中华整形外科杂志最新文献

{"title":"[Clinical application of orbicularis flap for eyelid groove deformity ].","authors":"Benshou Zhang,&nbsp;Xiangbing Shui,&nbsp;Hui Chu,&nbsp;Zengnan Li,&nbsp;Chao Xie,&nbsp;Zhijiu Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To discuss the correction of lower baggy eyelid with severe tear trough and eyelid sulcus (groove deformity) and its therapeutic effect.</p><p><strong>Methods: </strong>Through incision at the lower eyelid margin, the dissection was performed at the deep surface of the orbicularis muscle to expose the orbital septum and inferior orbital rim periosteum. The orbital fat which was released from orbital septum was repositioned at the inferior orbital rim and fixed on periosteum. If the depression was not completely corrected, the extra orbicularis fixed with periosteum. If the depression was not completely corrected, the extra orbicularis muscle was designed as muscle flap with interior pedicle to further correct the groove deformity.</p><p><strong>Results: </strong>60 cases were treated with no depression or unsmooth deformity. All the cases were followed up for 3-12 months with satisfactory aesthetic effect.</p><p><strong>Conclusions: </strong>Orbicularis flap combined with orbital fat reposition is a simple and effective method for correction of tear trough and eyelid sulcus deformity.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"122-4"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of Le Fort Ⅲ osteotomy with minimal invasive approach in the treatment of midfacial hypoplasia].","authors":"Ruichen Wang,&nbsp;Chunming Liu,&nbsp;Quanwen Gao,&nbsp;Min Hou,&nbsp;Limin Liang,&nbsp;Yusheng Yao,&nbsp;Zuo Ma,&nbsp;Zenggiang Jin,&nbsp;Shimin Chang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To describe a minimal invasive approach in the Le Fort Ⅲ osteotomy procedure.</p><p><strong>Methods: </strong>33 cases with midfacial hypoplasia were treated by Le Fort Ⅲ osteotomy.Incisions were performed with minimal invasive approach,through lower eyelid,intraoral and upper eyelid crease or medial part of eyebrow instead of coronal incision.After the completion of osteotomy,distraction osteogenesis or orthognathic procedures were followed.</p><p><strong>Results: </strong>The midfacial segments achieved enough advancement without obvious relapse.Bleeding and operative time were reduced compared with coronal approach.No obvious scar was left.</p><p><strong>Conclusion: </strong>The Le Fort Ⅲ osteotomy procedure could be successfully performed through minimal approach with steady results and minimal scars.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"93-7"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of the digital osteotomy template in the mandibular angle osteotomy ].","authors":"Chao Zhang,&nbsp;Li Zuo,&nbsp;Xiaolei Jin,&nbsp;Jiajie Xu,&nbsp;Jianjian Lu,&nbsp;Fang Jie,&nbsp;Huanhuan Wu,&nbsp;Liya Yang,&nbsp;Ran Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the application of the digital osteotomy template in the mandibular angle osteotomy,so as to increase the precision and symmetry of the osteotomy.</p><p><strong>Methods: </strong>8 cases were included in our study (female,average age 25.5).The CT data (DICOM format) were reformatted into 3D images using 3D imaging software (ProPlan).The osteotomy lines were designed on digital 3D theoretical model with ProPlan.Then the statistics of the ostectomy were imported into GeoMagic in the form of STL file to design the 3D osteotomy template.The osteotomy template was fabricated with FDA certificated PLA through RP machine. During operation,the template was inserted into operation area to guide the osteotomy.A line was drawn along the edge of ostectomy plate with a grinding ball and osteotomy was done along the curvilinear line using a goose saw.</p><p><strong>Results: </strong>The removed bone proved to be highly matched with the template.All the post-operative results were satisfactory.There were no complications such as fracture,life-threatening hemorrhage and infection.The post-operative measurement showed good symmetry.</p><p><strong>Conclusions: </strong>With the guidance of osteotomy templates,the surgeon can perform the osteotomy in an accurate way.The precision and symmetry of the osteotomy are greatly improved.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reconstruction of totally degloved fingers with a spiraled parallelogram medial arm free flap ].","authors":"Zhenglin Chi,&nbsp;Peng Yang,&nbsp;Dajiang Song","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic results of completely degloved digital injury using a parallelogram free flap from the medial arm in a spiral fashion.