Acta Diabetologica最新文献

{"title":"Protective effects of berberine against diabetes-associated cognitive decline in mice.","authors":"Mrinal Gupta, Mohammad Rumman, Babita Singh, Shivani Pandey","doi":"10.1007/s00592-024-02411-0","DOIUrl":"10.1007/s00592-024-02411-0","url":null,"abstract":"<p><strong>Aims: </strong>Diabetes associated cognitive decline (DACD) is a common CNS-related consequence of diabetes. The primary clinical manifestation of DACD includes learning and memory impairment. Unfortunately, there is no cure to delay the cognitive symptoms of diabetes. Although berberine (BBR) has shown promising effect in the treating diabetes and cognitive dysfunction, more research is needed to understand the mechanism of its therapeutic effect. For better understanding, we investigated the functions of BBR involved in anti-inflammation, anti-oxidant and neuroprotection in the hippocampus of diabetic mice.</p><p><strong>Methods: </strong>Diabetes was induced in mice using STZ. BBR was administered for 4 weeks before (pre-treatment), and after (post-treatment) STZ administration. The effect of BBR on cognitive functions in diabetic mice was determined using neurobehavioural test. Moreover, how BBR affected neuroinflammation, oxidative stress, and acetylcholine levels in the hippocampus and BBB permeability were analyzed using standard biochemical assays. Lastly, we evaluated the mRNA expression of neuroprotective genes in the hippocampus to uncover the mechanism of BBR.</p><p><strong>Results: </strong>Treatment with BBR improved cognition in diabetic mice. It significantly reduced the levels of IL-6, iNOS, TNF-α, IL-1β, ROS and MDA and increased the levels of TAC, GSH, SOD and Catalase. Moreover, levels of acetylcholine and BBB permeability were reduced in the diabetic mice which was reversed by BBR treatment and increased the expression of IGF and BDNF in the hippocampus of diabetic mice.</p><p><strong>Conclusion: </strong>Our results suggest that BBR might be a potential therapeutic candidate for the treatment of DACD. Our study might serve as a basis for developing novel drugs for treating DACD.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"943-955"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic significance of stress hyperglycemia ratio for all-cause and cardiovascular mortality in metabolic syndrome patients: prospective cohort study.","authors":"Jiasuer Alifu, Bin Xu, Guliziba Tuersun, Lu Liu, Lanqing Xiang, Abdul-Quddus Mohammed, Wen Zhang, Guoqing Yin, Chunyue Wang, Xian Lv, Tingting Shi, Qian Wu, Fuad A Abdu, Wenliang Che","doi":"10.1007/s00592-024-02407-w","DOIUrl":"10.1007/s00592-024-02407-w","url":null,"abstract":"<p><strong>Objective: </strong>The stress hyperglycemia ratio (SHR) is a new biomarker indicating acute hyperglycemia and predicting adverse outcomes in different conditions. Yet, its impact on metabolic syndrome (MetS) has not been studied. We explored the link between SHR and long-term all-cause and cardiovascular disease (CVD) mortality in MetS patients.</p><p><strong>Methods: </strong>We conducted a large prospective cohort study involving 9438 participants diagnosed with MetS, drawn from the 1999-2018 NHANES. MetS diagnosis was based on NCEP-ATPIII criteria. Participants were categorized into three groups based on SHR tertiles: T1 (SHR ≤ 0.890), T2 (SHR 0.890-0.992), and T3 (SHR ≥ 0.992). Cox regression and Kaplan-Meier curve analyses assessed the correlation between SHR and mortalities. Non-linear correlations were explored using restricted cubic splines, and stratification analysis was performed.</p><p><strong>Results: </strong>Out of 9438 MetS patients, 1929 deaths occurred during an average follow-up of 107 ± 64 months, including 541 CVD deaths. All-cause and CVD mortality rates were significantly higher with elevated SHR values (T3) than lower tertiles (23.4% vs. 19.5% and 18.3%, P < 0.001; 6.8% vs. 5.3% and 5.1%, P = 0.007, respectively). A U-shaped relationship was observed between SHR and all-cause and CVD mortality (all P for non-linear < 0.001). Kaplan-Meier analysis indicated higher SHR values associated with increased risk of all-cause and CVD mortality (all log-rank P < 0.001). After adjusting for confounders, multivariate Cox regression showed SHR remained associated with a 1.256-fold and 1.023-fold risk of all-cause and CVD mortality.