Acta Diabetologica最新文献

{"title":"High serum EDA concentration is associated with metabolic syndrome and its determinants.","authors":"Xia Deng, Yanyan Li, Tian Gu, Xunan Wu, Ziyan Sun, Haoxiang Li, Ling Yang, Guoyue Yuan","doi":"10.1007/s00592-024-02408-9","DOIUrl":"https://doi.org/10.1007/s00592-024-02408-9","url":null,"abstract":"<p><strong>Background: </strong>Ectodysplasin A (EDA) is a novel hepatokine that plays a role in multiple metabolic-related diseases. The aim of this study was to investigate the association between serum EDA levels and metabolic syndrome (MetS).</p><p><strong>Methods: </strong>A total of 348 subjects, 258 patients with MetS and 90 healthy controls were enrolled. Serum EDA levels were measured using an enzyme-linked immunosorbent assay (ELISA). The correlation between EDA and various metabolic components was assessed.</p><p><strong>Results: </strong>The serum EDA levels of subjects with metabolic syndrome (MetS) were significantly higher than those without [323.78 (259.68-400.74) vs. 254.82 (182.68-347.88) pg/mL, P < 0.001]. The serum EDA level increases with the increase in metabolic score. The linear regression model revealed that age, blood pressure, fasting insulin (FIns), high-density lipoprotein cholesterol (HDL-C), and HOMA-IR were independent factors influencing EDA levels. Furthermore, in the logistic regression model, subjects in the highest tertile of EDA had a significantly higher risk of MetS, higher blood pressure, hyperglycemia, and lower HDL-C compared to those in the lowest tertile. This conclusion remained valid after adjusting for multiple confounding factors.</p><p><strong>Conclusions: </strong>The research results for the first time found that the circulating EDA levels in patients with metabolic syndrome were significantly elevated and associated with hypertension, hyperglycemia, lower HDL-C, and insulin resistance risk, indicating that EDA may play a role in the occurrence of metabolic syndrome and may be a potential therapeutic target for metabolic syndrome.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The irreversible, towards fatalic neuropathy: from the genesis of diabetes","authors":"Bhaskar Pal,&nbsp;Rashmi Ghosh,&nbsp;Raktimava Das Sarkar,&nbsp;Gouranga Sundar Roy","doi":"10.1007/s00592-024-02429-4","DOIUrl":"10.1007/s00592-024-02429-4","url":null,"abstract":"<div><p>Diabetic neuropathy is the most prevalent diabetes-associated complication that negatively impacts the quality of life of the patients. The extensive complications of diabetic peoples in the world are the leading cause of neuropathic pain, and over-activation of different biochemical signalling process induces the pathogenic progression and are also corresponding the epidemic painful symptom of diabetic neuropathy. The main prevalent abnormality is neuropathy, which further causing distal symmetric polyneuropathy and focal neuropathy. The exact pathological complication of diabetes associated neuropathic algesia is still unclear, but the alteration in micro-angiopathy associated nerve fibre loss, hyper polyol formation, MAPK signalling, WNT signalling, tau-derived insulin signalling processes are well known. Furthermore, the post-translational modification of different ion channels, oxidative and nitrosative stress, brain plasticity and microvascular changes can contributes the development of neuropathic pain. However, in the current review we discussed about these pathogenic development of neuropathic pain from the genesis of diabetes, and how diabetes affects the physiological and psychological health, and quality of life of the patients. Furthermore, the treatment of diabetic neuropathy with conventional monotherapy and emerging therapy are discussed. In addition, the treatment with phytochemical constituents their mechanisms and clinical evidences are also reported. The future investigation is required on pathological alteration occurs in neuropathic individuals, and on molecular mechanisms as well as the adverse effect of phytochemicals to determine all aspects of neuropathic algesia including effective treatments, which will prevents the sympathetic pain in patients.