Acta Diabetologica最新文献_第8页

Automated insulin delivery in pregnant women with type 1 diabetes: a systematic review and meta-analysis. 1型糖尿病孕妇自动胰岛素输送：一项系统综述和荟萃分析。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-17 DOI: 10.1007/s00592-025-02454-x

Qin Yang, Jiayi Hao, Huijing Cui, Qingqing Yang, Feng Sun, Baoqi Zeng

{"title":"Automated insulin delivery in pregnant women with type 1 diabetes: a systematic review and meta-analysis.","authors":"Qin Yang, Jiayi Hao, Huijing Cui, Qingqing Yang, Feng Sun, Baoqi Zeng","doi":"10.1007/s00592-025-02454-x","DOIUrl":"https://doi.org/10.1007/s00592-025-02454-x","url":null,"abstract":"Aim: The outcomes of automated insulin delivery (AID) systems in pregnant women with type 1 diabetes (T1D) have not been systematically evaluated. This study aims to evaluate the efficacy and safety of AID in pregnancy.Material and methods: Literature searches were conducted until July 5, 2024, on Embase, PubMed, Cochrane Library, and ClinicalTrials.gov website. We included clinical trials and observational studies evaluating AID systems in T1D pregnant individuals. Time in the target range (TIR, 3.5-7.8 mmol/L) was the primary outcome. Secondary outcomes included time below range (TBR, < 3.5 mmol/L), time above range (TAR, > 7.8 mmol/L), and maternal and neonatal outcomes.Results: Eighteen studies (550 participants) were included. Compared with standard care, AID did not improve 24-h TIR (mean differences [MD] 3.56%, 95% CI - 0.60 to 7.72). However, the overnight TIR increased by 10.05% (95% CI 6.57 to 13.53). The association between AID and decreased TBR (MD - 0.90%, 95% CI - 1.60 to - 0.20) was found, but not with deceased TAR. Only 7 of the 17 studies achieved the goal of a 24-h TIR above 70%. Additionally, the maternal and neonatal outcomes were comparable between AID and standard care, and AID might reduce maternal weight gain (MD - 2.54 kg, 95% CI - 3.96 to - 1.11).Conclusions: AID did not exhibit favourable TIR when compared to standard care. However, AID could increase overnight TIR and decrease TBR. Available evidence indicates that employing AID to meet the target of a 24-h TIR above 70% remains challenging.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematically investigation of plasma complement and coagulation-related proteins and adiponectin in gestational diabetes mellitus by multiple reaction monitoring technology. 多反应监测技术对妊娠期糖尿病血浆补体、凝血相关蛋白及脂联素的系统研究。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-17 DOI: 10.1007/s00592-025-02451-0

Jing Lin, Zhiyuan Liang, Yi Liang, Xueshan Cao, Xiaoxiao Tang, Hongbin Zhuang, Xiaoping Yin, Danqing Zhao, Liming Shen

{"title":"A systematically investigation of plasma complement and coagulation-related proteins and adiponectin in gestational diabetes mellitus by multiple reaction monitoring technology.","authors":"Jing Lin, Zhiyuan Liang, Yi Liang, Xueshan Cao, Xiaoxiao Tang, Hongbin Zhuang, Xiaoping Yin, Danqing Zhao, Liming Shen","doi":"10.1007/s00592-025-02451-0","DOIUrl":"https://doi.org/10.1007/s00592-025-02451-0","url":null,"abstract":"Background: Gestational diabetes mellitus (GDM) is defined as a glucose intolerance resulting in hyperglycaemia of variable severity with onset during pregnancy, and is prevalent worldwide. The study of diagnostic markers of GDM in early pregnancy is important for early diagnosis and early intervention of GDM. The aim of this study was to search for biomarkers of GDM in early and mid-pregnancy using a targeted proteomics approach.Methods: Through multiple response monitoring (MRM) technology and bioinformatics analysis including machine learning, 44 proteins associated with complement and coagulation cascades, and one protein, adiponectin, which is frequently reported to be associated with GDM, were targeted for quantitative analysis, and potential biomarkers were screened.Results: The results showed that 7 and 6 proteins were identified as differentially expressed proteins (DEPs) between pregnant women subsequently diagnosed with GDM and controls during the first trimester, as well as between GDM cases and controls during the second trimester, respectively. Among them, C1QC and CFHR1 may serve as early predictive markers, and C1QC and adiponectin may serve as mid-term diagnostic markers.Discussion: Complement and coagulation-related proteins and adiponectin, have been implicated in the pathogenesis of GDM, and some of these proteins have the potential to serve as markers for the prediction or diagnosis of GDM.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving detection of monogenic diabetes through reanalysis of GCK variants of uncertain significance. 通过重新分析意义不确定的GCK变异，提高单基因糖尿病的检出率。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-16 DOI: 10.1007/s00592-025-02449-8

