Acta Diabetologica最新文献

{"title":"Comment to the letter to the editor “Gremlin-1 in pregnancy and postpartum: health risk monitoring of women with gestational diabetes mellitus” by Tamayuki Kawada, published in Acta Diabetologica as a comment to the publication “Gremlin-1 in pregnancy and postpartum: relation to the fatty liver index, markers of bone health, glucose metabolism and gestational diabetes mellitus status”","authors":"Carola Deischinger, Jürgen Harreiter","doi":"10.1007/s00592-023-02200-1","DOIUrl":"10.1007/s00592-023-02200-1","url":null,"abstract":"","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 1","pages":"137 - 138"},"PeriodicalIF":3.1,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54227270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of subclinical left ventricular myocardial systolic dysfunction in type 2 diabetes mellitus patients with and without diabetes peripheral neuropathy by global myocardial work","authors":"Guang-An Li,&nbsp;Hui-Ling Bai,&nbsp;Jun Huang,&nbsp;Qi-Yong Wu,&nbsp;Li Fan","doi":"10.1007/s00592-023-02197-7","DOIUrl":"10.1007/s00592-023-02197-7","url":null,"abstract":"<div><h3>Aims</h3><p>Speckle-tracking echocardiography can non-invasively estimate myocardial work (MW) to evaluate left ventricular (LV) myocardial systolic function. The present study evaluated whether MW may detect subclinical LV myocardial systolic dysfunction in type 2 diabetes mellitus (T2DM) patients with and without diabetes peripheral neuropathy (DPN).</p><h3>Methods</h3><p>A total of 127 T2DM patients were included in the present study, including 67 T2DM patients with DPN. In addition, 73 sex- and age- matched healthy individuals served as normal controls. The global myocardial work index (GWI), global constructive work (GCW), global waste work (GWW), global positive work (GPW), global negative work (GNW), global work efficiency (GWE) and GCW/GWW were measured and analysed. Furthermore, the differences in MW parameters among normal controls, T2DM patients, and T2DM patients with DPN were analysed. Multiple regression models were built to explore for the independent influencing factors of GWI and GPW values in T2DM patients with DPN. Receiver operating characteristic curve analysis was performed to evaluate the sensitivity and specificity of MW in evaluating subclinical LV myocardial systolic dysfunction in T2DM patients with DPN.</p><h3>Results</h3><p>The GWI, GCW and GPW of T2DM patients with DPN were significantly decreased compared with those of T2DM patients and normal controls (<i>P</i> &lt; 0.001) and showed a significant decreasing trend overall (<i>P</i> _trend &lt; 0.001). GWE and GCW/GWW were significantly decreased in T2DM patients with DPN compared with normal controls (<i>P</i> &lt; 0.05). Although GWW was not significantly different among the three groups, it showed an increasing trend (<i>P</i>_trend = 0.033). High-density lipoprotein cholesterol (HDL-C) levels were independent influencing factor for decreased GWI (β = 0.21, <i>P</i> = 0.031) and GPW (β = 0.19, <i>P</i> = 0.043) values in T2DM patients with DPN. The combination of the GWI, GCW, GWE, GPW and GCW /GWW had good sensitivity (62.69%) and specificity (89.04%) when evaluating subclinical LV myocardial systolic dysfunction in T2DM patients with DPN.</p><h3>Conclusions</h3><p>Non-invasive evaluation of LV myocardial work can detect subclinical LV myocardial systolic dysfunction in T2DM patients with and without DPN. DPN has additive deleterious effects on LV myocardial systolic function in T2DM patients. The reduction of HDL-C levels may indicate the occurrence of subclinical LV myocardial systolic dysfunction in T2DM patients with DPN.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 3","pages":"309 - 319"},"PeriodicalIF":3.1,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early lung diffusion abnormalities and airways’ inflammation in children with type 1 diabetes","authors":"Pierachille Santus,&nbsp;Marina Saad,&nbsp;Elisa Giani,&nbsp;Maurizio Rizzi,&nbsp;Chiara Mameli,&nbsp;Maddalena Macedoni,&nbsp;Stefano Pini,&nbsp;Laura Saderi,&nbsp;Moufida Ben Nasr,&nbsp;Ida Pastore,&nbsp;Maria Elena Lunati,&nbsp;Gian Vincenzo Zuccotti,&nbsp;Giovanni Sotgiu,&nbsp;Paolo Fiorina,&nbsp;Dejan Radovanovic","doi":"10.1007/s00592-023-02182-0","DOIUrl":"10.1007/s00592-023-02182-0","url":null,"abstract":"<div><h3>Background and aims of the study</h3><p>Type 1 diabetes (T1D) impacts lung function and exercise capacity in adults, but limited information is available in children. We hypothesize that T1D causes alterations in pulmonary function and cardiorespiratory fitness, i.e., exercise capacity, at early stages of the disease, due to the presence of inflammation and vascular damage. Therefore, we aim to investigate pulmonary function before and after exercise in children with T1D as compared to age matched healthy controls.