Acta Ophthalmologica最新文献

{"title":"Changes in choroidal thickness and blood flow in myopic children with 0.01% atropine or orthokeratology and atropine combination therapy.","authors":"Saiko Matsumura, Takashi Itokawa, Momoko Kawakami, Tadashi Matsumoto, Hitoshi Ishikawa, Yuichi Hori","doi":"10.1111/aos.17537","DOIUrl":"https://doi.org/10.1111/aos.17537","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate changes in choroidal thickness (CT), choroidal blood flow and axial length (AL) after therapy with either 0.01% atropine eye drops (AT) or the combination of orthokeratology and 0.01% AT (OKA) among Japanese myopic children.</p><p><strong>Methods: </strong>We analysed changes in CT, choroidal blood flow and AL among myopic children who received either 0.01% AT or the OKA therapy at Toho University Omori Hospital from January 2021 through December 2022 (n = 38 eyes, 8.26 ± 2.13 years old in the 0.01% AT group and n = 44 eyes, 8.36 ± 1.54 years old in the OKA group). Comprehensive ophthalmologic examinations were performed at baseline, 3, 6 and 12 months.</p><p><strong>Results: </strong>Subfoveal CT increased in the OKA group more than that in the AT group at 3, 6 and 12 months. Choroidal blood flow increase was greater in the OKA group compared to that in the AT group at 6 and 12 months. AL increase was less in the OKA group than that in the AT group at 6 and 12 months. AL changes were negatively correlated with choroidal blood flow and CT changes at both time points. In multivariate analysis, age, male, CT change and choroidal blood flow were independently associated with AL changes at 12 months.</p><p><strong>Conclusion: </strong>The increase in CT was more pronounced in the combination therapy group compared to the AT group. The increase in CT and choroidal blood flow was associated with a reduced AL progression.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for dysphotopsia and spectacle-independent visual function after implantation of non-diffractive extending focus intraocular lenses.","authors":"Raimo Tuuminen, Sohee Jeon, Byung Ju Jung, Kun Moon","doi":"10.1111/aos.17560","DOIUrl":"https://doi.org/10.1111/aos.17560","url":null,"abstract":"<p><strong>Background: </strong>Intraocular lenses (IOLs) employing extending focus and multifocality technologies are becoming increasingly popular in cataract and lens surgeries. However, research on the preoperative factors affecting subjective surgical outcomes remains elusive.</p><p><strong>Methods: </strong>188 emmetropic bilaterally operated patients were analysed. We compared the outcomes of non-diffractive enhanced monofocal Tecnis Eyhance (N = 86) and non-diffractive extended depth-of-focus AcrySof Vivity (N = 102) IOLs in terms of visual acuities, dysphotopsia (graded from 0 to 100) and spectacle-independent visual function index (VF)-14 questionnaire scores. Next, we analysed correlations between the baseline ocular parameters and refractive outcomes with the dysphotopsia and VF-14 scores. Multivariable linear regression analyses were adjusted for patient age, sex and IOL type.</p><p><strong>Results: </strong>Acrysof Vivity provided better uncorrected near (0.19 ± 0.12 vs. 0.27 ± 0.13 LogMAR units, p < 0.001) and uncorrected intermediate visual acuities (0.11 ± 0.10 vs. 0.15 ± 0.10 LogMAR units, p = 0.033), and better spectacle-independent VF-14 scores (93.2 ± 5.7 vs. 80.9 ± 12.2; p < 0.001), but higher glare scores (8.60 ± 17.2 vs. 2.16 ± 5.74; p = 0.035) compared to Tecnis Eyhance. Photopic (r = 0.283; B 9.39, 95% CI 4.66 to 14.1; p = 0.006) and mesopic pupil size (r = 0.263; B 6.35, 95% CI 2.91 to 9.79; p = 0.045) were associated with overall dysphotopsia scores. The axial length of the eye (r = -0.374; B -3.47, 95% CI -4.73 to -2.22; p < 0.001), total corneal irregular astigmatism (r = -0.388; B -27.3, 95% CI -39.2 to -15.5; p < 0.001), and corneal higher-order aberrations (r = -0.219; B -14.3, 95% CI -26.5 to -1.98; p = 0.023) inversely associated with VF-14 scores. Angles kappa and alpha were not associated with the levels of dysphotopsia or VF-14 scores.</p><p><strong>Conclusions: </strong>Patient-related factors, including corneal irregularity, pupil size and axial length of the eye, may explain the high patient-reported outcome measures variability after the implantation of non-diffractive extending focus IOLs.