Macromolecular Research最新文献

{"title":"Macrophage membrane-derived pH-responsive nanovesicles to target tumor cells with integrin α4β1 receptor","authors":"Jaehyun Kang,&nbsp;Eunsol Lee,&nbsp;Eun Seong Lee","doi":"10.1007/s13233-023-00226-6","DOIUrl":"10.1007/s13233-023-00226-6","url":null,"abstract":"<div><p>In this study, we developed macrophage-derived nanovesicles (MNVs) to specifically target tumor cells. Initially, we chemically coupled hyaluronic acid (HA) with 3-(diethylamino)propylamine (DEAP; with a pK_b value of approximately 7.0) to confer pH-responsive properties. The resulting polymer (HDEA) and chlorin e6 (Ce6, serving as a photosensitizing model drug) were incorporated into MNVs using a sonication process, resulting in Ce6-loaded HDEA@MNVs. Our experiments demonstrated that the integrin α4β1 expressed in MNVs selectively interacted with vascular cell adhesion molecule-1 (VCAM-1) in SK-N-MC tumor cells, leading to enhanced accumulation of MNVs within the tumor cells. Consequently, HDEA@MNVs exhibited significant accumulation within tumor cells, underwent structural destabilization at endosomal pH due to the protonation of pH-responsive DEAP within the HDEA@MNVs, and facilitated the release of Ce6. The released free Ce6 from MNVs exhibited improved effectiveness in photodynamic tumor therapy when exposed to laser irradiation. In vitro cell experiments demonstrated efficient internalization of HDEA@MNVs into tumor cells and high efficacy in photodynamic therapy.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 3","pages":"261 - 271"},"PeriodicalIF":2.8,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138743780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ternary liquid separation using PVDF nanofiber membranes with tunable structure and surface tension","authors":"Kyu Hong Kyung,&nbsp;Sae Hoon Kim,&nbsp;Jin Ho Kim","doi":"10.1007/s13233-023-00219-5","DOIUrl":"10.1007/s13233-023-00219-5","url":null,"abstract":"<div><p>Wastewater from industrial sources varies greatly in composition. Separating and recycling these waste remains challenging. The efficacy of nanofiber membranes in separating binary liquids has been demonstrated, which in this work we extend to the separation of ternary liquids. Polyvinylidene fluoride (PVDF) nanofiber membranes with different surface tensions were fabricated by electrospinning and surface coating. Membranes made from polyvinyl alcohol and polyacrylic acid (PVA-PAA), and PVDF nanofiber membranes were used in combination for separating water and oils. And pure PVDF and PVDF membranes coated with tetraethyl orthosilicate and decyltrimethoxysilane (TEOS/DTMS) were used together to separate different oils. The structural parameters of PVDF nanofiber membranes, e.g., pore size, thickness, and porosity were easily adjusted to achieve high flux and separation efficiency. For example, the average separation efficiencies for water, oleic acid, and silicon oil were 99.21%, 94.45%, and 84.61%, respectively. Finally, using a two-step setup, a ternary liquid mixture of water, oleic acid, and silicon oil was efficiently separated, which shows great promise for addressing the problem of separating wastewater with mixed compositions.</p><h3>Graphical abstract</h3><p>Schematic illustration of wettability relationship of PVDF membrane</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 2","pages":"121 - 131"},"PeriodicalIF":2.8,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of oral nanoemulsion drug delivery system loaded with punicalagin: in vitro antibacterial activity, drug release, and cell safety studies","authors":"Fei-Fei Shi,&nbsp;Yu-Juan Mao,&nbsp;Ying Wang,&nbsp;Hai-Feng Yang","doi":"10.1007/s13233-023-00224-8","DOIUrl":"10.1007/s13233-023-00224-8","url":null,"abstract":"<div><p>The objective of the present study was to develop a W/O/W nanoemulsion (NE) drug delivery system loaded with punicalagin (PGN) for oral delivery and evaluate its potential in antibacterial therapy. The W/O/W PGN-NE was prepared using a two-step process by combining ultrasonic with high-energy emulsification and subsequently characterized by its droplet size, zeta potential, and