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A label-free electrochemical genosensor based on maleimide-functionalised polypyrrole 基于马来酰亚胺功能化聚吡咯的无标记电化学基因传感器
IF 4.9 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc05463c
Bojin Zhang,Tingting Liu,Sepehr Talebian,Theja Prabhakar,Sina Naficy,John R. D. Hervey,Haoxiang Zeng,Markus Müllner,Fariba Dehghani,Bicheng Zhu,Jadranka Travas-Sejdic
{"title":"A label-free electrochemical genosensor based on maleimide-functionalised polypyrrole","authors":"Bojin Zhang,Tingting Liu,Sepehr Talebian,Theja Prabhakar,Sina Naficy,John R. D. Hervey,Haoxiang Zeng,Markus Müllner,Fariba Dehghani,Bicheng Zhu,Jadranka Travas-Sejdic","doi":"10.1039/d6cc05463c","DOIUrl":"https://doi.org/10.1039/d6cc05463c","url":null,"abstract":"An electropolymerised polypyrrole (PPy) doped with novel, functional poly(styrene sulfonate)-block-poly(ethylene glycol)-maleimide (PSS-b-maleimide) is developed for label-free electrochemical detection of the sxtA4 gene, a biomarker of saxitoxin-producing microalgae. In PSS-b-maleimide, the sulfonate block serves as a dopant for the growing PPy film, while the pendant maleimide functionality covalently anchors a thiolated oligonucleotide probe, specific to the sxtA4 gene, by thiol–maleimide coupling. The developed sensor provides a wide linear detection range spanning seven decades, from 1 fM to 10 nM, a detection limit of 0.83 fM and clear discrimination against non-complementary and single-base-mismatched targets.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"68 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EDA Complex-Enabled, Substituent-Controlled Switch in Anthranil Reactivity for Sequential Access to Azaaurones EDA络合物启用，取代基控制的蒽醌反应性开关顺序访问氮杂龙
IF 4.9 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc04638j
Khushboo Tiwari,Mayank Singh,Annapurna Awasthi,Rudraasingh Rajpoot,Supriya Rej,Dharmendra Kumar Tiwari
{"title":"EDA Complex-Enabled, Substituent-Controlled Switch in Anthranil Reactivity for Sequential Access to Azaaurones","authors":"Khushboo Tiwari,Mayank Singh,Annapurna Awasthi,Rudraasingh Rajpoot,Supriya Rej,Dharmendra Kumar Tiwari","doi":"10.1039/d6cc04638j","DOIUrl":"https://doi.org/10.1039/d6cc04638j","url":null,"abstract":"A sequential protocol has been developed for the synthesis of azaaurones from readily available anthranils and olefins. The transformation proceeds via palladium-catalyzed C3-alkenylation of anthranils to afford C3-styrylanthranil intermediates, which subsequently undergo skeletal rearrangement in the presence of THIQ·HCl. Mechanistic studies suggest that THIQ·HCl forms an electron donor–acceptor (EDA) complex with the styrylanthranil intermediate, facilitating N-O bond cleavage and nitrene generation. The resulting nitrene undergoes cyclization to form an aziridine intermediate, which subsequently rearranges to afford the azaaurone. Notably, the compatibility of this protocol with biologically relevant styrene derivatives highlights its potential for the late-stage functionalization of complex molecules.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"85 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repurposing a polymerization photoinitiator as a self-immolative photodynamic agent for hypoxic cancer therapy. 聚合光引发剂作为自焚光动力剂用于缺氧癌症治疗。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc04973g
Yueya Zhang, Yuxuan Tu, Zhishuo Li, Siyu Li, Fangxin Xu, Luyao Zhou, Biqing Bao, Lianhui Wang
{"title":"Repurposing a polymerization photoinitiator as a self-immolative photodynamic agent for hypoxic cancer therapy.","authors":"Yueya Zhang, Yuxuan Tu, Zhishuo Li, Siyu Li, Fangxin Xu, Luyao Zhou, Biqing Bao, Lianhui Wang","doi":"10.1039/d6cc04973g","DOIUrl":"https://doi.org/10.1039/d6cc04973g","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is limited by poor tissue penetration, oxygen dependence, and prolonged photosensitivity. A self-immolative near-infrared (NIR) nanoplatform that repurposes a commercial photoinitiator through upconversion-mediated NIR excitation was developed to overcome tumor hypoxia and minimize post-treatment phototoxicity.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneous g-C3N4/Pd metallaphotocatalysis for mild C(sp3)-Cl bond activation in α-chloro carbonyl compounds. α-氯羰基化合物中轻度C(sp3)-Cl键活化的异相g-C3N4/Pd金属光催化。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc04600b
Qiuxia Zhang, Jiancheng Yang, Yingying Wei, Zongwei Li, Shicong Wang, Xiaohan Hao, Shuying Wang, Heng Li, Bingxin Yuan
