Macromolecular Research最新文献

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Stimuli-responsive polystyrene derivative for a turbidity-based detection of a nerve agent mimic 基于浊度检测神经毒剂模拟物的刺激响应型聚苯乙烯衍生物
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-28 DOI: 10.1007/s13233-024-00314-1
Hyunjoo Seo, Jihyeon Heo, Jay Ryu, Chi Sup Ahn, Youjin Song, Byungjin Koo, Jeewoo Lim
{"title":"Stimuli-responsive polystyrene derivative for a turbidity-based detection of a nerve agent mimic","authors":"Hyunjoo Seo,&nbsp;Jihyeon Heo,&nbsp;Jay Ryu,&nbsp;Chi Sup Ahn,&nbsp;Youjin Song,&nbsp;Byungjin Koo,&nbsp;Jeewoo Lim","doi":"10.1007/s13233-024-00314-1","DOIUrl":"10.1007/s13233-024-00314-1","url":null,"abstract":"<div><p>Nerve agents, toxic organophosphorus compounds used in chemical warfare, present significant threats to security and public health. These agents disrupt physiological processes by covalently binding to acetylcholinesterase and blocking its ability to break down the neurotransmitter acetylcholine. Despite international efforts to eliminate such weapons, nerve agents continue to be employed due to their ease of production and stability. Their colorless, odorless nature, combined with their rapid action, underscores the importance of developing efficient detection techniques. Traditional detection methods, such as mass spectrometry, rely on the use of bulky, complex equipment and sample preparation procedures. Recent progress in the development of colorimetric and fluorescent probes has enabled direct visual confirmation of nerve agents without the need for such instrumentation. Building on these advancements, we present a turbidity-based approach to detect nerve agent mimics in water. Our method employs a polymer that, upon reacting with a nerve agent mimic, transforms from a water-insoluble polymer to a water-soluble polymer. This change causes a turbid polymer dispersion in water to become clear when exposed to a nerve agent mimic, offering a clear visual signal and a turn-on response in terms of light transmission. The method, which forgoes the need for spectroscopy, represents a platform for the future integration of the transparency-based detection scheme into sensor devices.</p><h3>Graphical abstract</h3><p>A schematic illustration of the turbidity-based sensing used in this study and the corresponding digital photographs of the opaque dispersion of P1 in water along with photographs taken after the injection of DCNP</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 1","pages":"39 - 48"},"PeriodicalIF":2.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress of functional atomic force microscopy at the interface of polymer nanocomposite dielectrics 聚合物纳米复合电介质界面功能原子力显微镜的研究进展
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-21 DOI: 10.1007/s13233-024-00307-0
Ting Tian, Hongwei Lu, Shijia Yang, Jinqi Qin, Shile Ma, Jingyi Meng, Yuxuan Huang, Linsheng Yang, Haiyang Mao, Weitao Su
{"title":"Research progress of functional atomic force microscopy at the interface of polymer nanocomposite dielectrics","authors":"Ting Tian,&nbsp;Hongwei Lu,&nbsp;Shijia Yang,&nbsp;Jinqi Qin,&nbsp;Shile Ma,&nbsp;Jingyi Meng,&nbsp;Yuxuan Huang,&nbsp;Linsheng Yang,&nbsp;Haiyang Mao,&nbsp;Weitao Su","doi":"10.1007/s13233-024-00307-0","DOIUrl":"10.1007/s13233-024-00307-0","url":null,"abstract":"<div><p>The interface is one of the most important factors affecting the macroscopic properties of polymer nanocomposite dielectrics. However, the study of the interface still faces many challenges, such as the evolution mechanism of the interface microstructure, interface compatibility, interface polarization, and the internal mechanism of crystallization. Due to the lack of direct observation and characterization of the interface, the theoretical research is seriously hindered. The influence of the nanoparticles embedded in the nanodielectric and the interfacial region on charge transport and accumulation is still unclear. Since the nanoscale interface is beyond the spatial resolution of traditional analytical techniques, the understanding of the interfacial charge behavior of polymer nanocomposites is largely dependent on speculation and indirect experimental results. Atomic force microscopy (AFM), as a nanometer high-resolution measuring instrument, has become an important means to study the interfacial microregions of polymer nanocomposite dielectrics. In this paper, the latest research progress of various interface models and functional AFM in interface structure, charge transport, and interface polarization are reviewed. The existing problems and possible development directions in the future are also discussed.