Changes in choroidal thickness and blood flow in myopic children with 0.01% atropine or orthokeratology and atropine combination therapy.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2025-07-16 DOI:10.1111/aos.17537

Saiko Matsumura, Takashi Itokawa, Momoko Kawakami, Tadashi Matsumoto, Hitoshi Ishikawa, Yuichi Hori

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引用次数: 0

Abstract

Purpose: To evaluate changes in choroidal thickness (CT), choroidal blood flow and axial length (AL) after therapy with either 0.01% atropine eye drops (AT) or the combination of orthokeratology and 0.01% AT (OKA) among Japanese myopic children.

Methods: We analysed changes in CT, choroidal blood flow and AL among myopic children who received either 0.01% AT or the OKA therapy at Toho University Omori Hospital from January 2021 through December 2022 (n = 38 eyes, 8.26 ± 2.13 years old in the 0.01% AT group and n = 44 eyes, 8.36 ± 1.54 years old in the OKA group). Comprehensive ophthalmologic examinations were performed at baseline, 3, 6 and 12 months.

Results: Subfoveal CT increased in the OKA group more than that in the AT group at 3, 6 and 12 months. Choroidal blood flow increase was greater in the OKA group compared to that in the AT group at 6 and 12 months. AL increase was less in the OKA group than that in the AT group at 6 and 12 months. AL changes were negatively correlated with choroidal blood flow and CT changes at both time points. In multivariate analysis, age, male, CT change and choroidal blood flow were independently associated with AL changes at 12 months.

Conclusion: The increase in CT was more pronounced in the combination therapy group compared to the AT group. The increase in CT and choroidal blood flow was associated with a reduced AL progression.

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0.01%阿托品或角膜塑形与阿托品联合治疗对近视儿童脉络膜厚度和血流的影响。

目的：评价0.01%阿托品滴眼液（AT）或角膜塑形术联合0.01% AT （OKA）治疗后日本近视儿童脉络膜厚度（CT）、脉络膜血流量和轴长（AL）的变化。方法：分析2021年1月至2022年12月在东宝大学大森医院接受0.01% AT或OKA治疗的近视儿童的CT、脉络膜血流量和AL的变化（n = 38眼，0.01% AT组，8.26±2.13岁；n = 44眼，OKA组，8.36±1.54岁）。分别于基线、3个月、6个月和12个月进行全面眼科检查。结果：在3、6、12个月时，OKA组的中央凹下CT值明显高于AT组。在6个月和12个月时，与AT组相比，OKA组脉络膜血流量增加更大。在6个月和12个月时，OKA组的AL升高幅度小于AT组。两个时间点AL变化与脉络膜血流量及CT变化呈负相关。在多变量分析中，年龄、男性、CT改变和脉络膜血流量与12个月时AL变化独立相关。结论：与AT组相比，联合治疗组CT增高更为明显。CT和脉络膜血流量的增加与AL进展减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.