Macromolecular Research最新文献

{"title":"Solvent casting-salt leaching synthesis, characterization, and biocompatibility of three-dimensional porous chitosan/nano-hydroxyapatite scaffolds for bone tissue engineering","authors":"Nguyen Kim Nga,&nbsp;Tran Thanh Hoai,&nbsp;Nguyen Thi Ngoc Anh,&nbsp;Sujin Kim,&nbsp;Sihyun Kim,&nbsp;Hwan D. Kim,&nbsp;Kang Moo Huh","doi":"10.1007/s13233-025-00397-4","DOIUrl":"10.1007/s13233-025-00397-4","url":null,"abstract":"<div><p>In this work, we developed three-dimensional (3D) porous chitosan/nano-hydroxyapatite scaffolds (CS/HAp) for bone tissue engineering (BTE) using a solvent casting-salt leaching technique. The physicochemical, morphological, and porous analyses of the scaffolds were performed using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy (SEM), and the liquid displacement method. Results indicated that nano-HAp particles were successfully integrated into the CS matrix to produce 3D CS/HAp scaffolds. These scaffolds exhibited a highly porous structure with a thickness of 2 mm and average pore sizes from 285 to 345 µm and porosity (76.76–86.52%), which are beneficial for cell growth. Additionally, the scaffolds showed increased Young’s modulus (10.9–14.8 MPa) and tensile strength (2.4–2.6 MPa) compared to pure CS scaffolds that are well-compatible with trabecular bone. The degradation rate of the CS/HAp scaffolds was slower than that of the CS scaffolds alone. Notably, a bone-like apatite layer was formed on the CS/HAp scaffold’s surfaces after 15 days of immersion in simulated body fluids (SBF). In contrast, no such mineral layer was observed on the CS scaffolds. The protein adsorption on the surfaces of the CS/HAp scaffolds was significantly high, with 840.96 µg of proteins adsorbed after 24 h in 10% of fetal bovine serum (FBS) in a minimum essential medium. In vitro tests with bone marrow-derived mesenchymal stem cells (BMSCs), including live/dead staining, MTT assay, and SEM, confirmed that all scaffolds exhibit excellent biocompatibility, providing a suitable substrate for cell proliferation and adhesion. Furthermore, the CS/HAp scaffolds demonstrated a high removal efficiency of <i>E. coli</i>, reaching up to 84.92% in 180 min. Our results revealed that the CS/HAp scaffolds are potential biomaterials for BTE applications.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"667 - 682"},"PeriodicalIF":2.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of the preparation of thiourea-based compounds modifying PVA adsorbents","authors":"Zhidong Shang,&nbsp;Cuiling Zhang,&nbsp;Yichen He,&nbsp;Xidan Lin,&nbsp;Huiling Jia,&nbsp;Heyuan Zhang,&nbsp;Changchun Deng","doi":"10.1007/s13233-024-00342-x","DOIUrl":"10.1007/s13233-024-00342-x","url":null,"abstract":"<div><p>In order to improve the adsorption capacity of poly(vinyl alcohol) (PVA) for heavy metals, a new thiourea-modified poly(vinyl alcohol) adsorbent (TU-SPVA) was prepared using PVA as the raw material, glutaraldehyde as the cross-linking agent and thiourea (TU) as the modifier. The preparation conditions of TU-SPVA were optimized by one-way experiments and response surface methodology (CCD), and the adsorption mechanism was investigated using adsorption kinetics, adsorption isotherm, and adsorption thermodynamics, and the results showed that the optimum conditions for the preparation of TU-SPVA were as follows: pH 6.06, m(TU):m(SPVA) = 6.1:1, and the preparation time of 2.47 h. The maximum removal rate of Cr(VI) by TU-SPVA was 99.37%. The modification reaction in the preparation of TU-SPVA mainly occurred on the hydroxyl group (-OH) of the PVA molecular structure, and the -NH₂ and -C = S functional groups, which can be coordinated with heavy metal ions, were introduced through hydroxyl aldehyde condensation and Schiff reaction. The adsorption of Cr(VI) by TU-SPVA was more consistent with the quasi-secondary kinetic equation and Langmuir model, and the adsorption is a non-spontaneous exothermic process. Combined with the results of scanning electron microscopy and infrared spectroscopy, the adsorption mechanism of TU-SPVA on Cr(VI) is mainly coordination, ion exchange and electrostatic effect, and void filling.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>The graft modification method was used to prepare TU-SPVA, and the optimum preparation conditions of TU-SPVA were investigated, TU-SPVA has a more obvious pore structure than PVA. The adsorption mechanism of TU-SPVA on Cr(VI) was analyzed using the Langmuir et al. adsorption model.