morphology. The PGN-NE was further evaluated for its pH, in vitro antibacterial activity, drug release property, and cytotoxicity. The results indicated the formation of spherical, nano-sized globules of PGN-NE had a mean particle size of 45.53 ± 2.2 nm, with a PDI value of 0.22 ± 0.028, zeta potential was −4.67 ± 0.88 mV, and pH value was 5.8. In vitro antibacterial activity studies showed a significantly higher antibacterial activity of PGN-NE in comparison to free PGN, suggesting that NE can effectively improve the antibacterial effect of natural pharmaceuticals. The drug release assay demonstrated that PGN was slowly released from the NE preparation and absorbed, helping to prolong the potency and improve the bioavailability of PGN. Cytotoxicity testing showed that PGN had reduced toxicity when encapsulated in NE. Thus, the developed NE formulation of PNG exhibited a greater potential for the slow-release effect delivery and in the treatment of microbial infections with favorable safety profile.</p><h3>Graphical abstract</h3><p>Micromorphology of W/O/W PGN nanoemulsion</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div><p>The W/O/W PGN-NE are uniform in size and non-adhesive, with a size distribution of 28.214 to 141.772 nm and a mean size of 45.53 ± 2.2 nm, respectively, with a PDI value of 0.22 ± 0.028.</p></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 3","pages":"243 - 252"},"PeriodicalIF":2.8,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138976802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the possibility of obtaining soft dosage forms based on polyanionic polysaccharides with prolonged yield of drugs","authors":"Anzhela Shurshina,&nbsp;Mariya Afanasyeva,&nbsp;Valentina Chernova,&nbsp;Mariya Lazdina,&nbsp;Elena Kulish","doi":"10.1007/s13233-023-00221-x","DOIUrl":"10.1007/s13233-023-00221-x","url":null,"abstract":"<div><p>The work is devoted to the creation of liquid and soft gel dosage forms of prolonged action. The main task to be solved in the work was to give certain rheological characteristics (namely, pseudoplastic behaviour and pronounced yield strength) to dosage forms based on solutions of pectin, sodium salt of carboxymethylcellulose and sodium salt of chitosan succinate, namely. The study has found that the effect of prolonging the release of the medicinal substance cefazolin from liquid and soft dosage forms based on polysaccharides is directly related to the rheological characteristics of the system and can manifest itself in two cases. First, it is possible for liquid dosage forms in the area of polymer concentrations in solution lower than the concentration at which the cell of meshes C &lt; C_e is formed. In this case, with an increase in the polymer concentration, there is a decrease in the rate of the drug substance release, due to an increase in the adduct of the polymer-drug reaction Secondly, it is possible for soft gel forms in the region of concentrations greater than the concentration at which the cell of meshes C &lt; C_e is formed, when using additives capable of ionotropic gel formation. Calcium and zinc salts were used as such additives in the work. It is in the case when the modifying additive is capable of forming a “bridging” bond between macromolecules and the gel formation is not accompanied by a decrease in the amount of the complex adduct of the reaction, there is a prolongation effect. If the gel is only formed by increasing the polymer content in the solution without the use of an additive, the compression of macromolecular tangles and the strengthening of intramolecular interaction between the polymer units in a concentrated solution results in a significant decrease in the amount of the polymer-drug reaction adduct and accelerated the drug release from the soft dosage form.