobials, biofilm formation, and microbial genetic adaptability. Additionally, it considers glycemic control, patient adherence, and recurrence rates as contributing factors to treatment failure. Emerging therapies, including new antimicrobial classes and innovative drug delivery systems, were evaluated for their potential efficacy.</p><h3>Results</h3><p>DFIs present unique treatment challenges, with high rates of antimicrobial resistance and poor response to standard therapies. Biofilm formation and the genetic adaptability of pathogens worsen resistance, complicating treatment. Current antimicrobial therapies are further hindered by poor glycemic control and patient adherence, leading to recurrent infections. Novel antimicrobial classes and innovative delivery systems show promise in addressing these challenges by offering more targeted, effective treatments. These new approaches aim to reduce resistance and improve treatment outcomes.</p><h3>Conclusion</h3><p>DFIs remain a clinical challenge due to their multifactorial nature and antimicrobial resistance. The development of novel antimicrobials and drug delivery systems is crucial to improving patient outcomes and combating resistance. Future research should focus on enhancing treatment efficacy, reducing resistance, and addressing patient adherence to reduce the burden of DFIs.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 3","pages":"303 - 321"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of continuous glucose monitoring on pregnancy outcomes in women with pregestational diabetes. 持续血糖监测对妊娠期糖尿病患者妊娠结局的影响。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-06 DOI: 10.1007/s00592-024-02439-2
Isabel Hinojal, Angel Chimenea, Guillermo Antiñolo, Lutgardo García-Díaz
{"title":"Impact of continuous glucose monitoring on pregnancy outcomes in women with pregestational diabetes.","authors":"Isabel Hinojal, Angel Chimenea, Guillermo Antiñolo, Lutgardo García-Díaz","doi":"10.1007/s00592-024-02439-2","DOIUrl":"https://doi.org/10.1007/s00592-024-02439-2","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to evaluate the impact of continuous glucose monitoring (CGM) on pregnancy outcomes in women with pregestational diabetes mellitus (PGDM).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 387 pregnant women with PGDM at Virgen del Rocío University Hospital in Seville, spanning from 2016 to 2022. The patients were categorized into two groups: 212 women who used continuous glucose monitoring (CGM) and 175 women who self-monitoring of blood glucose (SMBG). The study evaluated maternal characteristics, pregnancy complications, delivery methods, neonatal outcomes, and congenital anomalies.</p><p><strong>Results: </strong>The CGM group exhibited lower weight gain during pregnancy (9.6 kg vs. 10.0 kg, p = 0.02) and required fewer prenatal visits (7 vs. 8, p = 0.01). The rate of cesarean sections was significantly lower in the CGM group (53.1% vs. 58.2%, p = 0.03), and the incidence of macrosomia was reduced (12.9% vs. 22.2%, p = 0.04). There were no significant differences in congenital anomalies, intrauterine fetal deaths, or neonatal deaths between the groups.</p><p><strong>Conclusions: </strong>CGM in pregnant women with PGDM is associated with better pregnancy outcomes, including reduced cesarean section rates and lower incidence of macrosomia. These findings support the wider implementation of CGM for improved maternal and fetal health in PGDM pregnancies.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review 揭示肌肉质量和力量在预测2型糖尿病风险中的作用:一项系统综述。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-06 DOI: 10.1007/s00592-024-02440-9
Hans Putranata, Antoninus Hengky, Budhi Hartoko
{"title":"Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review","authors":"Hans Putranata,&nbsp;Antoninus Hengky,&nbsp;Budhi Hartoko","doi":"10.1007/s00592-024-02440-9","DOIUrl":"10.1007/s00592-024-02440-9","url":null,"abstract":"<div><h3>Introduction</h3><p>Skeletal muscle is the largest insulin-sensitive tissue in the human body, alteration in muscle mass and strength substantially impact glucose metabolism. This systematic review aims to investigate further the relationship between muscle mass and strength towards type 2 diabetes mellitus (T2DM) incidence.</p><h3>Methods</h3><p>This systematic review included cohort studies that examinedthe relationship between muscle mass and/or muscle strength on T2DM incidence. A comprehensive search was conducted across PubMed, EBSCO, ProQuest, and Google scholar employing specific Medical Subject Headings (MeSH) and relevant keywords related to or synonymous with “muscle mass”, “muscle strength”, and “Type 2 Diabetes Mellitus incidence”.</p><h3>Results</h3><p>Twenty-five cohort studies were included, 11 studies on muscle mass and 16 studies on muscle strength. Participants included were 278,475 for muscle mass and 400,181 for muscle strength. Skeletal muscle mass normalized to body weight (SMM/BW), appendicular skeletal musce mass normalized to body weight (ASM/BW), and handgrip strength normalized to body mass index (HGS/BMI) consistently demonstrate significant inverse association with T2DM even after sex and/or BMI stratification. Handgrip strength normalized to body weight (HGS/BW) demonstrates a strong inverse association with T2DM incidence, however, adiposity should be considered.