Acta Ophthalmologica最新文献_第6页

Deep learning model for detecting cystoid fluid collections on optical coherence tomography in X-linked retinoschisis patients. x连锁视网膜裂患者光学相干断层扫描检测囊样液收集的深度学习模型。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-04-04 DOI: 10.1111/aos.17495

Jonathan Hensman, Yasmine El Allali, Hind Almushattat, Coen de Vente, Clara I Sánchez, Camiel J F Boon

{"title":"Deep learning model for detecting cystoid fluid collections on optical coherence tomography in X-linked retinoschisis patients.","authors":"Jonathan Hensman, Yasmine El Allali, Hind Almushattat, Coen de Vente, Clara I Sánchez, Camiel J F Boon","doi":"10.1111/aos.17495","DOIUrl":"https://doi.org/10.1111/aos.17495","url":null,"abstract":"Purpose: To validate a deep learning (DL) framework for detecting and quantifying cystoid fluid collections (CFC) on spectral-domain optical coherence tomography (SD-OCT) in X-linked retinoschisis (XLRS) patients.Methods: A no-new-U-Net model was trained using 112 OCT volumes from the RETOUCH challenge (70 for training and 42 for internal testing). External validation involved 37 SD-OCT scans from 20 XLRS patients, including 20 randomly sampled B-scans and 17 manually selected central B-scans. Three graders manually delineated the CFC on these B-scans in this external test set. The model's efficacy was evaluated using Dice and intraclass correlation coefficient (ICC) scores, assessed exclusively on the test set comprising B-scans from XLRS patients.Results: For the randomly sampled B-scans, the model achieved a mean Dice score of 0.886 (±0.010), compared to 0.912 (±0.014) for the observers. For the manually selected central B-scans, the Dice scores were 0.936 (±0.012) for the model and 0.946 (±0.012) for the graders. ICC scores between the model and reference were 0.945 (±0.014) for the randomly selected and 0.964 (±0.011) for the manually selected B-scans. Among the graders, ICC scores were 0.979 (±0.008) and 0.981 (±0.011), respectively.Conclusions: Our validated DL model accurately segments and quantifies CFC on SD-OCT in XLRS, paving the way for reliable monitoring of structural changes. However, systematic overestimation by the DL model was observed, highlighting a key limitation for future refinement.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating uveal melanoma volume with ellipsoid tumour models. 用椭球肿瘤模型估计葡萄膜黑色素瘤体积。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-04-03 DOI: 10.1111/aos.17492

Lisa Klaassen, Teresa A Ferreira, Gregorius Luyten, Jan-Willem M Beenakker

{"title":"Estimating uveal melanoma volume with ellipsoid tumour models.","authors":"Lisa Klaassen, Teresa A Ferreira, Gregorius Luyten, Jan-Willem M Beenakker","doi":"10.1111/aos.17492","DOIUrl":"https://doi.org/10.1111/aos.17492","url":null,"abstract":"Purpose: Ellipsoid tumour models are used to approximate the tumour volume of uveal melanomas, as the conventionally used ultrasound does not provide a three-dimensional visualization of the tumour. However, these models are a simplification of the actual tumour geometry. The aim of this study was to determine to what extent several of these frequently used ellipsoid tumour models accurately describe uveal melanoma volume.Methods: Tumours were delineated on contrast-enhanced T1-weighted MRI for 70 uveal melanoma patients. The MRI-delineated volume was compared with three ellipsoid models, which used two-dimensional measurements such as thickness and basal diameters as input: half ellipsoids with round (Vroundbase) or oval base (Vovalbase) and a paraboloid consisting of two parts, also incorporating the curvature of the eye wall (Vtwoparts).Results: Statistically significant relative differences between MRI-delineated and model volume of 53 ± 32% (Vroundbase), 26 ± 24% (Vovalbase) and 15 ± 24% (Vtwoparts) were observed (p < 0.001). Tumour volume and shape did not influence the difference between the model volumes and MRI-delineated tumour volume.Conclusion: All tumour models result in considerable systematic overestimations of tumour volume, with large variations in overestimation between patients. Adding the perpendicular basal diameter to the model decreases this variation. Although ellipsoid tumour models have been shown to be valuable on a group level, they should be used with caution for individual patients.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and histopathological prognostic factors in uveal melanoma in a large Spanish series of enucleated eyes. 西班牙大量无核眼患者葡萄膜黑色素瘤的临床和组织病理学预后因素。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-04-03 DOI: 10.1111/aos.17493