</p><p><strong>Methods: </strong>From January 2011 to June 2013,13 defects in 13 patients with non-replantable degloved digital injury were treated with a parallelogram free flap from the medial arm in a spiral fashion.The longitudinal axis of the flap was along the line from the axilla to the medial humeral epicondyle.The medial brachial cutaneous nerve of the arm was harvested for sensory restoration.The non-replantable degloved finger was reconstructed with the medial arm flap in a spiral fashion.The digital artery and dorsal veins were prepared as the recipient pedicle,and the medial brachial cutaneous nerve was sutured to the digital nerve stump.All the wounds at the donor sites were closed directly.</p><p><strong>Results: </strong>The dimension of the flaps ranged from 5.0 cm × 2.0 cm to 7.5 cm × 4.0 cm.Excetp for one partial flap loss,all the other flaps survived uneventfully with conservative therapy.The static 2-point discrimination test varied from 6 to 13 mm.No linear scar contracture was recorded in these patients.All the patients were satisfied with the overall results.</p><p><strong>Conclusion: </strong>Resurfacing the defect in a spiral fashion is a valuable and reliable technique for the reconstruction of complete finger degloved injuries.The medial arm flap is a good option for this procedure,with satisfactory functional recovery and good aesthetic restoration.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"103-6"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Different effects of simvastatin on keloid fibroblasts under hypoxia and TGF-β1 treatment].","authors":"Bin Chen,&nbsp;Chunfu Kang,&nbsp;Dongning Yu,&nbsp;Xia Zhao,&nbsp;Yang An,&nbsp;Zelian Qin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of simvastatin on the proliferation, apoptosis and protein expressions of keloid fibroblasts under normoxia,hypoxia or TGF-β1 treatment.</p><p><strong>Methods: </strong>Keloid fibroblasts (KFs) were isolated by explants culture method. KFs were treated with different concentrations of simvastatin under normoxia or hypoxia (2％ O2) for 24 h and 48 h. The effects of simvastatin on cell proliferation were detected by CCK-8.Flow cytometer was used to detect the apoptosis of KFs treated with 10 μ mol/L simvastatin for 24 h or 48 h under normoxia, hypoxia or 10 ng/ml TGF-β1 treatment. Then the expressions of keloid-related proteins were analyzed by Western Blot.</p><p><strong>Results: </strong>It showed that simvastatin could inhibit the proliferation of KFs in a concentration-and time-dependent manner with the concentration range of 10-500 μ mol/L for 24 h and 0.1-500 μ mol/L for 48 h. This inhibitory effect could be significantly enhanced when cells were incubated under hypoxia for 48h with 10-500 μ mol/L simvastatin.10 μ mol/L simvastatin could not influence the apoptosis of KFs under normoxia or TGF-β1 treatment, neither incubated for 24 h nor 48 h.When incubated under hypoxia,10 μ mol/L simvastatin could significantly induce the apoptosis of KFs, with the rate of 155.6％ for 24 h and 478.8％ for 48 h, compared with no-drug control. There are no significant influences on the expression of type Ⅰ collagen, CTGF or TIMP-1 when KFs were treated with 10 μ mol/L simvastatin under normoxia for 48 h. When incubated with 10 ng/ml TGF-β1 together with 10 μmol/L simvastatin for 48 h, the expression of CTGF was significantly inhibited. KFs treated with 10 μ mol/L simvastatin under hypoxia for 48 h showed a significant decrease of type Ⅰ collagen and CTGF, and a significant increase of TIMP-1.</p><p><strong>Conclusions: </strong>Simvastatin has different effects on the proliferation, apoptosis and protein expressions of KFs in a dosedependent manner under different conditions. The effects are enhanced under hypoxia.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"130-5"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The experimental study of the effect of ASCs on the skin expansion rate in rabbit].","authors":"Zemin Zhang,&nbsp;He Yan,&nbsp;Yongming Yao,&nbsp;Caifeng Wu,&nbsp;Changying Niu,&nbsp;Shengxing Tan,&nbsp;Biaobing Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of adipose-derived stem cells (ASCs) on the skin expansion rate in rabbit.</p><p><strong>Methods: </strong>The rabbit ASCs were isolated from fat tissue and cultured in vitro. The ADSCs were identified by cell immunofluorescence and marked by Edu staining.20 new Zealand rabbits were randomly divided into experimental(n =10) and control group(n =10).An area of 1.5 cm ×1.5 cm on the one side back of each rabbit was tattooed and one 30 ml round expander was implanted subcutaneously. ASCs suspension (1 ml) was injected subcutaneously in the experimental group, while serum free DMEM medium(1 ml) in control group. The expansion was proceeded regularly under constant pressure for 4 weeks.The expanded tattooed square area was measured on the 7th,14th,28th day and analyzed statistically. The expanded skin was harvested for histological study. Immunohistochemical staining was used to detect the expression of vascular endothelial cell marker CD31,and the microvessel density determination. The expression of epidermal growth factor (EGF) and vascular endothelial growth factor(VEGF)was detected by ELISA for skin tissue specificity. Western Blot was used for detection of CK19 in the epidermal cells.