</p><p><strong>Conclusions: </strong>SHR independently correlates with all-cause and CVD mortality in MetS patients, displaying a U-shaped relationship with clinical endpoints.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"903-913"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interactions between melatonin and the renin-angiotensin system (RAS) in vascular attenuation in diabetic and non-diabetic conditions.","authors":"Nazar M Shareef Mahmood, Almas M R Mahmud, Ismail M Maulood","doi":"10.1007/s00592-025-02479-2","DOIUrl":"10.1007/s00592-025-02479-2","url":null,"abstract":"<p><strong>Background: </strong>The hormone melatonin (MEL), primarily acknowledged for its role in regulating circadian rhythms, has demonstrated itself to be a complicated molecule with significant implications for vascular physiology. Melatonin exerts extensive physiological effects directly via the MEL receptor type 1 (MT₁R) and the MEL receptor type 2 (MT₂R), as well as indirectly through the improvement of antioxidant vascular tone.</p><p><strong>Objective: </strong>This review aims to analyse the intricate relationships between MEL and the renin-angiotensin system (RAS) in the vascular attenuation of non-diabetic (non-DM) and diabetic (DM) contexts. Alterations in the expression of RAS components and their dysregulation are prevalent in diabetes. Melatonin exhibits vasoprotective advantages in non-diabetic conditions. In the context of DM, vascular problrms such as vascular endothelial dysfunction (VED), hypertension, and atherosclerosis result from the dysregulation of MEL-RAS interactions. Comprehending the actions of MEL on RAS components in diabetes vasculature is essential for formulating tailored pharmaceutical therapy methods.</p><p><strong>Conclusion: </strong>This review consolidates existing knowledge regarding the vascular effects of MEL in relation to RAS activation, emphasising its potential role as a modulating factor for angiotensin 1-8 (Ang 1-8), angiotensin-converting enzyme 2 (ACE₂), and angiotensin 1-7 (Ang 1-7) in the management of vascular complications associated with DM.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"801-809"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective cohort study on treatment outcomes of early vs late onset gestational diabetes mellitus.","authors":"Riccardo Candido, Barbara Toffoli, Giulia Manfredi, Anna Turisani, Veronica Delfauro, Alessandra Petrucco, Chiara Gottardi, Elena Manca, Iris Buda, Laura Travan, Gianpaolo Maso, Stella Bernardi","doi":"10.1007/s00592-024-02405-y","DOIUrl":"10.1007/s00592-024-02405-y","url":null,"abstract":"<p><strong>Background: </strong>Gestational diabetes mellitus (GDM) affects roughly 14% of pregnancies, its prevalence is increasing, and it is associated with a significant risk of complications for both mother and offspring. A high proportion of women with GDM can be detected early in pregnancy. In Italy, early GDM screening occurs in a selective way, as it is performed only in the presence of important risk factors. It remains to be elucidated not only how and when to diagnose early GDM but especially whether to treat it. This study aimed to compare the characteristics and complications of early vs late GDM as assessed and treated in a real-world setting, according to the Italian guidelines of the Istituto Superiore di Sanità.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study in women with GDM delivering singletons between 2017 and 2021.</p><p><strong>Results: </strong>Women with early GDM had higher BMI and a higher proportion of Middle Eastern or African women. Early GDM was independently associated with the use of insulin (p < 0.001). It required also higher doses of insulin, possibly due to the higher BMI. Early GDM was also independently associated with higher post-prandial (after dinner) glucose levels during the 3° trimester (p = 0.04). Nevertheless, early GDM women achieved glucose targets and put on less weight during gestation. Early GDM was independently associated with preeclampsia (p = 0.05). Otherwise, there were no other differences between early and late GDM in terms of pregnancy complications. After delivery, early GDM was independently associated with abnormal glucose tolerance.