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 2","pages":"139 - 156"},"PeriodicalIF":3.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes with the pregestational use of Minimed 780G compared to Minimed 640G: findings from a multicenter cohort study.","authors":"Verónica Perea, Carmen Quirós, María Teresa Herrera-Arranz, Sharona Azriel-Mira, Ana M Wägner, Pilar Beato-Vibora, Berta Soldevila, Beatriz Barquiel, Rosa Márquez Pardo, Gonzalo Díaz-Soto, Maria José Picón, Natalia Colomo, Judit Amigó, Elisenda Climent, María Durán-Martínez, Rosa Corcoy, Mercedes Codina, Martín Cuesta, Begoña Vega Guedes, Irene Vinagre","doi":"10.1007/s00592-024-02430-x","DOIUrl":"https://doi.org/10.1007/s00592-024-02430-x","url":null,"abstract":"<p><strong>Aim: </strong>To compare glycemic control and maternal-fetal outcomes of women with type 1 diabetes (T1D) using Minimed™ 780G (MM780G) with those women using Minimed™ 640G (MM640G) since before pregnancy.</p><p><strong>Methods: </strong>Multicenter prospective cohort study of pregnant women with T1D in Spain. We evaluated HbA1c, time spent within (TIRp), below (TBRp) and above (TARp) the pregnancy-specific glucose range 3.5-7.8 mmol/L (63-140 mg/dL) and glucose variability (CV).</p><p><strong>Results: </strong>Sixty-nine women were included (MM780G n = 40). At baseline, MM640G users had higher rates of severe hypoglycemia before pregnancy, without other between-group differences. The MM780G group had higher TIRp and lower TARp, TBRp and CV, but similar HbA1c in the first trimester of gestation. TBRp and CV remained significantly higher in the MM640G group throughout pregnancy. Higher HbA1c was observed in the MM780G group compared to the MM640G (6.28 ± 0.53% [45.1 ± 5.8 mmol/mol] vs. 5.97 ± 0.62 [41.8 ± 6.8], p = 0.003) in the second trimester. There were no differences in the mean change in HbA1c from the first to the third trimester of gestation between groups. MM780G users were more likely to have large-for-gestational-age infants (OR_adjusted 4.85, 95% CI 1.46-16.13, p = 0.010), macrosomia (OR_adjusted 12.17, 95% CI 1.49-99.72, p = 0.020) and cesarean section (OR_adjusted 4.19, 95% CI 1.34-13.11, p = 0.014) than the MM640G group.</p><p><strong>Conclusions: </strong>Pregestational use of MM780G led to an initial improvement in TIRp, but this was not sustained in the second and third trimesters, with a 4-fold increased risk of delivering a LGA infant and undergoing cesarean section compared to MM640G users.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.","authors":"Sheng-Xue Yu, Hong Dan Yu, Yu-Fei Wang, Tie-Feng Yao, Song-Ze Lv, Yan-Chuan Wang, Jun-Qi Li, Wen-Qiang Liu, Jia-Yuan Ding, Xue-Zheng Liu, Zhong-Fu Zuo, Wan-Peng Liu","doi":"10.1007/s00592-024-02384-0","DOIUrl":"https://doi.org/10.1007/s00592-024-02384-0","url":null,"abstract":"<p><strong>Background: </strong>Diabetic encephalopathy (DE) is one of the most serious complications of diabetes mellitus (DM), and its pathogenesis has not yet been clarified. Th22 cells are a newly discovered class of CD4⁺ T cells that play important roles in inflammatory, autoimmune and infectious diseases. However, it is unclear whether Th22 cells are involved in the pathogenesis of DE.</p><p><strong>Methods: </strong>We established a T2DM mouse model in vivo and cocultured Th22 cells with microglia under high glucose (HG) conditions in vitro. Cognitive dysfunction was evaluated using the Morris water maze (MWM) test; blood‒brain barrier (BBB) integrity was evaluated using the Evans blue (EB) extravasation assay; Th22 cells and IL-22 receptors were detected by immunofluorescence; and IL-1β, TNF-α, iNOS, CD86, Arg-1, and CD206 protein expression was measured by Western Blot (WB) analysis.</p><p><strong>Results: </strong>Th22 cells passed through the BBB into the hippocampus and secreted interleukin-22 (IL-22), and the mice subsequently exhibited decreased learning and memory abilities. In the DE model, IL-22 promoted the transformation of homeostatic microglia into reactive microglia as well as the inflammatory response. Additionally, coculture of Th22 cells with BV2 microglia cultured under HG conditions increased the production of proinflammatory cytokines, and the microglia showed reactive changes. Mechanistically, IL-22Rα1 acted as a ligand, and IL-22 bound to IL-22Rα1 on microglia to drive primary microglia-induced inflammatory responses. Interestingly, interleukin-22 binding protein (IL-22BP) directly binds to IL-22Rα1 on microglia to inhibit the proinflammatory effects of IL-22.