Patricia Valencia Nieto, Ciro García Álvarez, María Elena García Lagarto, María Fe Muñoz Moreno, Patricia Diezhandino García, María Antonia Saornil Álvarez

{"title":"Clinical and histopathological prognostic factors in uveal melanoma in a large Spanish series of enucleated eyes.","authors":"Patricia Valencia Nieto, Ciro García Álvarez, María Elena García Lagarto, María Fe Muñoz Moreno, Patricia Diezhandino García, María Antonia Saornil Álvarez","doi":"10.1111/aos.17493","DOIUrl":"https://doi.org/10.1111/aos.17493","url":null,"abstract":"Purpose: To analyze clinical and histopathological prognostic factors and overall and specific survival after enucleation in a Spanish cohort diagnosed with uveal melanoma.Methods: A prospective analysis was performed in a single-center case series of 138 patients with posterior uveal melanoma seen in the Adult Intraocular Tumour Unit at the University Clinical Hospital of Valladolid and treated by enucleation as the primary treatment between January 2006 and December 2021. Kaplan-Meier and Cox regression analyses were performed to identify prognostic factors.Results: Mean follow-up time was 54 months. Mean overall and melanoma-specific survival were 119 months (95% CI: 103.82-133.92) and 133 months (95% CI: 118.52-147.90) respectively. In univariate analysis of clinical parameters, only scleral extension was associated with poorer survival (p < 0.001). The histopathological characteristics associated with poorer survival were epithelioid cell type (p = 0.021), high Ki-67 expression (≥15%; p = 0.037), vortex vein invasion (p < 0.001), emissary canal invasion (p = 0.005), extrascleral extension (p = 0.001), and low percentage of necrosis (<10%; p = 0.015). In multivariate analysis, scleral extension (p = 0.008) and vortex vein invasion (p = 0.001) were associated with poorer overall survival.Conclusion: Spanish population has different racial characteristics to those of Anglo-Saxon cohorts in which uveal melanoma has been studied previously and shows a higher specific survival rate. Classic histopathological features have been confirmed as prognostic factors, but further studies should be performed to evaluate genetic and molecular factors to improve the prediction of survival in enucleated uveal melanoma patients.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACTA NOG abstracts ACTA仍然是抽象的

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-04-01 DOI: 10.1111/aos.17463

引用次数: 0

Cumulative incidence of macular edema in non-infectious uveitis indicates an early therapeutic window. 非感染性葡萄膜炎黄斑水肿的累积发生率提示早期治疗窗口。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-04-01 DOI: 10.1111/aos.17497

Bawan Halgurd, Viktor Skalkhøj Oest, Oliver Niels Klefter, Yousif Subhi, Maria Vittoria Cicinelli, Jimmi Wied, Steffen Heegaard, Piergiorgio Neri, Henrik Vorum, Marie Ørskov, Lasse Jørgensen Cehofski