</p><h3>Graphical abstract</h3><p>Modification of polymer chain</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 3","pages":"231 - 241"},"PeriodicalIF":2.8,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13233-023-00221-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138554209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-vinylcaprolactam-based temperature and pH-sensitive graft hydrogels for controlled drug release of 5-FU: a comprehensive study on synthesis, characterization, and release kinetics","authors":"İ. K. Akbay,&nbsp;T. Özdemir","doi":"10.1007/s13233-023-00222-w","DOIUrl":"10.1007/s13233-023-00222-w","url":null,"abstract":"<div><p>Stimuli-responsive polymers can be used for various purposes due to their amazing properties within the context of controlled release systems. In this study, the aim was to prepare hydrogels that are stimulus-responsive to temperature and pH and utilize them in drug release investigations. N-Vinyl caprolactam-based polymers were synthesized and optimized based on the swelling ratio data. Both temperature and pH sensitivity, along with their respective transition values, were determined. The best sample was selected based on 5-FU encapsulation efficiency. To enhance the swelling ratio and encapsulation values, different amounts of poly-(ethylene glycol) were added to improve water swelling ratio and 5-FU release properties. All obtained samples were characterized using water swelling ratio, SEM, FTIR, and DSC analyses. Additionally, the encapsulation and release of the 5-FU drug from the hydrogels were studied. According to the results, it was understood that it could release the 5-FU drug approximately 14% when below the transition temperature and pH value, and approximately 99% when above the transition temperature and pH value. The kinetics of the drug release were thoroughly examined. The results of thekinetic study revealed a drug release pattern consistent with Fick's law.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>Synthesis and drug release route for the study</p></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 3","pages":"217 - 230"},"PeriodicalIF":2.8,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138547382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of biomass furan-based PEF copolyester with glycerol","authors":"Chengzhi Liu,&nbsp;Dongsheng Zhao,&nbsp;Maliang Zhang,&nbsp;Kunmei Su,&nbsp;Zhenhuan Li","doi":"10.1007/s13233-023-00208-8","DOIUrl":"10.1007/s13233-023-00208-8","url":null,"abstract":"<div><p>In order to solve the problem of low molecular weight in the synthesis of poly(ethylene 2,5-furandicarboxylate) (PEF) copolyester with titanium-based catalysts, this paper introduce an appropriate amount of glycerol (GC) into PEF to branch the straight chain polyester though the transesterification-melt polycondensation method, which solve the problem of low resin viscosity and low molecular weight. The structures of the copolymers were characterized by ¹H-NMR and ¹³C-NMR, and the results showed that the modified PEF copolyesters and poly(ethylene-co-glycerol 2,5-furandicarboxylate) (PEGFs) were successfully prepared. The intrinsic viscosity ([η]) of PEGFs copolyesters was characterized by Ubbelohde viscosity, and the results showed that the copolyester [η] was increased from 0.25 dL/g to 0.755 dL/g. The thermal properties of copolyester were characterized by differential scanning calorimetry and thermo gravimetry, and it was found that the glass transition temperature of PEGFs copolyester increased from 67.8 °C to 89.5 °C, and the maximum pyrolysis rate temperature increased from 386.6 °C to 402.8 °C. We characterized the UV resistance of PEGFs copolyester, and the results showed that PEGFs copolyester could be well degraded under ultraviolet light.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 1","pages":"59 - 70"},"PeriodicalIF":2.8,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138505617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced physico-mechanical properties of EVA/PA blends via electron beam irradiation and vinyl acetate content","authors":"Jawad Ahmed","doi":"10.1007/s13233-023-00223-9","DOIUrl":"10.1007/s13233-023-00223-9","url":null,"abstract":"<div><p>This study investigates the effects of electron beam (E-beam) irradiation on ethylene-vinyl acetate copolymer/ternary polyamide (EVA/tPA) blends with varying vinyl acetate (VA) content (19%, 28%, and 33%). The EVA/tPA blends were exposed to E-beam doses ranging from 50 to 300 kGy, with