Acta Diabetologica最新文献_第4页

Diabetes prevalence and management patterns in US adults, 2001-2023. 2001-2023年美国成人糖尿病患病率和管理模式

IF 2.9 3区医学

Acta Diabetologica Pub Date : 2025-07-30 DOI: 10.1007/s00592-025-02572-6

Miaojin Hu, Michael H Le, Yee Hui Yeo, Karn Wijarnpreecha, Alisa Likhitsup, Donghee Kim, Vincent L Chen

{"title":"Diabetes prevalence and management patterns in US adults, 2001-2023.","authors":"Miaojin Hu, Michael H Le, Yee Hui Yeo, Karn Wijarnpreecha, Alisa Likhitsup, Donghee Kim, Vincent L Chen","doi":"10.1007/s00592-025-02572-6","DOIUrl":"https://doi.org/10.1007/s00592-025-02572-6","url":null,"abstract":"Background: Diabetes is a leading cause of morbidity and mortality in the United States. We aimed to characterize secular trends in diabetes prevalence, control of glucose and associated comorbidities, and medication use.Methods: This was a retrospective analysis of National Health and Nutrition Examination Series data from 2001 to 2023. We focused on three outcomes: (1) prevalence of diabetes defined by known diagnosis, hemoglobin A1c ≥ 6.5%, or fasting glucose ≥ 126 mg/dL, and among individuals with diabetes (2) control of glucose levels, low-density lipoprotein, and blood pressure and (3) medication therapy. Predictors were cycle (year) and demographics, specifically age, sex, race/ethnicity, educational level, and household income.Results: We included 27,437 participants of whom 3467 had diagnosed diabetes and an additional 1602 had undiagnosed diabetes. Diabetes prevalence increased from 10.0% in 2001-2002 to 15.1% in 2021-2023 and was higher in men versus women, and Hispanic/Latino or non-Hispanic Black vs. non-Hispanic White participants. Glycemic control declined over time, from 61.5 to 44.9% having hemoglobin A1c < 7% in 2001-2002 vs. 2021-2023; control was lower in younger participants and those with lower educational attainment. Lipid control improved over time but remained poor: 73.1% had low-density lipoprotein ≥ 70 mg/dL in 2017-2020, and only half of these individuals were taking a statin. There were no significant changes over time in blood pressure control, with 44-56% having blood pressure ≥ 130/80 mmHg. Other than lower lipid control in women, we did not observe differences in control of lipids or blood pressure, or in medication treatment, based on sex and race/ethnicity.Discussion: Diabetes has increased in prevalence from 2001 to 2023 and management of hyperglycemia and associated risk factors remains inadequate.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term follow-up of pancreatic islet transplantation in a patient with Wolfram syndrome: a case report. Wolfram综合征患者胰岛移植的长期随访1例。

IF 2.9 3区医学

Acta Diabetologica Pub Date : 2025-07-30 DOI: 10.1007/s00592-025-02558-4

Davide Catarinella, Costanza Festorazzi, Rossana Caldara, Lorenzo Piemonti

引用次数: 0

Striatopathy and stroke in diabetes: insights from two cases and literature review. 糖尿病纹状体病与脑卒中：两例分析及文献复习。

IF 2.9 3区医学

Acta Diabetologica Pub Date : 2025-07-30 DOI: 10.1007/s00592-025-02566-4

Subhankar Chatterjee, Samya Sengupta, Ritwik Ghosh, Shambaditya Das, Alak Pandit, Souvik Dubey