</p><p><strong>Conclusion: </strong>Th22 cells secrete IL-22 after passing through the BBB into the hippocampus and promote the transformation of homeostatic microglia into reactive microglia, which induces an inflammatory response, exacerbates learning and memory impairment and cognitive deficits, and contributes to and accelerates the development of DE.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated insulin delivery systems for the management of insulin therapy in post-transplant diabetes mellitus: a case series from a single center population.","authors":"Valeria Grancini, Irene Cogliati, Alessia Gaglio, Carlo Alfieri, Giuseppe Castellano, Emanuela Orsi, Veronica Resi","doi":"10.1007/s00592-024-02419-6","DOIUrl":"https://doi.org/10.1007/s00592-024-02419-6","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tight and stable glucose control is associated with better prognosis in patients hospitalized for Covid-19 and pneumonia.","authors":"Amelia Caretto, Gaetano Di Terlizzi, Erika Pedone, Renato Pennella, Francesco De Cobelli, Moreno Tresoldi, Marina Scavini, Emanuele Bosi, Andrea Laurenzi","doi":"10.1007/s00592-024-02409-8","DOIUrl":"https://doi.org/10.1007/s00592-024-02409-8","url":null,"abstract":"<p><strong>Aims: </strong>To investigate possible associations of glucose patterns with outcomes of Corona Virus Disease 19 (COVID-19) using continuous glucose monitoring (CGM) in 43 patients hospitalized for COVID-19 mild-to-moderate pneumonia, regardless of diabetes.</p><p><strong>Methods: </strong>Prospective observational study conducted during two pandemic waves in 2020-2021. Glucose sensor metrics of 7-day recording were obtained from blinded CGM. Respiratory function was evaluated as arterial partial pressure of oxygen (PaO₂) to fraction of inspired oxygen (FiO₂) ratio (PaO₂:FiO₂).</p><p><strong>Results: </strong>PaO₂:FiO₂ ratio was positively correlated with time in tight range (TITR) 70-140 (r = 0.49, p < 0.001) and time in range (TIR) 70-180 (r = 0.32, p < 0.05), and negatively correlated with average glucose (r =- 0.31, p < 0.05), coefficient of glucose variation (CV) (r =- 0.47, p < 0.01) and time above range (TAR) > 140 (r =- 0.49, p < 0.001). No relations were observed with HbA1c. Multivariate regression analysis showed that normal respiratory function at time of CGM removal correlated positively with TITR 70-140 mg/dL (p < 0.01), negatively with CV and TAR > 140 mg/dL (both p < 0.05) and not with TIR 70-180 and average glucose.</p><p><strong>Conclusions: </strong>Lower glucose variability and optimal glucose control, expressed as CV and TITR, are CGM metrics predictive of a better prognosis in COVID-19 patients with pneumonia.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the night-time effectiveness in achieving glycemic targets in adults with type 1 diabetes of three advanced hybryd closed-loop systems.","authors":"Nicolò Diego Borella, Antonio Ferramosca, Giona Castagna, Silvia Ippolito, Sara Ceresoli, Antonio Taverna, Beatrice Sonzogni, Roberto Trevisan, Giuseppe Lepore","doi":"10.1007/s00592-024-02397-9","DOIUrl":"https://doi.org/10.1007/s00592-024-02397-9","url":null,"abstract":"<p><strong>Context: </strong>Advanced hybrid closed loop (AHCL) systems currently represent the most advanced modality of insulin therapy.</p><p><strong>Aim: </strong>To compare the night-time (from 00 to 07 a.m.) effectiveness in achieving recommended glycemic targets of three different AHCL systems in adults with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>We retrospectively evaluated 55 adults with T1D (mean age 41 ± 16 years, male 40%, diabetes duration 19.4 ± 11.4 years, BMI 24.1 ± 4.1 kg/m²) with similar glycemic control (GMI 7.0-7.4%). Twenty-two participants were using the Minimed 780G system, 18 the Tandem t:slim X2 with Control-IQ system and 15 the DBLG1 system. Continuous glucose monitoring derived metrics and insulin requirement of 14 consecutive nights were analyzed.