</p><p><strong>Conclusions: </strong>Early GDM women exhibited more severe GDM features. However, after achieving recommended glucose and body weight targets, there were no substantial differences between early and late GDM in terms of pregnancy complications apart from preeclampsia. These data support diagnosis and treatment of women with early GDM.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"881-889"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive association between the γ-glutamyltransferase-high-density lipoprotein cholesterol ratio and all-cause mortality in the Korean genome and epidemiology study: health examinees cohort.","authors":"Hee Youn Han, Dong Hyuk Jung, Seok-Jae Heo, Yong Jae Lee","doi":"10.1007/s00592-025-02495-2","DOIUrl":"10.1007/s00592-025-02495-2","url":null,"abstract":"<p><strong>Objective: </strong>The ratio of γ-glutamyl transferase (GGT) and high-density lipoprotein cholesterol (HDL-C) is a novel noninsulin-based marker for assessing the risk of nonalcoholic fatty liver disease and type 2 diabetes mellitus. However, it is unclear whether the GGT/HDL-C ratio is related to all-cause mortality. Therefore, we aimed to investigate the longitudinal association of GGT/HDL-C on all-cause mortality in a large cohort of Korean adults.</p><p><strong>Methods: </strong>Data were assessed for 87,668 participants (25,767 men and 61,901 women) from the Korean Genome and Epidemiology Study-Health Examinees cohort. These data were combined with the death certificate database from the National Statistical Office. The participants were divided into four groups according to GGT/HDL-C quartiles. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for all-cause mortality in the 11.7 years following the baseline survey using multivariate Cox proportional hazard regression models including age, BMI, smoking status, and drinking habits, which are known to be major confounders.</p><p><strong>Results: </strong>During the follow-up period, 3,214 individuals (3.6%; 1,728 men and 1,486 women) died. The respective HRs (95% CIs) of mortality for GGT/HDL-C quartiles 2-4 were 1.15 (0.99-1.33), 1.48 (1.28-1.71), and 1.97 (1.70-2.29) in men and 1.22 (1.02-1.45), 1.36 (1.15-1.61), and 1.69 (1.42-2.00) in women after adjusting for confounders.</p><p><strong>Conclusions: </strong>GGT/HDL-C may be a useful predictive marker for all-cause mortality in men and women. We believe that GGT/HDL-C ratio will provide a complementary tool to help clinicians make decisions about prevention and disease management to improve survival.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"967-976"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the triglyceride glucose index with acute renal failure in diabetes mellitus: a cross-sectional study based on participants from the MIMIC-iv database.","authors":"Zi-Fan Zhuang, Hong-Rui Lu, Yang Zhou, Qing Ni","doi":"10.1007/s00592-024-02412-z","DOIUrl":"10.1007/s00592-024-02412-z","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride glucose (TyG) index serves as a dependable surrogate biomarker for evaluating insulin resistance. However, the role of the TyG index in patients with diabetes mellitus who also suffer from acute renal failure warrants further investigation. This study sought to investigate the association between the TyG index and the incidence of acute renal failure in individuals with diabetes.</p><p><strong>Methods: </strong>This study utilized data from the MIMIC-IV database, categorizing patients into tertiles according to their TyG index. Employing multivariate logistic regression models, we analyzed the relationship between the TyG index and the occurrence of acute renal failure among diabetic patients. To assess non-linear relationships, restricted cubic splines were utilized, and upon detection of non-linearity, a recursive algorithm was implemented to determine inflection points.</p><p><strong>Results: </strong>The study comprised a total of 1074 participants diagnosed with diabetes mellitus. In the model adjusted for all covariates, the odds ratio (OR) for the association between the TyG index and acute renal failure, accompanied by a 95% confidence interval (CI), was 1.22 (0.82, 1.82), which did not reach statistical significance. However, analysis using restricted cubic splines revealed a U-shaped relationship between the TyG index and acute renal failure, with an inflection point at 9.26. The relationship between the TyG index and acute renal failure was inverse before reaching the inflection point and became directly proportional thereafter, with an OR (95% CI) of 1.86 (1.12, 3.09) after the point.