</p></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 4","pages":"463 - 478"},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of poly(benzodifurandione) for bioelectronics: high conductivity, electrical stability, and biocompatibility","authors":"Seungju Kang,&nbsp;Eun Chae Kim,&nbsp;Hyung Woo Kim,&nbsp;Boseok Kang","doi":"10.1007/s13233-025-00385-8","DOIUrl":"10.1007/s13233-025-00385-8","url":null,"abstract":"<div><p>Poly(benzodifurandione) (PBFDO), a recently developed n-type conductive polymer, shows promise as an alternative material for bioelectronics, particularly in neural probes. This study systematically evaluates the electrical, mechanical, and biocompatibility properties of PBFDO and compares its performance with the widely used material for bioelectronics; poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). The intrinsic doping mechanism of PBFDO provides high electrical conductivity (up to 2000 S/cm) without requiring external dopants, enhancing its environmental stability and simplifying fabrication. Surface characterizations revealed uniform coatings and hydrophilic properties suitable for bioelectronics. Notably, PBFDO demonstrated exceptional electrical stability in phosphate-buffered saline (PBS), retaining 97% of its initial conductivity after three days. Biocompatibility assays using NIH-3T3 fibroblast cells showed no cytotoxic effects, with cell proliferation rates comparable to bare glass and crosslinked PEDOT:PSS. These findings establish PBFDO as a robust and biocompatible material for next-generation bioelectronic devices, including neural probes, biosensors, and implantable electrodes.</p><h3>Graphical abstract</h3><p>We highlight PBFDO as a promising biocompatible electrode material for neural probes. PBFDO demonstrates intrinsically high conductivity, exceptional stability in aqueous environments, and excellent biocompatibility, all without the need for modification or post-treatment, outperforming PEDOT:PSS. These properties make PBFDO an ideal candidate for use in neural probes, offering superior material performance.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 3","pages":"377 - 383"},"PeriodicalIF":2.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13233-025-00385-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Spermine Modified PNIPAAm Nano-Hydrogel Serving as Thermo-Responsive System for Delivery of Cisplatin","authors":"Soheila Ghasemi,&nbsp;Marzieh Owrang,&nbsp;Farzad Javaheri,&nbsp;Fatemeh Farjadian","doi":"10.1007/s13233-025-00387-6","DOIUrl":"10.1007/s13233-025-00387-6","url":null,"abstract":"","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 4","pages":"533 - 533"},"PeriodicalIF":2.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced strategies for thermal conductivity enhancement in polymer composites for application as thermal management materials","authors":"Soo Jeong Jeong,&nbsp;Ho Sun Lim","doi":"10.1007/s13233-025-00377-8","DOIUrl":"10.1007/s13233-025-00377-8","url":null,"abstract":"<div><p>Significant heat generation is observed in advanced miniature, thin, lightweight, and high-performance electronic devices, highlighting the importance of thermal control and thermal management technologies. To address excess heat generation, developing more efficient electronic packaging with thermal management materials that facilitate heat dissipation is critical for ensuring the durability and optimal functionality of electronic devices. Polymer composites are widely used as thermal management materials owing to their excellent adhesion, ease of fabrication, lightness, and robust mechanical properties; however, these systems typically exhibit lower thermal conductivities than metals and ceramics. Thus, several studies have attempted to improve the thermal properties of polymer composites. This review discusses various polymer composites and highlights the importance of thermal-pathway management for thermal conductivity enhancement, focusing on strategies for controlling the polymer-chain structure and interactions as well as optimizing the polymer–filler, and filler–filler interfaces in composites. This paper is expected to guide future research on high-performance polymer composites for specific thermal-management applications.