{"title":"Striatopathy and stroke in diabetes: insights from two cases and literature review.","authors":"Subhankar Chatterjee, Samya Sengupta, Ritwik Ghosh, Shambaditya Das, Alak Pandit, Souvik Dubey","doi":"10.1007/s00592-025-02566-4","DOIUrl":"https://doi.org/10.1007/s00592-025-02566-4","url":null,"abstract":"Introduction: There is varied phenotypic presentations of diabetic striatopathy (DS), traditionally characterized by hyperglycemia, acute-onset choreoballism, and/or specific neuroimaging findings. Emerging evidence indicates that DS may coexist with stroke, complicating diagnosis and treatment, as both conditions can influence each other's progression.Materials and methods: Two cases of DS with concurrent stroke at a single center and 15 similar previously published cases have been analyzed. The detailed evaluation included demographics, symptomatology, glycemic data, neuroimaging, management, and prognosis. Appropriate descriptive statistical analyses have been performed.Results: This study demonstrates how stroke symptoms and involuntary movements can coexist and interact. Four distinct phenotypes of the \"stroke-striatopathy model\" have been identified. It raises the possibility of patients with DS being at risk of imminent cerebrovascular events rather than being a mere bystander.Conclusion: The study underscores the necessity for ongoing monitoring of DS patients for potential cerebrovascular incidents and the implications for clinical management and long-term patient outcomes.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time in Tight Range (TITR) stratified by Time Below Range (TBR) in a cohort of patients with type 1 Diabetes Mellitus and Multiple Daily Injections. A real-life study. 在每日多次注射的1型糖尿病患者队列中，紧密范围时间（TITR）按低于范围时间（TBR）分层。一个真实的研究。

IF 2.9 3区医学

Acta Diabetologica Pub Date : 2025-07-30 DOI: 10.1007/s00592-025-02563-7

Sandra Herranz-Antolín, Sofía Ramos-Garrido, Verónica Esteban-Monge, Clara Coton-Batres, María Covadonga López-Virgos, Silvia Lallena-Pérez, Miguel Torralba

{"title":"Time in Tight Range (TITR) stratified by Time Below Range (TBR) in a cohort of patients with type 1 Diabetes Mellitus and Multiple Daily Injections. A real-life study.","authors":"Sandra Herranz-Antolín, Sofía Ramos-Garrido, Verónica Esteban-Monge, Clara Coton-Batres, María Covadonga López-Virgos, Silvia Lallena-Pérez, Miguel Torralba","doi":"10.1007/s00592-025-02563-7","DOIUrl":"https://doi.org/10.1007/s00592-025-02563-7","url":null,"abstract":"Objetive: To analyze the Time in Tight Range (TITR) (70-140 mg/dL) and assess their possible differences according to Time Below Range (TBR) in a cohort of type 1 diabetes mellitus people with Múltiple Daily Injections.Patients and methods: 355 adult users of Continuous Glucose Monitoring (CGM) with at least a HbA1c during the period October 1, 2023-October 1, 2024, and glucose data in the 90 days prior were included.Results: Age 46.9 years (SD 13.6); 57.2% male; time of evolution 21.6 years (SD 12.6). Mean TITR was 38.4% (SD 14.6) and 20.3% had a TITR ≥ 50%. The correlation TITR-TIR was strong (β = 0.83; CI 95% 0.8-0.87; R [2] Adjusted 0.89; p < 0.001) and varied according to TBR [TBR < 4% group (β = 0.81; CI 95% 0.78 to 0.85; R [2] Adjusted 0.9; p < 0.001) vs. TBR ≥ 4% (β = 0.9; CI 95% 0.86 to 0.94; R [2] Adjusted 0.93; p < 0.001)]. The variables independently associated with TITR in patient with TBR < 4% were HbA1c (β = -9.58; CI 95% -10.88 to -8.29; p < 0.001) and Coefficient of Variation (CV) (β = -0.38; CI 95% -0.66 to -0.11; p = 0.007). However, in those with TBR ≥ 4% were male gender (β = 2.86; CI 95% 0.26 to 5.45; p = 0.031), HbA1c (β = -7.53; CI 95% -9.1 to -5.96; p < 0.001) and CV (β = -0.69; CI 95% -1.01 to -0.37; p < 0.001).Conclusions: The correlation between TITR and TIR and the factors that were independently associated with TITR differ depending on the TBR.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drugs used in diabetes, statins and the risk of rhabdomyolysis reporting: a disproportionality analysis in the world health organization's pharmacovigilance database. 用于糖尿病的药物、他汀类药物和横纹肌溶解风险报告：世界卫生组织药物警戒数据库中的不相称性分析。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-07-24 DOI: 10.1007/s00592-025-02550-y

