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Acta leprologica最新文献

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Membrane attack complex in thickened cutaneous sensory nerves of leprosy patients. 麻风病患者增厚皮肤感觉神经的膜攻击复合体。
Acta leprologica Pub Date : 1995-01-01
O Parkash, V Kumar, A Mukherjee, U Sengupta, G N Malaviya, B K Girdhar
{"title":"Membrane attack complex in thickened cutaneous sensory nerves of leprosy patients.","authors":"O Parkash,&nbsp;V Kumar,&nbsp;A Mukherjee,&nbsp;U Sengupta,&nbsp;G N Malaviya,&nbsp;B K Girdhar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Membrane attack complex (MAC) is a terminal end product produced as a result of complement activation. The deposition of MAC, in tissues, is known to have a local tissue damaging effect in several clinical conditions. Therefore, an attempt was made to demonstrate MAC in peripheral nerve biopsies, collected from leprosy patients. Interestingly, we could demonstrate deposition of MAC in involved cutaneous sensory nerves from most of the lepromatous leprosy patients. Contrary to this, majority of nerve biopsies from tuberculoid leprosy patients did not stain for MAC. Though MAC positive sections showed reactivity for S-protein, our observations support the possibility that MAC, either acting directly or indirectly, may be implicated in nerve damage, at least, in lepromatous leprosy patients.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 4","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19685166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antileprosy polychemotherapy in the member states of the OCCGE: a decade of implementation (1983-19930). The National Coordinators of the Leprosy Program of the 8 states of the OCCGE]. [OCCGE成员国的抗麻风综合化疗:十年实施(1983-1993)]。OCCGE的8个州麻风病项目国家协调员。
Acta leprologica Pub Date : 1995-01-01
A Tiendrebeogo, L Blanc, P M Sylla
{"title":"[Antileprosy polychemotherapy in the member states of the OCCGE: a decade of implementation (1983-19930). The National Coordinators of the Leprosy Program of the 8 states of the OCCGE].","authors":"A Tiendrebeogo,&nbsp;L Blanc,&nbsp;P M Sylla","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>MDT for leprosy recommended by WHO in 1981 has been introduced and implemented in 8 Member States of OCCGE (an organization for leprosy control in francophone West Africa). This implementation from 1983 to 1993 can be divided in two phases: 1983-1987: introduction phase by pilot projects; 1988-1993: extension phase by national leprosy control programmes. During the ten years, MDT coverage rose to 68%, leprosy prevalence rate widely decreased (40.71 to 6.56 per 10,000), while annual detection rate weakly varied (1.89 to 1.26 per 10,000). Factors influencing this evolution of leprosy are brought out and recommendations are made about strategies to be developed for leprosy control up to year 2000.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 3","pages":"139-47"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18636423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement in the histological diagnosis of indeterminate leprosy by demonstration of mycobacterial antigens. 分枝杆菌抗原显示对不确定麻风病的组织学诊断的增强作用。
Acta leprologica Pub Date : 1995-01-01
M Natrajan, K Katoch, V M Katoch, V P Bharadwaj
{"title":"Enhancement in the histological diagnosis of indeterminate leprosy by demonstration of mycobacterial antigens.","authors":"M Natrajan,&nbsp;K Katoch,&nbsp;V M Katoch,&nbsp;V P Bharadwaj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a clinico-pathological study of Indeterminate leprosy, fifty-six cases were chosen based on specified clinical criteria. Their clinical features were noted, the smears for acid fast bacilli (AFB) were prepared from lesions, lepromin inoculation and biopsies were performed from the lesional edges. They were subsequently treated with a modified extended WHO regimen for paucibacillary leprosy. On routine hematoxylin eosin (HE) and Fite-Faraco staining of paraffin embedded sections, histopathological confirmation of Indeterminate leprosy was observed in only 17/56 (31%) of the clinically diagnosed cases whereas the remaining were labelled as non-specific pathology. Histometric analysis of all HE stained sections did not show any characteristic finding which could be considered as characteristic and discriminatory for Indeterminate leprosy. Immunoperoxidase staining for demonstration of mycobacterial antigen by direct staining procedure using conjugated rabbit anti-BCG and indirect three step procedure using primary rabbit anti-BCG and avidin biotin complex, was next performed on the sections exhibiting non-specific pathology. With the direct immunoperoxidase method, antigen was demonstrable in (11/35) 31% of the cases. The more sensitive indirect method could demonstrate the presence of antigen in (21/35) 60% of the cases. This study thus shows that demonstration of mycobacterial antigen by simple and inexpensive immunoperoxidase techniques enhances the histopathologic diagnosis of Indeterminate leprosy.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 4","pages":"201-7"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19685168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliography. 参考书目。