{"title":"Cumulative incidence of macular edema in non-infectious uveitis indicates an early therapeutic window.","authors":"Bawan Halgurd, Viktor Skalkhøj Oest, Oliver Niels Klefter, Yousif Subhi, Maria Vittoria Cicinelli, Jimmi Wied, Steffen Heegaard, Piergiorgio Neri, Henrik Vorum, Marie Ørskov, Lasse Jørgensen Cehofski","doi":"10.1111/aos.17497","DOIUrl":"https://doi.org/10.1111/aos.17497","url":null,"abstract":"Purpose: Uveitis-associated macular edema (UME) is a significant cause of visual impairment in non-infectious uveitis (NIU). However, the UME incidence remains unclear. Here, we evaluated the cumulative incidence of UME.Methods: Medical records of patients registered with a uveitis diagnosis code between 2010 and2024 were assessed to validate uveitis diagnoses of the patient registry of the North Denmark Region, a region of 600 000 inhabitants. Positive predictive values (PPV) were calculated for uveitis diagnosis and subtypes. The data from medical records were used to estimate prevalence, incidence and cumulative incidence of UME. The group differences were analysed by chi-squared test and cox proportional-hazards model.Results: A total of 1476 medical records were reviewed. The PPV for a uveitis diagnosis was 92.2% (95% CI: 90.7-93.5) and 88.4% (95% Cl: 86.8-90.0) for uveitis subtypes. Among 1218 patients with NIU, 6.9% had UME at referral. During follow-up, 8.3% of the NIU patients developed UME with an incidence rate of 1.4 per 100 person-years (95% CI: 1.3-1.7) and a cumulative incidence of 10.7% (95% CI: 8.5-13.5). A higher incidence of UME was observed for patients with bilateral uveitis, systemic disease, intermediate uveitis, posterior uveitis and panuveitis (p < 0.001). A substantial increase in the cumulative incidence of UME was observed in the first 2 years post-referral.Conclusion: The high PPV supported the registry's reliability for uveitis research. UME was frequently present at the first uveitis clinic visit. NIU patients were at heightened risk of UME within the first 2 years after referral, indicating an early time window with a critical need for inflammation management.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

'EarlyAMDRate': A grading instrument for OCT-based assessment of early lesions caused by age-related macular degeneration. EarlyAMDRate：一种基于oct评估老年性黄斑变性早期病变的分级工具。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-03-30 DOI: 10.1111/aos.17479

Marcus Wagner, Thomas Peschel, Carla J Leutloff, Franziska G Rauscher

{"title":"'EarlyAMDRate': A grading instrument for OCT-based assessment of early lesions caused by age-related macular degeneration.","authors":"Marcus Wagner, Thomas Peschel, Carla J Leutloff, Franziska G Rauscher","doi":"10.1111/aos.17479","DOIUrl":"https://doi.org/10.1111/aos.17479","url":null,"abstract":"Background and objectives: Long before any signs of age-related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation of deposits of extracellular debris and formation of lesions within the outermost layers of the retina. For a reliable imaging of lesions in these early stages, optical coherence tomography (OCT) turned out to be largely preferable to colour fundus photography. However, an adequate grading instrument for Early-AMD lesions within OCT data is missing in the literature as yet. The present paper aims to fill this gap.Methods: 'EarlyAMDRate', an instrument for OCT-based grading of Early-AMD lesions, is presented and documented. It comprises a questionnaire assessing a given lesion with respect to its relative position and interaction with the surrounding retinal layers, its brightness, special properties and state of progression (if applicable). Furthermore, the grading procedure includes a graphical masking of the lesion within the OCT image.Results: For a consecutive sample of N = 100 Early-AMD patients, the 'EarlyAMDRate' grading instrument has been applied to leading OCT scans. Examples of masked lesions and processed grading questionnaires are provided. Both raw lesion diameters and cutting sizes follow a log-normal sample distribution.Conclusions: 'EarlyAMDRate' allows for unprecedented detail of description for single Early-AMD lesions which is adequate to the precision of underlying OCT imaging. The obtained grading information allows for a tracking of single lesions and their properties over time as well as for the generation of well-differentiated metric phenotypes for description of Early-AMD.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations on the Haigis formula: Are better outcomes possible with tuning? 对Haigis公式的考虑：调整后的结果会更好吗？

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-03-29 DOI: 10.1111/aos.17491

Achim Langenbucher, Nóra Szentmáry, Jascha Wendelstein, Alan Cayless, Benj Fassbind, Peter Hoffmann