Jean-Louis Montastruc

引用次数: 0

Correction: BFGF alleviates diabetic endothelial dysfunction by downregulating endoplasmic reticulum stress. 更正：BFGF通过下调内质网应激减轻糖尿病内皮功能障碍。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-07-23 DOI: 10.1007/s00592-025-02551-x

Fei Hu, Jie Li, Xin Zhang, Yueyue Fu, Yufei Mao, Songlin Tong, Hongming Xu

引用次数: 0

Correction: Development and validation of prediction model for stage I patients with lower extremity atherosclerotic disease in type 2 diabetes mellitus in China. 修正：中国2型糖尿病I期患者下肢动脉粥样硬化性疾病预测模型的开发和验证。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-07-16 DOI: 10.1007/s00592-025-02541-z

Rong Zhu, Weifeng Cui, Ruixia Zhao, Huijuan Liu, Shuxun Yan, Mingyi Shao, Haibin Yu, Yu Fu

引用次数: 0

The impact of short maternal height on gestational diabetes. 母亲身高过矮对妊娠期糖尿病的影响。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-07-05 DOI: 10.1007/s00592-025-02530-2

Joan Crane, Phil Murphy, Donnette O'Brien

{"title":"The impact of short maternal height on gestational diabetes.","authors":"Joan Crane, Phil Murphy, Donnette O'Brien","doi":"10.1007/s00592-025-02530-2","DOIUrl":"https://doi.org/10.1007/s00592-025-02530-2","url":null,"abstract":"Aims: To evaluate the impact of short maternal height on gestational diabetes, by different body mass index (BMI) classes.Methods: We performed this population-based retrospective cohort study including individuals with singleton pregnancies delivering January 1st 2012 to December 31st 2019 in the Eastern Health region of the province of Newfoundland and Labrador, Canada. We divided maternal height into three groups: < 25% (short height), 25-75% (average height), and > 75% (tall height). We performed univariate and multivariate regression analyses (adjusting for potential confounders identified in univariate analyses) to determine if short height was an independent predictor of gestational diabetes, stratified by BMI class.Results: We assessed 15,803 pregnancies, with 1062 (6.7%) experiencing gestational diabetes. Among all BMI categories combined, short height was an independent predictor of gestational diabetes (OR = 1.20, 95% CI 1.02-1.41, p = 0.031). In stratified analyses, short height was an independent predictor of gestational diabetes among those with a normal BMI (OR = 1.75, 95% CI 1.23-2.50, p = 0.002) but not an independent predictor in higher BMI classes.Conclusions: The association between short maternal height and gestational diabetes varies by BMI class. Among those with a normal BMI, short maternal height is associated with the development of gestational diabetes.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-glucose stimulation triggers early transcription of a panel of proinflammatory mediators in rat Muller glia cells and retina primary explants. 在大鼠Muller神经胶质细胞和视网膜原代外植体中，高糖刺激可触发一组促炎介质的早期转录。

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-07-04 DOI: 10.1007/s00592-025-02543-x

Grazia Raffaella Tundo, Maria Grazia Atzori, Alessandra Boccaccini, Dario Cavaterra, Alessio Bocedi, Grazia Graziani, Stefano Marini, Pedro Miguel Lacal, Marika Villa, Flavia Pricci, Monica Varano, Mariacristina Parravano, Diego Sbardella