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal closure of a posterior perforation using amniotic membrane: A novel surgical technique.","authors":"J S Suwandi, B A van der Wel, E H C van Dijk, S S Manning, M Manzulli, P Geeraert, S van Romunde, K Faridpooya","doi":"10.1111/aos.17562","DOIUrl":"https://doi.org/10.1111/aos.17562","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘Ocular bee sting with retained stinger’","authors":"","doi":"10.1111/aos.17564","DOIUrl":"https://doi.org/10.1111/aos.17564","url":null,"abstract":"<p>Abstracts from the 2024 European Association for Vision and Eye Research Congress, 3-5 November 2024, Valencia</p><p>\u0000 https://doi.org/10.1111/aos.17234\u0000 </p><p>The full name of the main author that reads ‘Iatissam’ is incorrect. It should have read as follows: Iatissam El Belhadji.</p><p>We apologize for this error.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"103 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.17564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘An unusual cause of retinal vein occlusion’","authors":"","doi":"10.1111/aos.17563","DOIUrl":"https://doi.org/10.1111/aos.17563","url":null,"abstract":"<p>Abstracts from the 2024 European Association for Vision and Eye Research Congress, 3–5 November 2024, Valencia</p><p>\u0000 https://doi.org/10.1111/aos.17103\u0000 </p><p>The full name of the main author that reads ‘Iatissam’ is incorrect. It should have read as follows: Iatissam El Belhadji.</p><p>We apologize for this error.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"103 6","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.17563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144814727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis and determinants of survival after orbital exenteration for conjunctival melanoma: Experiences from a Dutch Referral Centre.","authors":"David Chetroiu, Niels J Brouwer, Marina Marinkovic, Gregorius P M Luyten, Jaco C Bleeker, Robert M Verdijk, T H Khanh Vu, Stijn W van der Meeren","doi":"10.1111/aos.17553","DOIUrl":"https://doi.org/10.1111/aos.17553","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the prognosis and determinants of survival after orbital exenteration in patients with conjunctival melanoma (CoM).</p><p><strong>Methods: </strong>In a retrospective study, 27 consecutive patients who underwent exenteration for CoM from 2001 to 2023 were included. Overall survival (OS), progression-free survival (PFS) and their risk factors were analysed.</p><p><strong>Results: </strong>The mean follow-up time since orbital exenteration was 42 ± 37 months. Eyelid sparing orbital exenteration was achieved in 24 patients (89%). Two patients (7%) developed local recurrences. Seven patients (26%) developed distant metastasis resulting in a metastasis-free survival of 100% at 1 year and 63% at 5 years. The PFS was 100% and 63% at 1 and 5 years, respectively. The OS for 1, 5 and 10 years was 92, 57 and 31%, respectively. Presence of recurrences prior to exenteration and longer time from diagnosis to exenteration were related to worse OS (both p = 0.02). Presence of metastasis prior to exenteration, orbital invasion and tumour-containing resection margins were related to a worse PFS at 5 years (p = 0.03, p = 0.03 and p = 0.02, respectively).</p><p><strong>Conclusion: </strong>For CoM patients treated with orbital exenteration, the presence of metastases and recurrences prior to exenteration, longer time from diagnosis to exenteration, orbital invasion and tumour-containing resection margins are unfavourable prognostic factors. Our study demonstrates relatively favourable outcomes, with no difference in survival between eyelid sparing or eyelid removing techniques, calling to consider orbital exenteration for advanced CoM cases when other (newer) therapies are not applicable.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fellowships across Europe: Insights from the European Board of Ophthalmology Survey.","authors":"Rémi Yaïci, Helena Prior Filipe, Lauriana Solecki, Léa Dormegny, Emilia Koestel, Sorcha Ní Dhubhghaill, Rimvydas Asoklis, Huban Atilla, Catherine Creuzot-Garcher, Denise Curtin, Barbara Cvenkel, Lisa Flanagan, Brendan Strong, Tero T Kivelä, Anna Maino, Rafael Martinez Costa, Renata Ivekovic, Siegfried Priglinger, Christian Pruente, Marcin Stopa, Marie José Tassignon, Wagih Aclimandos, Tristan Bourcier","doi":"10.1111/aos.17555","DOIUrl":"https://doi.org/10.1111/aos.17555","url":null,"abstract":"<p><strong>Purpose: </strong>Analyse the results of a European Board of Ophthalmology (EBO) survey on post-residency training (fellowship) opportunities across Europe, providing insights from ophthalmic educators on the current landscape.