the addition of trimethylolpropane triacrylate (TMPTMA) and triallyl isocyanurate (TAIC) as crosslinking co-agents. SEM analysis and FTIR spectroscopy confirmed that increasing the VA content in the EVA/tPA blends significantly improved compatibility after E-beam irradiation, resulting in enhanced tensile strength, storage modulus, and surface smoothness. The EVA/tPA/TMPTMA blend with 33% VA content exhibited a remarkable 132% increase in tensile strength and a 212% increase in storage modulus due to enhanced crosslinking formation post-irradiation. However, irradiation led to a decrease in elongation at break and blend crystallinity. TMPTMA co-agents demonstrated superior compatibility compared to TAIC, further enhancing the overall properties of the EVA/tPA blends. In conclusion, E-beam irradiation is an effective technique for producing high-performance EVA/tPA blends by utilizing higher VA content and suitable co-agents. These improved materials hold great potential for various applications, particularly in the oil pipeline and automotive industries.</p><h3>Graphical abstract</h3><p>Enhanced EVA/PA blend properties via electron beam crosslinking</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 3","pages":"207 - 216"},"PeriodicalIF":2.8,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138505598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance lithium–sulfur batteries utilizing charged binder and solid-state ionogel electrolyte","authors":"Jeong Mu Heo,&nbsp;Junyoung Mun,&nbsp;Keun Hyung Lee","doi":"10.1007/s13233-023-00214-w","DOIUrl":"10.1007/s13233-023-00214-w","url":null,"abstract":"<div><p>Lithium–sulfur (Li–S) batteries have garnered significant attention as next-generation energy storage devices owing to their eco-friendly nature and high theoretical energy density. However, the practical implementation of Li–S batteries faces several challenges, with the two primary issues being the shuttle effect caused by polysulfide dissolution and the slow reaction kinetics of sulfur. To address these challenges, we proposed the combination of a charged binder and a solid-state ionogel electrolyte. In this strategy, we employed charged poly(diallyldimethylammonium bis(trifluoromethylsulfonyl)imide) (PDDATFSI) as a binder to enhance the adsorption of polysulfides and facilitate the faster movement of lithium ions, thereby ensuring accelerated reaction kinetics. The ionogel further suppressed the shuttle effect owing to its low solubility in polysulfides, limited compatibility with the polymer host, and high viscosity. The resulting Li–S coin cells, using both the PDDATFSI binder and solid-state ionogel, exhibited a high initial discharge capacity of 1027 mAh/g at 0.1 °C, with superior discharge capacity retention exceeding 70% (750 mAh/g) after 100 cycles, maintaining 100% coulombic efficiency. Additionally, we successfully fabricated flexible pouch cells that powered a camp light and 100 LEDs in a bent state. These results highlight their significant potential as deformable and high-capacity energy storage devices in the future.</p><h3>Graphic abstract</h3><p>High-performance, flexible Lithium-sulfur (Li-S) batteries were fabricated using a charged binder and a solid-state ionogel electrolyte. Flexible Li-S cells successfully powered a camp light and 100 LEDs in a bent state, indicating their significant potential as next-generation, deformable, high-capacity energy storage devices. </p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 2","pages":"187 - 196"},"PeriodicalIF":2.8,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138505597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atractylodin induces apoptosis through downregulation of PI3Kγ-mediated PI3K/Akt/mTOR/p70S6K signalling in colon cancer cells and suppresses the tumour formation in xenograft mice model","authors":"Wenyi Lu,&nbsp;Jianxia Liu,&nbsp;Bin Wu,&nbsp;Shungen Huang,&nbsp;Jian Wang,&nbsp;Runda Wu,&nbsp;Zhongqi Mao","doi":"10.1007/s13233-023-00220-y","DOIUrl":"10.1007/s13233-023-00220-y","url":null,"abstract":"<div><p>This study used both in vitro and in vivo models to evaluate the efficacy of atractylodin as an