Sunita M C De Sousa, Jennifer M N Phan, Amanda Wells, Kathy H C Wu, Hamish S Scott

{"title":"Improving detection of monogenic diabetes through reanalysis of GCK variants of uncertain significance.","authors":"Sunita M C De Sousa, Jennifer M N Phan, Amanda Wells, Kathy H C Wu, Hamish S Scott","doi":"10.1007/s00592-025-02449-8","DOIUrl":"10.1007/s00592-025-02449-8","url":null,"abstract":"Aims: To assess the utility of reanalysing GCK variants of uncertain significance (VUS) as an intervention to improve the detection of monogenic diabetes.Methods: We examined GCK VUS in a local cohort of individuals with suspected monogenic diabetes and re-curated each variant against the recent ClinGen GCK-specific variant classification guidelines.Results: Variant reanalysis achieved a new 'likely pathogenic' classification (i.e., positive results) in 4/8 identified VUS. The single most common newly applied criterion indicating variant pathogenicity was a confirmed phenotype of GCK-hyperglycaemia. RNA sequencing and segregation studies were performed in two cases but not additive to reclassification.Conclusions: This is the first VUS reclassification study in monogenic diabetes using gene-specific guidelines. Within the limits of this small study, we observed a high rate (50%) of VUS upgrades to a positive result, thereby confirming the utility of VUS reanalysis- particularly with biochemical phenotyping- in increasing the detection of monogenic diabetes. We recommend HbA1c, fasting blood glucose and either pancreatic autoantibody negativity or a small oral glucose tolerance test increment as a feasible minimum dataset to inform variant classification at the individual patient level, noting the ongoing work of the ClinGen Monogenic Diabetes Expert Panel in systematically reviewing GCK variants at the international level.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like peptide 1 receptor agonists outperform basal insulin in cardiovascular and renal outcomes for type 2 diabetes mellitus: a retrospective cohort study. 胰高血糖素样肽1受体激动剂在2型糖尿病心血管和肾脏预后方面优于基础胰岛素：一项回顾性队列研究

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-15 DOI: 10.1007/s00592-024-02443-6

Tien-Hsing Chen, Chin-Ju Tseng, Yan-Rong Li, Yuan Lin, Dong-Yi Chen, Ning-I Yang, Te-Hsiung Wang, Ming-Jui Hung, Ming-Lung Tsai

{"title":"Glucagon-like peptide 1 receptor agonists outperform basal insulin in cardiovascular and renal outcomes for type 2 diabetes mellitus: a retrospective cohort study.","authors":"Tien-Hsing Chen, Chin-Ju Tseng, Yan-Rong Li, Yuan Lin, Dong-Yi Chen, Ning-I Yang, Te-Hsiung Wang, Ming-Jui Hung, Ming-Lung Tsai","doi":"10.1007/s00592-024-02443-6","DOIUrl":"https://doi.org/10.1007/s00592-024-02443-6","url":null,"abstract":"Purpose: Glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) and basal insulin are currently used in the treatment of type 2 diabetes mellitus (T2DM) as long-acting injectables. In this study, we aimed to compare the cardiovascular (CV) and renal outcomes of GLP-1 RAs and basal insulin treatment in patients with T2DM.Method: We conducted a propensity score-matched cohort study of patients from Chang Gung Memorial Hospital institutions between 2013 and 2021. A diverse patient base from multiple centers was enrolled to enhance the applicability of the findings, including patients with T2DM who were prescribed either GLP-1 RAs or basal insulin.Results: Over a mean follow-up period of 2.2 years, 10,839 patients were collected (mean age = 54.3 years; 54.2% men). Among the propensity score-matched patients, 45 (2.23%) in the GLP-1 RA group (2,854 patients) and 72 (3.56%) in the basal insulin group (7,985 patients) experienced 3-point major adverse cardiovascular events (3P-MACEs; hazard ratio [HR] 0.68, 95% CI 0.47-0.99, P =.44). Additionally, composite renal outcomes were observed in 237 (11.7%) patients in the GLP-1 RA group and 360 (17.8%) in the basal insulin group (HR 0.69, 95% CI 0.59-0.81, P <.001).Conclusions: In patients with T2DM, GLP-1 RAs were associated with more favorable cardiovascular and renal outcomes than basal insulin, suggesting that GLP-1 RA treatment may be a preferable option for managing T2DM with a lower risk of CV and renal complications.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Horizontal and longitudinal targeted metabolomics in healthy pregnancy and gestational diabetes mellitus. 健康妊娠和妊娠期糖尿病的横向和纵向靶向代谢组学研究。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-15 DOI: 10.1007/s00592-024-02428-5