</p><p><strong>Results: </strong>The expanded skin thickness and expansion rate in experimental group were significant higher than those in control group (P ＜ 0.05). Compared with control group, the expression of CK19,CD31 and EGF, VEGF, as well as the microvessel density were all markedly increased in experimental group(P ＜0.05).</p><p><strong>Conclusions: </strong>ASCs can increase the expansion rate of skin tissue by promotion of angiogenesis and tissue regeneration.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"136-41"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Repair of the skin and soft tissue defect on upper calf with the lateral popliteal artery perforator flap].","authors":"Kaiyu Nie,&nbsp;Wei Chen,&nbsp;Zairong Wei,&nbsp;Wenhu Jin,&nbsp;Chengliang Deng,&nbsp;Guangfeng Sun,&nbsp;Jianping Qi,&nbsp;Bo Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the feasibility and effect of the lateral popliteal artery perforator flap in repairing the skin and soft tissue defect on upper calf.</p><p><strong>Methods: </strong>The position and course of the perforators were confirmed with the color Doppler ultrasound. The flap was designed with the lateral popliteal artery perforator as the pedicle artery to repair the skin and soft tissue defect on upper calf according to the shape and size of the wound.</p><p><strong>Results: </strong>From January 2010 to January 2014,10 patients with traumatic upper calf skin and soft tissue defect were admitted. The wound size ranged from 3 cm ×2 cmto9 cm×6 cm, and the flap size ranged from3 cm×3 cm to 10 cm×8 cm. The wounds at donor sites were closed directly in 4 cases and were covered with split thickness skin graft in 6 cases. All flaps survived completely. Surgical incisions and wounds at donor sites and recipient sites healed primarily. All cases were followed up for 6-15 months (10 months on average) with good flaps color, texture and shape.</p><p><strong>Conclusions: </strong>The lateral popliteal artery perforator flap has reliable blood supply and is easily performed. It is one of the optional methods for repairing wound of the upper calf.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"107-10"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of popliteal intermediate cutaneous artery descending branch island flap for treatment of knee joint scar].","authors":"Guangfeng Sun,&nbsp;Wenhu Jin,&nbsp;Zairong Wei,&nbsp;Kaizuo Nie,&nbsp;Jianping Qi,&nbsp;Chengliang Deng,&nbsp;Dali Wang,&nbsp;Ziyang Zhang,&nbsp;Shujun Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect with the popliteal intermediate cutaneous artery descending branch island flap repair the wound in the knee joint after resection of scar.</p><p><strong>Methods: </strong>From January 2006 to December 2014,A total of 12 cases of knee joint contracture patients,8 cases were male,4 were female; the age ranged from 4 to 58 years old;8 cases of hot water scald, electric injury in 2 cases,2 cases of scar radioactive contracture,3 cases with ulcer. The knee extension 10 degrees to 30 degrees. For scar excision of knee joint loosening, the scar excision wound size (3-5) cm × (10-14) cm, popliteal intermediate cutaneous wounds with artery descending branch island flap, The flap size (4-6) cm × (11-15) cm. Donor sites were closed directly in 2 cases,10 cases of skin graft.</p><p><strong>Results: </strong>The all were followed up after operation. Follow-up 6 to 24 months, the 12 cases survived completely, and the skin graft donor site homogeneity of survival, the skin color and similar to the surrounding mucosa, soft texture, shape is not bloated, the knee extension of up to 0 degree, and the walking without a limp.</p><p><strong>Conclusions: </strong>The popliteal intermediate cutaneous artery descending branch island flap blood supply is reliable, donor and recipient adjacent region, which has the advantages of simple operation, is one of the ideal flap for repairing the knee joint wound.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"115-7"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reconstruction of trunk soft-tissue defect using the propeller flaps based on the perforators of the posterior intercostal artery ].","authors":"Shan Zhu,&nbsp;Yuanbo Liu,&nbsp;Shengii Yu,&nbsp;Mengging Zuo,&nbsp;Bo Chen,&nbsp;Qiang Ding,&nbsp;Jianhua Zhang,&nbsp;Zhenguo Zhao,&nbsp;Libin Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the feasibility and technical tips of the posterior intercostal artery perforator (PICAP) flaps for trunk defect reconstruction.