</p><h3>Graphic abstract</h3><p>The utilization of high thermal conductivity polymers is critical for enhancing the thermal performance of polymer composites. Polymers such as aligned semi-crystalline polymers, stretched amorphous polymers, and liquid crystalline polymers, which inherently exhibit superior thermal conductivity, significantly enhance the overall thermal conductivity of composites when used as the matrix, especially compared to those based on low thermal conductivity polymers. In this review, we highlight various approaches to enhancing thermal conductivity in polymers, including strategies such as optimizing molecular alignment, enhancing crystalline structures, and integrating highly conductive fillers.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"553 - 568"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research roadmap for sustainable polymeric materials in Korea","authors":"Jeong F. Kim,&nbsp;Hee Joong Kim,&nbsp;Jeyoung Park,&nbsp;Hyeonyeol Jeon,&nbsp;Jeung Gon Kim,&nbsp;Chungryong Choi,&nbsp;Ki-Ho Nam,&nbsp;Giyoung Shin,&nbsp;Sae Hume Park,&nbsp;Jihoon Shin,&nbsp;Dong-Ku Kang,&nbsp;Dongyeop X. Oh,&nbsp;Dong Yun Lee,&nbsp;Sung Woo Hong,&nbsp;Gi-Ra Yi","doi":"10.1007/s13233-024-00357-4","DOIUrl":"10.1007/s13233-024-00357-4","url":null,"abstract":"<div><p>Polymer technology has significantly transformed modern society and is a foundation for the global economy. However, the pervasive issue of plastic waste pollution has cast a negative light on the industry. As the world aims for a carbon–neutral future by 2050, a paradigm shift from fossil-based to sustainable polymeric materials is imperative. While biopolymers derived from renewable sources offer promising potential to mitigate plastic pollution and reduce carbon emissions, their current performance and cost disadvantages compared to conventional petrochemical-based polymers hinder their widespread adoption. As a global leader, the Korean plastics industry faces increasing competitive pressures and growing environmental concerns. To address these challenges, the Eco-materials Division of the Polymer Society of Korea (PSK) was established in 2023 to promote collaboration among academia, industry, and research institutions. This review consolidates the PSK's multidisciplinary research efforts, outlines key challenges, and proposes a roadmap for future research directions in sustainable polymer technologies. Key focus areas include mechanochemical plastic upcycling, biomass-derived smart materials, renewable gas barrier films for food packaging, microbial plastic degradation, biomass content analysis, bio-based membranes, self-healing materials, melt compounding, and biodegradable polymer synthesis. By sharing expertise and fostering collaborative partnerships, this roadmap aims to accelerate innovation in the sustainable polymer industry and create a unified vision among stakeholders.</p><h3>Graphical abstract</h3><p>Research roadmap of the Polymer Society of Korea (PSK) for sustainable polymeric materials.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"535 - 551"},"PeriodicalIF":2.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Superamphiphobic PDMS/silica nanoparticle surfaces with high liquid impact resistance: effect of structural hierarchy on superamphiphobicity","authors":"Su Hyun Kim,&nbsp;Jonghyun Son,&nbsp;Giwon Lee,&nbsp;Seung Goo Lee","doi":"10.1007/s13233-025-00386-7","DOIUrl":"10.1007/s13233-025-00386-7","url":null,"abstract":"","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 2","pages":"247 - 247"},"PeriodicalIF":2.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superamphiphobic PDMS/silica nanoparticle surfaces with high liquid impact resistance: effect of structural hierarchy on superamphiphobicity","authors":"Su Hyun Kim,&nbsp;Jonghyun Son,&nbsp;Giwon Lee,&nbsp;Seung Goo Lee","doi":"10.1007/s13233-025-00374-x","DOIUrl":"10.1007/s13233-025-00374-x","url":null,"abstract":"<div><p>We propose an efficient method for fabricating superamphiphobic surfaces with hierarchical micro/nano-structured morphologies on microhoodoo structures that exhibit high liquid impact resistance. The proposed method combines optical microscopy, photolithography, replica molding, and spray coating of polydimethylsiloxane (PDMS)/silica nanoparticle (SiNP) solutions. We systematically investigate key parameters influencing the water and hexadecane repellency of these surfaces, including (i) the center-to-center distance between PDMS microhoodoo structures, (ii) the PDMS-to-SiNP mixing ratio, and (iii) the spray volume. Notably, optimizing the spray volume within a critical range improves the uniformity of the hierarchical surface texture, stabilizes the Cassie–Baxter state, and facilitates liquid bounce. This innovative approach provides valuable insights into the design of superamphiphobic surfaces, resulting in practical applications such as water- and oil-resistant, self-cleaning, anti-icing, and antifouling surfaces.