Dysregulation and therapeutic prospects of regulatory T cells in type 1 diabetes.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-03-21 DOI:10.1007/s00592-025-02478-3

Azharuddin Sajid Syed Khaja, Naif K Binsaleh, Husam Qanash, Hamad Alshetaiwi, Ibrahim Abdelmageed Mohamed Ginawi, Mohd Saleem

引用次数: 0

Abstract

Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys β-cells in the pancreas that produce insulin. Several studies have implicated and elaborated the significant role of regulatory T cells (Tregs) in the pathogenesis of T1D. Tregs are a specialized subset of T cells and are critical regulators of peripheral self-tolerance. However, if the number, function, or stability of these cells is altered, it can lead to autoimmunity. This review summarizes the current knowledge and understanding about Treg function in both health and T1D, Tregs dysregulation, and various factors, including microRNAs, that affect their dysregulation in T1D. The review also focuses on the advantages and challenges of Treg-based therapies for T1D.

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调节性T细胞在1型糖尿病中的失调及其治疗前景。

1型糖尿病（T1D）是一种自身免疫性疾病，它选择性地破坏胰腺中产生胰岛素的β细胞。一些研究暗示并阐述了调节性T细胞（Tregs）在T1D发病机制中的重要作用。treg是T细胞的一个特殊子集，是外周自我耐受性的关键调节因子。然而，如果这些细胞的数量、功能或稳定性发生改变，就会导致自身免疫。本文综述了目前对Treg在健康和T1D中的功能、Treg的失调以及影响Treg在T1D中失调的各种因素（包括microrna）的认识和理解。本文还将重点讨论基于treg的T1D治疗的优势和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.