Fang-Fang Chen, Sha Lu, Wen Hua, Meng-Wei Shang, Wen-Sheng Hu

{"title":"Horizontal and longitudinal targeted metabolomics in healthy pregnancy and gestational diabetes mellitus.","authors":"Fang-Fang Chen, Sha Lu, Wen Hua, Meng-Wei Shang, Wen-Sheng Hu","doi":"10.1007/s00592-024-02428-5","DOIUrl":"https://doi.org/10.1007/s00592-024-02428-5","url":null,"abstract":"Objective: The objective is to investigate the differences in urinary organic acid (OA) profiles and metabolism between healthy control (HC) pregnant women and those with gestational diabetes mellitus (GDM) during the second trimester and third trimester of pregnancy.Methods: A total of 66 HC pregnant women and 32 pregnant women with GDM were assessed for 107 hydrophilic metabolites in urine samples collected during the second and third trimester of pregnancy using tandem mass spectrometry. The urine OA profiles for each group were obtained, and metabolomic analysis and discussion were conducted.Results: This study identified a total of 50 metabolic biomarkers. In the third trimester of pregnancy, short-chain dicarboxylic acids (DCAs) and tryptophan (Trp)-related metabolites were significantly upregulated in the urine of both the HC group and the GDM group. Comparatively, the glycine (Gly) levels and related synthetic precursor metabolites were lower in the GDM2 group. The overall dietary polyphenol metabolic intermediates level in the GDM group was lower than in the HC group. Among the pathways enriched for differentially expressed metabolites, the predominant metabolic pathway in the GDM group was the citric acid cycle. In contrast, in the HC group, it was the metabolism of alanine, aspartate, and glutamate.Conclusions: The study reveals the differences in metabolomics between pregnant women with HC and those with GDM, identifying several metabolites associated with the occurrence and development of GDM. Demonstrating the presence of abnormal mitochondrial and peroxisomal functions at the metabolite level in GDM will contribute to future exploration of the condition.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nationwide registry-based cohort study of the association between childhood dental caries and gingivitis with type 2 diabetes in adulthood. 一项全国性的基于登记的队列研究，研究儿童龋齿和牙龈炎与成年期2型糖尿病的关系。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-13 DOI: 10.1007/s00592-024-02437-4

Nikoline Nygaard, Anne Kirstine Eriksen, Lars Ängquist, Daniel Belstrøm, Evelina Stankevic, Torben Hansen, Anja Olsen, Merete Markvart

{"title":"A nationwide registry-based cohort study of the association between childhood dental caries and gingivitis with type 2 diabetes in adulthood.","authors":"Nikoline Nygaard, Anne Kirstine Eriksen, Lars Ängquist, Daniel Belstrøm, Evelina Stankevic, Torben Hansen, Anja Olsen, Merete Markvart","doi":"10.1007/s00592-024-02437-4","DOIUrl":"https://doi.org/10.1007/s00592-024-02437-4","url":null,"abstract":"Background: Evidence suggests a bidirectional relationship between oral health status and type 2 diabetes (T2D) in adults. Studies on associations between childhood oral health and T2D in adulthood are lacking.Methods: This is a nationwide Danish registry-based cohort study of individuals born between 1963 and 1972, having at least one registration in the National Child Odontology Registry between 1972 and 1987 (n = 627,758). Follow-up lasted from 1995 to 2018. Main exposure variables were the highest achieved levels of dental caries and gingivitis between 1972 and 1987. The outcome was T2D diagnosis during follow-up. Data was analyzed using Cox-regression, stratified on sex, with age as the underlying timescale and highest achieved level of education between age 25-30 years as Cox-strata. Main analyses were conducted with and without age-restrictions (T2D diagnosis before/after age 40).Results: Compared to lowest-level references, high levels of gingivitis associated with increased hazard ratios (HRs) of T2D in both males (HR [95% confidence interval]: 1.59 [1.47; 1.72]) and females (1.87 [1.68; 2.08]), as did severe dental caries (males: (1.15 [1.04; 1.27], in females: 1.19 [1.06; 1.35]). Below age 40, gingivitis associated with increased HRs in males (1.84 ([1.58; 2.15]) and females (1.94 [1.63; 2.30]). Above age 40, both exposures displayed higher HRs in males (high gingivitis: 1.52 [1.39; 1.66] vs. severe caries: 1.23 [1.09; 1.38]) and females (1.83 [1.59; 2.10] vs. 1.37 [1.17; 1.59]).Conclusions: Data suggest an association between childhood dental caries and gingivitis with risk of receiving a T2D diagnosis in adulthood. However, results are affected by residual confounding warranting further studies.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated insulin delivery in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis 1型糖尿病孕妇自动胰岛素输送：一项系统综述和荟萃分析

