Acta Diabetologica最新文献

{"title":"Metabolic challenges of glucose and lipid dysregulation in psoriatic arthritis: a narrative review from pathogenesis to clinical practice.","authors":"Mauro Fatica, Sara Ferrigno, Eneida Çela, Arianna D'Antonio, Paola Conigliaro, Marina Cardellini, Susanna Longo, Massimo Federici, Maria Sole Chimenti","doi":"10.1007/s00592-025-02565-5","DOIUrl":"https://doi.org/10.1007/s00592-025-02565-5","url":null,"abstract":"<p><p>Emerging evidence highlights a complex interconnection between metabolic dysfunction and chronic inflammation in psoriatic arthritis (PsA), positioning glucose and lipid abnormalities not only as comorbidities but as active contributors to disease pathogenesis. In fact, rather than being incidental findings, conditions such as insulin resistance, atherogenic dyslipidemia, and visceral obesity interact with the immune system, amplifying inflammatory circuits and promoting joint and systemic damage. This review delves into the metabolic dimension of PsA, shedding light on how pro-inflammatory cytokines and adipokine imbalances reshape glucose and lipid homeostasis. Special attention is given to molecular pathways, such as impaired insulin signaling and altered lipid uptake, that link systemic inflammation to cardiometabolic risk. Furthermore, we examine the impact of these metabolic alterations in clinical practice and how antirheumatic therapies might improve metabolic balance and promote long-term cardiovascular protective effects. By unraveling these interactions, we aim to provide new insights into the clinical management of PsA and underscore the need for integrated therapeutic strategies that address both inflammation and metabolic health.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulforaphane inhibits cardiac fibrosis induced by advanced glycation end product-receptor axis through its anti-oxidative property","authors":"Takanori Matsui,&nbsp;Tatsuya Sakaguchi,&nbsp;Yuichiro Higashimoto,&nbsp;Yuri Nishino,&nbsp;Ami Sotokawauchi,&nbsp;Yoshinori Koga,&nbsp;Sho-ichi Yamagishi","doi":"10.1007/s00592-025-02545-9","DOIUrl":"10.1007/s00592-025-02545-9","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"62 9","pages":"1569 - 1572"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of use and value for different types of digital health solutions among people with type 1 and 2 diabetes in France.","authors":"Norbert Hermanns, Paco Cerletti, Julie Laurent, Renza Scibilia, Sören Skovlund","doi":"10.1007/s00592-025-02564-6","DOIUrl":"https://doi.org/10.1007/s00592-025-02564-6","url":null,"abstract":"<p><strong>Aims: </strong>This study examines the use, perceptions, and inequalities in access to Digital Health Solutions (DHS) among people with diabetes (PwD). It aims to identify factors influencing adoption and explore perceived benefits and barriers to using DHS, focusing on person-important outcomes such as physical health, mental burden, and access to care.</p><p><strong>Methods: </strong>The primary objective of this feasibility study was to assess the intervention acceptability, feasibility, and app usability. The secondary aim is to explore preliminary intervention effects.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted in France from April to July 2022. A total of 301 PwD (149 with type 1 diabetes [T1D], 152 with type 2 diabetes [T2D]) completed the study. The survey assessed the use of three DHS categories: information/education (DHS1), self-management support (DHS2), and data-sharing/collaborative care (DHS3). We used univariate and multivariate logistic regression to identify predictors of DHS use, including demographic, socioeconomic, psychological, and medical variables.</p><p><strong>Results: </strong>DHS1 was the most commonly used category, followed by DHS2 and DHS3. PwD with T1D were more likely to use multiple DHS. Type of diabetes and perceived health status were the strongest predictors of DHS use. Surprisingly, people in poorer health were less likely to use DHS despite potentially benefiting most from them. DHS-naïve individuals expected more benefits but reported greater concerns, especially about information overload and data security. These concerns were stronger than the perceived benefits. For example, concerns about data security reduced the likelihood of using DHS2 and DHS3 by up to 89%.</p><p><strong>Conclusion: </strong>The study highlights disparities in DHS adoption and the critical role of perceived barriers. Addressing these concerns-particularly among PwD in poorer health-and aligning DHS with outcomes that matter to patients may improve equitable adoption and diabetes care.