</p><p><strong>Conclusion: </strong>In individuals diagnosed with diabetes mellitus, our analysis revealed a non-linear relationship between the TyG index and the incidence of acute renal failure. Beyond the inflection point, elevated TyG index levels were markedly linked to a higher prevalence of acute renal failure.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"957-965"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation and therapeutic prospects of regulatory T cells in type 1 diabetes.","authors":"Azharuddin Sajid Syed Khaja, Naif K Binsaleh, Husam Qanash, Hamad Alshetaiwi, Ibrahim Abdelmageed Mohamed Ginawi, Mohd Saleem","doi":"10.1007/s00592-025-02478-3","DOIUrl":"10.1007/s00592-025-02478-3","url":null,"abstract":"<p><p>Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys β-cells in the pancreas that produce insulin. Several studies have implicated and elaborated the significant role of regulatory T cells (Tregs) in the pathogenesis of T1D. Tregs are a specialized subset of T cells and are critical regulators of peripheral self-tolerance. However, if the number, function, or stability of these cells is altered, it can lead to autoimmunity. This review summarizes the current knowledge and understanding about Treg function in both health and T1D, Tregs dysregulation, and various factors, including microRNAs, that affect their dysregulation in T1D. The review also focuses on the advantages and challenges of Treg-based therapies for T1D.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"785-800"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of heterozygous mutations of ABCC8 gene responsible for maturity-onset diabetes of the young with exome sequencing.","authors":"Yanxia Liu, Shuxin Ren, Chaofeng Zhu, Sufang Chen, Huijuan Zhang, Juan Zhang, Jianhua Li, Yanyan Jiang","doi":"10.1007/s00592-024-02410-1","DOIUrl":"10.1007/s00592-024-02410-1","url":null,"abstract":"<p><strong>Background: </strong>Although the MODY12 subtype, caused by ABCC8 mutations, is rare, it is highly sensitive to sulfonylureas. The identification of ABCC8 mutations in patients clinically diagnosed with MODY has the ability to contribute to the precise management of diabetes.</p><p><strong>Methods: </strong>Genetic analysis of two families with MODY were conducted using whole-exome sequencing (WES) and Sanger sequencing. The spatial structures of the mutant proteins were constructed using MODELLER and PyMOL software to provide further evidence of pathogenicity.</p><p><strong>Results: </strong>The heterozygous missense mutations V357I and R1393H in ABCC8 were found in probands of two unrelated MODY pedigrees, which co-segregated with the hyperglycemic phenotypes in these two pedigrees. Detection of the V357I mutation enabled the proband of family A to successfully transfer from insulin to sulfonylurea (SU). After 3 months of follow-up for the SU trial, the HbA1c level of proband A improved from 12.4% at the initial diagnosis to 7.20%. Proband B was treated with insulin because of pregnancy and poor islet function. In silico analysis indicated that the R1393H mutation resulted in a longer hydrogen bond distance to L1389 and cleavage of carbon-hydrogen bonds to V1395, A1390, and L1389.</p><p><strong>Conclusions: </strong>We have described two pathogenic missense mutations in ABCC8 in Chinese families with MODY. Our findings support the heterogeneity in the clinical features of MODY12 caused by ABCC8 mutations.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"935-942"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mir-509-3p targets SLC25A13 to regulate ferroptosis and protect retinal endothelial cells in diabetic retinopathy.","authors":"Meiqing Ren, Qian Xu, Jie Luan, Yan Ni, Bo Xie","doi":"10.1007/s00592-024-02400-3","DOIUrl":"10.1007/s00592-024-02400-3","url":null,"abstract":"<p><strong>Aims: </strong>Diabetic retinopathy (DR) is a major complication of diabetes that leads to vision impairment. The aim of this study was to investigate the regulatory role of miR-509-3p in DR, focusing on its interaction with SLC25A13 and its impact on retinal endothelial cell function, oxidative stress, apoptosis, and ferroptosis.