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using an anonymous 31-question online survey distributed to educators in all EBO-affiliated countries.</p><p><strong>Results: </strong>The response rate was 61% with participation of 392 ophthalmic educators. Despite broad participation, Southwestern Europe was overrepresented, while Northern and Central Europe were underrepresented, affecting regional balance. Respondents had a mean age of 51 ± 11 years, with 37.8% as professors and 46.6% as department heads. Most (54.1%) were affiliated with university hospitals. The reported median percentage of residents pursuing post-residency training was 25%, varying between 15% and 100%, with 15.3% of respondents uncertain about their existence, especially in non-university hospitals. Post-residency training durations were predominantly 1 or 2 years. National diplomas were highly valued except in the United Kingdom; language proficiency was required in 84.2% of countries. Respondents reported a median of three positions per department, with 60% filled by local residents. Surgical activity accounted for 65%, with regional variations, whereas 40% of positions involved research. Observerships remained rare (10%). Financial compensation was provided in 67% of cases. A national medical licence was deemed essential, whereas the EBO diploma and letters of recommendation were moderately valued, especially in Northern Europe. Fellowships were highly recommended by 76.2%, while 63% believed that grants would improve access to positions.</p><p><strong>Conlusion: </strong>This survey represents the largest data set on post-residency training in Europe. Results highlight a lack of cohesion in fellowship opportunities, with many respondents uncertain about national programmes. A national medical licence remains the primary requirement, while language proficiency and financial support are key factors influencing access. Institutional support for medical educators is increasing, yet challenges persist regarding time, resources and funding. Focusing on subspecialty training and research, fellowships are crucial for career progression. Expanding training opportunities through international initiatives could further enhance accessibility and standardisation across Europe.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae.","authors":"Ingemar Gustafsson, Thorbjörg Olafsdottir, Olof Neumann, Dimitrios Bizios, Anders Ivarsen, Jesper Ø Hjortdal","doi":"10.1111/aos.17551","DOIUrl":"10.1111/aos.17551","url":null,"abstract":"<p><strong>Purpose: </strong>To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae.</p><p><strong>Methods: </strong>A randomised study using epithelium-off corneal cross-linking (CXL) with continuous UVA irradiance 9 mW/cm² for 10 min (total fluence 5.4 J/cm²) and two kinds of riboflavin solutions: (i) isoosmolar dextran-based riboflavin (n = 27) and (ii) hypoosmolar dextran-free riboflavin (n = 27) for the treatment of progressive keratoconus. Visual acuity (corrected and uncorrected), tomographic parameters and endothelial cell count were obtained at baseline and after 1 year. Corneae thinner than 400 μm were also included. A safety limit of 400 μm was used, and sterile water was added if the corneae fell short of this limit during the treatment.</p><p><strong>Primary outcome: </strong>Change in Kmax.</p><p><strong>Results: </strong>There were no statistically significant differences in any of the parameters between the isoosmolar and hypoosmolar groups. In the isoosmolar group, 74% of the patients required the addition of sterile water, while only 15% required it in the hypoosmolar group. The measurements of densitometry in the 0-2 mm zone improved less in the group that received sterile water; otherwise, there were no statistically significant differences in any of the parameters between the groups that did and did not receive the addition of sterile water.