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, safety, and legal considerations of do-it-yourself artificial pancreas systems: a position statement from italian diabetes societies.","authors":"Concetta Irace, Roberta Assaloni, Angelo Avogaro, Riccardo Candido, Valentino Cherubini, Sara Coluzzi, Ilaria Dicembrini, Paolo Di Bartolo, Sergio Di Molfetta, Roberto Franceschi, Elena Frattolin, Valeria Grancini, Vincenzo Guardasole, Daniela Marcello, Matteo Neri, Stefano Nervo, Ivana Rabbone, Alessandro Rapellino, Antonietta Maria Scarpitta, Davide Tinti, Maddalena Trombetta, Angela Zanfardino, Andrea Scaramuzza","doi":"10.1007/s00592-025-02559-3","DOIUrl":"https://doi.org/10.1007/s00592-025-02559-3","url":null,"abstract":"<p><p>Do-It-Yourself Artificial Pancreas Systems (DIY-APS)-which combine commercially available devices with open-source software-are increasingly used for the management of type 1 diabetes, despite a lack of formal regulatory approval in many jurisdictions, including in Italy. This position statement, endorsed by Italian diabetes societies (Associazione Medici Diabetologici, Societa Italiana di Diabetologia, and Società Italiana di Endocrinologia e Diabetologia Pediatrica) and \"Diabete Italia\", the national patient association, addresses the efficacy, safety, and legal implications of DIY-APS in Italy. Real-world evidence and clinical trials demonstrate that DIY-APS improves glycemic control and quality of life and reduce fear of hypoglycemia in users. This statement outlines the reasons driving patient adoption of DIY-APS, including limitations of commercial systems and the need for greater personalization. It emphasizes the ethical responsibility of healthcare professionals to support patients using DIY-APS while acknowledging the legal complexities surrounding their unregulated use. The statement concludes with recommendations to enhance education for patients and healthcare professionals and advocates for clearer regulatory pathways to ensure patient safety and optimize care.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with non-automated insulin pumps or multiple daily injections during pregnancy and post-delivery in women with type 1 diabetes: A secondary analysis of the CopenFast trial.","authors":"Katrine Christiansen, Sidse K Nørgaard, Kirsten Nørgaard, Tine D Clausen, Peter Damm, Elisabeth R Mathiesen, Lene Ringholm","doi":"10.1007/s00592-025-02560-w","DOIUrl":"https://doi.org/10.1007/s00592-025-02560-w","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate pregnancy and post-delivery outcomes with non-automated insulin pumps or multiple daily injections (MDI) in women with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>A preplanned secondary analysis of the CopenFast trial including women with T1D using continuous glucose monitoring (CGM), primarily intermittently scanned CGM, routinely. Pregnancy and post-delivery outcomes were compared between insulin pump users and MDI users. Insulin pump settings during pregnancy and post-delivery were compared to pre-pregnancy.</p><p><strong>Results: </strong>Of 141 women, 39 used non-automated insulin pumps and 102 used MDI. Median diabetes duration was 17 (IQR 12-20) vs. 14 (8-21) years (P = 0.12). HbA_1c was 48 (44-53) mmol/mol vs. 47 (42-53) at 9 weeks (P = 0.65) and 43 (40-46) vs. 43 (39-46) at 35 weeks (P = 0.53). Mean sensor glucose decreased from ~ 7.0 mmol/l at 9 weeks to 6.3 mmol/l at 33 weeks in both groups. Preterm delivery (< 37 weeks) was more common with insulin pumps (25.9% vs. 16.7%, P = 0.01), as was caesarean section (59% vs. 40%, P = 0.04), which was independent of diabetes duration, age and microvascular complications. At 1 and 3 months post-delivery, maternal and infant outcomes, including breastfeeding, were similar between groups. In insulin pump users, basal insulin rates were ~ 37% higher, and carbohydrate-to-insulin ratios ~ 61% lower at 33 weeks while basal insulin rates were ~ 20% lower, and carbohydrate-to-insulin ratios were similar 3 months post-delivery, compared to pre-pregnancy.</p><p><strong>Conclusion: </strong>Despite routine use of CGM and similar glycaemic control, non-automated insulin pump users did not achieve improved pregnancy outcomes compared to MDI users.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual pathway inhibition versus antiplatelet therapy for \"symptomatic\" lower-extremities peripheral artery disease in diabetes mellitus: a systematic review and a meta-analysis of randomized controlled trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome.","authors":"Giuseppe Murdolo, Francesco Gaggia, Eleonora Bianchini, Matteo Monami, Cesare Miranda, Luca Monge, Luigi Uccioli, Mauro Gargiulo, Alessia Scatena, Germano Scevola, Eugenio Stabile, Cristiana Vermigli","doi":"10.1007/s00592-025-02562-8","DOIUrl":"https://doi.org/10.1007/s00592-025-02562-8","url":null,"abstract":"<p><strong>Background and aims: </strong>Dual pathway inhibition (DPI) with aspirin and low-dose rivaroxaban (LDR) has shown benefits in reducing major adverse cardiovascular (MACEs) and limb (MALEs) events in patients with lower extremity peripheral artery disease (LE-PAD). This study aimed to determine whether DPI is preferable to anti-platelet therapy alone in reducing adverse outcomes in diabetic patients with \"symptomatic\" LE-PAD and to assess the safety of DPI, specifically bleeding risks. The findings aim to support development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome.</p><p><strong>Methods: </strong>A Medline and Embase search was conducted through October 31, 2024, to identify RCTs comparing DPI with anti-platelet therapy in diabetic patients with symptomatic LE-PAD. Key efficacy outcomes included MALEs, MACE, and a composite of cardiovascular death, myocardial infarction, ischemic stroke, acute limb ischemia, and major amputation. Safety outcomes primarily focused on major bleeding and fatal/critical organ bleeding. Mantel-Haenzel odds ratios and 95% confidence intervals (MH-OR, 95%CI) were calculated.</p><p><strong>Results: </strong>From a total 153 items retrieved, 4 studies were assessed for eligibility; however only one study met the inclusion criteria for efficacy and safety outcomes component of the review. Due to lack of disaggregated data, efficacy and safety outcomes were estimated indirectly through proportional calculations. DPI demonstrated a reduced risk of MALEs [MH-OR 0.52; (95% CI 0.26-1.06)], MACE or MALE [MH-OR 0.67; (95% CI 0.45-1.00)], and the overall composite (MH-OR 0.70 [95% CI, 0.46-1.05]) compared to aspirin alone. A similar pattern was observed for MACE [MH-OR 0.70; (95% CI 0.44-1.11)]. While DPI did not significantly increase the risk of major or fatal/critical organ bleeding, a trend towards lower major bleeding rate in favor of aspirin was found. The net clinical benefit favored DPI (MH-OR 0.55 [95%CI, 0.36-0.84]).</p><p><strong>Conclusions: </strong>In diabetic patients with symptomatic LE-PAD, LDR plus aspirin is preferable to aspirin alone in reducing cardiovascular and limb outcomes, with acceptable bleeding risk.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucokinase activators contribute to gastrointestinal disease risks through metabolic-immune interplay in the gut-liver axis: insights from a multi-omics study.","authors":"Yunlan Zhou, Bingqian Zhou, Xing Ke, Yanhui Ma","doi":"10.1007/s00592-025-02571-7","DOIUrl":"https://doi.org/10.1007/s00592-025-02571-7","url":null,"abstract":"<p><strong>Aims: </strong>Glucokinase activators (GKAs) lower glucose by directly activating glucokinase (GK) or dissociating it from GK regulatory protein (GK-GKRP). Their long-term effects on gastrointestinal (GI) diseases remain unclear. This study explores how two approaches influence GI disorders through metabolic-immune interplay.</p><p><strong>Methods: </strong>We used genetic variants near GCK and GCKR associated with fasting glucose as proxies for direct GK activation and GK-GKRP dissociation. Using Mendelian Randomization and meta-analysis, we assessed their associations with 20 GI diseases and explored mediation by lipid traits and inflammatory proteins (pQTL). MR-prioritized lipid and immune mediators underwent multi-omics analysis including functional enrichment, protein-protein interaction networks, single-cell RNA sequencing (scRNA-seq) and Cellchat in disease models, investigating metabolic-immune interactions and intercellular signaling.</p><p><strong>Results: </strong>Direct GK activation and GK-GKRP dissociation exerted distinct causal effects on GI diseases. GK-GKRP dissociation increased risks of irritable bowel syndrome, Crohn's disease, ulcerative colitis, beyond its established association with metabolic dysfunction-associated steatotic liver disease (MASLD). Lipid traits and inflammatory proteins interconnected through PPAR and NF-κB signaling, mediating GCKR's associations with GI diseases. Key mediators such as FGF-21, CSF1, CD40, CXCL9 were localized to disease-specific niches in MASLD and IBD scRNA-seq models, highlighting GCKR-centered metabolic-immune crosstalk. Intercellular communication via CSF, CXCL, CCL, TGFβ, Visfatin, Galectin, and MIF signaling linked immune, parenchymal, and stromal cells in disease pathogenesis.</p><p><strong>Conclusions: </strong>GK-GKRP dissociation, but not direct GK activation, increases IBD and MASLD risks through metabolic-immune interplay in gut-liver axis. Tailoring GKA therapies for patients with comorbidities is essential.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart insulin pen after pancreatectomy: a successful strategy for managing type 3c diabetes.","authors":"Miriam Longo, Michela Petrizzo, Paola Caruso, Maria Ida Maiorino, Katherine Esposito","doi":"10.1007/s00592-025-02567-3","DOIUrl":"https://doi.org/10.1007/s00592-025-02567-3","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of tricarboxylic acid cycle-related diagnostic biomarkers for diabetic nephropathy via weighted gene co-expression network analysis and single-cell transcriptome analysis.","authors":"Xuelin He, Yichen Wu, Guanghui Ying, Min Xia, Qien He, Zhaogui Chen, Qiao Zhang, Li Liu, Xia Liu, Yongtao Li","doi":"10.1007/s00592-025-02557-5","DOIUrl":"https://doi.org/10.1007/s00592-025-02557-5","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is a prevalent and serious complication of diabetes, characterized by high incidence and significant morbidity. Despite growing evidence that the tricarboxylic acid (TCA) cycle plays a crucial role in DN progression, the diagnostic potential of TCA-related genes has yet to be fully explored.