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-10 DOI: 10.1007/s00592-025-02446-x

Athina Stamati, Athanasios Christoforidis

{"title":"Automated insulin delivery in pregnant women with type 1 diabetes mellitus: a systematic review and meta-analysis","authors":"Athina Stamati, Athanasios Christoforidis","doi":"10.1007/s00592-025-02446-x","DOIUrl":"10.1007/s00592-025-02446-x","url":null,"abstract":"<div><h3>Aims</h3>To assess the efficacy and safety of automated insulin delivery (AID) systems compared to standard care in managing glycaemic control during pregnancy in women with Type 1 Diabetes Mellitus (T1DM).<h3>Methods</h3>We searched MEDLINE, Cochrane Library, registries and conference abstracts up to June 2024 for randomized controlled trials (RCTs) and observational studies comparing AID to standard care in pregnant women with T1DM. We conducted random effects meta-analyses for % of 24-h time in range of 63–140 mg/dL (TIR), time in hyperglycaemia (> 140 mg/dl and > 180 mg/dL), hypoglycaemia (< 63 mg/dl and < 54 mg/dL), total insulin dose (units/kg/day), glycemic variability (%), changes in HbA1c (%), maternal and fetal outcomes.<h3>Results</h3>Thirteen studies (450 participants) were included. AID significantly increased TIR (Mean difference, MD 7.01%, 95% CI 3.72–10.30) and reduced time in hyperglycaemia > 140 mg/dL and > 180 mg/dL (MD – 5.09%, 95% CI – 9.41 to – 0.78 and MD – 2.44%, 95% CI – 4.69 to – 0.20, respectively). Additionally, glycaemic variability was significantly reduced (MD – 1.66%, 95% CI – 2.73 to – 0.58). Other outcomes did not differ significantly.<h3>Conclusion</h3>AID systems effectively improve glycaemic control during pregnancy in women with T1DM by increasing TIR and reducing hyperglycaemia without any observed adverse short-term effects on maternal and fetal outcomes.</div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 4","pages":"441 - 452"},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00592-025-02446-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk. 内脏脂肪组织与代谢健康状况和心血管疾病风险的年龄特异性和性别特异性关联

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-10 DOI: 10.1007/s00592-025-02447-w

Wenhao Zhang, Xiaoyu Su, SiHua Liu, Tong Yue, Zhixin Tu, Hongqiang Zhang, Chenghua Li, Haifeng Yao, Jumei Wang, Xueying Zheng, Sihui Luo, Yu Ding

{"title":"Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk.","authors":"Wenhao Zhang, Xiaoyu Su, SiHua Liu, Tong Yue, Zhixin Tu, Hongqiang Zhang, Chenghua Li, Haifeng Yao, Jumei Wang, Xueying Zheng, Sihui Luo, Yu Ding","doi":"10.1007/s00592-025-02447-w","DOIUrl":"https://doi.org/10.1007/s00592-025-02447-w","url":null,"abstract":"Background: Visceral adipose tissue (VAT) is known to play a role in the development of metabolic and cardiovascular disease (CVD). However, the age- and sex-specific associations between VAT and these diseases remain unclear.Methods: In this cross-sectional study, 1,150 participants (39.5% women; mean age 61.5 years) underwent VAT measurement using dual abdominal bioelectrical impedance analysis (BIA). The four age groups that the participants were divided into were 18-44, 45-59, 60-74, and ≥ 75 years. The relationships between VAT and cardiometabolic outcomes were analyzed by age and sex using multivariable logistic regression.Results: Significant associations between VAT and metabolic health status were observed in middle-aged (45-59 years; OR = 1.41, 95% CI: 1.04-1.92) and elderly adults (60-74 years; OR = 1.45, 95% CI: 1.10-1.92). VAT demonstrated age-dependent relationships with cardiovascular risk factors, with the strongest associations found in the 60-74 years group for hypertension (OR: 1.55, 95% CI: 1.22-1.98) and low high-density lipoprotein cholesterol (OR: 1.66, 95% CI: 1.33-2.08). Notably, the VAT-CVD association was most pronounced in elderly women (60-74 years; OR: 1.86, 95% CI: 1.14-3.11), while no significant associations were observed in men across all age groups.Conclusions: The impact of VAT on metabolic and cardiovascular disease risk varies by age and sex, with particularly strong associations observed in elderly women. This highlights the need for tailored prevention and treatment strategies.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS). 衰弱指数与新发糖尿病的关系：来自中国健康与退休纵向研究（CHARLS）