</p><h3>Graphical Abstract</h3><p>Nanodielectrics show excellent dielectric properties, and many scholars try to explain this phenomenon from different angles, among which, the interface effect between nanoparticles and polymer matrix has aroused great interest of researchers. However, due to the complexity of the interface region, it is impossible to intuitively obtain the microstructure and interaction mechanism between the polymer chain and the nanoparticles in the interface region, so researchers have proposed different interface models to speculate and explain the macroscopic properties of the nanocomposites. Such as diffusion electric double layer model, multi-core model, interphase volume model, double layer model, water shell model, multi-zone structure model, penetration theory model, three-dimensional electrostatic model, deep trap model, etc.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 12","pages":"1159 - 1185"},"PeriodicalIF":2.8,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photocatalytic performance of copper ferrite/polypyrrole nanohybrids: studies on visible light induced degradation of urea and microwave-assisted degradation of polyethylene films 铜铁氧体/聚吡咯纳米杂化物的光催化性能:可见光诱导的尿素降解和微波辅助的聚乙烯薄膜降解研究
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-21 DOI: 10.1007/s13233-024-00311-4
Shayista Gaffar, Ufana Riaz
{"title":"Photocatalytic performance of copper ferrite/polypyrrole nanohybrids: studies on visible light induced degradation of urea and microwave-assisted degradation of polyethylene films","authors":"Shayista Gaffar,&nbsp;Ufana Riaz","doi":"10.1007/s13233-024-00311-4","DOIUrl":"10.1007/s13233-024-00311-4","url":null,"abstract":"<div><p>The present work reports formulation of nanohybrids of CuFe<sub>2</sub>O<sub>4</sub> using polypyrrole (PPy) in the weight ratios of 1%, 3% and 5%. The synthesized nanohybrids were characterized using FTIR, UV–Vis, XRD and SEM–EDS. The optical band gaps were calculated to be 2.31 eV, 2.11 eV and 1.74 eV for 1-PPy/CuFe<sub>2</sub>O<sub>4</sub>, 3-PPy/CuFe<sub>2</sub>O<sub>4</sub>, and 5-PPy/CuFe<sub>2</sub>O<sub>4</sub>, respectively. The photocatalytic degradation of urea and polyethene (PE) was carried out under visible light irradiation to study the effect of degradation of pollutants in presence of an organic–inorganic hybrid photocatalyst. The nanohybrids showed superior photocatalytic performance when compared with pure CuFe<sub>2</sub>O<sub>4</sub>. The maximum photocatalytic degradation was found to be 62% within 120 min using 5-Ppy/CuFe<sub>2</sub>O<sub>4</sub> as photocatalyst and 40% degradation of PE films was achieved under microwave irradiation. The catalysts showed promising results for the highly efficient degradation of polymers.</p><h3>Graphical abstract</h3><p>Photocatalytic activity of polypyrrole/copper ferrite nanohybrids</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 1","pages":"15 - 25"},"PeriodicalIF":2.8,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13233-024-00311-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced photostability of polyvinyl chloride films through antipyrine derivatives: a comprehensive study on UV resistance and degradation inhibition 通过抗吡啶衍生物增强聚氯乙烯薄膜的光稳定性:抗紫外线和抑制降解的综合研究
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-19 DOI: 10.1007/s13233-024-00310-5
Safaa Mohamed, Emad Yousif, Mohammed Kadhom, Muna Bufaroosha
