Xiaoling Liu, Ze Zhang, Lu Lin, Jinghui Li, Bende Liu, Xiangjin Xu, Huaqian Chen, Junwei Zhou, Pin Chen
{"title":"血红蛋白与2型糖尿病肾病的相关性分析：一项双中心回顾性研究。","authors":"Xiaoling Liu, Ze Zhang, Lu Lin, Jinghui Li, Bende Liu, Xiangjin Xu, Huaqian Chen, Junwei Zhou, Pin Chen","doi":"10.1007/s00592-025-02529-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationship between hemoglobin (Hb) levels and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>We recruited patients with T2DM from two centers, collected their clinical data, and analyzed the relationship between Hb levels and DN using binary logistic regression analysis and restricted cubic spline squares (RCS) plots.</p><p><strong>Results: </strong>A total of 1956 patients with T2DM were enrolled, including 784 (40.1%) with DN. After adjusting for several confounding factors, the proportion of patients with DN in Q1 of Hb was significantly higher than that in the other group. The RCS curve revealed that Hb levels were inversely proportional to DN. Subgroup analysis demonstrated that age, gender, history of hypertension, history of nonalcoholic fatty liver disease and history of diabetic retinopathy exhibited no significant correlation with Hb levels and DN.</p><p><strong>Conclusions: </strong>Low Hb level is closely associated with DN occurrence, and can be used as a predictive biomarker for DN.</p>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation analysis between hemoglobin and type 2 diabetic nephropathy: a two-center retrospective study.\",\"authors\":\"Xiaoling Liu, Ze Zhang, Lu Lin, Jinghui Li, Bende Liu, Xiangjin Xu, Huaqian Chen, Junwei Zhou, Pin Chen\",\"doi\":\"10.1007/s00592-025-02529-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to investigate the relationship between hemoglobin (Hb) levels and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>We recruited patients with T2DM from two centers, collected their clinical data, and analyzed the relationship between Hb levels and DN using binary logistic regression analysis and restricted cubic spline squares (RCS) plots.</p><p><strong>Results: </strong>A total of 1956 patients with T2DM were enrolled, including 784 (40.1%) with DN. After adjusting for several confounding factors, the proportion of patients with DN in Q1 of Hb was significantly higher than that in the other group. The RCS curve revealed that Hb levels were inversely proportional to DN. Subgroup analysis demonstrated that age, gender, history of hypertension, history of nonalcoholic fatty liver disease and history of diabetic retinopathy exhibited no significant correlation with Hb levels and DN.</p><p><strong>Conclusions: </strong>Low Hb level is closely associated with DN occurrence, and can be used as a predictive biomarker for DN.</p>\",\"PeriodicalId\":6921,\"journal\":{\"name\":\"Acta Diabetologica\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Diabetologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00592-025-02529-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Diabetologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00592-025-02529-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Correlation analysis between hemoglobin and type 2 diabetic nephropathy: a two-center retrospective study.
Objective: This study aimed to investigate the relationship between hemoglobin (Hb) levels and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).
Methods: We recruited patients with T2DM from two centers, collected their clinical data, and analyzed the relationship between Hb levels and DN using binary logistic regression analysis and restricted cubic spline squares (RCS) plots.
Results: A total of 1956 patients with T2DM were enrolled, including 784 (40.1%) with DN. After adjusting for several confounding factors, the proportion of patients with DN in Q1 of Hb was significantly higher than that in the other group. The RCS curve revealed that Hb levels were inversely proportional to DN. Subgroup analysis demonstrated that age, gender, history of hypertension, history of nonalcoholic fatty liver disease and history of diabetic retinopathy exhibited no significant correlation with Hb levels and DN.
Conclusions: Low Hb level is closely associated with DN occurrence, and can be used as a predictive biomarker for DN.
期刊介绍：
Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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