{"title":"High-glucose stimulation triggers early transcription of a panel of proinflammatory mediators in rat Muller glia cells and retina primary explants.","authors":"Grazia Raffaella Tundo, Maria Grazia Atzori, Alessandra Boccaccini, Dario Cavaterra, Alessio Bocedi, Grazia Graziani, Stefano Marini, Pedro Miguel Lacal, Marika Villa, Flavia Pricci, Monica Varano, Mariacristina Parravano, Diego Sbardella","doi":"10.1007/s00592-025-02543-x","DOIUrl":"https://doi.org/10.1007/s00592-025-02543-x","url":null,"abstract":"Several preclinical data support a main role of Muller glia, a type of retinal glial cells, in sensing hyperglycemia and, subsequently, acquiring a pro-inflammatory polarization during diabetic retinopathy onset and progression. Recently, we reported that stimulation of rat Muller glia cells (rMC1) with high glucose triggers a very early (< 15 min) and atypical signaling cascade, regulated by a Ca2+-calmodulin/proteasome axis, which induces the nuclear translocation of p65-p50 heterodimer, the principal transcription factor of pro-inflammatory NFkB pathway. In the present study, the repertoire of NF-kB pro-inflammatory genes was early monitored after high-glucose stimulation, in rMC1, as compared to cells stimulated with normal glucose or hyper-osmolar mannitol. The occurrence of an early transcriptional upregulation of most stimulated genes was also verified in rat retina cultures isolated from Sprague-Dawley rats. The overall analysis showed that: (i) high glucose triggers a pro-inflammatory polarization of rMC1 much earlier than previously thought and (ii) this early upregulation recapitulates also in rat retinal culture. Importantly, it has emerged a prominent role played by IL-8 in the early stages of hyperglycemic insult, opening to further studies on its role in primary diabetic retinopathy pathogenesis and envisaging the development of novel potential clinical treatments based on IL-8 blockade.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of platelet-rich plasma versus conventional care in diabetic foot ulcers: a meta-analysis of randomized controlled trials. 富血小板血浆治疗糖尿病足溃疡的疗效和安全性：一项随机对照试验的荟萃分析

IF 3.1 3区医学

Acta Diabetologica Pub Date : 2025-07-02 DOI: 10.1007/s00592-025-02555-7

Hongyan Xu, Kai Huang, Xiaohong Tao

{"title":"Efficacy and safety of platelet-rich plasma versus conventional care in diabetic foot ulcers: a meta-analysis of randomized controlled trials.","authors":"Hongyan Xu, Kai Huang, Xiaohong Tao","doi":"10.1007/s00592-025-02555-7","DOIUrl":"https://doi.org/10.1007/s00592-025-02555-7","url":null,"abstract":"Purpose: This meta-analysis aims to assess the efficacy and safety of platelet-rich plasma (PRP) through topical application and local injection methods compared to conventional care in patients with diabetic foot ulcers (DFU).Methods: A comprehensive literature search was conducted across PubMed, Embase, and Web of Science databases up to November 2024. Randomized controlled trials evaluating the efficacy and safety of PRP versus conventional care in DFU patients were included. Pooled weighted mean differences (WMD) and risk ratios (RR) were calculated with 95% confidence intervals.Results: Fifteen randomized controlled trials (1,010 patients) were included. The PRP group showed significantly improved complete healing rates compared to conventional care (RR: 1.53, 95% CI: 1.39-1.58, P < 0.001), with comparable effectiveness between topical application and local injection methods (P = 0.57). Notably, PRP demonstrated a shorter healing time compared to conventional care (WMD: -19.48 days, 95% CI: -27.91 to -11.05, P < 0.001). The PRP group exhibited lower wound infection rates and amputation rates (RR: 0.51, 95% CI: 0.35 to 0.75, P < 0.001; RR: 0.45, 95% CI: 0.26 to 0.79, P = 0.005). The PRP group did not lead to a higher incidence of treatment-related adverse events compared to conventional care (RR: 0.80, 95% CI: 0.05 to 12.30, P = 0.87).Conclusions: This meta-analysis confirms that PRP application, both topically and via local injection, improves the complete healing rate, reduces healing time, infection rates, and amputations, without increasing adverse events. These findings support the integration of PRP into clinical practice for the management of diabetic foot ulcers.","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0