</p><h3>Method</h3><p>Twenty-four children with T1D and twenty healthy controls underwent body plethysmography, diffusion lung capacity for carbon monoxide and fractional exhaled nitric oxide at rest and after cardio-pulmonary exercise test.</p><h3>Results</h3><p>In children with T1D, baseline total lung capacity and diffusion lung capacity for carbon monoxide were reduced as compared to healthy controls. Children with T1D also showed a reduced exercise capacity associated with poor aerobic fitness. Accordingly, diffusion lung capacity for carbon monoxide tended to increase with exercise in healthy controls, while no change was observed in children with T1D. Fractional exhaled nitric oxide was significantly higher at baseline and tended to increase with exercise in children with T1D, while no changes were observed in healthy controls.</p><h3>Conclusions</h3><p>Altered diffusion lung capacity for carbon monoxide, increased fractional exhaled nitric oxide and a poor aerobic fitness to exercise suggests the presence of early pulmonary abnormalities in children with T1D.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 3","pages":"289 - 295"},"PeriodicalIF":3.1,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of diabetes self-care activities in patients with type 2 diabetes based on self-determination theory","authors":"Hassan Okati-Aliabad,&nbsp;Athare Nazri-Panjaki,&nbsp;Mahdi Mohammadi,&nbsp;Elham Nejabat,&nbsp;Alireza Ansari-Moghaddam","doi":"10.1007/s00592-023-02186-w","DOIUrl":"10.1007/s00592-023-02186-w","url":null,"abstract":"<div><h3>Aims</h3><p>In type 2 diabetes control, self-management is an effective way to minimize the risk of developing complications and improve the quality of life. Self-determination theory (SDT) proposed a promising explanatory framework to predict self-regulated behavior which was particularly relevant for self-management. This study aimed to investigate whether SDT constructs can affect the self-management and controlling glycated hemoglobin A1c (HbA1c) levels in type 2 diabetic patients or not.</p><h3>Methods</h3><p>This cross-sectional study was conducted from August to December 2022 at two diabetes clinics in Zahedan. The study included 300 patients with type 2 diabetes. Data collection was done using a researcher-administrated questionnaire that included demographic data, diabetes self-care activities, and self-determination constructs including autonomous support, autonomous motivation, and perceived competence.</p><h3>Results</h3><p>The mean of the overall score of self-care activities was 34.62 ± 11.86 out of a maximum of 70. Patients in the fourth quarter (wealthiest) of the socioeconomic status had the highest mean self-care score (<i>P</i> = 0.003). There was a significant relationship between diet score with perceived competence (<i>P</i> = 0.009). Perceived competence (<i>P</i>&lt;0.001) and controlled self-regulation (<i>P</i>&lt;0.001) were the predictors of exercise score in diabetes patients. Independent self-regulation (<i>P</i>&lt;0.001, <i>r</i> = 0.21) and overall self-regulation (<i>P</i> = 0.001, <i>r</i> = 0.19) were significantly related to blood-glucose testing score. There was a significant relationship between foot care score with perceived competence (<i>P</i> = 0.048, <i>r</i> = 0.11) and autonomous support (<i>P</i> = 0.013, <i>r</i> = 0.14). Multiple regression showed that exercise was the predictor of HbA1c (<i>P</i> = 0.014).</p><h3>Conclusion</h3><p>Exercise is crucial for achieving good individualized glycemic control and reducing the risk of diabetes complications. The findings provided valuable insights into the determinants of self-care activities in patients with type 2 diabetes and underscore the need for interventions that address socioeconomic disparities, enhance perceived competence, and provide autonomy support to improve diabetes self-care.