Relationships between atherogenic index of plasma and body mass index with the risk of type 2 diabetes mellitus: insights from CHARLS.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-05-07 DOI:10.1007/s00592-025-02516-0

Genghang Chen, Shaonan Liu, Wenwei Ouyang, Lihong Yang, Yu Chen, Xinfeng Guo

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引用次数: 0

Abstract

Background: The complex relationship between obesity and dyslipidemia in type 2 diabetes mellitus (T2DM) remains an area of interest but is not fully understood. This study aimed to evaluate the intricate links between atherogenic index of plasma (AIP), body mass index (BMI), and T2DM risk.

Methods: Based on data from the China Health and Retirement Longitudinal Study, this analysis comprised 6754 individuals aged 45 and over, free of T2DM in 2011. BMI and AIP were the exposures, with T2DM incidence as the primary focus. Logistic regression models generated odds ratios (ORs), and a thorough decomposition of BMI's impact on T2DM revealed natural indirect and direct effects. The study also examined the complex interactions and combined effects of these two exposures.

Results: By the end of 2018, 972 individuals were diagnosed with T2DM. The AIP played a significant association in the relationship between BMI and T2DM, explaining 21.7% and 18.9% of the association in different BMI ranges. A significant additive effect was observed between BMI and AIP, with a relative excess risk due to interaction of 0.62. BMI ≥ 24.0 kg/m² and AIP above the median together conferred the highest risk of T2DM, with an OR of 2.31 and a 95% confidence interval (CI) of 1.92-2.79.

Conclusion: Exposure to overweight/obesity or high AIP raises T2DM risk among Chinese ≥ 45 years, AIP partly mediates BMI-T2DM link.

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血浆动脉粥样硬化指数和体重指数与2型糖尿病风险的关系：CHARLS的见解

背景：肥胖和2型糖尿病（T2DM）血脂异常之间的复杂关系仍然是一个令人感兴趣的领域，但尚未完全了解。本研究旨在评估血浆动脉粥样硬化指数（AIP）、体重指数（BMI）和T2DM风险之间的复杂联系。方法：基于中国健康与退休纵向研究的数据，该分析纳入了6754名年龄在45岁及以上、2011年无2型糖尿病的个体。BMI和AIP是暴露点，T2DM发病率是主要焦点。Logistic回归模型生成优势比（or），并对BMI对T2DM的影响进行彻底分解，揭示了自然的间接和直接影响。该研究还检查了这两种暴露的复杂相互作用和综合影响。结果：截至2018年底，有972人被诊断为T2DM。AIP在BMI与T2DM的关系中发挥了显著的关联作用，在不同BMI范围内分别解释了21.7%和18.9%的关联。BMI和AIP之间存在显著的加性效应，相互作用导致的相对过量风险为0.62。BMI≥24.0 kg/m2和AIP高于中位值共同赋予T2DM的最高风险，OR为2.31,95%可信区间（CI）为1.92-2.79。结论：在年龄≥45岁的中国人中，超重/肥胖或高AIP暴露会增加2型糖尿病的风险，AIP在一定程度上介导了bmi - 2型糖尿病的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.