Attempts to cultivate Mycobacterium leprae in fat tissue.

Acta leprologica Pub Date : 1993-01-01
C M Godard
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Abstract

The behaviour of M. leprae in fat tissue was studied. Preadipocyte cells were infected with M. leprae and injected intradermally (I.D.) into nude mice. Adipose nodules obtained by in vivo differentiation of infected cells were maintained in vivo for 3 months and subsequently incubated in vitro for 3 months. Counts of bacilli showed no increase over this 6 months period. It is concluded that undifferentiated preadipocyte and mature fat cells are not permissive for M. leprae. The morphological changes observed following passage of M. leprae into adipose nodules might be related to the process of adipose cell differentiation.

尝试在脂肪组织中培养麻风分枝杆菌。
研究了麻风分枝杆菌在脂肪组织中的行为。用麻风分枝杆菌感染裸鼠前脂肪细胞,皮下注射麻风分枝杆菌。通过感染细胞体内分化获得的脂肪结节在体内维持3个月,随后在体外培养3个月。在这6个月期间,杆菌计数未见增加。结论:未分化的前脂肪细胞和成熟脂肪细胞不允许麻风分枝杆菌存在。麻风分枝杆菌进入脂肪结节后的形态变化可能与脂肪细胞分化过程有关。
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