{"title":"Enhanced photostability of polyvinyl chloride films through antipyrine derivatives: a comprehensive study on UV resistance and degradation inhibition","authors":"Safaa Mohamed,&nbsp;Emad Yousif,&nbsp;Mohammed Kadhom,&nbsp;Muna Bufaroosha","doi":"10.1007/s13233-024-00310-5","DOIUrl":"10.1007/s13233-024-00310-5","url":null,"abstract":"<div><p>Almost all fabricated polymers need high stabilization to prevent harmful effects. Adding specialized chemicals that rule as light stabilizers (or UV stabilizers) and tailor to the resin's characteristics might accomplish the desired stability. In this work, five antipyrine derivatives were synthesized by the Schiff bases using five benzaldehyde substituents (benzaldehyde, 4-bromobenzaldehyde, 4-nitrobenzaldehyde, 4-dimethylaminobenzaldehyde, and 4-hydroxybenzaldehyde) with 4-aminoantipyrene. The produced complexes are characterized using hydrogen-1 and carbon-13 nuclear magnetic resonance (<sup>1</sup>H-NMR and <sup>13</sup>C-NMR, respectively) and Fourier-transform infrared (FTIR) spectroscopy; then they are filled with polyvinyl chloride (PVC) films. Further techniques are used to study the effects of long-term radiation exposure on these films. The IR spectra of PVC films showed side products containing polyene and carbonyl groups before, during, and after irradiation. The presence of antipyrine derivatives led to a decrease in the intensity of their associated functional groups. Furthermore, it is shown that films with antipyrine compounds performed lower weight loss when exposed to radiation compared with the virgin film.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 1","pages":"85 - 103"},"PeriodicalIF":2.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poly(D, L-lactic-co-glycolic acid)-based microspheres loaded with camphor regulate skeletal muscle atrophy 负载樟脑的聚(D, L-乳酸-共聚-乙醇酸)基微球可调节骨骼肌萎缩
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-16 DOI: 10.1007/s13233-024-00299-x
Hyun Joo Jang, Chung Su Han, Suhyun Kwon, Seung Hae Kwon, Solomon Ko, Jae Hyuk Kim, Myeong Sik Yoon, Suji Baek, Kang Pa Lee
{"title":"Poly(D, L-lactic-co-glycolic acid)-based microspheres loaded with camphor regulate skeletal muscle atrophy","authors":"Hyun Joo Jang,&nbsp;Chung Su Han,&nbsp;Suhyun Kwon,&nbsp;Seung Hae Kwon,&nbsp;Solomon Ko,&nbsp;Jae Hyuk Kim,&nbsp;Myeong Sik Yoon,&nbsp;Suji Baek,&nbsp;Kang Pa Lee","doi":"10.1007/s13233-024-00299-x","DOIUrl":"10.1007/s13233-024-00299-x","url":null,"abstract":"<div><p>As effective treatments for sarcopenia other than exercise have not yet been established, research is needed on treatment methods using drugs that can control muscle atrophy. Therefore, in this study, we aimed to assess the use of intramuscular sustained-release drug delivery systems and direct intramuscular injection for the control of muscle atrophy. First, we evaluated the inhibitory effects of camphor on skeletal muscle atrophy in vitro. L6 skeletal muscle cells were analyzed by WST-1 cell viability, 3D tomographic lipid accumulation, and mitochondrial length. These results indicated that camphor significantly regulates L6 cell atrophy. Next, we established poly(lactic-co-glycolic acid) (PLGA)-based microspheres loaded with camphor (PLGA-camphor), with each PLGA-camphor microsphere have a size of ~ 66–75 μm. Camphor was released ~ 93.29% over 10 days. Finally, we administered the PLGA-camphor by intramuscular injection in the starved fed mice model and performed immunohistological and histological analyses. The results indicate that PLGA-camphor is able to significantly regulate skeletal muscle atrophy in vivo. Our results suggest that PLGA-camphor may affect skeletal muscle atrophy.</p><h3>Graphical abstract</h3><p>In the present study, our research findings indicate that camphor significantly reduces muscle atrophy in vitro. It used gravity to load camphor into PLGA-based microspheres, which were 66–75 μm in size. The sustained release properties of PLGA-camphor microsphere were shown to release 93.29% of camphor over ten days. When directly injected into the muscle of mice with muscular dystrophy, the PLGA-camphor microsphere resulted in a noteworthy reduction in muscle atrophy, particularly in the starved-induced muscle atrophy model mice. Our results suggest that PLGA-camphor microsphere could be a promising method for addressing skeletal muscle atrophy.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 10","pages":"971 - 979"},"PeriodicalIF":2.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lanthanide-doped zinc gallium oxide (ZnGa2O4) nanocrystals and their engineered photoluminescence 掺杂镧系元素的氧化锌镓(ZnGa2O4)纳米晶体及其工程光致发光技术
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-13 DOI: 10.1007/s13233-024-00312-3
Kihyo Kim, Kicheol Kim, Hyo-Geun Kwon, Sunghoon Kim, Sang-Wook Kim