{"title":"Considerations on the Haigis formula: Are better outcomes possible with tuning?","authors":"Achim Langenbucher, Nóra Szentmáry, Jascha Wendelstein, Alan Cayless, Benj Fassbind, Peter Hoffmann","doi":"10.1111/aos.17491","DOIUrl":"https://doi.org/10.1111/aos.17491","url":null,"abstract":"Purpose: To design a vergence-based lens power formula based on the classical Haigis formula for better outcomes while retaining the original formula architecture.Methods: Four new formula variants (A-D) incorporating a sum of segments correction for axial length, harmonic mean of corneal radii instead of arithmetic mean (all variants), and differing combinations of lower keratometer index (C, D) and an additional term (a3) representing the lens thickness in the effective lens position (B, D) were assessed in an analysis based on four datasets of IOLMaster 700 biometric data for eyes treated with the Hoya Vivinex lens (dataset 1), Alcon SA60AT lens (2), Johnson & Johnson ZCB00 lens (3), and the Bausch & Lomb MX60 lens (4). All parameters (formula constants and keratometer index) were calculated by nonlinear iterative optimisation techniques for minimising the root mean squared prediction error (RMSPE). Performance was assessed in terms of the final RMSPE.Results: All four variants showed reductions in RMSPE ranging from 2.8% to 12.6% over the original Haigis formula. For each of the four datasets, variants B and D (with the additional a3 constant) performed better in this respect than variants A and C. In all four cases, variants C and D (with the adjusted keratometer index) performed slightly better than A and B, respectively.Conclusion: Although not amenable to statistical analysis, the % improvements in RMSPE would appear to be clinically relevant. However, the benefit has to be proven in a prospective multicentric study with a large sample size.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-quantified schisis volume as a structural endpoint for gene therapy clinical trials in X-linked retinoschisis. 人工智能量化裂体积作为基因治疗x连锁视网膜裂临床试验的结构终点。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-03-29 DOI: 10.1111/aos.17485

Tien-En Tan, Peilun Dai, Jonathan Hensman, Peter Kiraly, Beau J Fenner, Yong Liu, Rick S M Goh, Ian C Han, Daniel S W Ting, Camiel J F Boon, M Dominik Fischer

{"title":"Artificial intelligence-quantified schisis volume as a structural endpoint for gene therapy clinical trials in X-linked retinoschisis.","authors":"Tien-En Tan, Peilun Dai, Jonathan Hensman, Peter Kiraly, Beau J Fenner, Yong Liu, Rick S M Goh, Ian C Han, Daniel S W Ting, Camiel J F Boon, M Dominik Fischer","doi":"10.1111/aos.17485","DOIUrl":"https://doi.org/10.1111/aos.17485","url":null,"abstract":"Purpose: To use artificial intelligence (AI) for quantifying schisis volume (ASV) in X-linked retinoschisis (XLRS) for use as a structural endpoint in gene therapy clinical trials.Methods: We used data from Singapore, the United Kingdom, the Netherlands, and the United States. The AI model was developed on 250 optical coherence tomography (OCT) slices, with human annotation of schisis cavities (Dataset 1). ASV was quantified on Dataset 2 - 16 OCT scans from 8 eyes with XLRS at two time points, and Dataset 4 - 62 OCT scans from 31 eyes at two time points before and after carbonic anhydrase inhibitor (CAI) treatment. A clinical trial was simulated comparing CAI treatment against control. Changes in ASV, central subfield thickness (CST) and central foveal thickness (CFT) were compared. Effect size (Cohen's d) of the three structural endpoints was determined and used in sample size calculations for a future XLRS gene therapy clinical trial, at a 0.05 significance level and 80% power.Results: In the simulated clinical trial, all structural metrics showed greater reductions with intervention than with control, but only change in ASV reached statistical significance (p = 0.004). Cohen's d for ASV, CST and CFT were 0.972, 0.685 and 0.521, respectively. For the future gene therapy clinical trial, sample sizes required in each arm for ASV, CST and CFT were 18, 35 and 59 participants, respectively.Conclusions: ASV measurements can track changes in schisis volume in response to treatment. As an endpoint, ASV has a greater statistical effect size than CST/CFT, which reduces sample size requirements for future XLRS gene therapy clinical trials.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of artificial tears on corneal parameter measurement using three different devices: Keratometry and Scheimpflug technology, a randomized trial. 人工泪液对角膜参数测量的影响，使用三种不同的设备：角膜测量仪和Scheimpflug技术，一项随机试验。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-03-28 DOI: 10.1111/aos.17487