{"title":"Heterogeneous g-C<sub>3</sub>N<sub>4</sub>/Pd metallaphotocatalysis for mild C(sp<sup>3</sup>)-Cl bond activation in α-chloro carbonyl compounds.","authors":"Qiuxia Zhang, Jiancheng Yang, Yingying Wei, Zongwei Li, Shicong Wang, Xiaohan Hao, Shuying Wang, Heng Li, Bingxin Yuan","doi":"10.1039/d6cc04600b","DOIUrl":"https://doi.org/10.1039/d6cc04600b","url":null,"abstract":"<p><p>Photoinduced electron transfer from g-C<sub>3</sub>N<sub>4</sub> to Pd generates electron-rich Pd species that facilitate challenging C(sp<sup>3</sup>)-Cl activation in α-chlorocarbonyl compounds. The heterogeneous metallaphotocatalytic system enables visible-light-driven Suzuki-Miyaura coupling under mild aqueous conditions using a recyclable catalyst.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ynone-triggered ring expansion of indandiones: transition-metal-free access to benzoannulated seven-membered rings. 壬烯引发的吲哚酮的环扩张：无过渡金属的苯并环七元环。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc05404h
Sahil Mondal, Sayanta Roy, Priyanka Priyadarshini, Tarun Kumar Roy, Barla Thirupathi
{"title":"Ynone-triggered ring expansion of indandiones: transition-metal-free access to benzoannulated seven-membered rings.","authors":"Sahil Mondal, Sayanta Roy, Priyanka Priyadarshini, Tarun Kumar Roy, Barla Thirupathi","doi":"10.1039/d6cc05404h","DOIUrl":"https://doi.org/10.1039/d6cc05404h","url":null,"abstract":"<p><p>A transition-metal-free ring expansion of 2-(2'-ketoalkyl)-1,3-indandiones with ynones provides access to benzotropones and cyclohepta-fused furans under mild basic conditions. The transformation proceeds through a ynone-triggered annulation followed by cyclization and dehydration, generating a key intermediate that undergoes retro-Claisen-type C-C bond cleavage to furnish structurally complex fused furan-tropone frameworks. The method exhibits broad substrate scope and good functional-group tolerance, including heteroaryl and aliphatic ynone partners, and its synthetic utility is demonstrated by gram-scale synthesis and diverse product derivatizations.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifunctional molecule interface engineering enables the development of efficient and stable inorganic CsPbI3 perovskite solar cells. 多功能分子界面工程是开发高效稳定无机CsPbI3钙钛矿太阳能电池的重要手段。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc05456k
Fuling Guo, Chao Wang, Fufan Huang, Feng Chen, Yunyun Wu, Meng Wang, Jiajiu Ye
{"title":"Multifunctional molecule interface engineering enables the development of efficient and stable inorganic CsPbI<sub>3</sub> perovskite solar cells.","authors":"Fuling Guo, Chao Wang, Fufan Huang, Feng Chen, Yunyun Wu, Meng Wang, Jiajiu Ye","doi":"10.1039/d6cc05456k","DOIUrl":"https://doi.org/10.1039/d6cc05456k","url":null,"abstract":"<p><p>A multifunctional molecule, methyl 3-formyl-4-hydroxybenzoate (MHBA), was applied as an interface modification layer for inverted inorganic CsPbI<sub>3</sub> solar cells. The MHBA enabled strong interactions with undercoordinated species, effectively passivating interfacial defects and stabilizing the surface lattice of CsPbI<sub>3</sub> films. Consequently, an enhanced PCE of 21.11% was achieved with a remarkably improved <i>V</i><sub>oc</sub> of 1.211 V and retained ∼91% of the initial PCE after ∼1000 h of storage under an N<sub>2</sub> atmosphere at 25 °C in the dark without encapsulation.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The acridone anion as a highly reducing visible-light photocatalyst. 吖啶酮阴离子作为高还原性可见光光催化剂。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc05207j
Alejandro Heredero Sánchez, Burkhard König, Indrajit Ghosh
{"title":"The acridone anion as a highly reducing visible-light photocatalyst.","authors":"Alejandro Heredero Sánchez, Burkhard König, Indrajit Ghosh","doi":"10.1039/d6cc05207j","DOIUrl":"https://doi.org/10.1039/d6cc05207j","url":null,"abstract":"<p><p>Highly reducing photocatalysts enable the activation of strong chemical bonds under mild conditions. Here, we report that, upon visible-light excitation, deprotonated acridone generates a highly reducing excited state that activates (hetero)aryl halides, including chlorides, for C-B, C-P, C-S, and C-C bond formation, and, in combination with nickel catalysis, enables C-N bond formation. Mechanistic studies confirm that the excited-state acridone anion is capable of a single-electron transfer to aryl halides for bond activation.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-mode fluorescence sensing platform based on Zn2+@UiO-66-NH2 nanozyme for sensitive and wide-range detection of ATP 基于Zn2+@UiO-66-NH2纳米酶的双模荧光传感平台，用于ATP的灵敏和大范围检测
