Association between nailfold capillaroscopic findings and diabetes: a systematic review and meta-analysis.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-05-07 DOI:10.1007/s00592-025-02520-4

Wanling He, Mengjing Zhang, Runxin Mao, Chaoying Han, Lili Shi, Huiqun Wu

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引用次数: 0

Abstract

Purpose: People with diabetes often experience abnormal microcirculation, which can lead to various complications. This study aimed to investigate the relevance of nailfold capillaroscopy-a non-invasive imaging modality-in characterizing microvascular alterations specific to diabetes mellitus (DM).

Methods: PubMed, Web of Science, and Baidu Academic were searched for relavant studies that investigated the associations between nailfold microcirculation abnormalities and DM. The quality of included studies was assessed using the National Institutes of Health (NIH) Quality Assessment tool for Observational Cohort and Cross-Sectional Studies. Meta-analysis was conducted to assess the relationship of various nailfold capillaroscopic findings with DM, and subgroup analysis was used to explore heterogeneity.

Results: Ten studies with 1,423 participants were included. The quality of two studies was rated as Good, one as Poor, and the other seven were rated as Normal. The pooled analysis revealed significant correlations between various nailfold capillaroscopic findings and DM, including tortuosity (odds ratio [OR] 8.33, 95% confidence interval [CI]: 2.31-30.04), abnormal morphology (OR 5.00, 95% CI 3.03-8.26), ectasia (OR 4.86, 95% CI 2.56-9.20), bushy capillaries (OR 29.09, 95% CI 5.90-143.55), hemorrhage (OR 5.33, 95% CI 2.31-12.34), avascular areas (OR 6.14, 95% CI 1.40-26.86), bizarre capillaries (OR 10.33, 95% CI 2.79-38.31), and meander capillaries (OR: 2.84, 95% CI 1.25-6.45). Subgroup analysis showed strong associations between nailfold capillaroscopic findings and type 2 diabetes mellitus (T2DM).

Conclusion: Our findings demonstrated that distinct nailfold capillary abnormalities aresignificantly correlated with DM, particularly T2DM.

Protocol registration: Protocol registered in PROSPERO (registration number: CRD42024608214).

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甲襞毛细血管镜检查结果与糖尿病之间的关系：一项系统综述和荟萃分析。

目的：糖尿病患者经常出现微循环异常，导致各种并发症。本研究旨在探讨甲襞毛细血管镜-一种非侵入性成像方式-在糖尿病（DM）特异性微血管改变特征中的相关性。方法：检索PubMed、Web of Science和百度Academic中有关甲襞微循环异常与糖尿病相关性的相关研究。采用美国国立卫生研究院（NIH）观察性队列和横断面研究质量评估工具对纳入研究的质量进行评估。采用meta分析评估各种甲襞毛细血管镜检查结果与糖尿病的关系，并采用亚组分析探讨异质性。结果：纳入10项研究，1423名参与者。两项研究的质量被评为良好，一项为差，其他七项被评为正常。合并分析显示各种甲襞毛细血管镜检查结果与DM（包括扭曲）之间存在显著相关性（优势比[OR] 8.33, 95%可信区间[CI]）：2.31-30.04)、形态异常（OR 5.00, 95% CI 3.03-8.26）、扩张（OR 4.86, 95% CI 2.56-9.20）、浓密毛细血管（OR 29.09, 95% CI 5.90-143.55）、出血（OR 5.33, 95% CI 2.31-12.34）、无血管区（OR 6.14, 95% CI 1.40-26.86）、奇异毛细血管（OR 10.33, 95% CI 2.79-38.31）和弯曲毛细血管（OR 2.84, 95% CI 1.25-6.45）。亚组分析显示甲襞毛细血管镜检查结果与2型糖尿病（T2DM）有很强的相关性。结论：我们的研究结果表明，明显的甲襞毛细血管异常与糖尿病，特别是2型糖尿病有显著的相关性。协议注册：协议在PROSPERO注册（注册号：CRD42024608214）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.