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-06 DOI: 10.1007/s00592-024-02441-8

Lisha Zhang, Chao Chu, Yan Zhang, Man Wang

{"title":"Association of frailty index with new-onset diabetes: from the China Health and Retirement Longitudinal Study (CHARLS).","authors":"Lisha Zhang, Chao Chu, Yan Zhang, Man Wang","doi":"10.1007/s00592-024-02441-8","DOIUrl":"https://doi.org/10.1007/s00592-024-02441-8","url":null,"abstract":"Background: To investigate the association of frailty status and its changes with new-onset diabetes.Methods: A total of 4638 participants from the China Health and Retirement Longitudinal Study (CHARLS) were included. Frailty status was assessed by the frailty index (FI) and categorized as robust, pre-frail, and frail. Changes in frailty were assessed based on frailty status at wave1 and wave3 of CHARLS. New-onset diabetes was identified by self-reported physician-diagnosed or diagnosed by glucose or glycosylated haemoglobin during follow-up period. Logistic regression was used to examine the association of frailty and outcomes.Results: 51.6%, 38.1% and 10.3% of the individuals were respectively classified as robust, pre-frail, and frail at baseline. The risk of new-onset diabetes was significantly higher in the pre-frailty [odds ratio (OR) (95% confidence interval (CI)): 1.326 (1.101-1.597), p = 0.003)] and frailty [OR(95% CI): 1.721 (1.304-2.271), p < 0.001)] than the robust. A total of 3145 participants were included in the changes of frailty status analyses. Compared with the stable robust individuals, individuals who developed from robust to frailty status [OR (95%CI): 3.752 (1.647-8.547), p = 0.002] had an elevated risk of new-onset diabetes. In addition, participants who ever had a robust status in the two surveys had a significantly lower risk of new-onset diabetes compared to those who never had a robust status [OR (95%CI) 0.666 (0.483-0.920), p = 0.014)].Conclusion: Frailty status is significantly associated with the risk of new-onset diabetes. The progression from robust to frailty or pre-frailty increased the risk of new-onset diabetes.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel antimicrobial strategies for diabetic foot infections: addressing challenges and resistance 糖尿病足感染的新型抗菌策略：解决挑战和耐药性。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-01-06 DOI: 10.1007/s00592-024-02438-3

Fahaad Alenazi, Mohd Shahid Khan

{"title":"Novel antimicrobial strategies for diabetic foot infections: addressing challenges and resistance","authors":"Fahaad Alenazi, Mohd Shahid Khan","doi":"10.1007/s00592-024-02438-3","DOIUrl":"10.1007/s00592-024-02438-3","url":null,"abstract":"<div><h3>Aims</h3>This review examines the challenges posed by Diabetic Foot Infections (DFIs), focusing on the impact of neuropathy, peripheral arterial disease, immunopathy, and the polymicrobial nature of these infections. The aim is to explore the factors contributing to antimicrobial resistance and assess the potential of novel antimicrobial treatments and drug delivery systems in improving patient outcomes.<h3>Method</h3>A comprehensive analysis of existing literature on DFIs was conducted, highlighting the multifactorial pathogenesis and polymicrobial composition of these infections. The review delves into the rise of antimicrobial resistance due to the overuse of antimicrobials, biofilm formation, and microbial genetic adaptability. Additionally, it considers glycemic control, patient adherence, and recurrence rates as contributing factors to treatment failure. Emerging therapies, including new antimicrobial classes and innovative drug delivery systems, were evaluated for their potential efficacy.<h3>Results</h3>DFIs present unique treatment challenges, with high rates of antimicrobial resistance and poor response to standard therapies. Biofilm formation and the genetic adaptability of pathogens worsen resistance, complicating treatment. Current antimicrobial therapies are further hindered by poor glycemic control and patient adherence, leading to recurrent infections. Novel antimicrobial classes and innovative delivery systems show promise in addressing these challenges by offering more targeted, effective treatments. These new approaches aim to reduce resistance and improve treatment outcomes.<h3>Conclusion</h3>DFIs remain a clinical challenge due to their multifactorial nature and antimicrobial resistance. The development of novel antimicrobials and drug delivery systems is crucial to improving patient outcomes and combating resistance. Future research should focus on enhancing treatment efficacy, reducing resistance, and addressing patient adherence to reduce the burden of DFIs.</div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 3","pages":"303 - 321"},"PeriodicalIF":3.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0