{"title":"Lanthanide-doped zinc gallium oxide (ZnGa2O4) nanocrystals and their engineered photoluminescence","authors":"Kihyo Kim,&nbsp;Kicheol Kim,&nbsp;Hyo-Geun Kwon,&nbsp;Sunghoon Kim,&nbsp;Sang-Wook Kim","doi":"10.1007/s13233-024-00312-3","DOIUrl":"10.1007/s13233-024-00312-3","url":null,"abstract":"<div><p>Zinc gallate (ZnGa<sub>2</sub>O<sub>4</sub>) has been introduced in various studies as a good host phosphorescent material, and the change of its optical properties by ion doping has received much attention. However, ZnGa<sub>2</sub>O<sub>4</sub> is mostly synthesized through solid-state reactions, the reaction conditions of high temperature and pressure were required, and its low dispersibility often limited its applications. In this study, we synthesized normal spinel structured ZnGa<sub>2</sub>O<sub>4</sub> nanocrystals through a colloidal method. Lanthanide doping specifically with europium and terbium resulted in red (614 nm, photoluminescence quantum yield (PLQY): 2.2%) and green (545 nm, PLQY: 13.6%) emissions under 254 nm UV excitation. By applying the novel co-doping system of europium and terbium to the synthesis of colloidal ZnGa<sub>2</sub>O<sub>4</sub> for the first time, we were able to achieve various color conversions including green, red, and white by adjusting amount and ratio of lanthanide ions.</p><h3>Graphic Abstract</h3><p>PL emission spectra by adjusting the ratios of Eu<sup>3+</sup> and Tb<sup>3+</sup> doping and the CIE 1931 chromatography diagram of Eu<sup>3+</sup> and Tb<sup>3+</sup> co-doping system of ZnGa<sub>2</sub>O<sub>4</sub> nanocrystals</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 1","pages":"69 - 75"},"PeriodicalIF":2.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PEDOT:PSS-based high-performance thermoelectrics 基于 PEDOT:PSS 的高性能热电技术
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-13 DOI: 10.1007/s13233-024-00309-y
Daegun Kim
{"title":"PEDOT:PSS-based high-performance thermoelectrics","authors":"Daegun Kim","doi":"10.1007/s13233-024-00309-y","DOIUrl":"10.1007/s13233-024-00309-y","url":null,"abstract":"<div><p>Global warming and environmental pollution from fossil fuels have spurred the need for clean energy technologies, among which thermoelectric (TE) devices are promising due to their ability to convert waste heat into electricity. Conducting polymers, particularly poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), have emerged as notable organic TE materials owing to their inherent low thermal conductivity, non-toxicity, and mechanical flexibility. PEDOT:PSS exhibits good stability under high doping level, yielding high electrical conductivity over 1000 S cm<sup>−1</sup>. This review focuses on the enhancement of the TE performance of PEDOT:PSS through strategies such as post-solvent treatments to selectively remove excess PSS, thereby improving charge carrier mobility and electrical conductivity. Additionally, modifying the interaction between PEDOT and PSS can optimize the macro- and microstructure, leading to improved charge transport properties. The formation of PEDOT:PSS nanocomposites further enhances the Seebeck coefficient and electrical conductivity by enabling effective energy-filtering and improved charge transport pathways. These advancements underscore the potential of PEDOT:PSS in developing efficient, flexible, and stable TE generators for various applications.</p><h3>Graphical abstract</h3><p>Strategies to improve thermoelectric performance of PEDOT:PSS</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 12","pages":"1187 - 1198"},"PeriodicalIF":2.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of smart polymer blend filament from waste PET obtained water bottles: investigation of thermal and shape memory behavior 利用废 PET 水瓶生产智能聚合物共混长丝:热记忆和形状记忆行为研究
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-09 DOI: 10.1007/s13233-024-00303-4
Ecem Özen Öner, Mediha Kök, Mustafa Ersin Pekdemir, Ercan Aydoğmuş, Sinan Saydam, Yıldırım Aydoğdu