</p><p><strong>Methods: </strong>This study began by analyzing the GSE131882 dataset to reveal the expression patterns of TCA-related genes in various renal cell types and to identify genes that differ in expression between high and low subgroups. The GSE30122 dataset was then examined to identify genes with differential expression in DN. Single-sample gene set enrichment analysis (ssGSEA) and weighted gene co-expression network analysis (WGCNA) were applied to pinpoint TCA-related gene modules. Following this, multiple machine learning techniques were employed to analyze the TCA gene set that showed differential expression at both cellular and sample levels, allowing us to identify the hub genes. A diagnostic model was constructed, with its effectiveness validated through ROC analysis. The immune landscape of DN was assessed using ssGSEA. GeneMANIA and NetworkAnalyst were also utilized to predict genes with similar functions, as well as miRNAs and transcription factors (TFs) that may regulate these diagnostic genes. Finally, single-cell RNA sequencing (scRNA-seq) data confirmed the expression patterns of these genes.</p><p><strong>Results: </strong>Two TCA-related genes, HPGD and G6PC, were identified as potential diagnostic markers for DN. ROC analysis demonstrated that these genes and their predictive model exhibited strong diagnostic performance in both training and validation cohorts. Immune landscape analysis revealed a more active immune microenvironment in DN patients compared to controls. Additionally, 59 miRNAs and 15 TFs were predicted to regulate the expression of HPGD and G6PC, along with 20 functionally related genes. scRNA-seq data highlighted that HPGD and G6PC are predominantly expressed in glomerular and proximal tubular cells.</p><p><strong>Conclusion: </strong>Two reliable TCA-related biomarkers were pinpointed, potentially advancing early diagnosis and management of DN.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary investigation on the association of dietary total antioxidant capacity, alternative healthy eating index, and dietary inflammatory index with intestinal microbiota in patients with diabetic nephropathy.","authors":"Fatemeh Zali, Solaleh Emamgholipour, Akram Vatannejad, Seyed Dawood Mousavi Nasab, Abdorrahim Absalan, Hanieh-Sadat Ejtahed, Ensieh Nasli-Esfahani, Nayebali Ahmadi, Seyed Davar Siadat, Parvin Pasalar, Farideh Razi, Fataneh Esmaeili","doi":"10.1007/s00592-025-02568-2","DOIUrl":"https://doi.org/10.1007/s00592-025-02568-2","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is one of the most abundant microangiopathy complications among diabetic patients. Gut dysbiosis and the correlation with dietary factors in diabetic participants is undeniable. This study aims to evaluate the alteration of intestinal microbiota and its association with dietary indices, including dietary total antioxidant capacity (dTAC), dietary inflammatory index (DII), and alternative healthy eating index (AHEI) scores among healthy controls (HC) and diabetic participants with and without DN.</p><p><strong>Methods: </strong>The participants were categorized into type 2 diabetes mellitus (T2DM) group, DN group, and HC group. The intestinal microbiota was assessed using a quantitative real-time polymerase chain reaction (qPCR) method targeting the bacterial 16 S rRNA gene. Dietary data were obtained using a 168-item semi-quantitative food frequency questionnaire (FFQ).</p><p><strong>Results: </strong>A higher level of Escherichia, Prevotella, Facalibacterium, and Bacteroides was observed among the HC group than the T2DM and DN individuals. Higher AHEI was observed in the DN group than T2DM group. Lower DII was seen among the T2DM group compared to the HC and DN groups. dTAC index had no significant differences between the studied groups. Furthermore, in the HC group, dTAC showed a marginally significant positive correlation with Bacteroides. dTAC was negatively correlated with Lactobacillus in T2DM subjects. In the whole studied population, a marginally significant positive correlation between Prevotella and dTAC and DII was observed.</p><p><strong>Conclusions: </strong>Alterations in the intestinal microbiota were observed in participants suffering from T2DM and DN. Furthermore, some intestinal microbiota were associated with AHEI, DII, and dTAC dietary indices.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}