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 3","pages":"297 - 307"},"PeriodicalIF":3.1,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher circulating levels of non-esterified fatty acids are associated with faster kidney function decline in post-menopausal women with type 2 diabetes: a pilot prospective study","authors":"Alessandro Mantovani,&nbsp;Alessandro Csermely,&nbsp;Davide Cappelli,&nbsp;Antonio Taverna,&nbsp;Elena Sani,&nbsp;Emigela Shtembari,&nbsp;Micol Pagani,&nbsp;Giovanni Targher","doi":"10.1007/s00592-023-02198-6","DOIUrl":"10.1007/s00592-023-02198-6","url":null,"abstract":"<div><h3>Aims</h3><p>Currently, there is little and inconsistent evidence regarding the possible adverse effects of circulating levels of non-esterified fatty acids (NEFA) on kidney function decline in patients with type 2 diabetes mellitus (T2DM).</p><h3>Methods</h3><p>We followed for a median of 4.6 years 85 post-menopausal women with non-insulin-treated T2DM and preserved kidney function at baseline. Serum NEFA concentrations were measured using an enzymatic colorimetric method. Glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.</p><h3>Results</h3><p>Enrolled patients had a baseline mean eGFR_CKD-EPI of 83 ± 12 mL/min/1.73 m² and a median serum NEFA concentration of 662 uEq/L (interquartile range 524–842 uEq/L). During the follow-up period, 13 patients developed kidney function decline at follow-up (defined as an eGFR_CKD-EPI decline ≥ 30% from baseline). In Cox proportional hazards regression analyses, higher serum NEFA levels were significantly associated with an increased risk of developing kidney function decline (adjusted-hazard ratio 3.67, 95% CI 1.64–8.22, <i>p</i> &lt; 0.001; for each 1-SD increment, i.e., 262 uEq/L), even after adjustment for waist circumference, hemoglobin A1c, C-reactive protein, HOMA-estimated insulin resistance, hypertension, dyslipidemia, microalbuminuria, baseline eGFR_CKD-EPI, as well as temporal changes in HbA1c levels or the use of renin-angiotensin system inhibitors over the follow-up.</p><h3>Conclusions</h3><p>The findings of this exploratory prospective study show that in post-menopausal women with T2DM and preserved kidney function at baseline, higher circulating levels of NEFA were strongly associated with a faster kidney function decline, even after adjustment for established renal risk factors and potential confounders.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 3","pages":"281 - 288"},"PeriodicalIF":3.1,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In blood we trust: anemia as a negative healing prognostic factor in diabetic foot patients","authors":"Francesco Giangreco,&nbsp;Elisabetta Iacopi,&nbsp;Vittorio Malquori,&nbsp;Letizia Pieruzzi,&nbsp;Chiara Goretti,&nbsp;Alberto Piaggesi","doi":"10.1007/s00592-023-02188-8","DOIUrl":"10.1007/s00592-023-02188-8","url":null,"abstract":"<div><h3>Aim</h3><p>Anemia has been associated with severity of diabetic foot (DF) disease. Our study aimed to evaluate whether the presence of anemia could decrease the healing chances in DF.</p><h3>Methods</h3><p>We retrospectively analyzed all patients admitted in our department in 2021 for DF, dividing them according to presence (Group A) or absence (Group B) of anemia. Groups were compared for clinical and demographic characteristics, procedures and outcomes: healing rate (HR) at 6 months, healing time (HT) and recurrence rate (RR) at 12 months.</p><h3>Results</h3><p>We sorted out data from 196 consecutive patients: 114 (58%) in Group A and 82 (42%) in B. Group A had a higher male prevalence and a longer duration of disease. Group A showed lower hemoglobin concentration (10.3 ± 1.3 g/dL vs 13.1 ± 1.4 g/dL, <i>p</i> &lt; 0.002) and red blood cells count (3.4 ± 0.5 × 10⁶/mL vs 4.8 ± 0.6 × 10⁶/mL, <i>p</i> = 0.004). Group A presented a lower HR (55.2% vs 76.8%, <i>p</i> = 0.0028), no differences in HT and a higher RR (23.6% vs 17.1%, <i>p</i> &lt; 0.02). Cox’s logistic regression on healing confirmed the negative impact of anemia: hazard ratio 2.8 (CI 95% 1.4–5.4, <i>p</i> = 0.0037).