</p><p><strong>Results: </strong>All three groups achieved the recommended mean TIR > 70%, mean TBR < 4%, and mean CV < 36% with a similar insulin requirement (Minimed 780G system: TIR 73.9 ± 11.2%, TBR 0.9 ± 1.2%, CV 29 ± 6.7%; Tandem t:slim X2 with Control-IQ system: TIR 74.1 ± 11.1%, TBR 1.1 ± 1.0%, CV 34.5 ± 6.6%; DBLG1 System TIR 71.7 ± 11.3%, TBR 1.4 ± 3.7%, CV 32.4 ± 7.1%). Tight TIR% (70-140 mg/dl) was significantly higher (p < 0.01) in the Tandem t:slim X2 with Control-IQ group (51.5 ± 9.8%) when compared to Minimed 780G group (42.1 ± 13.7%) and DBLG1 System (40.1 ± 10.5%). In all three groups the insulin infusion similarly decreased from midnight to 05.00 am and then increased.</p><p><strong>Conclusions: </strong>All the three AHCL systems achieved the recommended TIR, TBR and CV without difference in insulin requirement. The Tandem Control-IQ system obtained a higher tight TIR.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular disease and severe COVID-19 outcomes in UKBiobank participants with diabetes","authors":"Claire Tochel,&nbsp;Justin Engelmann,&nbsp;Ylenia Giarratano,&nbsp;Baljean Dhillon,&nbsp;Roly Megaw,&nbsp;Miguel O. Bernabeu","doi":"10.1007/s00592-024-02420-z","DOIUrl":"10.1007/s00592-024-02420-z","url":null,"abstract":"<div><h3>Aims</h3><p>Early in the COVID-19 pandemic, evidence emerged suggesting that people with diabetic retinopathy (DR) or other microvascular diseases had greater risk of severe short-term outcomes. This study evaluated longer-term outcomes, providing more generalisable evidence.</p><h3>Methods</h3><p>We identified a cohort of UKBiobank participants with diabetes and retrieved their diagnostic codes for a variety of microvascular diseases, complications of diabetes and systemic comorbidities. We investigated relationships between diagnoses and the study outcome: admission to Critical Care or death from COVID-19, taking age, sex and diabetes duration into account. We tested relationships, adding baseline covariates and weighting diagnostic codes according to their recency prior to COVID-19 diagnosis.</p><h3>Results</h3><p>In univariate analyses, DR (OR: 1·519, <i>p</i> = 0·016) and microvascular disease (OR: 2·001, <i>p</i> = 0·000) were associated with greater risk of the outcome. In multivariate analyses, as expected, respiratory disease was most strongly associated with the study outcome, microvascular disease second. Adjusting analyses by number of admissions (general health proxy) and weighted diagnostic coding (comorbidity severity at COVID-19 diagnosis indicator), did not improve predictive power of the model.</p><h3>Conclusions</h3><p>The presence of microvascular disease in routinely-collected healthcare data predicts risk of COVID-19 severe outcomes, independently of general health, in a cohort of people with diabetes.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 3","pages":"293 - 301"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00592-024-02420-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome analysis of serum extracellular vesicles in gestational diabetes patients","authors":"Chih-Jung Chang,&nbsp;Yu-Ci Bai,&nbsp;Hong Jiang,&nbsp;Qi-Wen Ma,&nbsp;Cheng-Hsien Hsieh,&nbsp;Chien-Chun Liu,&nbsp;Hung-Chien Huang,&nbsp;Tien-Jui Chen","doi":"10.1007/s00592-024-02358-2","DOIUrl":"10.1007/s00592-024-02358-2","url":null,"abstract":"<div><h3>Aim</h3><p>Gestational Diabetes Mellitus (GDM) is among the most common complications during pregnancy, posing serious risks to both the patient’s and offspring’s health and well-being. Alterations in the maternal microbiome are closely associated with the pathogenesis of GDM, with Extracellular Vesicles (EVs) facilitating communication between microbiota and the host. However, little is known about the relationship between the microbial composition within EVs and the pathogenesis of GDM. Therefore, this study aims to characterize the microbiota within serum EVs of GDM Patients (GDM group) and to identify microbial communities that significantly differ from those in Women With Normal Pregnancies (NonGDM group).