IF 4.9 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc06324a
Tong Xu,Yuefei Luo,Ruting Zheng,Liqiang Yang,Min Wang
{"title":"Dual-mode fluorescence sensing platform based on Zn2+@UiO-66-NH2 nanozyme for sensitive and wide-range detection of ATP","authors":"Tong Xu,Yuefei Luo,Ruting Zheng,Liqiang Yang,Min Wang","doi":"10.1039/d6cc06324a","DOIUrl":"https://doi.org/10.1039/d6cc06324a","url":null,"abstract":"A dual-mode fluorescence platform based on a Zn2+@UiO-66-NH2 nanozyme is developed for ATP detection, utilizing both the material's intrinsic fluorescence and its phosphatase-like activity. This strategy achieves a broad linear range (0.05–35 μM) with high sensitivity (LOD as low as 0.046 μM), offering a versatile tool for ATP analysis in biomedical research and pharmaceutical quality control.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"1 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149152657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Who Stores the Charge? Mechanism Validation in Aqueous Multivalent-Ion Batteries 谁来储存电荷？多价离子电池的机理验证
IF 4.9 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc05610e
Chen Chen,Lien Zhu,Farah Qayyum,Ke Chang,Shihzad Shakil,Jiarui Huang
{"title":"Who Stores the Charge? Mechanism Validation in Aqueous Multivalent-Ion Batteries","authors":"Chen Chen,Lien Zhu,Farah Qayyum,Ke Chang,Shihzad Shakil,Jiarui Huang","doi":"10.1039/d6cc05610e","DOIUrl":"https://doi.org/10.1039/d6cc05610e","url":null,"abstract":"Aqueous multivalent-ion batteries are widely regarded as promising systems for safe and low-cost energy storage. However, a central assumption underlying this field remains insufficiently validated: that the named multivalent cation is the primary charge carrier. This review critically examines charge-storage mechanisms in aqueous batteries based on Zn2+, Mg2+, Ca2+, Al3+, and Mn-based chemistries, with emphasis on identifying the actual charge carrier, the operative reaction pathway, and the level of evidence required for mechanistic assignment. Across these systems, proton insertion, co-insertion, dissolution–deposition, and conversion reactions can dominate or coexist with nominal multivalent-ion intercalation, depending on electrode and electrolyte chemistry. Electrochemical signatures alone are shown to be insufficient for mechanism identification, as distinct processes can produce similar voltage profiles and cycling behavior. A critical assessment of experimental approaches reveals that reliable validation requires quantitative ion tracking, operando characterization, and correlation across multiple techniques. On this basis, a framework is proposed to distinguish competing mechanisms and define minimum standards for mechanistic claims. Establishing clear validation criteria is essential for directing material design and avoiding misinterpretation in aqueous battery research.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"26 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tools for DNA-encoded library synthesis. dna编码文库合成工具。
IF 4.3 2区 化学
Chemical Communications Pub Date : 2026-10-14 DOI: 10.1039/d6cc05320c
Johannes Bingold, Zhuo Li, Lisa Liang, Johannes Schmidt, Chun Zhang, Andreas Brunschweiger
{"title":"Tools for DNA-encoded library synthesis.","authors":"Johannes Bingold, Zhuo Li, Lisa Liang, Johannes Schmidt, Chun Zhang, Andreas Brunschweiger","doi":"10.1039/d6cc05320c","DOIUrl":"https://doi.org/10.1039/d6cc05320c","url":null,"abstract":"<p><p>DNA-encoded libraries (DELs) are a widely used technology for screening drug-like compounds en masse on biological targets. DEL screens help in assessing the ligandability of biological targets, yielding chemical biology probes, and identifying starting points for clinical drug development. DELs are most often synthesized by combinatorial chemistry routes in homogeneous aqueous solutions to obtain libraries with vast numbers of compounds. Aqueous conditions, the chemical reactivity of the DNA barcode, and the combinatorial workflow limit the synthesis methodology to a few validated DEL synthesis methods. In this review, we will discuss strategies to broaden the scope of reactions for DEL synthesis. These are barcoding strategies that include chemically modified DNA barcodes, solid-phase strategies, methods to solubilize the polar, polycationic DNA in non-aqueous organic solvents, and tailored catalysts for DNA-encoded chemistry.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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