</p><p><strong>Methods: </strong>The PICAPs were thoroughly explored with the hand-held ultrasound Doppler.According to the size,shape and location of the defect,a perforator flap was raised based on the chosen PICAP,rotated in a certain degree and used to reconstruct the torso defect.</p><p><strong>Results: </strong>From October 2009 to October 2015,22 patients underwent defect reconstruction using the PICAP propeller flaps.The chosen perforators derived from the vertebral segments of the posterior intercostal arteries in 2 patients,from costal groove segments in 15,from intermuscular segments in 4,and from subcostal artery in 1.The skin paddle dimension ranged from 12 cm × 4 cm-30 cm × 10 cm.The length of the perforator pedicle was 3.5-7.0 cm (average 4.8 cm).The flaps were rotated 180° in 15 patients,150° in 4 patients,and 90° in 3 patients.19 flaps survived completely.Distal partial flap necrosis occurred in two flaps and total flap necrosis in one.All wounds at donor sites were closed directly.The patients were followed up for 1 to 5 years (average 3.5 years) with satisfactory outcomes and no tumor recurrence.</p><p><strong>Conclusions: </strong>The PICAP propeller flap provides a valuable option for different torso defects reconstruction.</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"98-102"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The feasibility of adenoviral co-transduction of BMP2 and BMP7 for the expression of recombinant human BMP2/7 heterodimer in rat bone marrow mesenchymal stem cells].","authors":"Tao Gao,&nbsp;Shengjian Tang,&nbsp;Changying Niu,&nbsp;Chinlei Miao,&nbsp;Wei Zhang,&nbsp;Lulu Zhou,&nbsp;Caifeng Wu,&nbsp;Fangjun Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the feasibility of rat bone marrow mesenchymal stem cells (BMSCs) as the target cell of adenovirus-mediated co-transduction of BMP2 and BMP7 genes and then facilitate the expression of recombinant BMP2/7 heterodimer protein.</p><p><strong>Methods: </strong>3 adult male Fischer 344 rats of about 10 weeks of age were used for harvest and in vitro culture of rat BMSCs. Recombinant adenovirus vector carrying BMP2 or BMP7 target genes were constructed with AdMax vector system, and production of high-titer adenoviruses were packaged with HEK293T cells and then concentrated with CSCl2 density-gradient ultra-centrifugation. Rat BMSCs from passage 3 were seeded in 6-well plates at the concentration of 10 000 cells/cm2.After overnight pre-culture, BMSCs were allowed to culture in 200 μl serum-free alpha MEM containing both Ad-BMP2 and Ad-BMP7 adenovirus (100 MOI of each virus). After 7 days in vitro culture, conditioned cell culture supernatants were collected and followed by immunoprecipitation through immune protein G columns pre-loaded with mouse anti-human BMP7 antibody. The resulted protein immune-precipitates were used to assay the expression of BMP2/7 heterodimers via Western Blot and ELISA assay. As a negative control, Rat BMSCs were also genetically transduced with Ad-GFP virus at a concentration of 200 MOI.</p><p><strong>Results: </strong>Our data demonstrated that recombinant adenoviruses carrying BMP2 or BMP7 target gene was successfully reconstructed, packaged, and confirmed via Western Blot assay, which as respected, presented as an unique band at 55 000 size for BMP2 or 49 000 size for BMP7.Adenovirus Ad-GFP was used to verify the integrity of recombinant virus and its transfection efficiency in rat BMSCs, which showed well cell attachment to culture plate and had no cytotoxicity. Green fluorescent protein in BMSCs was also noted eminently under fluorescent microscope. Combined transduction with AdBMP2 plus Ad-BMP7 resulted in the formation of BMP2/7 heterodimers from rat BMSCs. Analysis of conditioned medium via Western Blot assay showed a single protein band of about 47 000 size, just as expected. Quantitative ELISA analysis presented a prominent expression of about (4.33 ± 0.42) ng/ml for recombinant BMP2/7 heterodimers. A paired t test showed significant difference (P ＜ 0.05),when compare to control groups of (0.08 ± 0.02) ng/ml.</p><p><strong>Conclusions: </strong>As an ideal cell source for tissue engineering, rat BMSCs can be genetically modified with Ad-BMP2 plus Ad-BMP7 mediated co-transduction strategy, and efficiently produce recombinant human BMP2/7 heterodimers in vitro, which should facilitate further studies on the beneficial effect of BMP2/7 heterodimers to ex vivo osteogenesis of BMSCs</p>","PeriodicalId":69147,"journal":{"name":"中华整形外科杂志","volume":"32 2","pages":"125-29"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36327895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}