</p><h3>Conclusion</h3><p>Muscle mass and strength demonstrate strong association with T2DM incidence. Adiposity, a key T2DM risk factor, should also be assessed through a simple BMI or a sophisticated technique with BIA or CT-scan. The combination of muscle variables and adiposity could further enhance T2DM risk assessment. However, T2DM risks are multifactorial, with various contributing factors, further large-scale studies are needed to validate these findings.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 2","pages":"157 - 176"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Association of the triglyceride glucose index with acute renal failure in diabetes mellitus: a cross-sectional study based on participants from the MIMIC-iv database. 更正:甘油三酯葡萄糖指数与糖尿病急性肾功能衰竭的关联:一项基于MIMIC-iv数据库参与者的横断面研究。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2025-01-03 DOI: 10.1007/s00592-024-02431-w
Zi-Fan Zhuang, Hong-Rui Lu, Yang Zhou, Qing Ni
{"title":"Correction: Association of the triglyceride glucose index with acute renal failure in diabetes mellitus: a cross-sectional study based on participants from the MIMIC-iv database.","authors":"Zi-Fan Zhuang, Hong-Rui Lu, Yang Zhou, Qing Ni","doi":"10.1007/s00592-024-02431-w","DOIUrl":"https://doi.org/10.1007/s00592-024-02431-w","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary and lifestyle oxidative balance score was negatively associated with the risk of diabetic kidney disease: NHANES 2005-2020. 饮食和生活方式氧化平衡评分与糖尿病肾病风险呈负相关:NHANES 2005-2020。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2024-12-28 DOI: 10.1007/s00592-024-02399-7
Yanhong Lu, Kai Huang, Youjuan Fu, Xiaoyan Huang, Ken Chen, Qiaojun Zheng, Guangda Xiang, Ling Yue
{"title":"Dietary and lifestyle oxidative balance score was negatively associated with the risk of diabetic kidney disease: NHANES 2005-2020.","authors":"Yanhong Lu, Kai Huang, Youjuan Fu, Xiaoyan Huang, Ken Chen, Qiaojun Zheng, Guangda Xiang, Ling Yue","doi":"10.1007/s00592-024-02399-7","DOIUrl":"https://doi.org/10.1007/s00592-024-02399-7","url":null,"abstract":"<p><strong>Aims: </strong>There is a potential association between oxidative stress and the development of diabetic kidney disease (DKD). The Oxidative Balance Score (OBS), derived from dietary and lifestyle factors, acts as a comprehensive marker of oxidative stress. Research examining the relationship between OBS and DKD is scarce. This study aims to evaluate the association between OBS and the risk of DKD among U.S. adults.</p><p><strong>Methods: </strong>This study enrolled 6,725 eligible participants from the U.S. population through the National Health and Nutrition Examination Survey (2005-2020). Patients with DKD were defined as those with diabetes who had a urinary albumin-to-creatinine ratio ≥ 30 mg/g and/or an estimated glomerular filtration rate < 60 mL/min/1.73 m². The OBS consists of 20 composite scores derived from dietary and lifestyle factors. To assess the potential relationship between OBS and DKD, weighted logistic regression and restricted cubic spline statistical approaches were employed.</p><p><strong>Results: </strong>The risk of DKD was inversely correlated with OBS, dietary OBS, and lifestyle OBS (p < 0.05). Compared to the lowest quartile of OBS, the adjusted odds ratios (OR) for OBS, lifestyle OBS and dietary OBS, and DKD in the highest quartile were 0.58 (95% CI: 0.48-0.70), 0.64 (95% CI: 0.51-0.81), and 0.57 (95% CI: 0.46-0.70), respectively. A substantial nonlinear relationship between lifestyle OBS and DKD was identified using the RCS curve (p for nonlinearity = 0.0081), which appeared as an inverted 'L' shape. Using the two-piecewise logistic regression model, a turning point in lifestyle OBS was identified at a score of 3 (p < 0.001).</p><p><strong>Conclusions: </strong>Among the American population, OBS and DKD are significantly negatively correlated, suggesting that maintaining a higher OBS may reduce the risk of developing DKD.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Expert panel opinion on the optimal educational pathway for diabetes educators for training people with type 1 diabetes on the MiniMed™ 780G system: a Delphi consensus. 更正:专家小组对糖尿病教育者在MiniMed™780G系统上培训1型糖尿病患者的最佳教育途径的意见:德尔菲共识。
IF 3.1 3区 医学
Acta Diabetologica Pub Date : 2024-12-26 DOI: 10.1007/s00592-024-02435-6
Geraldine Gallen, Alice Rosso, Núria Alonso Carril, Sima Arbeli, Virginie Bahon, Vanessa Brown, Kerstin Endlich, Francesca Gulotta, Audrey Hansart, Amy Jolley, Rea Jussila, Anna Stefanowicz-Bielska, Paola Cardano
{"title":"Correction: Expert panel opinion on the optimal educational pathway for diabetes educators for training people with type 1 diabetes on the MiniMed™ 780G system: a Delphi consensus.","authors":"Geraldine Gallen, Alice Rosso, Núria Alonso Carril, Sima Arbeli, Virginie Bahon, Vanessa Brown, Kerstin Endlich, Francesca Gulotta, Audrey Hansart, Amy Jolley, Rea Jussila, Anna Stefanowicz-Bielska, Paola Cardano","doi":"10.1007/s00592-024-02435-6","DOIUrl":"https://doi.org/10.1007/s00592-024-02435-6","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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