Acta leprologica Pub Date : 1995-01-01
{"title":"Bibliography.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 3","pages":"153-64"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18636425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Apropos of a case of perforating, leprous plantar ulcer occuring at 15 years of age]. [关于一例15岁发生的穿孔，麻风病足底溃疡]。
Acta leprologica Pub Date : 1994-01-01
R Nouira, J Zili, M Denguezli, C Belajouza, B Jomaa
{"title":"[Apropos of a case of perforating, leprous plantar ulcer occuring at 15 years of age].","authors":"R Nouira,&nbsp;J Zili,&nbsp;M Denguezli,&nbsp;C Belajouza,&nbsp;B Jomaa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Perforating ulcers of the foot occurring in leprosy are frequent, chronic, often giving mutilations. They usually affect the adult. Plantar ulcer occurred in a 15 year-old young patient affected by tuberculoid leprosy has incited us to report it.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 1","pages":"31-4"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19200965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical correction of saddle nose deformity in leprosy--one stage procedure. 麻风病鞍鼻畸形的一期手术矫正。
Acta leprologica Pub Date : 1994-01-01
G N Malaviya, S Husain
{"title":"Surgical correction of saddle nose deformity in leprosy--one stage procedure.","authors":"G N Malaviya,&nbsp;S Husain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In twenty-four leprosy patients having mild to moderate nasal deformity, a corticoperiosteal bone graft obtained from second metatarsal bone was placed in a pocket created between the lining and cover of the nose. The cases were evaluated later, mean follow-up period being 4 1/2 years. The results were satisfactory in 13 patients. Improved shape was reported in 7 and poor in 3. The bone graft got incorporated and consolidated at the recipient site in 16 cases. The main donor site problem was overriding of the donor toe. The operated cases need health education for after-care of nose since nasal mucosa is atrophic.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoprecipitation of mycobacterial antigens with sera from patients with leprosy. 麻风病患者血清分枝杆菌抗原的免疫沉淀。
Acta leprologica Pub Date : 1994-01-01
J A Kode, S V Chiplunkar, P D Samson, M G Deo, S G Gangal
{"title":"Immunoprecipitation of mycobacterial antigens with sera from patients with leprosy.","authors":"J A Kode,&nbsp;S V Chiplunkar,&nbsp;P D Samson,&nbsp;M G Deo,&nbsp;S G Gangal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pooled sera from leprosy patients across the clinical spectrum, tuberculosis patients and healthy individuals were tested for their reactivity with antigens of Mycobacterium leprae and a panel of cultivable mycobacteria by immunoprecipitation technique. Sera from lepromatous leprosy patients demonstrated exclusive reactivity with the 26-kDa protein of M. tuberculosis H37Ra, 28-kDa protein of M. kansasii, 45-kDa protein of M. smegmatis, and 158, 40 and 14 kDa proteins of M. phlei. Sera from patients with borderline tuberculoid leprosy, tuberculoid leprosy, tuberculosis and health individuals failed to identify these antigens. Our studies indicate that analysis and characterization of immunodominant antigenic epitopes present on proteins of cultivable mycobacteria, sharing cross-reactive epitopes with M. leprae may prove to be important in the serodiagnosis of multibacillary leprosy as well as for developing vaccines for immunotherapy of leprosy.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Measures related to epidemiology, prevention, and control of leprosy]. [与麻风病流行病学、预防和控制有关的措施]。
Acta leprologica Pub Date : 1994-01-01
{"title":"[Measures related to epidemiology, prevention, and control of leprosy].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"59-60"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Guidelines for the administrators of campaigns against leprosy]. [防治麻风病运动的管理者指南]。
Acta leprologica Pub Date : 1994-01-01
{"title":"[Guidelines for the administrators of campaigns against leprosy].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 2","pages":"66-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18862525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Proceedings of the workshops of the 14th International Leprology Congress. Orland (USA). 29 August-4 September 1993]. [第十四届国际麻风大会研讨会论文集。奥兰(美国)。1993年8月29日至9月4日]。
Acta leprologica Pub Date : 1994-01-01
{"title":"[Proceedings of the workshops of the 14th International Leprology Congress. Orland (USA). 29 August-4 September 1993].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"9 1","pages":"3-23"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18908831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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