</p><h3>Conclusions</h3><p>Anemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 2","pages":"245 - 251"},"PeriodicalIF":3.1,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1RAs inhibit the activation of the NLRP3 inflammasome signaling pathway to regulate mouse renal podocyte pyroptosis","authors":"Xiang Li,&nbsp;Xiao Jiang,&nbsp;Mei Jiang,&nbsp;Zhi-feng Wang,&nbsp;Tao Zhao,&nbsp;Si-ming Cao,&nbsp;Qiu-Mei Li","doi":"10.1007/s00592-023-02184-y","DOIUrl":"10.1007/s00592-023-02184-y","url":null,"abstract":"<div><h3>Objective</h3><p>Podocytes are closely related to renal function as an important part of the glomerulus. The reduction and damage of podocytes lead to further decline of renal function and aggravate the progression of DKD. Glucagon-like peptide-1 receptor agonists (GLP-1RAS) have recently attracted great attention in improving podocyte dysfunction, but the specific mechanism remains uncertain.</p><h3>Methods</h3><p>We used mouse kidney podocyte MPC5 to construct a high-glucose injury model. Cell viability was detected by the MTT method; RT-qPCR and western blotting were used to detect the expressions of NF-κB p65, NLRP3, GSDMD, N-GSDMD, caspase-1 and cleaved-caspase-1, and we used ELISA to detect the expressions of inflammatory factors IL-1β and IL-18.</p><h3>Results</h3><p>Our results showed that high glucose decreased podocyte survival, while liraglutide and semaglutide increased podocyte survival under high glucose. Liraglutide and semaglutide can inhibit the expression of pyroptosis-related genes and proteins and also inhibit the expression of inflammatory factors IL-1β, IL-18 increase.</p><h3>Conclusion</h3><p>The protective effect of liraglutide and semaglutide on podocytes may be achieved by regulating the NLRP3 inflammasome pathway and inhibiting pyroptosis, and there were no significant differences between the two GLP-1RAs (liraglutide and semaglutide) in inhibiting podocyte pyroptosis.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 2","pages":"225 - 234"},"PeriodicalIF":3.1,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family structures and parents’ occupational models: its impact on children’s diabetes","authors":"Pauline Schlarb,&nbsp;Janina M. Büttner,&nbsp;Sascha R. Tittel,&nbsp;Kirsten Mönkemöller,&nbsp;Esther Müller-Godeffroy,&nbsp;Claudia Boettcher,&nbsp;Angela Galler,&nbsp;Gabriele Berger,&nbsp;Burkhard Brosig,&nbsp;Reinhard W. Holl","doi":"10.1007/s00592-023-02187-9","DOIUrl":"10.1007/s00592-023-02187-9","url":null,"abstract":"<div><h3>Aims</h3><p>This study examines how family-related factors influence the management of children and adolescents with type 1 diabetes (T1DM). We investigate the relationship between family patterns, parental work schedules and metabolic control.</p><h3>Materials and methods</h3><p>We analysed data from a nationwide diabetes survey (DPV) focusing on HbA1c, severe hypoglycaemia, diabetic ketoacidosis, hospital admissions and inpatient treatment duration. We used linear regression and negative binomial regression models. Our study includes 15,340 children under the age of 18 with data on family structure and parental division of labour.</p><h3>Results</h3><p>Children from two-parent households have better HbA_1c outcomes than children from single-parent, blended or no-parent households (<i>p</i> &lt; .0001). Higher HbA_1C levels are associated with children living with an unemployed father, as opposed to those with full-time working parents or with a full-time working father and a part-time working mother (<i>p</i> &lt; .001).</p><h3>Conclusions</h3><p>These findings emphasise the importance of carefully considering family structure and working time models in the management of paediatric T1DM. Our results highlight risk factors within the family environment and emphasise the need for family-focused counselling of high-risk patients or severe cases in clinical practice.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 2","pages":"235 - 244"},"PeriodicalIF":3.1,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality's impact on children with type 1 diabetes: a proof-of-concept randomized cross-over trial on anxiety, pain, adherence, and glycemic control","authors":"Noah Gruber,&nbsp;Moran Shemesh-Iron,&nbsp;Ethel Kraft,&nbsp;Karen Mitelberg,&nbsp;Elinor Mauda,&nbsp;Michal Ben-Ami,&nbsp;Kineret Mazor-Aronovitch,&nbsp;Yael Levy-Shraga,&nbsp;Neriya Levran,&nbsp;Noah Levek,&nbsp;Eyal Zimlichman,&nbsp;Orit Pinhas-Hamiel","doi":"10.1007/s00592-023-02195-9","DOIUrl":"10.1007/s00592-023-02195-9","url":null,"abstract":"<div><h3>Aims</h3><p> Assess the effectiveness of virtual reality (VR) technology, in reducing pain and anxiety, and improving adherence and glycemic control among children with type 1 diabetes (T1D).