</p><p><strong>Conclusions: </strong>The results of this study demonstrate the efficacy and safety in using hypoosmolar riboflavin when performing CXL for progressive keratoconus. The results also demonstrate the efficacy and safety of using sterile water in corneae thinner than 400 μm.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle tendon elongation with bovine pericardium (Tutopatch®) in patients with Graves' orbitopathy; a prospective, observational, multicentre study.","authors":"H M Jellema, M Oeverhaus, A Eckstein, I Mombaerts, R J H M Kloos, D T Hartong, P Nieuwkerk, P Saeed","doi":"10.1111/aos.17545","DOIUrl":"https://doi.org/10.1111/aos.17545","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with severe ocular motility restriction and/or large angle strabismus due to Graves' orbitopathy (GO) cannot be adequately addressed with conventional strabismus surgery using large muscle recessions. Muscle tendon elongation surgery, using a spacer of bovine pericardium (Tutopatch®) has emerged as a valuable alternative. The purpose of this study was to assess the long-term outcome of muscle elongation surgery in patients with GO.</p><p><strong>Methods: </strong>A prospective observational cohort study in three University centres was conducted. All GO patients requiring strabismus surgery with elongation material of one or more rectus muscles were included. One week preoperatively and 3 and 6 months postoperatively, ophthalmic and orthoptic examinations were performed.</p><p><strong>Results: </strong>Thirty-five patients were enrolled in the study. The mean length of spacer used was 8.2 mm (range 4-13 mm). Tendon elongation was performed on 15 inferior rectus muscles, 33 medial rectus muscles and 9 superior rectus muscles. The field of BSV improved from 0 points [IQR 0-0] preoperatively to 80 points [IQR 6-92] postoperatively (p < 0.001). QoL for functional questions changed from 47 points [IQR 31-63] preoperatively to 78 points [IQR 73-100] postoperatively (p = <0.001). HADS level of anxiety and depression remained below the cut-off score of 15 points (preoperative 11.5 and postoperative 5.7 points).</p><p><strong>Conclusions: </strong>Using the muscle tendon elongation technique with Tutopatch® in GO patients with severely restricted strabismus, 3 months after surgery a stable large field of BSV can be achieved with associated improvement of the QoL. It is a safe and effective alternative to large muscle recessions for restricted muscle.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuity of care and risk of vision loss in patients with newly developed macular degeneration.","authors":"In Hwan Cho, Minah Park, Dae Joong Ma, In Hwan Hong, Hyunkyu Kim, Seung Hoon Kim","doi":"10.1111/aos.17547","DOIUrl":"https://doi.org/10.1111/aos.17547","url":null,"abstract":"<p><strong>Purpose: </strong>Neovascular age-related macular degeneration (AMD) is a major cause of vision loss. Effective treatment requires sustained care, which may be influenced by continuity of care (COC). Understanding this association is crucial for improving patient outcomes. We investigated the association between COC and the risk of visual impairment in patients newly diagnosed with neovascular AMD.</p><p><strong>Methods: </strong>This nationwide cohort study sourced data from the South Korean National Health Insurance Service database (2014-2021). In total, 15 563 (6210 females) newly diagnosed patients with neovascular AMD were included. The COC index, based on the frequency of ophthalmology visits over the first 2 years post-diagnosis, was assessed; a threshold of 0.75 was used to define good continuity. The primary outcome was visual impairment. Statistical models were used to assess the association between COC and the visual impairment risk, with adjustment for relevant confounding variables.</p><p><strong>Results: </strong>Patients with a bad COC index had a significantly higher cumulative incidence (6.86% vs. 4.78%) and a higher incidence rate of visual impairment (909 vs. 704 cases per 100 000 person-years; 95% confidence interval, 764.0-1080.4, p < 0.001). This elevated risk was especially notable for female patients, patients aged ≥70 years, and patients with lower comorbidity burdens.</p><p><strong>Conclusions: </strong>Poor COC is associated with increased visual impairment risk in patients with neovascular AMD. Strategies to improve COC may reduce this risk, particularly among older adults and high-risk groups.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}