</p><h3>Methods</h3><p>Blood samples were collected from both groups of patients, and EVs derived from serum were isolated via centrifugation. Identification and characterization of EVs were performed using transmission electron microscopy and nanoparticle flow cytometry. Microbiome analysis of serum EVs from both groups was conducted using 16S rRNA sequencing.</p><h3>Results</h3><p>Results indicated altered diversity in microbial communities within serum EVs of GDM patients. Further analysis at the phylum, family, genus, and species levels revealed that <i>Proteobacteria</i>, <i>Actinobacteria</i>, <i>Bacteroidetes</i>, and <i>Firmicutes</i> were the dominant taxa in the EVs of both the NonGDM and GDM groups. Specifically, <i>Actinobacteria</i> and <i>Firmicutes</i> showed increased relative abundance in GDM group EVs compared to NonGDM, leading to a higher <i>Firmicutes</i>/<i>Bacteroidetes</i> ratio, while <i>Proteobacteria</i> and <i>Bacteroidetes</i> exhibited decreased relative abundance. Tax4Fun analysis revealed enrichment of microbial functions related to amino acid metabolism, carbohydrate metabolism, energy metabolism, and metabolism of cofactors and vitamins in both patient groups.</p><h3>Conclusion</h3><p>In conclusion, this study reveals a potential correlation between changes in the microbial composition and diversity of serum EVs and the onset and development of GDM. Furthermore, changes in the relative abundance of <i>Actinobacteria</i>, <i>Proteobacteria</i>, <i>Bacteroidetes</i>, and <i>Firmicutes</i> may play an important role in the pathogenesis of GDM.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 3","pages":"329 - 341"},"PeriodicalIF":3.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of remnant cholesterol with progression and regression of prediabetes in middle-aged and older adults: a nationwide cohort study.","authors":"Jinyan Jiang, Meichen Chen, Ran Li, Jifang Zhu, Fang Qin, Qian Peng","doi":"10.1007/s00592-024-02416-9","DOIUrl":"https://doi.org/10.1007/s00592-024-02416-9","url":null,"abstract":"<p><strong>Background: </strong>The relationship between remnant cholesterol (RC) and outcome of patients with prediabetes remains unclear. This study aims to explore the association between dynamic changes in RC and progression to diabetes or regression to normal blood glucose in pre-diabetic population through a nationwide cohort study.</p><p><strong>Methods: </strong>Based on the China Health and Retirement Longitudinal Study (CHARLS), 2304 participants aged 45 years or older (58.60 ± 8.04 years) who participated in two surveys in 2011 and 2015 were included. Participants were divided into 3 groups according to the tertiles of dynamic changes in RC levels between the two surveys (Q1: ≤ - 1.59, Q2: - 1.59-12.73, Q3: ≥ 12.73, mmol/L). Multivariate Logistic regression models were used to analyze the association of the dynamic changes in RC and the progression and regression of prediabetes. Restricted cubic splines were used to analyze the dose-response relationship between RC and dynamic changes in RC and progression in the prediabetic population.</p><p><strong>Results: </strong>During follow-up, 522 (22.30%) participants developed diabetes, 1283 (54.8%) participants remained prediabetic, and 536 (22.9%) participants regressed to normoglycemia. Further analysis of dynamic changes in RC revealed that reducing RC levels during follow-up reduced the risk of developing diabetes (OR = 0.76, 95% CI: 0.58-0.99, P = 0.04). However, compared with people with increased RC levels, people with prediabetes and stable RC levels are more likely to return to normal blood glucose (OR = 1.45,95% CI: 1.12-1.88, P = 0.005). In the pre-diabetic population, there was non-linear dose-response relationship between the level of RC and dynamic change in RC and the risk of developing diabetes (P nonlinearity < 0.001).</p><p><strong>Conclusion: </strong>Our findings revealed a substantial and non-linear association between dynamic change in RC levels and the outcome of prediabetes. Decreased RC level were associated with reduced risk of progression to diabetes in prediabetes.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}