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>Efficient fabrication of superamphiphobic surfaces with hierarchical micro/nano-structures on microhoodoo structures, achieved through optical microscopy, photolithography, replica molding, and spray coating of PDMS/SiNP solutions. Key factors influencing liquid repellency—such as microhoodoo spacing, PDMS/SiNP ratio, and spray volume—are systematically explored. Optimizing spray volume enhances surface texture uniformity, stabilizes the Cassie–Baxter state, and promotes liquid bounce, leading to practical applications in self-cleaning, anti-icing, and antifouling surfaces.</p></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 2","pages":"235 - 245"},"PeriodicalIF":2.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel-based wet adhesive with enhanced adhesion and stretchability","authors":"Byeong Su Kang,&nbsp;Jin-Young Yu,&nbsp;Min Bae,&nbsp;Sei Bin Kim,&nbsp;Minsu Cho,&nbsp;Yong Min Kim,&nbsp;Seong Min Kang","doi":"10.1007/s13233-024-00359-2","DOIUrl":"10.1007/s13233-024-00359-2","url":null,"abstract":"<div><p>In this study, we developed a hydrogel wet adhesives characterized by exceptional elasticity and adhesion. The hydrogel composition comprises acrylamide (AM) and [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) as monomers. Water and glycerol serve as the solvent, N, N′-methylenebisacrylamide as the crosslinker, and 2-hydroxy-2-methylpropiophenone as the photoinitiator. Notably, SBMA, functioning as a zwitterionic ion, establishes SBMA–SBMA ionic bonds within the hydrogel without crosslinking, thereby enhancing the elasticity of the hydrogel. Furthermore, SBMA promotes adhesion between the hydrogel and other substrates through dipole–dipole interaction forces. Importantly, the resultant high adhesion force remains unaffected by humidity, ensuring maintenance even under high humidity conditions (relative humidity (RH) 90%). By adjusting the AM and SBMA ratio, diverse adhesion forces can be achieved. And, by optimizing the ratio, high stretchability can also be attained. Furthermore, by measuring the adhesion to various substrates, it demonstrates the potential applications of the adhesive by exhibiting stable reactivity.</p><h3>Graphic Abstract</h3><p>Tunable adhesive and enhanced elastic hydrogel-based wet adhesive are proposed by adjusting the acrylamide (AM) and [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) zwitterion incorporation.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"593 - 600"},"PeriodicalIF":2.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of conjugation length on conjugated polymer-mediated intracellular protein delivery","authors":"Golam Sabbir Sarker,&nbsp;Carlos R. Romagosa,&nbsp;Joong Ho Moon","doi":"10.1007/s13233-024-00360-9","DOIUrl":"10.1007/s13233-024-00360-9","url":null,"abstract":"<div><p>Conjugated polymers (CPs) are π-electron-conjugated intrinsic fluorescent materials exhibiting unique photophysical and biophysical properties useful in sensing, labeling, and cargo delivery. While the photophysical properties related to conjugation lengths are known, the effect of conjugation lengths on intracellular cargo delivery has not been investigated yet. This study examined the impact of varying conjugation lengths in poly(<i>p</i>-phenylene ethynylene)s (PPEs) on intracellular protein delivery by evaluating protein loading capacity, serum stability, cellular entry pathway, and the amounts of proteins delivered into a model cancer cell line. While the protein loading, hydrodynamic diameter, and surface charge of all PPEs/protein complexes were similar regardless of backbone conjugation lengths, a fully conjugated PPE with a conjugation length of ~ 12 showed the highest intracellular protein delivery than PPEs containing shorter conjugation length than 12. The relatively poor delivery efficiency of other PPEs with a conjugation length of 9 or less was due to poor PPE/protein complex stability in the presence of serum, suggesting the critical role of backbone hydrophobicity. These findings signify the importance of conjugated polymer’s conjugation length in protein delivery efficiency, providing valuable insights into the design criteria for CP-based nanocarriers.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"643 - 654"},"PeriodicalIF":2.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}