</p><h3>Methods</h3><p>Children with T1D, managed with continuous glucose monitoring and insulin pumps, were recruited for a randomized cross-over trial. Children were randomized to one of two interventions for diabetes management: group 1 used VR glasses first and group 2 listened to vocal-guided affective imagery first (audio). After 1 month, the interventions were crossed over. The outcome measures included pain and anxiety assessment, adherence, glycemic control, and patient-reported outcome measures (PROMs) of VR satisfaction and effectiveness.</p><h3>Results</h3><p> Forty children, mean age 11.4 ± 1.8 years, were participated. During the VR part, the monthly mean pain score compared to the baseline improved in both groups by 30% (<i>p</i> = 0.03). A 14% reduction in the state anxiety score was observed from baseline to 1 month in both groups (<i>p</i> = 0.009). Glycemic control measures including time in range, time above range, and glucose management indicator improved in both groups during VR part (<i>p</i> &lt; 0.004 for all), compared to audio part. After one month, the patient-reported outcome measure (PROM) of satisfaction and effectiveness was sixfold higher after 1 month in group 1 compared to group 2 (<i>p</i> = 0.002). Adherence improved for both groups.</p><h3>Conclusions</h3><p>VR was shown to be effective in reducing pain and anxiety, improving adherence, PROM, and glycemic control among children with T1D. We suggest incorporating VR technology in pediatric diabetes clinics to facilitate and improve coping and management of diabetes.</p><h3>Trial registration</h3><p>Trial registration number and date of registration for prospectively registered trials:ClinicalTrials.gov Identifier: NCT05883267, May 10th, 2023.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 2","pages":"215 - 224"},"PeriodicalIF":3.1,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect between pre-pregnancy smoking and assisted reproductive technology on gestational diabetes mellitus in twin pregnancies","authors":"Lingyu Zhang,&nbsp;Yan Huang,&nbsp;Mingjin Zhang,&nbsp;Yanqi Jin","doi":"10.1007/s00592-023-02183-z","DOIUrl":"10.1007/s00592-023-02183-z","url":null,"abstract":"<div><h3>Aim</h3><p>Women with twin pregnancies have an increased risk of gestational diabetes mellitus (GDM). Assisted reproductive technology (ART) and pre-pregnancy smoking were both associated with GDM. However, the relationships between pre-pregnancy smoking and ART and GDM in twin pregnancies were unclear. Herein, this study aims to explore the roles of pre-pregnancy smoking and ART in GDM among women with twin pregnancies.</p><h3>Methods</h3><p>Data of women with twin pregnancies were extracted from the National Vital Statistics System (NVSS) database in 2016–2020 in this retrospective cohort study. Univariate and multivariate logistic regression analyses were used to explore the associations between pre-pregnancy smoking and ART and GDM in women with twin pregnancies. The evaluation index was odds ratios (ORs) with 95% confidence intervals (CIs). Subgroup analysis of age and BMI was also performed.</p><h3>Results</h3><p>A total of 19,860 (9.15%) women had GDM in our study. After adjusting for covariates, we found that receiving ART was associated with high odds of GDM [OR = 1.41, 95% CI (1.34–1.48)], while pre-pregnancy smoking combined with ART was associated with higher odds of GDM [OR = 1.66, 95% CI (1.14–2.42)]. In addition, these relationships were also found in women who aged ≥ 35 years old [OR = 1.98, 95% CI (1.14–3.44)] and with BMI ≥ 25 kg/m² [OR = 1.69, 95% CI (1.11–2.55)].</p><h3>Conclusion</h3><p>Pre-pregnancy smoking may further increase the risk of GDM from ART in women with twin pregnancies. In clinical, women who are ready to receive ART treatment are recommend to quit smoking, which may reduce the risk of GDM and prevent adverse pregnancy outcomes.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 2","pages":"205 - 214"},"PeriodicalIF":3.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}