{"title":"[Determining factors of non-compliance among patients undergoing polychemotherapy in the district of Bamako (Mali)].","authors":"P M Sylla, L Blanc, S Sow, A S Diallo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to examine the factors determining irregularity among patients undergoing multidrug therapy in Bamako district, we conducted a non-experimental study based, in the first instance, on medical records and later on a questionnaire. One thousand one hundred and seventy-five (1,175) treatment cards were reviewed in this way. The results of our study show that 3.1% of the patients fail to attend treatment sessions regularly and that multibacillary patients have more irregular attendance than paucibacillary patients. We have not observed any statistically meaningful difference between old and new patients as far as irregularity in attending multidrug therapy sessions is concerned. The second part of our research based on a questionnaire targeting a group of cases (36 patients who did not attend regularly) and a random control group (50 patients who attended treatment regularly but had missed at least one treatment) has shown that it is only for Item VI (\"Have you ever missed your appointment because you perhaps considered yourself cured?\") that a statistically meaningful difference emerges between cases and controls regarding the rates of affirmative responses (p < 0.05).</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Lombardi, S Cohen, D L Leiker, J M Souza, P R Cunha, C M Martelli, A L Andrade, F Zicker
{"title":"Agreement between histopathological results in clinically diagnosed cases of indeterminate leprosy in São Paulo, Brazil.","authors":"C Lombardi, S Cohen, D L Leiker, J M Souza, P R Cunha, C M Martelli, A L Andrade, F Zicker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Histopathological slides from skin biopsies of fifty-seven self-reporting patients diagnosed as indeterminate leprosy by the Leprosy Control Programme in São Paulo, were sent to three independent histopathologists. Agreement between the reports were based on the following diagnosis: \"indeterminate leprosy\", \"suggestive leprosy\" or \"no leprosy\". A great variation was observed in the interpretation of the histopathological examination. The three pathologists reported \"indeterminate leprosy\" respectively in 7.0%, 54.4% and 84.2%, of the cases studied. A kappa index of agreement between any two pathologists ranged from 0.08 to 0.32, showing poor agreement between observers. Agreement improved by pooling together the reports \"suggestive leprosy\" and \"indeterminate leprosy\". The three pathologists agreed in the results of 24 biopsies of the 27 classified as leprosy by any one of the three observers. Eight cases were considered as \"no leprosy\" by all pathologists. Higher agreement indices were obtained for positive and negative proportionate concordance between any two examiners. The implications of the variation in the diagnosis of indeterminate leprosy and early leprosy are discussed in the context of public health and case-management.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"83-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Characterization of chronic plantar ulcers in former leprosy patients].","authors":"M Y Grauwin, B Gentile, A Chevallard, J L Cartel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Between 1988 and 1992, 21 biopsies for pathological examination were taken from 20 Senegalese leprosy patients suffering from chronic plantar ulcers (CPU) suspected of malignant transformation. The diagnosis of squamous cell carcinoma was effectively made in 13 cases and that of pseudoepitheliomatous hyperplasia in the remaining 8 cases. The mean period of time between the onset of CPU and that of malignant transformation was 10 years (range: 1 to 15 years); the mean annual frequency of the malignant transformation was 2 per 1,000 CPU. In countries where pathological examination is not available, below knee amputation could be considered whenever main clinical signs of malignant transformation are present. In countries where pathological examination is available, the therapeutic decision may differ according to the diagnosis: below knee amputation supplemented with block dissection of inguinal lymph nodes whenever possible in cases of carcinoma; below knee amputation depending on the function status of the foot and on the volume of tumor in case of pseudo-epitheliomatous hyperplasia.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19200964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Consumer and community participation in care and readaptation programs targeted to people with leprosy].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"61-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D L Vu, B Chabaud, K K Nguyen, V T Nguyen, T Q Hoang
{"title":"[An original experience through the creation of a new functional rehabilitation center for Vietnamese lepers].","authors":"D L Vu, B Chabaud, K K Nguyen, V T Nguyen, T Q Hoang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since 1990, the creation of a Rehabilitation Center for Vietnamese leprosy patients under the aegis of \"Oeuvres Hospitalières Françaises de l'Ordre de Malte\" is the result of emphasized collaboration between governmental and non-governmental organizations, and between medical and paramedical specialists. This humanitarian action is not \"a present home delivery\". The end of this action is to set progressively a realist enterprise that depends on preliminary epidemiologic investigations on the spot to analyse means and necessities. Frequency of disabilities (49.6%) and predominance of grades 1 and 2 (83.5%) require aids. The realisation of technology transfer at all medical care levels is necessary. But at the same time, it is essential to build surroundings adapted infrastructure, to equip with effective material giving comfort and security for patients, and even to supply with pharmaceutic drugs in order to continue rehabilitation's activities. In short range, patient's selection and regular control give first objective results.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 1","pages":"35-43"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19200966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myiasis in leprosy.","authors":"A Husain, S Husain, G N Malaviya, R R Bahadur","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the 1989-1991 year period, leprosy patients with various ulcers, attending the surgical O.P.D. at CJIL, Agra were seen. Of these, 64 cases were found to be infested with maggots. Live maggots were collected in all cases from different sites viz. nasal cavity, hand, great toe and second toe. It was possible to rear the maggots into flies in 53 out of 64 cases. In 11 cases the maggots did not survive and died in the early part of their life cycle. Four different types of flies were identified viz. Sarcophaga haemorrhoidalis, Chrysomya bezziana, Callitroga americana and Musca domestica.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"8 3","pages":"137-41"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19204409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Attempts to cultivate Mycobacterium leprae in fat tissue.","authors":"C M Godard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The behaviour of M. leprae in fat tissue was studied. Preadipocyte cells were infected with M. leprae and injected intradermally (I.D.) into nude mice. Adipose nodules obtained by in vivo differentiation of infected cells were maintained in vivo for 3 months and subsequently incubated in vitro for 3 months. Counts of bacilli showed no increase over this 6 months period. It is concluded that undifferentiated preadipocyte and mature fat cells are not permissive for M. leprae. The morphological changes observed following passage of M. leprae into adipose nodules might be related to the process of adipose cell differentiation.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"8 3","pages":"133-5"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19204408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}