[前麻风病患者慢性足底溃疡的特征]。

Acta leprologica Pub Date : 1994-01-01
M Y Grauwin, B Gentile, A Chevallard, J L Cartel
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引用次数: 0

摘要

1988年至1992年间,对20名患有慢性足底溃疡(CPU)的塞内加尔麻风病患者进行了21次病理活检。13例有效诊断为鳞状细胞癌,8例诊断为假上皮瘤性增生。CPU发病至恶性转化的平均时间为10年(范围:1 ~ 15年);恶性转化的年平均频率为2 / 1000 CPU。在没有病理检查的国家,只要出现恶性转化的主要临床症状,就可以考虑进行膝下截肢。在可以进行病理检查的国家,治疗决定可能根据诊断而有所不同:在癌症病例中,只要可能,膝关节下截肢并辅以腹股沟淋巴结的块性清扫;假性上皮瘤增生时,视足部功能状况及肿瘤体积而定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Characterization of chronic plantar ulcers in former leprosy patients].

Between 1988 and 1992, 21 biopsies for pathological examination were taken from 20 Senegalese leprosy patients suffering from chronic plantar ulcers (CPU) suspected of malignant transformation. The diagnosis of squamous cell carcinoma was effectively made in 13 cases and that of pseudoepitheliomatous hyperplasia in the remaining 8 cases. The mean period of time between the onset of CPU and that of malignant transformation was 10 years (range: 1 to 15 years); the mean annual frequency of the malignant transformation was 2 per 1,000 CPU. In countries where pathological examination is not available, below knee amputation could be considered whenever main clinical signs of malignant transformation are present. In countries where pathological examination is available, the therapeutic decision may differ according to the diagnosis: below knee amputation supplemented with block dissection of inguinal lymph nodes whenever possible in cases of carcinoma; below knee amputation depending on the function status of the foot and on the volume of tumor in case of pseudo-epitheliomatous hyperplasia.

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