anticancer treatment for colorectal cancer. The cytotoxicity of atractylodin on colon cancer cells was assessed using the MTT assay, and atractylodin-induced apoptosis was determined using flow cytometry. The expression of cleaved caspase 3 and other apoptotic proteins was examined using Western blotting to determine the mechanism underlying atractylodin's anticancer activity. In addition, the role of PI3K/Akt/mTOR/p70S6K signalling in atractylodin-induced apoptosis in colon cancer cells was analyzed. The study found that atractylodin caused dose-dependent ROS-mediated apoptosis and DNA damage in colon cancer cells and activated caspase 3. Furthermore, atractylodin inhibited the PI3K/Akt/mTOR/p70S6K signalling pathway by targeting PI3Kγ in colon cancer cells. Molecular docking analysis indicated that atractylodin binds to the Akt binding pocket of PI3Kγ. The study also evaluated the antitumour effects of atractylodin on a colon cancer tumour xenograft model and found that it significantly reduced tumour growth and volume by inducing apoptosis. These results suggest that atractylodin has potential as a candidate for the treatment of colorectal cancer, although further research is necessary.</p><h3>Graphical abstract</h3><p>\u0000Atractylodin induces apoptosis in colon cancer cells. </p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 2","pages":"159 - 171"},"PeriodicalIF":2.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13233-023-00220-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138505542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of acid-activated reversible conversion supramolecular nanoplatform: application in drug delivery and anti-tumor activity","authors":"Cuiting Yang,&nbsp;Xiangyu Chen,&nbsp;Jinkui Teng,&nbsp;Shuai Chen,&nbsp;Jianmei Yang,&nbsp;Xiaoqing Liu,&nbsp;Junnan He,&nbsp;Jin Zhang,&nbsp;Yan Zhao","doi":"10.1007/s13233-023-00209-7","DOIUrl":"10.1007/s13233-023-00209-7","url":null,"abstract":"<div><p>Supramolecular nanoplatforms with stimuli-responsive behavior feature sensitive performance and effective drug delivery, which are desirable as intelligent drug delivery systems. Generally, tumor cells are characterized by excessive acid production, resulting in a lower pH in the tumor microenvironment (pH &lt; 6.5) than in normal tissues (pH ≈7.4) and providing the possibility for the drug delivery system to exploit this decrease in pH as a trigger for drug release. Here, an acid-sensitive supramolecular nanoplatform (CM-β-CD/FC₁₂⁺Br⁻ NPs) with assembly/disassembly properties was designed and constructed, which was exploited to capture, deliver, and release anti-tumor compound CSL. 2D NOESY was utilized to examine the host–guest interaction and the potential mechanism for CM-β-CD/FC₁₂⁺Br⁻ NPs loading CSL. CM-β-CD/FC₁₂⁺Br⁻ NPs present good blood compatibility. Cytotoxicity assay revealed that CSL-loaded NPs display minimal toxicity against normal cells BEAS-2B and good anticancer ability against five human cancer cell lines, especially for Human hepatoma cell line SMMC-7721. In addition, cell apoptosis and cycle assay further verified that CSL-loaded NPs-induced apoptosis in SMMC-7721 cells up to ~ 93%, as well as blocking the cells in G0/G1 phase and inhibiting the proliferation of SMMC-7721 cells in a dose-dependent manner. We expect that CM-β-CD/FC₁₂⁺Br⁻ NPs will be potential acid-answered drug delivery candidates.</p><h3>Graphical Abstract</h3><p>The acid-activated reversible conversion CM-β-CD/ FC₁₂⁺Br⁻ nanoparticles (NPs) are constructed to trap, deliver and release anti-liver cancer compound Celastrol (CSL). CSL-loaded NPs display a high release rate of CSL at the acidic environment within hepatoma cells, exhibit a high cytotoxicity and apoptotic rate for SMMC-7721 cells and arrest the cells at G0/G1 phase in a dose-dependent manner. CM-β-CD/ FC₁₂⁺Br⁻ NPs help to realize liver cancer treatment.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 1","pages":"71 - 83"},"PeriodicalIF":2.8,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13233-023-00209-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138505543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}