{"title":"Production of smart polymer blend filament from waste PET obtained water bottles: investigation of thermal and shape memory behavior","authors":"Ecem Özen Öner,&nbsp;Mediha Kök,&nbsp;Mustafa Ersin Pekdemir,&nbsp;Ercan Aydoğmuş,&nbsp;Sinan Saydam,&nbsp;Yıldırım Aydoğdu","doi":"10.1007/s13233-024-00303-4","DOIUrl":"10.1007/s13233-024-00303-4","url":null,"abstract":"<div><p>Waste (polyethylene terephthalate) (PET) water bottles are among the most common plastic wastes in nature. These plastic wastes disappear within hundreds of years after they are released into nature. Therefore, it causes serious environmental pollution. Therefore, it is important to make these wastes reusable. This study aims to bring a new perspective to the reuse literature. It is aimed to produce smart polymer blend from waste PET, which is highly demanded and important in practical applications. Therefore, in this study, waste polymer PET was blended with smart polymer PLA into filament blends. The thermal properties of the blends were analysed by Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA), chemical bond structures were determined by Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR spectroscopy) and shape memory tests were performed to determine whether the blends exhibit smart material properties. As a result of this study, it was observed that the thermal stability of the blended filaments varied according to the polymer ratio and the blend was characterized as an immiscible polymer blend. It was also found that the polymer blends exhibit shape memory properties.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 12","pages":"1267 - 1274"},"PeriodicalIF":2.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injectable mesquite gum and carboxymethyl chitosan hydrogel using schiff base crosslinks: a versatile platform for drug delivery in wound care 使用席夫碱交联的可注射介壳胶和羧甲基壳聚糖水凝胶:伤口护理中的多功能给药平台
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-09 DOI: 10.1007/s13233-024-00300-7
Jitendra Kumar, Roli Purwar
{"title":"Injectable mesquite gum and carboxymethyl chitosan hydrogel using schiff base crosslinks: a versatile platform for drug delivery in wound care","authors":"Jitendra Kumar,&nbsp;Roli Purwar","doi":"10.1007/s13233-024-00300-7","DOIUrl":"10.1007/s13233-024-00300-7","url":null,"abstract":"<div><p>The novel injectable hydrogel (IH) is developed at 37 ℃ using the dynamic imine bond between mesquite gum with multi-aldehyde groups (MG-CHO) and carboxymethyl chitosan (CMCh). The investigation consists of determining the ideal concentration of an oxidizing agent to maximize the amount of aldehydes in mesquite gum. Then, the oxidized mesquite gum with the optimized aldehyde content (47.6%) determines the minimum gelation time (7 to 2 min.). Structural characterization is conducted through Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance spectroscopy (<sup>1</sup>H-NMR). The scanning electron microscopy (pore size = 14 to 34 µm) and rheometer examine surface morphology and rheological properties. The swelling ratio in phosphate buffer saline (PBS) at varying pH levels (5.5, 7.4, and 8.5) is measured for both dry and gel forms, revealing a decrease in the swelling ratio with increasing pH (5.5 to 7.4), followed by an increase at pH 8.5. Ciprofloxacin HCl is employed as a model drug for release experiments, and drug release behavior is compared in PBS at pH 5.5, 7.4, and 8.5, using the Korsemeyer–Peppas model to determine the release mechanism. Biocompatibility of injectable hydrogels is assessed regarding in vitro cytotoxicity using L-929 fibroblast cell lines and hemolysis assay. Additionally, the antibacterial study is analyzed using gram-positive and gram-negative bacteria. Furthermore, the hydrolytic biodegradability of IHs in phosphate buffer saline at pH 7.4 is evaluated.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div><div><p>Synthesis of self-healing, biocompatible, and biodegradable injectable hydrogel using mesquite gum and carboxymethyl chitosan crosslinked through Schiff base mechanism utilized for drug delivery application</p></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 12","pages":"1237 - 1254"},"PeriodicalIF":2.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable polyurethane nanocomposite foam from waste poly(ethylene terephthalate): preparation, thermal stability, and flame retardancy 利用废弃聚对苯二甲酸乙二醇酯制备可持续聚氨酯纳米复合泡沫:制备、热稳定性和阻燃性
IF 2.8 4区 工程技术
Macromolecular Research Pub Date : 2024-08-07 DOI: 10.1007/s13233-024-00304-3
Hai Vothi, VietHien Le, TuyetMinh Nguyen-Ha, DongQuy Hoang
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