</p><p><strong>Methods: </strong>HRVECs were cultured in high-glucose (HG) conditions to establish an in vitro DR model. miR-509-3p mimics and inhibitors were transfected into HRVECs to assess their effects on SLC25A13 expression, cell viability, apoptosis, reactive oxygen species (ROS) levels, and ferroptosis markers. A luciferase reporter assay and RNA immunoprecipitation were used to confirm the binding of miR-509-3p to SLC25A13 mRNA. For in vivo validation, agomiR-509-3p was injected into the vitreous of DR mice, and retinal thickness, pathological damage, and apoptosis were evaluated. Ferroptosis-related markers (GPX4, TlR4, ASCL4) were analyzed in HRVECs to explore the mechanism of miR-509-3p in regulating ferroptosis.</p><p><strong>Results: </strong>In vitro, miR-509-3p significantly decreased SLC25A13 expression, resulting in enhanced HRVEC viability, reduced apoptosis, and lower ROS levels under HG conditions. Overexpression of SLC25A13 reversed these protective effects, while miR-509-3p knockdown exacerbated oxidative stress and apoptosis. In vivo, agomiR-509-3p increased retinal thickness, reduced pathological damage, and decreased apoptosis in DR mice. Ferroptosis marker analysis revealed that miR-509-3p upregulated GPX4 expression and downregulated TlR4 and ASCL4, whereas SLC25A13 overexpression reversed these effects, further linking miR-509-3p to the regulation of ferroptosis.</p><p><strong>Conclusions: </strong>miR-509-3p exerts a protective effect in DR by targeting SLC25A13, reducing oxidative stress, apoptosis, and ferroptosis in retinal endothelial cells. These findings highlight the potential of miR-509-3p as a therapeutic target for DR management.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"831-844"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of new onset diabetes on cardiovascular risks in orthotopic liver transplant recipients: findings from the COLT study.","authors":"Alfredo Caturano, Anna di Martino, Gaetana Albanese, Carmine Coppola, Vincenzo Russo, Kateřina Koudelková, Raffaele Galiero, Luca Rinaldi, Celestino Sardu, Aldo Marrone, Marcellino Monda, Raffaele Marfella, Jan Gojda, Ferdinando Carlo Sasso, Teresa Salvatore","doi":"10.1007/s00592-024-02406-x","DOIUrl":"10.1007/s00592-024-02406-x","url":null,"abstract":"<p><strong>Background: </strong>Orthotopic liver transplantation (OLT) has greatly improved short-term survival for end-stage liver disease. However, cardiovascular events (CVE) still pose a significant threat to long-term post-transplant health. Aim of this study is to assess the occurrence of long-term cardiovascular events and whether it relates to new-onset diabetes after liver transplantation (NODALT).</p><p><strong>Methods: </strong>We conducted a multicentric retrospective analysis of adult OLT recipients with regular follow-up visits spanning from January 1995 to December 2020. Data collection included anamnestic, clinical, anthropometric, and laboratory data from two centers. NODALT was diagnosed following ADA guidelines. The primary outcome was incident CVE (a composite of fatal and non-fatal stroke and myocardial infarction). CVE occurrence was analyzed in relation to NODALT diagnosis, along with clinical characteristics associated with its development.</p><p><strong>Results: </strong>Ninety-three eligible Caucasian patients, with a median age of 57.0 years (IQR: 49.0-62.0, 69.9% male), were enrolled. Over the median follow-up period of 100.5 months, 29 patients (31.2%) developed NODALT, and 14 patients (15.1%) developed any CVE, with 9 being in the NODALT group. A significant association between NODALT and cardiovascular complications was confirmed by both generalized estimating equation (OR 5.31; 95% CI 1.59-17.72, p = 0.006) and Kaplan-Meier analysis (log-rank = 0.046). Metabolic syndrome and impaired fasting glucose were identified as baseline risk factors for the incident NODALT (OR 5.75; 95% CI 1.44-22.92, p = 0.013 and OR 7.29; 95% CI 1.46-36.41, p = 0.015, respectively).</p><p><strong>Conclusions: </strong>Post-OLT cardiovascular events are less frequent than previously reported but are notably linked to NODALT, highlighting the interplay between metabolic syndrome and impaired fasting glucose.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":"891-901"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}