Titus Schug, Thomas Kohnen, Klemens Paul Kaiser, Christoph Lwowski

{"title":"Influence of artificial tears on corneal parameter measurement using three different devices: Keratometry and Scheimpflug technology, a randomized trial.","authors":"Titus Schug, Thomas Kohnen, Klemens Paul Kaiser, Christoph Lwowski","doi":"10.1111/aos.17487","DOIUrl":"https://doi.org/10.1111/aos.17487","url":null,"abstract":"Purpose: To evaluate the effect of artificial tear (AT) application on the repeatability of corneal parameters with three different devices.Methods: In this prospective, randomized clinical trial, 145 patients were measured with one of three devices in the Department of Ophthalmology, Goethe University, Frankfurt, Germany. Two baseline measurements and four measurements following AT application after 30 s, 2, 5 and 10 min were performed.Results: Forty-eight eyes were measured with the IOLMaster 700 (Carl Zeiss Meditec AG, Oberkochen, Germany) and Galilei G6 (Ziemer, Port, Switzerland), and 49 with the Pentacam AXL (Oculus, Wetzlar, Germany) (145 total). Repeatability of the mean corneal power (Km) between baseline measurements was high (0.049 ± 0.008 D for IOLMaster, 0.061 ± 0.011 for the Pentacam AXL and 0.065 ± 0.009 for Galilei G6) but significantly variable after 30 s and 2 min for IOLMaster 700 (0.177 ± 0.021 D, p < 0.001 and 0.079 ± 0.009, p = 0.004) and Galilei G6 (0.163 ± 0.020 D, p < 0.001 and 0.119 ± 0.014 D, p = 0.003). Km differed significantly from baseline at 30 s, 2 and 5 min with Pentacam AXL (0.215 ± 0.041 D, p < 0.001; 0.157 ± 0.025 D, p < 0.001 and 0.094 ± 0.012 D, p = 0.007). Variability was highest at 30 s and decreased over time.Conclusion: The use of AT leads to high variability of keratometric measurements for each device. This should be considered after use, and at least 5 min should elapse before measurements.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased prevalence of myopia in Swedish conscripts between 1975 and 1995 - associations with education and verbal ability. 1975年至1995年间瑞典应征入伍者近视发生率增加——与教育和语言能力有关。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-03-19 DOI: 10.1111/aos.17488

Tomas Bro

{"title":"Increased prevalence of myopia in Swedish conscripts between 1975 and 1995 - associations with education and verbal ability.","authors":"Tomas Bro","doi":"10.1111/aos.17488","DOIUrl":"https://doi.org/10.1111/aos.17488","url":null,"abstract":"Background: The objective of this study is to examine the trends in the prevalence of myopia in Swedish young men over a 30-year period and identify potential risk factors for myopia development.Method: This retrospective, cross-sectional study analysed testing results from three cohorts of Swedish military conscripts: 1975, 1985 and 1995. Myopia was defined as a spherical equivalent (SE) of ≤ -0.5 D and high myopia as SE ≤ -5 D. Myopia prevalence was analysed in combination with physical measures (height, weight and BMI), social measures (theoretical upper secondary school) and cognitive measures (4 different abilities). The results from the cognitive tests used a STANdard NINE scale (stanine or S9), a method of scaling test scores on a nine-point standard scale, with a mean of five and a standard deviation of two.Results: The study included a total of 13 075 males aged 17 to 19 years. Adequate data on physical measures and vision were available for 95%-98% of participants. The proportion of individuals with myopia increased significantly from 22% to 29% between 1975 and 1995 (p < 0.001). High myopia increased from 1.9% to 3.3% (p < 0.001). Multivariate logistic regression indicated associations between myopia and year of testing (OR = 1.15), presence of theoretical upper secondary school (OR 1.71, compared to the absence of theoretical upper secondary school), verbal ability (OR 1.08 per stanine) and visuospatial perception (OR 1.05 per stanine).Conclusion: Over the 30-year period from 1975 to 1995, the prevalence of myopia among Swedish conscripts increased from 22% to 29%. A higher level of education and higher verbal and visuospatial ability were risk factors for myopia.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0