钯催化亲电试剂吡啶基磷盐与芳噻吩盐交叉偶联制备c4 -芳基化吡啶

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-09-25 DOI:10.1039/d5cc05044h

Chen Chen, Zi-Yi Wang, Xiao-Xu Zhang, Kui Wang, Bolin Zhu

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引用次数: 0

摘要

我们报道了钯催化的吡啶基磷和芳噻吩盐之间的亲电交叉偶联，使芳烃与吡啶能够选择性地形成C-H / C-H交叉偶联，在温和的条件下提供c4 -芳基化吡啶。该方法为生物相关分子的后期功能化提供了良好的官能团耐受性，可扩展性和宝贵的潜力。

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Pd-Catalyzed Electrophile Cross-Coupling of Pyridylphosphonium Salts with Arylthianthrenium Salts to Access C4-Arylated Pyridines

We reported a palladium-catalyzed electrophilic cross-coupling between pyridylphosphonium and arylthianthrenium salts that enables site-selective formal C–H/C–H cross-coupling of arenes with pyridines, providing C4-arylated pyridines under mild conditions. This methodology offers excellent functional group tolerance, scalability, and valuable potential for late-stage functionalization of biorelevant molecules.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.